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PRJNA195909:zebrafish embryo and larva development

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Results for hoxd12a

Z-value: 0.95

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Transcription factors associated with hoxd12a

Gene Symbol Gene ID Gene Info
hoxd12a
ENSDARG00000059263 homeobox D12a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxd12adr11_v1_chr9_-_1984604_1984604-0.771.5e-02Click!

Activity profile of hoxd12a motif

Sorted Z-values of hoxd12a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_1550709 2.71 ENSDART00000110097
si:ch73-303b9.1
si:ch73-303b9.1
chr24_+_34069675 2.32 ENSDART00000143995
si:ch211-190p8.2
si:ch211-190p8.2
chr23_+_17926279 1.39 ENSDART00000012540
chia.4
chitinase, acidic.4
chr22_-_10440688 1.19 ENSDART00000111962
nol8
nucleolar protein 8
chr5_-_31856681 1.16 ENSDART00000187817
pkn3
protein kinase N3
chr21_-_43665537 1.12 ENSDART00000157610
si:dkey-229d11.3
si:dkey-229d11.3
chr1_-_52210950 1.12 ENSDART00000083946
pld6
phospholipase D family, member 6
chr8_+_23861461 1.08 ENSDART00000037109
srpk1a
SRSF protein kinase 1a
chr20_+_405811 1.02 ENSDART00000149311
gpr63
G protein-coupled receptor 63
chr24_+_39027481 0.97 ENSDART00000085565
capn15
calpain 15
chr8_+_52442785 0.95 ENSDART00000189958
zgc:77112
zgc:77112
chr13_-_34862452 0.91 ENSDART00000134573
ENSDART00000047552
sptlc3
serine palmitoyltransferase, long chain base subunit 3
chr14_-_8940499 0.91 ENSDART00000129030
zgc:153681
zgc:153681
chr15_-_4967490 0.90 ENSDART00000180551
lipt2
lipoyl(octanoyl) transferase 2
chr18_-_41161828 0.85 ENSDART00000114993
CABZ01005876.1

chr19_+_28291062 0.81 ENSDART00000163382
lpcat1
lysophosphatidylcholine acyltransferase 1
chr10_-_31805923 0.80 ENSDART00000077785
vps26bl
vacuolar protein sorting 26 homolog B, like
chr17_+_49500820 0.79 ENSDART00000170306
AREL1
apoptosis resistant E3 ubiquitin protein ligase 1
chr15_+_5132439 0.79 ENSDART00000010350
pgm2l1
phosphoglucomutase 2-like 1
chr19_+_28291376 0.78 ENSDART00000139433
ENSDART00000103855
lpcat1
lysophosphatidylcholine acyltransferase 1
chr8_-_12432604 0.77 ENSDART00000133350
ENSDART00000140699
ENSDART00000101174
traf1
TNF receptor-associated factor 1
chr25_-_37121335 0.77 ENSDART00000017805
nfat5a
nuclear factor of activated T cells 5a
chr7_-_55051692 0.76 ENSDART00000170637
tpcn2
two pore segment channel 2
chr21_+_3928947 0.76 ENSDART00000149777
setx
senataxin
chr13_+_35472803 0.76 ENSDART00000011583
mkks
McKusick-Kaufman syndrome
chr17_+_17764979 0.76 ENSDART00000105013
alkbh1
alkB homolog 1, histone H2A dioxygenase
chr13_+_29925397 0.76 ENSDART00000123482
cuedc2
CUE domain containing 2
chr13_-_37631092 0.75 ENSDART00000108855
si:dkey-188i13.7
si:dkey-188i13.7
chr18_+_18000887 0.74 ENSDART00000147797
si:ch211-212o1.2
si:ch211-212o1.2
chr22_-_9860792 0.73 ENSDART00000155908
si:dkey-253d23.2
si:dkey-253d23.2
chr2_-_37458527 0.73 ENSDART00000146820
si:dkey-57k2.7
si:dkey-57k2.7
chr16_-_4610255 0.72 ENSDART00000081852
ENSDART00000123253
ENSDART00000127554
ENSDART00000029485
arnt
aryl hydrocarbon receptor nuclear translocator
chr21_-_22357985 0.72 ENSDART00000101751
skp2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr19_+_7424347 0.72 ENSDART00000004622
sf3b4
splicing factor 3b, subunit 4
chr13_-_17860307 0.71 ENSDART00000135920
ENSDART00000054579
march8
membrane-associated ring finger (C3HC4) 8
chr7_+_55292959 0.70 ENSDART00000147539
ENSDART00000073555
ctu2
cytosolic thiouridylase subunit 2 homolog (S. pombe)
chr15_-_20412286 0.69 ENSDART00000008589
chp2
calcineurin-like EF-hand protein 2
chr13_+_35856463 0.68 ENSDART00000171056
ENSDART00000017202
kcnk1b
potassium channel, subfamily K, member 1b
chr11_-_13341483 0.68 ENSDART00000164978
mast3b
microtubule associated serine/threonine kinase 3b
chr15_-_1590858 0.68 ENSDART00000081875
nnr
nanor
chr20_-_45772306 0.67 ENSDART00000062092
trmt6
tRNA methyltransferase 6 homolog (S. cerevisiae)
chr11_+_43751263 0.67 ENSDART00000163843
zgc:153431
zgc:153431
chr11_-_26832685 0.66 ENSDART00000153519
iqsec1b
IQ motif and Sec7 domain 1b
chr9_+_500052 0.65 ENSDART00000166707
CU984600.1

chr23_+_4226341 0.65 ENSDART00000012445
zgc:113278
zgc:113278
chr9_-_2892045 0.65 ENSDART00000137201
cdca7a
cell division cycle associated 7a
chr5_-_32396929 0.65 ENSDART00000023977
fbxw2
F-box and WD repeat domain containing 2
chr4_+_16768961 0.64 ENSDART00000143926
BX649500.1

chr24_-_5713799 0.64 ENSDART00000137293
dia1b
deleted in autism 1b
chr18_-_17087138 0.64 ENSDART00000135597
zc3h18
zinc finger CCCH-type containing 18
chr3_+_16663373 0.64 ENSDART00000100961
zgc:55558
zgc:55558
chr13_+_39182099 0.62 ENSDART00000131434
fam135a
family with sequence similarity 135, member A
chr6_-_13376060 0.62 ENSDART00000104732
ENSDART00000125271
arl6ip6
ADP-ribosylation factor-like 6 interacting protein 6
chr16_+_5898878 0.62 ENSDART00000180930
ulk4
unc-51 like kinase 4
chr24_-_26632171 0.62 ENSDART00000008374
ENSDART00000017384
tnikb
TRAF2 and NCK interacting kinase b
chr11_+_6881001 0.60 ENSDART00000170331
klhl26
kelch-like family member 26
chr10_-_14943281 0.59 ENSDART00000143608
smad2
SMAD family member 2
chr11_-_36040549 0.59 ENSDART00000112684
setmar
SET domain and mariner transposase fusion gene
chr16_-_30655980 0.59 ENSDART00000146508
ldlrad4b
low density lipoprotein receptor class A domain containing 4b
chr2_+_31330358 0.58 ENSDART00000178066
clul1
clusterin-like 1 (retinal)
chr6_-_13709591 0.58 ENSDART00000151771
chpfb
chondroitin polymerizing factor b
chr7_-_25133783 0.57 ENSDART00000173781
ENSDART00000121943
ENSDART00000077219
badb
BCL2 associated agonist of cell death b
chr19_-_25081711 0.57 ENSDART00000058513
xkr8.3
XK, Kell blood group complex subunit-related family, member 8, tandem duplicate 3
chr22_-_31517300 0.57 ENSDART00000164799
slc6a6b
solute carrier family 6 (neurotransmitter transporter), member 6b
chr19_+_19989380 0.56 ENSDART00000142841
osbpl3a
oxysterol binding protein-like 3a
chr5_-_23696926 0.56 ENSDART00000021462
rnf128a
ring finger protein 128a
chr24_+_21174851 0.56 ENSDART00000154940
ENSDART00000155977
ENSDART00000122762
naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr5_-_32489796 0.56 ENSDART00000168870
gpr107
G protein-coupled receptor 107
chr21_+_11865972 0.55 ENSDART00000081676
ubap1
ubiquitin associated protein 1
chr2_-_34138064 0.55 ENSDART00000133381
cenpl
centromere protein L
chr11_-_18557929 0.55 ENSDART00000110882
ENSDART00000181381
ENSDART00000189312
dido1
death inducer-obliterator 1
chr2_+_55199721 0.54 ENSDART00000016143
zmp:0000000521
zmp:0000000521
chr10_+_2975974 0.53 ENSDART00000147918
zfyve16
zinc finger, FYVE domain containing 16
chr25_-_21066136 0.53 ENSDART00000109520
fbxl14a
F-box and leucine-rich repeat protein 14a
chr15_-_28904371 0.53 ENSDART00000155154
eml2
echinoderm microtubule associated protein like 2
chr15_-_38129845 0.53 ENSDART00000057095
si:dkey-24p1.1
si:dkey-24p1.1
chr4_+_9279515 0.53 ENSDART00000048707
srgap1b
SLIT-ROBO Rho GTPase activating protein 1b
chr2_+_22409249 0.52 ENSDART00000182915
zgc:56628
zgc:56628
chr25_-_37084032 0.52 ENSDART00000025494
hprt1l
hypoxanthine phosphoribosyltransferase 1, like
chr9_-_2892250 0.52 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr3_-_48612078 0.52 ENSDART00000169923
ndel1b
nudE neurodevelopment protein 1-like 1b
chr20_-_44576949 0.52 ENSDART00000148639
ubxn2a
UBX domain protein 2A
chr19_-_7321221 0.51 ENSDART00000092375
oxr1b
oxidation resistance 1b
chr16_+_9713850 0.51 ENSDART00000164103
ecm1b
extracellular matrix protein 1b
chr9_+_20483846 0.51 ENSDART00000192067
ENSDART00000145111
parp4
poly (ADP-ribose) polymerase family, member 4
chr3_-_26191960 0.50 ENSDART00000113843
ypel3
yippee-like 3
chr4_+_16777715 0.50 ENSDART00000148344
BX649476.1

chr9_-_38399432 0.50 ENSDART00000148268
znf142
zinc finger protein 142
chr11_+_25560632 0.50 ENSDART00000033914
mbd1b
methyl-CpG binding domain protein 1b
chr7_-_30624435 0.50 ENSDART00000173828
rnf111
ring finger protein 111
chr22_-_11078988 0.49 ENSDART00000126664
ENSDART00000006927
use1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr24_+_30392834 0.48 ENSDART00000162555
dpyda.1
dihydropyrimidine dehydrogenase a, tandem duplicate 1
chr23_-_27506161 0.48 ENSDART00000145007
asb8
ankyrin repeat and SOCS box containing 8
chr19_-_1948236 0.47 ENSDART00000163344
znrf2a
zinc and ring finger 2a
chr6_+_33885828 0.47 ENSDART00000179994
gpbp1l1
GC-rich promoter binding protein 1-like 1
chr19_+_42227400 0.47 ENSDART00000131574
ENSDART00000135436
jtb
jumping translocation breakpoint
chr3_-_40254634 0.47 ENSDART00000154562
top3a
DNA topoisomerase III alpha
chr23_-_14769523 0.46 ENSDART00000054909
gss
glutathione synthetase
chr15_-_4967302 0.46 ENSDART00000101992
lipt2
lipoyl(octanoyl) transferase 2
chr9_-_29039506 0.45 ENSDART00000100744
tmem177
transmembrane protein 177
chr2_+_54696042 0.45 ENSDART00000074270
ankrd12
ankyrin repeat domain 12
chr25_-_18002498 0.45 ENSDART00000158688
cep290
centrosomal protein 290
chr16_+_42471455 0.45 ENSDART00000166640
si:ch211-215k15.5
si:ch211-215k15.5
chr24_-_24796583 0.45 ENSDART00000144791
ENSDART00000146570
pde7a
phosphodiesterase 7A
chr24_-_16979728 0.44 ENSDART00000005331
klhl15
kelch-like family member 15
chr7_+_18176162 0.44 ENSDART00000109171
rce1a
Ras converting CAAX endopeptidase 1a
chr7_+_31120766 0.44 ENSDART00000173703
tjp1a
tight junction protein 1a
chr6_-_34838397 0.43 ENSDART00000060169
ENSDART00000169605
mier1a
mesoderm induction early response 1a, transcriptional regulator
chr2_-_22966076 0.43 ENSDART00000143412
ENSDART00000146014
ENSDART00000183443
ENSDART00000191056
ENSDART00000183539
sap130b
Sin3A-associated protein b
chr23_-_27505825 0.43 ENSDART00000137229
ENSDART00000013797
asb8
ankyrin repeat and SOCS box containing 8
chr10_+_2582254 0.41 ENSDART00000016103
nxnl2
nucleoredoxin like 2
chr19_-_7272921 0.41 ENSDART00000102075
ENSDART00000132887
ENSDART00000130234
ENSDART00000193535
ENSDART00000136528
rxrba
retinoid x receptor, beta a
chr9_-_9242777 0.41 ENSDART00000021191
u2af1
U2 small nuclear RNA auxiliary factor 1
chr6_-_18228358 0.41 ENSDART00000167937
p4hb
prolyl 4-hydroxylase, beta polypeptide
chr12_-_33646010 0.40 ENSDART00000111259
tmem94
transmembrane protein 94
chr9_+_55321322 0.40 ENSDART00000111111
ENSDART00000191579
nlgn4b
neuroligin 4b
chr6_-_57476465 0.40 ENSDART00000128065
ddx27
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
chr24_+_21174523 0.39 ENSDART00000183849
naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr25_-_34973211 0.39 ENSDART00000045177
cdk10
cyclin-dependent kinase 10
chr6_+_32326074 0.39 ENSDART00000042134
ENSDART00000181177
dock7
dedicator of cytokinesis 7
chr7_-_73846995 0.38 ENSDART00000188079
FP236812.4

chr16_-_31452416 0.38 ENSDART00000140880
ENSDART00000008297
ENSDART00000147373
csnk2a1
casein kinase 2, alpha 1 polypeptide
chr20_-_154989 0.38 ENSDART00000064542
rpf2
ribosome production factor 2 homolog
chr20_-_26391958 0.38 ENSDART00000078062
armt1
acidic residue methyltransferase 1
chr16_-_33650578 0.37 ENSDART00000058460
utp11l
UTP11-like, U3 small nucleolar ribonucleoprotein (yeast)
chr25_+_7241084 0.37 ENSDART00000190501
ENSDART00000190588
hmg20a
high mobility group 20A
chr2_-_6065416 0.37 ENSDART00000037698
uck2b
uridine-cytidine kinase 2b
chr6_-_7711349 0.37 ENSDART00000032494
ttc26
tetratricopeptide repeat domain 26
chr17_+_21760032 0.37 ENSDART00000190425
ikzf5
IKAROS family zinc finger 5
chr11_-_16115804 0.36 ENSDART00000143436
ENSDART00000157928
rpf1
ribosome production factor 1 homolog
chr5_-_23783739 0.36 ENSDART00000139502
GBGT1 (1 of many)
si:ch211-287c22.1
chr12_-_29233738 0.36 ENSDART00000153175
si:ch211-214e3.5
si:ch211-214e3.5
chr6_+_42338309 0.35 ENSDART00000015277
gpx1b
glutathione peroxidase 1b
chr18_+_13275735 0.35 ENSDART00000148127
plcg2
phospholipase C, gamma 2
chr22_+_20169352 0.35 ENSDART00000169055
ENSDART00000061617
hmg20b
high mobility group 20B
chr16_+_32014552 0.35 ENSDART00000047570
mboat7
membrane bound O-acyltransferase domain containing 7
chr12_-_11560794 0.34 ENSDART00000149098
ENSDART00000169975
plekha1b
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b
chr4_-_20108833 0.34 ENSDART00000100867
fam3c
family with sequence similarity 3, member C
chr6_+_3730843 0.34 ENSDART00000019630
FO704755.1

chr18_-_39188664 0.33 ENSDART00000162983
mapk6
mitogen-activated protein kinase 6
chr21_+_13128180 0.32 ENSDART00000081426
odf2a
outer dense fiber of sperm tails 2a
chr6_-_14038804 0.32 ENSDART00000184606
ENSDART00000184609
etv5b
ets variant 5b
chr7_+_30240791 0.32 ENSDART00000109243
sema4bb
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Bb
chr17_+_30843881 0.32 ENSDART00000149600
ENSDART00000148547
tpp1
tripeptidyl peptidase I
chr7_+_14005111 0.32 ENSDART00000187365
furina
furin (paired basic amino acid cleaving enzyme) a
chr24_-_16980337 0.32 ENSDART00000183812
klhl15
kelch-like family member 15
chr15_+_834697 0.31 ENSDART00000154861
ENSDART00000160694
si:dkey-7i4.14
zgc:174573
si:dkey-7i4.14
zgc:174573
chr10_+_15967643 0.31 ENSDART00000136709
apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr11_-_6880725 0.31 ENSDART00000007204
ddx49
DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
chr14_+_8940326 0.31 ENSDART00000159920
rps6kal
ribosomal protein S6 kinase a, like
chr21_-_3007412 0.31 ENSDART00000190839
CKS2
zgc:86839
chr20_-_20355577 0.30 ENSDART00000018500
hif1ab
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b
chr5_-_24542726 0.30 ENSDART00000182975
trmt2a
tRNA methyltransferase 2 homolog A
chr14_+_989733 0.30 ENSDART00000161487
ENSDART00000127317
si:ch73-308l14.2
si:ch73-308l14.2
chr22_+_10440991 0.29 ENSDART00000064805
cenpp
centromere protein P
chr3_-_27065477 0.29 ENSDART00000185660
atf7ip2
activating transcription factor 7 interacting protein 2
chr22_+_10676981 0.29 ENSDART00000138016
hyal2b
hyaluronoglucosaminidase 2b
chr23_+_39611688 0.29 ENSDART00000034690
otud3
OTU deubiquitinase 3
chr16_-_47426482 0.28 ENSDART00000148631
ENSDART00000149723
sept7b
septin 7b
chr17_+_38295847 0.28 ENSDART00000008532
mbip
MAP3K12 binding inhibitory protein 1
chr25_-_3192405 0.28 ENSDART00000104835
hps5
Hermansky-Pudlak syndrome 5
chr6_-_30485009 0.28 ENSDART00000025698
zgc:153311
zgc:153311
chr2_-_45510699 0.28 ENSDART00000024034
ENSDART00000145634
gpsm2
G protein signaling modulator 2
chr2_-_45510223 0.28 ENSDART00000113058
gpsm2
G protein signaling modulator 2
chr5_+_32490595 0.27 ENSDART00000165417
ndor1
NADPH dependent diflavin oxidoreductase 1
chr4_-_74367912 0.27 ENSDART00000174199
ENSDART00000165257
ptprb
protein tyrosine phosphatase, receptor type, b
chr15_+_2857556 0.26 ENSDART00000157758
mre11a
MRE11 homolog A, double strand break repair nuclease
chr3_-_34599662 0.26 ENSDART00000055259
nmrk1
nicotinamide riboside kinase 1
chr7_-_24994722 0.26 ENSDART00000131671
rcor2
REST corepressor 2
chr7_-_26125092 0.26 ENSDART00000079364
snapc2
small nuclear RNA activating complex, polypeptide 2
chr3_-_18373604 0.26 ENSDART00000148132
spag9a
sperm associated antigen 9a
chr5_-_26764880 0.26 ENSDART00000140392
ENSDART00000134728
rnf181
ring finger protein 181
chr14_-_31060082 0.26 ENSDART00000111601
ENSDART00000161113
mbnl3
muscleblind-like splicing regulator 3
chr2_+_26240339 0.26 ENSDART00000191006
palm1b
paralemmin 1b
chr20_-_2355357 0.26 ENSDART00000085281
EPB41L2
si:ch73-18b11.1
chr1_+_45671687 0.25 ENSDART00000146101
mcoln1a
mucolipin 1a
chr25_-_18002937 0.25 ENSDART00000149696
cep290
centrosomal protein 290
chr2_+_26240631 0.25 ENSDART00000129895
palm1b
paralemmin 1b
chr11_-_21303946 0.25 ENSDART00000185786
RASSF5
si:dkey-85p17.3
chr16_-_12060488 0.25 ENSDART00000188733
si:ch211-69g19.2
si:ch211-69g19.2
chr2_-_13254821 0.25 ENSDART00000022621
kdsr
3-ketodihydrosphingosine reductase
chr19_+_30884960 0.24 ENSDART00000140603
ENSDART00000183224
ENSDART00000135484
ENSDART00000139599
yars
tyrosyl-tRNA synthetase
chr10_-_5857548 0.24 ENSDART00000166933
si:ch211-281k19.2
si:ch211-281k19.2
chr3_-_18373425 0.24 ENSDART00000178522
spag9a
sperm associated antigen 9a
chr25_+_3294150 0.24 ENSDART00000030683
tmpob
thymopoietin b
chr16_+_10429770 0.23 ENSDART00000173132
vars
valyl-tRNA synthetase
chr14_+_16287968 0.22 ENSDART00000106593
prpf19
pre-mRNA processing factor 19
chr22_+_12366516 0.22 ENSDART00000157802
r3hdm1
R3H domain containing 1
chr15_-_28262632 0.22 ENSDART00000134601
ENSDART00000175022
prpf8
pre-mRNA processing factor 8
chr25_-_20024829 0.22 ENSDART00000140182
ENSDART00000174776
cnot4a
CCR4-NOT transcription complex, subunit 4a
chr5_+_29715040 0.22 ENSDART00000192563
ddx31
DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
chr10_-_41397663 0.21 ENSDART00000158038
gpat4
glycerol-3-phosphate acyltransferase 4
chr11_+_7214353 0.21 ENSDART00000156764
nwd1
NACHT and WD repeat domain containing 1
chr20_-_23656516 0.21 ENSDART00000149735
cbr4
carbonyl reductase 4
chr7_+_29167744 0.21 ENSDART00000076345
slc38a8b
solute carrier family 38, member 8b
chr16_+_4078240 0.21 ENSDART00000160890
inpp5b
inositol polyphosphate-5-phosphatase B
chr16_-_10071886 0.20 ENSDART00000136168
ENSDART00000130382
ptpn2a
protein tyrosine phosphatase, non-receptor type 2, a
chr16_+_4078608 0.19 ENSDART00000166241
inpp5b
inositol polyphosphate-5-phosphatase B
chr6_+_49742164 0.19 ENSDART00000024578
npepl1
aminopeptidase like 1
chr20_+_38837238 0.18 ENSDART00000061334
ift172
intraflagellar transport 172

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxd12a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0072592 oxygen metabolic process(GO:0072592) regulation of oxygen metabolic process(GO:2000374) positive regulation of oxygen metabolic process(GO:2000376)
0.2 1.0 GO:0071962 establishment of mitotic sister chromatid cohesion(GO:0034087) mitotic sister chromatid cohesion, centromeric(GO:0071962)
0.2 0.7 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.2 0.5 GO:0032263 guanine salvage(GO:0006178) GMP salvage(GO:0032263) guanine biosynthetic process(GO:0046099)
0.2 0.8 GO:0035513 oxidative RNA demethylation(GO:0035513)
0.1 0.4 GO:0071586 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.1 1.4 GO:0006032 chitin catabolic process(GO:0006032)
0.1 0.6 GO:0010991 SMAD protein complex assembly(GO:0007183) regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.7 GO:0032447 tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.1 0.7 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 0.5 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.1 1.1 GO:0043046 DNA methylation involved in gamete generation(GO:0043046)
0.1 0.8 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.4 GO:1990167 protein K27-linked deubiquitination(GO:1990167)
0.1 0.6 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 0.4 GO:0071867 response to monoamine(GO:0071867) response to catecholamine(GO:0071869) response to epinephrine(GO:0071871)
0.1 0.5 GO:0006212 uracil catabolic process(GO:0006212) uracil metabolic process(GO:0019860)
0.1 0.8 GO:2000290 regulation of myotome development(GO:2000290)
0.1 0.4 GO:0030220 platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.1 0.3 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.1 0.5 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 0.9 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.1 0.5 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.4 GO:0008594 photoreceptor cell morphogenesis(GO:0008594)
0.1 0.4 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.1 0.8 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.1 0.4 GO:0016572 histone phosphorylation(GO:0016572)
0.1 0.6 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.3 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.1 0.3 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 0.2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.1 0.6 GO:0071479 cellular response to ionizing radiation(GO:0071479)
0.1 0.6 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.1 0.8 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.3 GO:0061641 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.3 GO:0048069 eye pigmentation(GO:0048069)
0.0 1.0 GO:0010962 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.0 0.7 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.4 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.3 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.8 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.6 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.3 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.6 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.5 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 1.2 GO:0048538 thymus development(GO:0048538)
0.0 0.5 GO:0006265 DNA topological change(GO:0006265)
0.0 0.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 2.3 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.2 GO:0033687 osteoblast proliferation(GO:0033687)
0.0 0.9 GO:0001895 retina homeostasis(GO:0001895)
0.0 0.1 GO:0036316 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.5 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 0.1 GO:0009450 gamma-aminobutyric acid catabolic process(GO:0009450)
0.0 0.5 GO:0030500 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.0 0.3 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 1.1 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.7 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.7 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.4 GO:0021508 floor plate formation(GO:0021508) floor plate morphogenesis(GO:0033505)
0.0 0.3 GO:0021979 hypothalamus cell differentiation(GO:0021979) limb morphogenesis(GO:0035108)
0.0 0.3 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.7 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0010269 response to selenium ion(GO:0010269)
0.0 1.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.4 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.1 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.0 0.6 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.9 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.4 GO:0032526 response to retinoic acid(GO:0032526)
0.0 0.5 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.3 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 0.2 GO:1901655 cellular response to ketone(GO:1901655)
0.0 0.8 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.2 GO:0099638 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 0.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.8 GO:0006006 glucose metabolic process(GO:0006006)
0.0 0.0 GO:0051823 regulation of synapse structural plasticity(GO:0051823)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0031415 NatA complex(GO:0031415)
0.1 0.7 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.1 0.8 GO:1902636 kinociliary basal body(GO:1902636)
0.1 0.9 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.8 GO:0030904 retromer complex(GO:0030904)
0.1 0.7 GO:0034451 centriolar satellite(GO:0034451)
0.1 1.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.7 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.4 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.4 GO:0089701 U2AF(GO:0089701)
0.0 0.3 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.4 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.1 GO:0034709 methylosome(GO:0034709)
0.0 0.6 GO:0000813 ESCRT I complex(GO:0000813)
0.0 1.6 GO:0005811 lipid particle(GO:0005811)
0.0 0.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.8 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.4 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.2 GO:0005682 U5 snRNP(GO:0005682)
0.0 2.2 GO:0000786 nucleosome(GO:0000786)
0.0 0.4 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.7 GO:0043204 perikaryon(GO:0043204)
0.0 0.5 GO:0030496 midbody(GO:0030496)
0.0 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.5 GO:0016605 PML body(GO:0016605)
0.0 0.3 GO:0031082 BLOC complex(GO:0031082)
0.0 0.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.1 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0033819 lipoyl(octanoyl) transferase activity(GO:0033819)
0.3 1.6 GO:0047192 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.3 0.8 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.2 0.8 GO:0035516 oxidative DNA demethylase activity(GO:0035516)
0.2 0.6 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 0.5 GO:0004422 hypoxanthine phosphoribosyltransferase activity(GO:0004422)
0.2 0.5 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.7 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.1 0.9 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 1.0 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 1.4 GO:0004568 chitinase activity(GO:0004568)
0.1 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.5 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.5 GO:0017113 uracil binding(GO:0002058) pyrimidine nucleobase binding(GO:0002061) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
0.1 1.0 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.1 0.5 GO:0043295 glutathione binding(GO:0043295)
0.1 0.2 GO:0030623 U5 snRNA binding(GO:0030623)
0.1 0.3 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.1 0.8 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 0.6 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 1.0 GO:2001069 glycogen binding(GO:2001069)
0.1 0.7 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 0.2 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.0 0.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 1.2 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.4 GO:0010340 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0 0.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.4 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.3 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.0 0.4 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0 0.5 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 1.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.6 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.7 GO:0022840 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.0 0.3 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.3 GO:0071617 lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.7 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.6 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.6 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0042936 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.6 GO:0019003 GDP binding(GO:0019003)
0.0 0.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.4 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.6 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.0 0.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.1 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.3 GO:0048038 quinone binding(GO:0048038)
0.0 0.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 1.1 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 1.1 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 2.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.8 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.7 PID MYC PATHWAY C-MYC pathway
0.0 0.7 PID ATM PATHWAY ATM pathway
0.0 0.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.5 PID BMP PATHWAY BMP receptor signaling
0.0 0.4 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.2 0.3 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.1 0.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.7 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.9 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.3 REACTOME MEIOSIS Genes involved in Meiosis
0.0 1.1 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.1 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.3 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.3 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase