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PRJNA195909:zebrafish embryo and larva development

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Results for hic1

Z-value: 1.02

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Transcription factors associated with hic1

Gene Symbol Gene ID Gene Info
hic1
ENSDARG00000055493 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hic1dr11_v1_chr15_+_25683069_256830690.863.2e-03Click!

Activity profile of hic1 motif

Sorted Z-values of hic1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_77561679 2.36 ENSDART00000180809
AL935186.9

chr4_+_55778679 2.26 ENSDART00000183009
CT583728.19

chr4_+_55794876 2.26 ENSDART00000189043
CT583728.17

chr4_+_55810436 2.26 ENSDART00000182875
CT583728.16

chr4_-_68568233 2.26 ENSDART00000184284
BX548011.1

chr4_-_55728559 2.16 ENSDART00000186201
CT583728.14

chr23_+_45845159 1.42 ENSDART00000023944
lmnl3
lamin L3
chr23_+_45845423 1.11 ENSDART00000183404
lmnl3
lamin L3
chr16_+_25285998 1.09 ENSDART00000154112
si:dkey-29h14.10
si:dkey-29h14.10
chr1_-_8928841 1.01 ENSDART00000103652
grin2ab
glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b
chr5_+_393738 1.00 ENSDART00000161456
june
JunE proto-oncogene, AP-1 transcription factor subunit
chr1_+_45839927 0.97 ENSDART00000148086
ENSDART00000180413
ENSDART00000048191
ENSDART00000179047
map2k7
mitogen-activated protein kinase kinase 7
chr6_+_28203 0.96 ENSDART00000191561
CZQB01141835.1

chr17_-_8976307 0.96 ENSDART00000092113
zranb1b
zinc finger, RAN-binding domain containing 1b
chr16_+_41067586 0.87 ENSDART00000181876
scap
SREBF chaperone
chr23_-_31060350 0.84 ENSDART00000145598
ENSDART00000191491
si:ch211-197l9.5
si:ch211-197l9.5
chr8_+_54137350 0.68 ENSDART00000164153
brpf1
bromodomain and PHD finger containing, 1
chr3_+_17653784 0.68 ENSDART00000159984
ENSDART00000157682
ENSDART00000187937
kat2a
K(lysine) acetyltransferase 2A
chr2_-_19354622 0.64 ENSDART00000168627
zfyve9a
zinc finger, FYVE domain containing 9a
chr3_+_37083765 0.59 ENSDART00000125611
retreg3
reticulophagy regulator family member 3
chr1_+_18863060 0.59 ENSDART00000139241
rnf38
ring finger protein 38
chr9_-_14992730 0.52 ENSDART00000137117
pard3bb
par-3 family cell polarity regulator beta b
chr15_-_9421481 0.51 ENSDART00000189045
ENSDART00000177158
sacs
sacsin molecular chaperone
chr11_-_6420917 0.48 ENSDART00000193717
FO681393.2

chr5_-_42123794 0.46 ENSDART00000051135
emc6
ER membrane protein complex subunit 6
chr17_-_49412313 0.39 ENSDART00000152100
mthfd1b
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
chr19_-_38830582 0.38 ENSDART00000189966
ENSDART00000183055
adgrb2
adhesion G protein-coupled receptor B2
chr10_-_2682198 0.36 ENSDART00000183727
pdxp
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr2_-_36819624 0.35 ENSDART00000140844
slitrk3b
SLIT and NTRK-like family, member 3b
chr8_-_13678415 0.32 ENSDART00000134153
ENSDART00000143331
si:dkey-258f14.3
si:dkey-258f14.3
chr2_+_21063660 0.32 ENSDART00000022765
riok1
RIO kinase 1 (yeast)
chr4_-_797831 0.29 ENSDART00000158970
ENSDART00000170012
mapre3b
microtubule-associated protein, RP/EB family, member 3b
chr25_-_1687481 0.28 ENSDART00000163553
ENSDART00000179460
mon2
MON2 homolog, regulator of endosome-to-Golgi trafficking
chr19_-_12967986 0.28 ENSDART00000151064
slc25a32a
solute carrier family 25 (mitochondrial folate carrier), member 32a
chr7_-_24995631 0.27 ENSDART00000173955
ENSDART00000173791
rcor2
REST corepressor 2
chr12_-_979789 0.23 ENSDART00000128188
daglb
diacylglycerol lipase, beta
chr13_+_421231 0.23 ENSDART00000188212
ENSDART00000017854
lgi1a
leucine-rich, glioma inactivated 1a
chr12_-_54375 0.21 ENSDART00000152304
si:ch1073-357b18.4
si:ch1073-357b18.4
chr3_+_46762703 0.17 ENSDART00000133283
prkcsh
protein kinase C substrate 80K-H
chr19_+_17642356 0.14 ENSDART00000176431
CR382334.1

chr14_-_48588422 0.09 ENSDART00000161147
si:ch211-154c21.1
si:ch211-154c21.1
chr6_-_1874664 0.09 ENSDART00000007972
dlgap4b
discs, large (Drosophila) homolog-associated protein 4b
chr22_-_18116635 0.08 ENSDART00000005724
ncanb
neurocan b
chr3_-_56896702 0.03 ENSDART00000023265
ush1ga
Usher syndrome 1Ga (autosomal recessive)
chr5_+_62723233 0.01 ENSDART00000183718
nanos2
nanos homolog 2
chr16_+_50006145 0.01 ENSDART00000049375
ube2e2
ubiquitin-conjugating enzyme E2E 2

Network of associatons between targets according to the STRING database.

First level regulatory network of hic1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.1 0.5 GO:0051660 establishment of centrosome localization(GO:0051660)
0.1 0.6 GO:0072575 hepatocyte proliferation(GO:0072574) epithelial cell proliferation involved in liver morphogenesis(GO:0072575)
0.1 0.4 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.1 0.9 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 0.5 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.1 0.6 GO:0061709 reticulophagy(GO:0061709)
0.1 0.2 GO:0098920 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.1 0.7 GO:1903010 regulation of bone development(GO:1903010)
0.1 1.0 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 0.7 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 1.0 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 0.3 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 0.4 GO:0035999 tetrahydrofolate interconversion(GO:0035999)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.7 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.5 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.2 GO:0017177 glucosidase II complex(GO:0017177)
0.0 0.7 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.3 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.9 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 2.2 GO:0005882 intermediate filament(GO:0005882)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 0.3 GO:0008517 folic acid transporter activity(GO:0008517)
0.1 1.0 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.4 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.5 GO:0032977 membrane insertase activity(GO:0032977)
0.1 1.0 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.7 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 0.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.9 GO:0032934 sterol binding(GO:0032934)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.9 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.7 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.0 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.2 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling