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PRJNA195909:zebrafish embryo and larva development

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Results for hoxb4a

Z-value: 0.50

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Transcription factors associated with hoxb4a

Gene Symbol Gene ID Gene Info
hoxb4a
ENSDARG00000013533 homeobox B4a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb4adr11_v1_chr3_+_23721808_23721808-0.963.6e-05Click!

Activity profile of hoxb4a motif

Sorted Z-values of hoxb4a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_57473980 0.83 ENSDART00000149353
ENSDART00000150034
pias4b
protein inhibitor of activated STAT, 4b
chr24_+_26402110 0.83 ENSDART00000133684
si:ch211-230g15.5
si:ch211-230g15.5
chr4_-_17257435 0.79 ENSDART00000131973
lrmp
lymphoid-restricted membrane protein
chr17_+_19626479 0.77 ENSDART00000044993
ENSDART00000131863
rgs7a
regulator of G protein signaling 7a
chr11_-_13341051 0.74 ENSDART00000121872
mast3b
microtubule associated serine/threonine kinase 3b
chr23_+_27756984 0.66 ENSDART00000137103
kmt2d
lysine (K)-specific methyltransferase 2D
chr13_-_33207367 0.65 ENSDART00000146138
ENSDART00000109667
ENSDART00000182741
trip11
thyroid hormone receptor interactor 11
chr15_+_25489406 0.64 ENSDART00000162482
zgc:152863
zgc:152863
chr11_-_13341483 0.62 ENSDART00000164978
mast3b
microtubule associated serine/threonine kinase 3b
chr25_+_5604512 0.62 ENSDART00000042781
plxnb2b
plexin b2b
chr25_+_5972690 0.62 ENSDART00000067517
si:ch211-11i22.4
si:ch211-11i22.4
chr5_-_18446483 0.61 ENSDART00000180027
si:dkey-215k6.1
si:dkey-215k6.1
chr12_-_20616160 0.59 ENSDART00000105362
snx11
sorting nexin 11
chr6_+_18367388 0.56 ENSDART00000163394
dgke
diacylglycerol kinase, epsilon
chr5_-_64103863 0.54 ENSDART00000135014
ENSDART00000083684
pappab
pregnancy-associated plasma protein A, pappalysin 1b
chr18_-_12957451 0.53 ENSDART00000140403
srgap1a
SLIT-ROBO Rho GTPase activating protein 1a
chr13_-_22961605 0.52 ENSDART00000143112
ENSDART00000057641
tspan15
tetraspanin 15
chr25_-_29072162 0.51 ENSDART00000169269
arid3b
AT rich interactive domain 3B (BRIGHT-like)
chr3_+_19687217 0.51 ENSDART00000141937
tlk2
tousled-like kinase 2
chr2_+_44972720 0.46 ENSDART00000075146
alg3
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
chr7_-_19369002 0.46 ENSDART00000165680
ntn4
netrin 4
chr4_-_13255700 0.46 ENSDART00000162277
ENSDART00000026593
grip1
glutamate receptor interacting protein 1
chr15_-_15968883 0.42 ENSDART00000166583
ENSDART00000154042
synrg
synergin, gamma
chr11_+_18205766 0.41 ENSDART00000175559
tmcc1b
transmembrane and coiled-coil domain family 1b
chr21_+_20901505 0.39 ENSDART00000132741
c7b
complement component 7b
chr19_+_33139164 0.38 ENSDART00000043039
fam84b
family with sequence similarity 84, member B
chr9_+_45605410 0.35 ENSDART00000136444
ENSDART00000007189
ENSDART00000158713
ENSDART00000182671
traf3ip1
TNF receptor-associated factor 3 interacting protein 1
chr2_+_23731194 0.35 ENSDART00000155747
slc22a13a
solute carrier family 22 member 13a
chr23_+_384850 0.35 ENSDART00000114000
zgc:101663
zgc:101663
chr16_-_32672883 0.29 ENSDART00000124515
ENSDART00000190920
ENSDART00000188776
pnisr
PNN-interacting serine/arginine-rich protein
chr16_-_18960613 0.29 ENSDART00000183197
fhod3b
formin homology 2 domain containing 3b
chr5_+_20112032 0.29 ENSDART00000130554
isg15
ISG15 ubiquitin-like modifier
chr18_-_42172101 0.29 ENSDART00000124211
cntn5
contactin 5
chr7_+_13988075 0.26 ENSDART00000186812
furina
furin (paired basic amino acid cleaving enzyme) a
chr9_-_3653259 0.26 ENSDART00000140425
ENSDART00000025332
gad1a
glutamate decarboxylase 1a
chr2_-_36818132 0.25 ENSDART00000110447
slitrk3b
SLIT and NTRK-like family, member 3b
chr9_-_15789526 0.25 ENSDART00000141318
si:dkey-103d23.3
si:dkey-103d23.3
chr13_+_18321140 0.24 ENSDART00000180947
eif4e1c
eukaryotic translation initiation factor 4E family member 1c
chr23_-_3721444 0.22 ENSDART00000141682
nudt3a
nudix (nucleoside diphosphate linked moiety X)-type motif 3a
chr18_+_6126506 0.22 ENSDART00000125725
si:ch1073-390k14.1
si:ch1073-390k14.1
chr17_-_114121 0.22 ENSDART00000172408
ENSDART00000157784
arhgap11a
Rho GTPase activating protein 11A
chr19_+_20177208 0.20 ENSDART00000166807
tra2a
transformer 2 alpha homolog
chr8_+_21406769 0.18 ENSDART00000135766
si:dkey-163f12.6
si:dkey-163f12.6
chr4_+_43408004 0.17 ENSDART00000150476
si:dkeyp-53e4.2
si:dkeyp-53e4.2
chr1_+_1712140 0.17 ENSDART00000081047
atp1a1a.1
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 1
chr6_-_43047774 0.16 ENSDART00000161722
glyctk
glycerate kinase
chr18_-_25401002 0.14 ENSDART00000055567
gnrhr4
gonadotropin releasing hormone receptor 4
chr11_+_13223625 0.12 ENSDART00000161275
abcb11b
ATP-binding cassette, sub-family B (MDR/TAP), member 11b
chr2_+_37480669 0.11 ENSDART00000029801
sppl2
signal peptide peptidase-like 2
chr24_+_32472155 0.11 ENSDART00000098859
neurod6a
neuronal differentiation 6a
chr5_+_32924669 0.11 ENSDART00000085219
lmo4a
LIM domain only 4a
chr1_+_11881559 0.10 ENSDART00000166981
snx8b
sorting nexin 8b
chr3_-_51109286 0.09 ENSDART00000172010
si:ch211-148f13.1
si:ch211-148f13.1
chr25_-_4482449 0.08 ENSDART00000056278
ENSDART00000149425
slc25a22a
solute carrier family 25 member 22a
chr1_-_11372456 0.07 ENSDART00000144164
ENSDART00000141238
sdk1b
sidekick cell adhesion molecule 1b
chr23_-_33038423 0.07 ENSDART00000180539
plxna2
plexin A2
chr14_-_30876299 0.06 ENSDART00000180305
ubl3b
ubiquitin-like 3b
chr4_-_2637689 0.06 ENSDART00000192550
ENSDART00000021953
ENSDART00000150344
cog5
component of oligomeric golgi complex 5
chr14_-_30876708 0.06 ENSDART00000147597
ubl3b
ubiquitin-like 3b
chr17_-_8727699 0.06 ENSDART00000049236
ENSDART00000149505
ENSDART00000148619
ENSDART00000149668
ENSDART00000148827
ctbp2a
C-terminal binding protein 2a
chr20_-_32188897 0.05 ENSDART00000133887
si:ch211-51a19.5
si:ch211-51a19.5
chr10_-_15910974 0.04 ENSDART00000148169
pip5k1ba
phosphatidylinositol-4-phosphate 5-kinase, type I, beta a
chr6_+_34870374 0.04 ENSDART00000149356
il23r
interleukin 23 receptor
chr19_-_10425140 0.04 ENSDART00000145319
si:ch211-171h4.3
si:ch211-171h4.3
chr8_-_912821 0.02 ENSDART00000082296
ptger4a
prostaglandin E receptor 4 (subtype EP4) a
chr15_+_17251191 0.02 ENSDART00000156587
si:ch73-223p23.2
si:ch73-223p23.2
chr7_+_27317174 0.01 ENSDART00000193058
sox6
SRY (sex determining region Y)-box 6
chr23_+_3721042 0.01 ENSDART00000143323
smim29
small integral membrane protein 29
chr19_+_28256076 0.01 ENSDART00000133354
irx4b
iroquois homeobox 4b

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb4a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0035046 pronuclear migration(GO:0035046)
0.1 0.7 GO:0003422 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.1 0.5 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.2 GO:1901908 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.4 GO:0090660 regulation of microtubule polymerization(GO:0031113) cerebrospinal fluid circulation(GO:0090660)
0.0 0.5 GO:0099638 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 0.7 GO:1902287 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 0.1 GO:0032782 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0 0.8 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.2 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.1 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.3 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.0 0.5 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.4 GO:0019835 cytolysis(GO:0019835)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.2 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.7 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.8 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.7 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.4 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510) clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.5 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.5 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 0.8 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0008887 glycerate kinase activity(GO:0008887)
0.0 0.1 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.0 0.1 GO:0015432 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.0 0.7 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.6 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling