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PRJNA195909:zebrafish embryo and larva development
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Results for hey2_hey1+heyl
Z-value: 0.73
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Transcription factors associated with hey2_hey1+heyl
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000013441 | hes-related family bHLH transcription factor with YRPW motif 2 | |
| ENSDARG00000055798 | hes related family bHLH transcription factor with YRPW motif like | |
| ENSDARG00000070538 | hes-related family bHLH transcription factor with YRPW motif 1 | |
| ENSDARG00000112770 | hes related family bHLH transcription factor with YRPW motif like |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| heyl | dr11_v1_chr19_+_32553874_32553874 | 0.66 | 5.3e-02 | Click! |
| hey2 | dr11_v1_chr20_-_39596338_39596338 | -0.41 | 2.8e-01 | Click! |
| hey1 | dr11_v1_chr19_-_31802296_31802296 | 0.40 | 2.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_7607114 Show fit | 1.20 |
ENSDART00000158095
|
solute carrier family 16, member 9b |
|
| chr19_-_24555935 Show fit | 1.18 |
ENSDART00000132660
ENSDART00000162801 |
polymerase (RNA) III (DNA directed) polypeptide G like a |
|
| chr4_-_13580348 Show fit | 1.10 |
ENSDART00000067160
|
opsin 1 (cone pigments), short-wave-sensitive 1 |
|
| chr19_-_24555623 Show fit | 1.10 |
ENSDART00000176022
|
polymerase (RNA) III (DNA directed) polypeptide G like a |
|
| chr1_-_39943596 Show fit | 0.98 |
ENSDART00000149730
|
storkhead box 2a |
|
| chr9_-_56272465 Show fit | 0.91 |
ENSDART00000039235
|
lymphocyte cytosolic protein 1 (L-plastin) |
|
| chr6_+_12968101 Show fit | 0.89 |
ENSDART00000013781
|
minichromosome maintenance complex component 6 |
|
| chr24_-_12938922 Show fit | 0.85 |
ENSDART00000024084
|
phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
|
| chr17_+_25414033 Show fit | 0.84 |
ENSDART00000001691
|
L-threonine dehydrogenase 2 |
|
| chr11_-_3552067 Show fit | 0.79 |
ENSDART00000163656
|
si:dkey-33m11.6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of hey2_hey1+heyl
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.0 | 1.9 | GO:0007601 | visual perception(GO:0007601) |
| 0.4 | 1.2 | GO:0071830 | chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831) |
| 0.0 | 1.1 | GO:0007602 | phototransduction(GO:0007602) |
| 0.2 | 0.9 | GO:0019626 | glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548) |
| 0.1 | 0.9 | GO:0036388 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 0.3 | 0.8 | GO:0048389 | intermediate mesoderm development(GO:0048389) |
| 0.1 | 0.8 | GO:0006567 | threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567) |
| 0.1 | 0.8 | GO:0006285 | base-excision repair, AP site formation(GO:0006285) |
| 0.0 | 0.8 | GO:0043049 | otic placode formation(GO:0043049) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 1.7 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.3 | 1.2 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.1 | 1.0 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 0.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.8 | GO:0042555 | MCM complex(GO:0042555) |
| 0.2 | 0.7 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 0.0 | 0.7 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.6 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 0.5 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 1.3 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.4 | 1.2 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 1.1 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
| 0.2 | 0.9 | GO:1990518 | ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518) |
| 0.0 | 0.9 | GO:0030145 | manganese ion binding(GO:0030145) |
| 0.2 | 0.8 | GO:0004365 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.2 | 0.8 | GO:0008743 | L-threonine 3-dehydrogenase activity(GO:0008743) |
| 0.1 | 0.8 | GO:0008263 | mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263) |
| 0.2 | 0.7 | GO:0004903 | growth hormone receptor activity(GO:0004903) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.4 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.3 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 0.3 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 0.3 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.2 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.2 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 0.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 0.6 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.6 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.6 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.5 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.5 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.4 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.4 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |