ISMARA results: irf10+irf8+irf9

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PRJNA195909:zebrafish embryo and larva development

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Results for irf10+irf8+irf9

Z-value: 1.38

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Transcription factors associated with irf10+irf8+irf9

Gene Symbol	Gene ID	Gene Info
irf9 NCBI UniProt	ENSDARG00000016457	interferon regulatory factor 9
irf10 NCBI UniProt	ENSDARG00000027658	interferon regulatory factor 10
irf8 NCBI UniProt	ENSDARG00000056407	interferon regulatory factor 8

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
irf8	dr11_v1_chr18_+_30567945_30567945	-0.83	5.5e-03	Click!
irf9	dr11_v1_chr12_+_13282797_13282807	-0.63	6.9e-02	Click!
irf10	dr11_v1_chr23_+_642395_642395	0.09	8.2e-01	Click!

Activity profile of irf10+irf8+irf9 motif

Sorted Z-values of irf10+irf8+irf9 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_-_43625549 Show fit	1.97	ENSDART00000168589	ctsc NCBI UniProt Show fit	cathepsin C
chr9_-_35633827 Show fit	1.78	ENSDART00000077745	zp2l1 NCBI UniProt Show fit	zona pellucida glycoprotein 2, like 1
chr22_+_25274712 Show fit	1.53	ENSDART00000137341	BX950205.1 NCBI UniProt Show fit
chr22_+_25289360 Show fit	1.38	ENSDART00000143782	si:ch211-154a22.8 NCBI UniProt Show fit	si:ch211-154a22.8
chr23_+_43668756 Show fit	1.32	ENSDART00000112598	otud4 NCBI UniProt Show fit	OTU deubiquitinase 4
chr16_+_29509133 Show fit	1.25	ENSDART00000112116	ctss2.1 NCBI UniProt Show fit	cathepsin S, ortholog2, tandem duplicate 1
chr11_-_19775182 Show fit	1.21	ENSDART00000037894	namptb NCBI UniProt Show fit	nicotinamide phosphoribosyltransferase b
chr23_-_29357764 Show fit	1.15	ENSDART00000156512	si:ch211-129o18.4 NCBI UniProt Show fit	si:ch211-129o18.4
chr14_-_45967712 Show fit	1.04	ENSDART00000043751 ENSDART00000141357	macrod1 NCBI UniProt Show fit	MACRO domain containing 1
chr2_+_41926707 Show fit	0.99	ENSDART00000023208	zgc:110183 NCBI UniProt Show fit	zgc:110183

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of irf10+irf8+irf9

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.7	GO:0017148	negative regulation of translation(GO:0017148)
0.3	1.3	GO:2000660	regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1	1.0	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.9	GO:0018231	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1	0.8	GO:0061193	rhombomere 5 development(GO:0021571) rhombomere 6 development(GO:0021572) tongue development(GO:0043586) tongue morphogenesis(GO:0043587) taste bud development(GO:0061193) taste bud morphogenesis(GO:0061194) taste bud formation(GO:0061195)
0.1	0.8	GO:0070475	rRNA base methylation(GO:0070475)
0.0	0.8	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
0.0	0.8	GO:0016575	histone deacetylation(GO:0016575)
0.0	0.7	GO:0009395	phospholipid catabolic process(GO:0009395)
0.0	0.6	GO:0007035	vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)

Showing 1 to 10 of 57 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.1	GO:0005764	lysosome(GO:0005764)
0.0	1.6	GO:0016607	nuclear speck(GO:0016607)
0.1	1.0	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.9	GO:0005637	nuclear inner membrane(GO:0005637)
0.1	0.8	GO:0032797	SMN complex(GO:0032797)
0.0	0.8	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1	0.6	GO:0008537	proteasome activator complex(GO:0008537)
0.1	0.6	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1	0.5	GO:0044611	nuclear pore inner ring(GO:0044611)
0.1	0.5	GO:1902737	dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)

Showing 1 to 10 of 26 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.5	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.1	1.7	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.1	1.4	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.1	1.0	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	1.0	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.9	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2	0.8	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.1	0.8	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.8	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0	0.7	GO:0004629	phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)

Showing 1 to 10 of 47 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
1.0	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.7	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.6	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.5	PID IL23 PATHWAY	IL23-mediated signaling events
0.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.2	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Showing 1 to 7 of 7 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.0	1.5	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.0	0.7	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.1	0.5	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.5	REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	Genes involved in Transport of Mature Transcript to Cytoplasm
0.0	0.4	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	0.3	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.3	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.3	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.0	0.2	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation

Showing 1 to 10 of 13 entries

Results for irf10+irf8+irf9

Z-value: 1.38

Motif logo

Transcription factors associated with irf10+irf8+irf9

Activity-expression correlation:

Activity profile of irf10+irf8+irf9 motif

Sorted Z-values of irf10+irf8+irf9 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of irf10+irf8+irf9

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: