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PRJNA195909:zebrafish embryo and larva development

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Results for hnf1a

Z-value: 1.76

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Transcription factors associated with hnf1a

Gene Symbol Gene ID Gene Info
hnf1a
ENSDARG00000009470 HNF1 homeobox a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hnf1adr11_v1_chr8_+_39802506_39802506-0.627.4e-02Click!

Activity profile of hnf1a motif

Sorted Z-values of hnf1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_-_45920 4.54 ENSDART00000040422
bhmt
betaine-homocysteine methyltransferase
chr5_+_32345187 3.90 ENSDART00000147132
c9
complement component 9
chr8_+_999421 3.72 ENSDART00000149528
fabp1b.1
fatty acid binding protein 1b, tandem duplicate 1
chr22_-_23625351 3.66 ENSDART00000192588
ENSDART00000163423
cfhl4
complement factor H like 4
chr24_-_39610585 3.30 ENSDART00000066506
cox6b1
cytochrome c oxidase subunit VIb polypeptide 1
chr17_+_4030493 3.19 ENSDART00000151849
hao1
hydroxyacid oxidase (glycolate oxidase) 1
chr22_-_23668356 3.11 ENSDART00000167106
ENSDART00000159622
ENSDART00000163228
cfh
complement factor H
chr16_-_42894628 2.85 ENSDART00000045600
hfe2
hemochromatosis type 2
chr1_+_10051763 2.83 ENSDART00000011701
fgb
fibrinogen beta chain
chr22_-_17595310 2.77 ENSDART00000099056
gpx4a
glutathione peroxidase 4a
chr20_+_10544100 2.69 ENSDART00000113927
serpina1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr25_+_31323978 2.68 ENSDART00000067030
lsp1
lymphocyte-specific protein 1
chr13_-_40726865 2.65 ENSDART00000099847
st3gal7
ST3 beta-galactoside alpha-2,3-sialyltransferase 7
chr2_+_55984788 2.28 ENSDART00000183599
nmrk2
nicotinamide riboside kinase 2
chr22_-_23748284 2.22 ENSDART00000162005
cfhl2
complement factor H like 2
chr25_-_27541621 2.21 ENSDART00000130678
spam1
sperm adhesion molecule 1
chr22_+_12770877 2.13 ENSDART00000044683
ftcd
formimidoyltransferase cyclodeaminase
chr20_+_18741089 2.13 ENSDART00000183218
fam167ab
family with sequence similarity 167, member Ab
chr3_+_15505275 2.09 ENSDART00000141714
nupr1
nuclear protein 1
chr22_-_17611742 2.05 ENSDART00000144031
gpx4a
glutathione peroxidase 4a
chr23_+_32335871 1.95 ENSDART00000149698
slc39a5
solute carrier family 39 (zinc transporter), member 5
chr16_+_11724230 1.93 ENSDART00000060266
ceacam1
carcinoembryonic antigen-related cell adhesion molecule 1
chr1_-_12126535 1.87 ENSDART00000164817
ENSDART00000015251
mttp
microsomal triglyceride transfer protein
chr12_+_15666949 1.81 ENSDART00000079803
nmt1b
N-myristoyltransferase 1b
chr8_+_26522013 1.73 ENSDART00000046863
sema3bl
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl
chr24_-_32665283 1.73 ENSDART00000038364
ca2
carbonic anhydrase II
chr15_+_27364394 1.70 ENSDART00000122101
tbx2b
T-box 2b
chr21_+_25236297 1.70 ENSDART00000112783
tmem45b
transmembrane protein 45B
chr21_-_23308286 1.68 ENSDART00000184419
zbtb16a
zinc finger and BTB domain containing 16a
chr12_-_20373058 1.63 ENSDART00000066382
aqp8a.1
aquaporin 8a, tandem duplicate 1
chr5_-_56513825 1.62 ENSDART00000024207
tbx2a
T-box 2a
chr7_-_25895189 1.60 ENSDART00000173599
ENSDART00000079235
ENSDART00000173786
ENSDART00000173602
ENSDART00000079245
ENSDART00000187568
ENSDART00000173505
cd99l2
CD99 molecule-like 2
chr10_-_41664427 1.58 ENSDART00000150213
ggt1b
gamma-glutamyltransferase 1b
chr8_+_13106760 1.51 ENSDART00000029308
itgb4
integrin, beta 4
chr4_+_7827261 1.51 ENSDART00000129568
phyh
phytanoyl-CoA 2-hydroxylase
chr10_-_8033468 1.49 ENSDART00000140476
atp6v0a2a
ATPase H+ transporting V0 subunit a2a
chr23_-_20345473 1.47 ENSDART00000140935
si:rp71-17i16.6
si:rp71-17i16.6
chr21_+_37442458 1.42 ENSDART00000180161
ENSDART00000186950
cox7b
cytochrome c oxidase subunit VIIb
chr5_-_37886063 1.42 ENSDART00000131378
ENSDART00000132152
si:ch211-139a5.9
si:ch211-139a5.9
chr11_+_43419809 1.41 ENSDART00000172982
slc29a1b
solute carrier family 29 (equilibrative nucleoside transporter), member 1b
chr6_+_7977611 1.38 ENSDART00000112290
palm3
paralemmin 3
chr22_-_26100282 1.37 ENSDART00000166075
pdgfaa
platelet-derived growth factor alpha polypeptide a
chr24_-_17039638 1.37 ENSDART00000048823
c8g
complement component 8, gamma polypeptide
chr2_-_17828279 1.36 ENSDART00000083314
ptprfb
protein tyrosine phosphatase, receptor type, f, b
chr21_-_44104600 1.35 ENSDART00000044599
oatx
organic anion transporter X
chr7_-_4296771 1.35 ENSDART00000128855
cbln11
cerebellin 11
chr9_+_21151138 1.33 ENSDART00000133903
hao2
hydroxyacid oxidase 2 (long chain)
chr9_-_14108896 1.31 ENSDART00000135209
prkag3b
protein kinase, AMP-activated, gamma 3b non-catalytic subunit
chr24_+_14713776 1.31 ENSDART00000134475
gdap1
ganglioside induced differentiation associated protein 1
chr11_-_23332592 1.29 ENSDART00000125024
golt1a
golgi transport 1A
chr12_-_6177894 1.29 ENSDART00000152292
a1cf
apobec1 complementation factor
chr12_+_31673588 1.28 ENSDART00000152971
dnmbp
dynamin binding protein
chr12_-_6172154 1.27 ENSDART00000185434
a1cf
apobec1 complementation factor
chr8_-_18535822 1.27 ENSDART00000100558
nexn
nexilin (F actin binding protein)
chr5_+_26795773 1.26 ENSDART00000145631
tcn2
transcobalamin II
chr22_-_26005894 1.26 ENSDART00000105088
pdgfaa
platelet-derived growth factor alpha polypeptide a
chr24_-_4765740 1.23 ENSDART00000121576
cpb1
carboxypeptidase B1 (tissue)
chr2_+_26647472 1.23 ENSDART00000145415
ENSDART00000157409
ttpa
tocopherol (alpha) transfer protein
chr16_+_55059026 1.23 ENSDART00000109391
LO017815.1
Danio rerio nuclear receptor coactivator 7-like (LOC792958), mRNA.
chr25_-_27541288 1.22 ENSDART00000187245
spam1
sperm adhesion molecule 1
chr22_-_23706771 1.22 ENSDART00000159771
cfhl1
complement factor H like 1
chr7_+_27250186 1.21 ENSDART00000150068
sox6
SRY (sex determining region Y)-box 6
chr10_+_20108557 1.20 ENSDART00000142708
dmtn
dematin actin binding protein
chr8_-_47800754 1.11 ENSDART00000115050
ENSDART00000133669
kank3
KN motif and ankyrin repeat domains 3
chr5_+_9348284 1.09 ENSDART00000149417
tal2
T-cell acute lymphocytic leukemia 2
chr3_+_49521106 1.09 ENSDART00000162799
crb3a
crumbs homolog 3a
chr3_+_40170216 1.08 ENSDART00000011568
syngr3a
synaptogyrin 3a
chr2_-_43635777 1.07 ENSDART00000148633
itgb1b.1
integrin, beta 1b.1
chr8_-_13013123 1.05 ENSDART00000147802
dennd2da
DENN/MADD domain containing 2Da
chr10_+_4499943 1.02 ENSDART00000125299
plk2a
polo-like kinase 2a (Drosophila)
chr16_-_9675982 1.02 ENSDART00000113724
mal2
mal, T cell differentiation protein 2 (gene/pseudogene)
chr10_-_8032885 1.00 ENSDART00000188619
atp6v0a2a
ATPase H+ transporting V0 subunit a2a
chr20_+_22666548 0.99 ENSDART00000147520
lnx1
ligand of numb-protein X 1
chr10_+_35439952 0.98 ENSDART00000006284
hhla2a.2
HERV-H LTR-associating 2a, tandem duplicate 2
chr21_+_44684577 0.96 ENSDART00000099528
spry4
sprouty homolog 4 (Drosophila)
chr7_-_59564011 0.94 ENSDART00000186053
zgc:112271
zgc:112271
chr15_-_23467750 0.93 ENSDART00000148804
pdzd3a
PDZ domain containing 3a
chr1_-_22851481 0.92 ENSDART00000054386
qdprb1
quinoid dihydropteridine reductase b1
chr21_+_43669943 0.90 ENSDART00000136025
tmlhe
trimethyllysine hydroxylase, epsilon
chr18_+_13182528 0.90 ENSDART00000166298
zgc:56622
zgc:56622
chr20_+_18740799 0.89 ENSDART00000174532
fam167ab
family with sequence similarity 167, member Ab
chr6_+_30456788 0.87 ENSDART00000121492
FP236735.1

chr6_+_34028532 0.87 ENSDART00000155827
si:ch73-185c24.2
si:ch73-185c24.2
chr24_+_23791758 0.86 ENSDART00000066655
ENSDART00000146580
mybl1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr13_+_23988442 0.86 ENSDART00000010918
agt
angiotensinogen
chr3_+_26734162 0.86 ENSDART00000114552
si:dkey-202l16.5
si:dkey-202l16.5
chr2_-_5475910 0.83 ENSDART00000100954
ENSDART00000172143
ENSDART00000132496
proca
proca
protein C (inactivator of coagulation factors Va and VIIIa), a
protein C (inactivator of coagulation factors Va and VIIIa), a
chr3_-_16250527 0.83 ENSDART00000146699
ENSDART00000141181
bckdhbl
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr6_+_54221654 0.83 ENSDART00000128456
pacsin1b
protein kinase C and casein kinase substrate in neurons 1b
chr1_-_21409877 0.81 ENSDART00000102782
gria2a
glutamate receptor, ionotropic, AMPA 2a
chr9_+_4429593 0.81 ENSDART00000184855
FP015810.1

chr22_-_36770649 0.77 ENSDART00000169442
acy1
aminoacylase 1
chr2_-_5466708 0.74 ENSDART00000136682
proca
protein C (inactivator of coagulation factors Va and VIIIa), a
chr1_+_26667872 0.73 ENSDART00000152803
ENSDART00000152144
ENSDART00000152785
ENSDART00000152393
hemgn
hemogen
chr17_+_15033822 0.71 ENSDART00000154987
samd4a
sterile alpha motif domain containing 4A
chr19_-_22387141 0.71 ENSDART00000151234
eppk1
epiplakin 1
chr7_-_35066457 0.71 ENSDART00000058067
zgc:112160
zgc:112160
chr13_-_42579437 0.71 ENSDART00000135172
fam83ha
family with sequence similarity 83, member Ha
chr15_-_17869115 0.71 ENSDART00000112838
atf5b
activating transcription factor 5b
chr8_+_7144066 0.69 ENSDART00000146306
slc6a6a
solute carrier family 6 (neurotransmitter transporter), member 6a
chr24_-_20016817 0.68 ENSDART00000082201
ENSDART00000189448
slc22a13b
solute carrier family 22 member 13b
chr19_+_24882845 0.67 ENSDART00000010580
si:ch211-195b13.1
si:ch211-195b13.1
chr23_-_24394719 0.67 ENSDART00000044918
epha2b
eph receptor A2 b
chr15_-_17868870 0.67 ENSDART00000170950
atf5b
activating transcription factor 5b
chr7_-_29625509 0.66 ENSDART00000173723
rorab
RAR-related orphan receptor A, paralog b
chr2_-_5404466 0.66 ENSDART00000152907
si:ch1073-184j22.2
si:ch1073-184j22.2
chr9_+_30720048 0.63 ENSDART00000146115
klf12b
Kruppel-like factor 12b
chr5_+_45322734 0.60 ENSDART00000084411
adamts3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr21_-_23307653 0.60 ENSDART00000140284
ENSDART00000134103
zbtb16a
zinc finger and BTB domain containing 16a
chr14_-_32884138 0.60 ENSDART00000105726
slc25a5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr2_+_49417900 0.59 ENSDART00000122742
ENSDART00000160783
rorcb
RAR-related orphan receptor C b
chr24_-_23675446 0.58 ENSDART00000066644
hnf4g
hepatocyte nuclear factor 4, gamma
chr22_+_38978084 0.56 ENSDART00000025482
arhgef3
Rho guanine nucleotide exchange factor (GEF) 3
chr4_+_57881965 0.56 ENSDART00000162234
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr20_-_7293837 0.54 ENSDART00000100060
dsc2l
desmocollin 2 like
chr8_+_1187928 0.54 ENSDART00000127252
slc35d2
solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
chr7_-_10560964 0.54 ENSDART00000172761
ENSDART00000170476
mthfs
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
chr9_+_29994439 0.54 ENSDART00000012447
tmem30c
transmembrane protein 30C
chr18_-_5111449 0.52 ENSDART00000046902
pdcd10a
programmed cell death 10a
chr20_-_25481306 0.52 ENSDART00000182495
si:dkey-183n20.15
si:dkey-183n20.15
chr6_+_20647155 0.51 ENSDART00000193477
slc19a1
solute carrier family 19 (folate transporter), member 1
chr20_+_18740518 0.51 ENSDART00000142196
fam167ab
family with sequence similarity 167, member Ab
chr15_+_9297340 0.46 ENSDART00000055554
slc37a4a
solute carrier family 37 (glucose-6-phosphate transporter), member 4a
chr4_+_2620751 0.46 ENSDART00000013924
gpr22a
G protein-coupled receptor 22a
chr5_+_21225017 0.44 ENSDART00000141573
si:dkey-13n15.11
si:dkey-13n15.11
chr11_+_25129013 0.40 ENSDART00000132879
ndrg3a
ndrg family member 3a
chr3_-_34337969 0.40 ENSDART00000151634
tnrc6c1
trinucleotide repeat containing 6C1
chr10_+_21867307 0.39 ENSDART00000126629
cbln17
cerebellin 17
chr21_+_39100289 0.39 ENSDART00000075958
slc13a2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr3_+_31039923 0.38 ENSDART00000147706
cox6a2
cytochrome c oxidase subunit VIa polypeptide 2
chr5_-_63302944 0.38 ENSDART00000047110
gsnb
gelsolin b
chr21_+_38002879 0.37 ENSDART00000065183
cldn2
claudin 2
chr4_-_9533345 0.37 ENSDART00000128501
si:ch73-139j3.4
si:ch73-139j3.4
chr14_-_17622080 0.37 ENSDART00000112149
si:ch211-159i8.4
si:ch211-159i8.4
chr6_+_8622228 0.36 ENSDART00000110470
tspeara
thrombospondin-type laminin G domain and EAR repeats a
chr6_-_39344259 0.36 ENSDART00000104074
zgc:158846
zgc:158846
chr7_-_29534001 0.35 ENSDART00000124028
anxa2b
annexin A2b
chr6_+_28141135 0.35 ENSDART00000113405
ENSDART00000179795
inpp5d
inositol polyphosphate-5-phosphatase D
chr15_+_29283981 0.33 ENSDART00000099895
rap1gap2a
RAP1 GTPase activating protein 2a
chr20_+_35473288 0.32 ENSDART00000047195
mep1a.1
meprin A, alpha (PABA peptide hydrolase), tandem duplicate 1
chr14_+_740032 0.32 ENSDART00000165014
klb
klotho beta
chr1_-_59348118 0.32 ENSDART00000170901
cyp3a65
cytochrome P450, family 3, subfamily A, polypeptide 65
chr1_-_19502322 0.32 ENSDART00000181888
ENSDART00000044030
kitb
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b
chr20_+_6543674 0.31 ENSDART00000134204
tns3.1
tensin 3, tandem duplicate 1
chr9_-_9977827 0.31 ENSDART00000187315
ENSDART00000010246
ugt1ab
UDP glucuronosyltransferase 1 family a, b
chr5_+_9377005 0.30 ENSDART00000124924
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr23_+_25856541 0.30 ENSDART00000145426
ENSDART00000028236
hnf4a
hepatocyte nuclear factor 4, alpha
chr4_+_18804317 0.30 ENSDART00000101043
slc26a3.2
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr19_-_22568203 0.29 ENSDART00000182888
pleca
plectin a
chr16_+_11623956 0.29 ENSDART00000137788
cxcr3.1
chemokine (C-X-C motif) receptor 3, tandem duplicate 1
chr3_+_54761569 0.29 ENSDART00000135913
ENSDART00000180983
si:ch211-74m13.1
si:ch211-74m13.1
chr20_-_25436389 0.27 ENSDART00000153266
itsn2a
intersectin 2a
chr16_+_11603096 0.26 ENSDART00000146286
si:dkey-11o1.3
si:dkey-11o1.3
chr4_+_76416268 0.26 ENSDART00000174351
ENSDART00000191591
zgc:113209
FP074874.1
zgc:113209

chr5_-_29488245 0.26 ENSDART00000047719
ENSDART00000141154
ENSDART00000171165
cacna1ba
calcium channel, voltage-dependent, N type, alpha 1B subunit, a
chr9_-_9982696 0.25 ENSDART00000192548
ENSDART00000125852
ugt1ab
UDP glucuronosyltransferase 1 family a, b
chr4_-_56954002 0.25 ENSDART00000160934
si:dkey-269o24.1
si:dkey-269o24.1
chr5_+_9382301 0.25 ENSDART00000124017
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr18_+_9382847 0.24 ENSDART00000061886
sema3ab
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab
chr3_-_34084387 0.24 ENSDART00000155365
ighv4-3
immunoglobulin heavy variable 4-3
chr4_+_34119824 0.24 ENSDART00000165637
si:ch211-223g7.6
si:ch211-223g7.6
chr12_+_6117682 0.23 ENSDART00000146650
asah2
N-acylsphingosine amidohydrolase 2
chr6_+_38381957 0.23 ENSDART00000087300
gabrb3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr5_+_9417409 0.22 ENSDART00000125421
ENSDART00000130265
ugt2b5
UDP glucuronosyltransferase 2 family, polypeptide B5
chr25_+_23280220 0.21 ENSDART00000153940
ptprjb.1
protein tyrosine phosphatase, receptor type, Jb, tandem duplicate 1
chr6_-_56103718 0.19 ENSDART00000191002
gcnt7
glucosaminyl (N-acetyl) transferase family member 7
chr4_+_45484774 0.19 ENSDART00000150573
si:dkey-256i11.6
si:dkey-256i11.6
chr18_+_15683157 0.19 ENSDART00000140933
si:ch211-264e16.2
si:ch211-264e16.2
chr3_+_28576173 0.19 ENSDART00000151189
sept12
septin 12
chr2_-_41942666 0.18 ENSDART00000075673
ebi3
Epstein-Barr virus induced 3
chr21_+_21803596 0.18 ENSDART00000084600
ENSDART00000184899
neu3.3
sialidase 3 (membrane sialidase), tandem duplicate 3
chr19_+_20274491 0.18 ENSDART00000090860
ENSDART00000151693
oxnad1
oxidoreductase NAD-binding domain containing 1
chr2_-_48396061 0.17 ENSDART00000161657
si:ch211-195j11.30
si:ch211-195j11.30
chr17_-_47305034 0.17 ENSDART00000150116
alk
ALK receptor tyrosine kinase
chr21_-_31286428 0.16 ENSDART00000185334
ca4c
carbonic anhydrase IV c
chr14_-_11507211 0.16 ENSDART00000186873
ENSDART00000109181
ENSDART00000186166
ENSDART00000186986
zgc:174917
zgc:174917
chr5_-_65158203 0.15 ENSDART00000171656
sh2d3cb
SH2 domain containing 3Cb
chr9_-_1459985 0.15 ENSDART00000124777
osbpl6
oxysterol binding protein-like 6
chr19_+_20274944 0.14 ENSDART00000151237
oxnad1
oxidoreductase NAD-binding domain containing 1
chr2_-_24402341 0.12 ENSDART00000155442
ENSDART00000088572
zgc:154006
zgc:154006
chr21_-_38853737 0.11 ENSDART00000184100
tlr22
toll-like receptor 22
chr4_-_32642681 0.11 ENSDART00000188695
ENSDART00000193974
si:dkey-265e7.1
si:dkey-265e7.1
chr2_-_44746723 0.10 ENSDART00000041806
acsm3
acyl-CoA synthetase medium chain family member 3
chr5_+_13385837 0.10 ENSDART00000191190
ccl19a.1
chemokine (C-C motif) ligand 19a, tandem duplicate 1
chr21_+_21803363 0.10 ENSDART00000081184
neu3.3
sialidase 3 (membrane sialidase), tandem duplicate 3
chr9_+_27339505 0.09 ENSDART00000011822
slc10a2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr12_+_5209822 0.09 ENSDART00000152610
SLC35G1
si:ch211-197g18.2
chr6_+_28140816 0.09 ENSDART00000137907
inpp5d
inositol polyphosphate-5-phosphatase D
chr11_-_37997419 0.08 ENSDART00000102870
slc41a1
solute carrier family 41 (magnesium transporter), member 1
chr2_-_27609189 0.06 ENSDART00000040555
lyn
LYN proto-oncogene, Src family tyrosine kinase
chr10_+_7255695 0.05 ENSDART00000161506
ENSDART00000181304
fut10
fucosyltransferase 10
chr9_+_28688574 0.05 ENSDART00000101319
zgc:162396
zgc:162396
chr4_-_67980261 0.05 ENSDART00000182305
si:ch211-223k15.1
si:ch211-223k15.1
chr16_-_31980948 0.05 ENSDART00000182427
CR854927.4

chr18_+_17786548 0.04 ENSDART00000189493
ENSDART00000146133
ZNF423
si:ch211-216l23.1
chr19_+_31043002 0.04 ENSDART00000171591
ankmy2b
ankyrin repeat and MYND domain containing 2b
chr18_+_3530769 0.04 ENSDART00000163469
si:ch73-338a16.3
si:ch73-338a16.3
chr3_-_18047150 0.04 ENSDART00000020376
hsd17b1
hydroxysteroid (17-beta) dehydrogenase 1
chr15_+_35139457 0.03 ENSDART00000059204
slc19a3a
solute carrier family 19 (thiamine transporter), member 3a
chr5_+_9405283 0.03 ENSDART00000127306
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7

Network of associatons between targets according to the STRING database.

First level regulatory network of hnf1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.1 3.3 GO:0072068 distal convoluted tubule development(GO:0072025) late distal convoluted tubule development(GO:0072068)
0.7 2.1 GO:0015942 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.7 4.9 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.6 1.8 GO:0006499 N-terminal protein myristoylation(GO:0006499) N-terminal peptidyl-glycine N-myristoylation(GO:0018008) protein myristoylation(GO:0018377)
0.5 2.6 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.4 1.7 GO:0015670 carbon dioxide transport(GO:0015670)
0.4 1.3 GO:0006824 cobalt ion transport(GO:0006824) cobalamin transport(GO:0015889)
0.3 1.6 GO:0031179 peptide modification(GO:0031179)
0.3 4.5 GO:0009086 methionine biosynthetic process(GO:0009086)
0.2 3.1 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.2 1.4 GO:0015862 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.2 1.9 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.2 1.9 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.2 1.0 GO:0045056 transcytosis(GO:0045056)
0.2 2.8 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.2 2.6 GO:0016556 mRNA modification(GO:0016556)
0.2 1.3 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.2 2.5 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.2 2.3 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.2 0.5 GO:1903358 regulation of Golgi organization(GO:1903358)
0.2 0.5 GO:0051958 folic acid transport(GO:0015884) drug transport(GO:0015893) methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.2 1.4 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.1 0.6 GO:0015865 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.1 0.9 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.5 GO:0002159 desmosome assembly(GO:0002159)
0.1 0.7 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.1 1.0 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.1 1.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.0 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.1 1.3 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.3 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.1 0.5 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.1 0.4 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.1 0.7 GO:0060612 adipose tissue development(GO:0060612)
0.1 1.2 GO:0006775 fat-soluble vitamin metabolic process(GO:0006775)
0.1 0.4 GO:0090024 negative regulation of leukocyte chemotaxis(GO:0002689) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.1 0.2 GO:0044320 leptin-mediated signaling pathway(GO:0033210) cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.1 1.1 GO:1902017 regulation of cilium assembly(GO:1902017)
0.1 0.8 GO:0048899 anterior lateral line development(GO:0048899)
0.1 0.9 GO:0001990 regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.0 1.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.2 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.8 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.9 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 1.3 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 1.1 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 4.8 GO:0006979 response to oxidative stress(GO:0006979)
0.0 0.9 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 1.1 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 1.1 GO:0021514 ventral spinal cord interneuron differentiation(GO:0021514)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.7 GO:0045104 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.0 1.6 GO:0007596 blood coagulation(GO:0007596)
0.0 0.3 GO:0070365 hepatocyte differentiation(GO:0070365)
0.0 1.4 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.3 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 1.3 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of chemotaxis(GO:0050922) negative regulation of axon guidance(GO:1902668)
0.0 0.8 GO:0072348 sulfur compound transport(GO:0072348)
0.0 1.0 GO:0032465 regulation of cytokinesis(GO:0032465)
0.0 0.2 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0 1.6 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.6 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.5 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.0 1.5 GO:0032272 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 1.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.1 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 0.2 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.5 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0044218 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.9 2.8 GO:0005577 fibrinogen complex(GO:0005577)
0.3 3.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 2.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 0.5 GO:0090443 FAR/SIN/STRIPAK complex(GO:0090443)
0.2 1.8 GO:0045095 keratin filament(GO:0045095)
0.1 1.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 2.0 GO:0008305 integrin complex(GO:0008305)
0.0 1.1 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.2 GO:0030428 cell septum(GO:0030428)
0.0 2.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.4 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.8 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.3 GO:0030018 Z disc(GO:0030018)
0.0 1.3 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.0 GO:0000922 spindle pole(GO:0000922)
0.0 0.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.0 GO:0016324 apical plasma membrane(GO:0016324)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.8 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.9 2.7 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.6 1.8 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379)
0.5 2.6 GO:0005542 folic acid binding(GO:0005542)
0.5 1.9 GO:1904121 phosphatidylethanolamine transporter activity(GO:1904121)
0.5 4.5 GO:0008172 S-methyltransferase activity(GO:0008172)
0.3 2.3 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.3 0.9 GO:0030251 cyclase inhibitor activity(GO:0010852) guanylate cyclase inhibitor activity(GO:0030251)
0.3 2.6 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.3 1.6 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.2 3.7 GO:0005504 fatty acid binding(GO:0005504)
0.2 3.1 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.2 1.4 GO:0019215 intermediate filament binding(GO:0019215)
0.2 1.1 GO:0098634 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.2 4.5 GO:0010181 FMN binding(GO:0010181)
0.2 1.6 GO:0015250 water channel activity(GO:0015250)
0.2 1.3 GO:0031419 cobalamin binding(GO:0031419)
0.2 0.9 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 2.5 GO:0051117 ATPase binding(GO:0051117)
0.1 0.6 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.1 0.5 GO:0005463 UDP-glucuronic acid transmembrane transporter activity(GO:0005461) UDP-N-acetylgalactosamine transmembrane transporter activity(GO:0005463)
0.1 2.0 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 1.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 1.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 1.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.7 GO:0004046 aminoacylase activity(GO:0004046)
0.1 0.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.8 GO:0033691 sialic acid binding(GO:0033691)
0.0 1.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.3 GO:0016208 AMP binding(GO:0016208)
0.0 0.7 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 1.3 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 2.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 2.6 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.7 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.7 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.4 GO:0055102 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.0 1.5 GO:0005178 integrin binding(GO:0005178)
0.0 0.3 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.3 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 2.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.2 GO:0004100 chitin synthase activity(GO:0004100)
0.0 0.8 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.0 1.0 GO:0019842 vitamin binding(GO:0019842)
0.0 2.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.7 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 2.0 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.0 GO:0008201 heparin binding(GO:0008201)
0.0 2.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 2.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 1.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.3 PID BMP PATHWAY BMP receptor signaling
0.0 0.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 3.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.2 PID IL27 PATHWAY IL27-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.3 2.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 5.3 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.2 4.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 1.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.7 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 1.9 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 4.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 2.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.9 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 2.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 5.2 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 0.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.6 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 0.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors