ISMARA results: hmx2

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PRJNA195909:zebrafish embryo and larva development

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Results for hmx2_hmx3a

Z-value: 1.79

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Transcription factors associated with hmx2_hmx3a

Gene Symbol	Gene ID	Gene Info
hmx2 NCBI UniProt	ENSDARG00000070954	H6 family homeobox 2
hmx2 NCBI UniProt	ENSDARG00000115364	H6 family homeobox 2
hmx3a NCBI UniProt	ENSDARG00000070955	H6 family homeobox 3a
hmx3a NCBI UniProt	ENSDARG00000115051	H6 family homeobox 3a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
hmx2	dr11_v1_chr17_-_21784152_21784152	-0.95	1.1e-04	Click!
hmx3a	dr11_v1_chr17_-_21793113_21793113	-0.92	4.4e-04	Click!

Activity profile of hmx2_hmx3a motif

Sorted Z-values of hmx2_hmx3a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr24_-_9997948 Show fit	3.45	ENSDART00000136274	si:ch211-146l10.7 NCBI UniProt Show fit	si:ch211-146l10.7
chr24_-_10014512 Show fit	3.43	ENSDART00000124341 ENSDART00000191630	zgc:171474 NCBI UniProt Show fit	zgc:171474
chr17_-_27223965 Show fit	2.67	ENSDART00000192577	asap3 NCBI UniProt Show fit	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr11_+_18157260 Show fit	2.66	ENSDART00000144659	zgc:173545 NCBI UniProt Show fit	zgc:173545
chr17_+_50701748 Show fit	2.55	ENSDART00000191938 ENSDART00000183220 ENSDART00000049464	fermt2 NCBI UniProt Show fit	fermitin family member 2
chr10_-_1961930 Show fit	2.54	ENSDART00000122446	tdgf1 NCBI UniProt Show fit	teratocarcinoma-derived growth factor 1
chr11_+_18130300 Show fit	2.51	ENSDART00000169146	zgc:175135 NCBI UniProt Show fit	zgc:175135
chr7_-_4461104 Show fit	2.21	ENSDART00000023090 ENSDART00000140770	slc12a10.1 NCBI UniProt Show fit	solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 1
chr19_-_868187 Show fit	2.18	ENSDART00000186626	eomesa NCBI UniProt Show fit	eomesodermin homolog a
chr15_-_41689981 Show fit	2.08	ENSDART00000059327	spsb4b NCBI UniProt Show fit	splA/ryanodine receptor domain and SOCS box containing 4b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of hmx2_hmx3a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.2	GO:0043547	positive regulation of GTPase activity(GO:0043547)
0.1	3.6	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
0.0	2.8	GO:0048545	response to steroid hormone(GO:0048545)
0.0	2.8	GO:0032259	methylation(GO:0032259)
0.8	2.5	GO:0090008	hypoblast development(GO:0090008)
0.3	2.5	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.7	2.2	GO:0055109	invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.1	2.2	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.1	2.2	GO:0006884	cell volume homeostasis(GO:0006884)
0.2	2.0	GO:0006797	polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)

Showing 1 to 10 of 220 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.5	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.0	2.8	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	2.7	GO:0000151	ubiquitin ligase complex(GO:0000151)
0.0	2.7	GO:0009897	external side of plasma membrane(GO:0009897)
0.4	2.6	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	2.6	GO:0005882	intermediate filament(GO:0005882)
0.1	2.1	GO:0071565	nBAF complex(GO:0071565)
0.5	1.9	GO:0005880	nuclear microtubule(GO:0005880)
0.1	1.9	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	1.9	GO:0005802	trans-Golgi network(GO:0005802)

Showing 1 to 10 of 98 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.5	GO:0005096	GTPase activator activity(GO:0005096)
0.0	4.2	GO:0042393	histone binding(GO:0042393)
0.3	3.8	GO:0070697	activin receptor binding(GO:0070697)
0.3	3.6	GO:0031729	CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.0	3.2	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	3.1	GO:0019208	phosphatase regulator activity(GO:0019208)
0.2	2.5	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	2.3	GO:0043130	ubiquitin binding(GO:0043130)
0.4	2.2	GO:0003980	UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.2	2.2	GO:0008511	sodium:potassium:chloride symporter activity(GO:0008511)

Showing 1 to 10 of 175 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.1	2.2	PID AURORA A PATHWAY	Aurora A signaling
0.0	1.7	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	1.6	PID REELIN PATHWAY	Reelin signaling pathway
0.1	1.3	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	1.3	PID AURORA B PATHWAY	Aurora B signaling
0.1	1.2	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	1.2	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.1	1.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	1.1	PID FOXM1 PATHWAY	FOXM1 transcription factor network

Showing 1 to 10 of 29 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.3	2.5	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.1	2.0	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	2.0	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	1.9	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	1.8	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.1	1.6	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1	1.5	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.1	1.4	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.1	1.2	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels

Showing 1 to 10 of 50 entries

Results for hmx2_hmx3a

Z-value: 1.79

Motif logo

Transcription factors associated with hmx2_hmx3a

Activity-expression correlation:

Activity profile of hmx2_hmx3a motif

Sorted Z-values of hmx2_hmx3a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of hmx2_hmx3a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: