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PRJNA195909:zebrafish embryo and larva development

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Results for irf1b+irf2+irf2a

Z-value: 1.68

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Transcription factors associated with irf1b+irf2+irf2a

Gene Symbol Gene ID Gene Info
irf2a
ENSDARG00000007387 interferon regulatory factor 2a
irf2
ENSDARG00000040465 interferon regulatory factor 2
irf1b
ENSDARG00000043249 interferon regulatory factor 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irf2adr11_v1_chr1_+_39865748_398657530.972.1e-05Click!
irf2dr11_v1_chr14_-_4121052_4121052-0.853.6e-03Click!
irf1bdr11_v1_chr21_+_45626136_45626136-0.617.9e-02Click!

Activity profile of irf1b+irf2+irf2a motif

Sorted Z-values of irf1b+irf2+irf2a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_+_43668756 5.08 ENSDART00000112598
otud4
OTU deubiquitinase 4
chr20_+_54295213 3.23 ENSDART00000074085
zp2.3
zona pellucida glycoprotein 2, tandem duplicate 3
chr4_+_279669 2.70 ENSDART00000184884
CABZ01085275.1

chr11_+_37638873 2.18 ENSDART00000186384
ENSDART00000184291
ENSDART00000131782
ENSDART00000140502
sh2d5
SH2 domain containing 5
chr20_+_54309148 2.08 ENSDART00000099360
zp2.1
zona pellucida glycoprotein 2, tandem duplicate 1
chr9_-_35633827 2.00 ENSDART00000077745
zp2l1
zona pellucida glycoprotein 2, like 1
chr10_-_21542702 1.90 ENSDART00000146761
ENSDART00000134502
zgc:165539
zgc:165539
chr18_-_38270430 1.89 ENSDART00000139519
caprin1b
cell cycle associated protein 1b
chr9_+_8401796 1.89 ENSDART00000180047
ENSDART00000132339
ENSDART00000137527
si:ch1073-75o15.3
si:ch1073-75o15.3
chr14_-_45967712 1.88 ENSDART00000043751
ENSDART00000141357
macrod1
MACRO domain containing 1
chr5_-_30382925 1.87 ENSDART00000125381
gig2o
grass carp reovirus (GCRV)-induced gene 2o
chr21_+_20901505 1.84 ENSDART00000132741
c7b
complement component 7b
chr9_-_20853439 1.83 ENSDART00000028247
ENSDART00000133321
gdap2
ganglioside induced differentiation associated protein 2
chr13_-_6252498 1.80 ENSDART00000115157
tuba4l
tubulin, alpha 4 like
chr14_-_45967981 1.76 ENSDART00000188062
macrod1
MACRO domain containing 1
chr18_-_12858016 1.74 ENSDART00000130343
parp12a
poly (ADP-ribose) polymerase family, member 12a
chr6_+_38896158 1.74 ENSDART00000029930
ENSDART00000131347
slc48a1b
solute carrier family 48 (heme transporter), member 1b
chr7_+_19600262 1.73 ENSDART00000007310
zgc:171731
zgc:171731
chr3_-_3413669 1.72 ENSDART00000113517
ENSDART00000179861
ENSDART00000115331
zgc:171446
zgc:171446
chr8_-_14604606 1.70 ENSDART00000090254
ENSDART00000188953
cep350
centrosomal protein 350
chr10_+_44641599 1.68 ENSDART00000172128
sez6l
seizure related 6 homolog (mouse)-like
chr5_-_26247215 1.67 ENSDART00000136806
erap1b
endoplasmic reticulum aminopeptidase 1b
chr14_-_41467497 1.66 ENSDART00000181220
mid1ip1l
MID1 interacting protein 1, like
chr21_-_40557281 1.63 ENSDART00000172327
taok1b
TAO kinase 1b
chr14_+_36414856 1.59 ENSDART00000123343
ENSDART00000015761
neil3
nei-like DNA glycosylase 3
chr15_-_18209672 1.57 ENSDART00000141508
ENSDART00000136280
btr16
bloodthirsty-related gene family, member 16
chr13_-_37631092 1.57 ENSDART00000108855
si:dkey-188i13.7
si:dkey-188i13.7
chr5_+_40835601 1.54 ENSDART00000147767
si:dkey-3h3.3
si:dkey-3h3.3
chr3_-_36127234 1.53 ENSDART00000130917
coil
coilin p80
chr5_-_57723929 1.49 ENSDART00000144237
gig2p
grass carp reovirus (GCRV)-induced gene 2p
chr11_+_1584747 1.45 ENSDART00000154583
si:dkey-40c23.2
si:dkey-40c23.2
chr10_-_45229877 1.43 ENSDART00000169281
pargl
poly (ADP-ribose) glycohydrolase, like
chr7_-_54430505 1.42 ENSDART00000167905
ano1
anoctamin 1, calcium activated chloride channel
chr13_-_34858500 1.42 ENSDART00000184843
sptlc3
serine palmitoyltransferase, long chain base subunit 3
chr18_+_14342326 1.41 ENSDART00000181013
ENSDART00000138372
si:dkey-246g23.2
si:dkey-246g23.2
chr21_+_34992550 1.40 ENSDART00000109041
ENSDART00000135400
tmprss15
transmembrane protease, serine 15
chr9_-_39547907 1.39 ENSDART00000163635
erbb4b
erb-b2 receptor tyrosine kinase 4b
chr2_-_42552666 1.39 ENSDART00000141399
dip2cb
disco-interacting protein 2 homolog Cb
chr18_-_38270077 1.38 ENSDART00000185546
caprin1b
cell cycle associated protein 1b
chr21_-_21514176 1.35 ENSDART00000031205
nectin3b
nectin cell adhesion molecule 3b
chr21_+_4256291 1.32 ENSDART00000148138
lrrc8aa
leucine rich repeat containing 8 VRAC subunit Aa
chr1_-_51266394 1.29 ENSDART00000164016
kif16ba
kinesin family member 16Ba
chr3_-_34586403 1.29 ENSDART00000151515
sept9a
septin 9a
chr4_-_26095755 1.28 ENSDART00000100611
ENSDART00000191266
si:ch211-244b2.3
si:ch211-244b2.3
chr18_-_38270596 1.28 ENSDART00000098889
caprin1b
cell cycle associated protein 1b
chr15_+_25489406 1.27 ENSDART00000162482
zgc:152863
zgc:152863
chr1_-_52201266 1.24 ENSDART00000143805
ENSDART00000023757
rab3da
RAB3D, member RAS oncogene family, a
chr18_+_13248956 1.24 ENSDART00000080709
plcg2
phospholipase C, gamma 2
chr2_+_9757453 1.19 ENSDART00000168972
pcyt1aa
phosphate cytidylyltransferase 1, choline, alpha a
chr22_+_31023205 1.17 ENSDART00000111561
zmp:0000000735
zmp:0000000735
chr17_-_35076730 1.15 ENSDART00000146590
mboat2a
membrane bound O-acyltransferase domain containing 2a
chr15_+_20352123 1.13 ENSDART00000011030
ENSDART00000163532
ENSDART00000169537
ENSDART00000161047
il15l
interleukin 15, like
chr12_+_17154655 1.12 ENSDART00000028003
ankrd22
ankyrin repeat domain 22
chr7_+_55518519 1.12 ENSDART00000098476
ENSDART00000149915
cdt1
chromatin licensing and DNA replication factor 1
chr13_-_42066299 1.12 ENSDART00000111536
rmdn2
regulator of microtubule dynamics 2
chr9_-_14273652 1.10 ENSDART00000135458
abcb6b
ATP-binding cassette, sub-family B (MDR/TAP), member 6b
chr15_-_29162193 1.09 ENSDART00000138449
ENSDART00000099885
xaf1
XIAP associated factor 1
chr1_-_55750208 1.08 ENSDART00000142244
dnajb1b
DnaJ (Hsp40) homolog, subfamily B, member 1b
chr22_-_8174244 1.07 ENSDART00000156571
si:ch73-44m9.3
si:ch73-44m9.3
chr2_+_35603637 1.07 ENSDART00000147278
plk3
polo-like kinase 3 (Drosophila)
chr25_-_12803723 1.07 ENSDART00000158787
ca5a
carbonic anhydrase Va
chr7_+_40081630 1.06 ENSDART00000173559
zgc:112356
zgc:112356
chr22_-_37565348 1.06 ENSDART00000149482
ENSDART00000104478
fxr1
fragile X mental retardation, autosomal homolog 1
chr19_+_4066449 1.04 ENSDART00000162461
btr26
bloodthirsty-related gene family, member 26
chr24_-_34680956 1.04 ENSDART00000171009
ctnna1
catenin (cadherin-associated protein), alpha 1
chr8_-_19051906 1.04 ENSDART00000089024
sema6bb
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb
chr11_+_1608348 1.02 ENSDART00000162438
si:dkey-40c23.3
si:dkey-40c23.3
chr14_+_9485070 1.01 ENSDART00000161486
ENSDART00000137274
st3gal5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr14_+_12169979 1.01 ENSDART00000129953
rhogd
ras homolog gene family, member Gd
chr15_-_44077937 1.00 ENSDART00000110112
lamtor1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr21_+_31253048 0.99 ENSDART00000178521
ENSDART00000132317
ENSDART00000040190
asl
argininosuccinate lyase
chr20_+_49787584 0.99 ENSDART00000193458
ENSDART00000181511
ENSDART00000185850
ENSDART00000185613
ENSDART00000191671
CABZ01078261.1

chr18_+_19990412 0.99 ENSDART00000155054
ENSDART00000090310
pias1b
protein inhibitor of activated STAT, 1b
chr6_-_1566407 0.98 ENSDART00000112118
trim107
tripartite motif containing 107
chr22_-_5958066 0.97 ENSDART00000145821
si:rp71-36a1.3
si:rp71-36a1.3
chr8_-_16725959 0.96 ENSDART00000183593
depdc1a
DEP domain containing 1a
chr23_+_45229198 0.96 ENSDART00000172445
ttc39b
tetratricopeptide repeat domain 39B
chr2_-_32688905 0.95 ENSDART00000041146
nrbp2a
nuclear receptor binding protein 2a
chr5_+_57726425 0.95 ENSDART00000134684
fdxacb1
ferredoxin-fold anticodon binding domain containing 1
chr19_-_35492693 0.94 ENSDART00000135838
ENSDART00000051745
ENSDART00000177052
ptp4a2b
protein tyrosine phosphatase type IVA, member 2b
chr13_+_7387822 0.93 ENSDART00000148240
exoc3l4
exocyst complex component 3-like 4
chr21_+_40695345 0.93 ENSDART00000143594
ccdc82
coiled-coil domain containing 82
chr10_+_5954787 0.93 ENSDART00000161887
ENSDART00000160345
ENSDART00000190046
map3k1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr18_-_6534357 0.93 ENSDART00000192886
ddx11
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
chr15_-_25126842 0.93 ENSDART00000193670
vps53
vacuolar protein sorting 53 homolog (S. cerevisiae)
chr3_+_36127287 0.92 ENSDART00000058605
ENSDART00000182500
scpep1
serine carboxypeptidase 1
chr8_-_51367298 0.91 ENSDART00000060628
chmp7
charged multivesicular body protein 7
chr13_+_7578111 0.91 ENSDART00000175431
gbf1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr23_-_21758253 0.91 ENSDART00000046613
vps13d
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr15_-_1484795 0.91 ENSDART00000129356
si:dkeyp-97b10.3
si:dkeyp-97b10.3
chr5_-_37116265 0.90 ENSDART00000057613
il13ra2
interleukin 13 receptor, alpha 2
chr17_-_42799104 0.90 ENSDART00000154755
prkd3
protein kinase D3
chr3_-_40136743 0.90 ENSDART00000149546
myo15aa
myosin XVAa
chr6_-_1566581 0.90 ENSDART00000192993
trim107
tripartite motif containing 107
chr25_-_12804450 0.89 ENSDART00000169717
ca5a
carbonic anhydrase Va
chr18_-_6534516 0.89 ENSDART00000009217
ddx11
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
chr9_-_40683722 0.88 ENSDART00000141979
ENSDART00000181228
bard1
BRCA1 associated RING domain 1
chr2_-_40889465 0.88 ENSDART00000192631
ENSDART00000180824
uggt1
UDP-glucose glycoprotein glucosyltransferase 1
chr11_-_30341431 0.88 ENSDART00000078378
cflara
CASP8 and FADD-like apoptosis regulator a
chr1_-_55058795 0.88 ENSDART00000187293
peli1a
pellino E3 ubiquitin protein ligase 1a
chr16_+_53710416 0.87 ENSDART00000155929
nod1
nucleotide-binding oligomerization domain containing 1
chr15_+_14592624 0.87 ENSDART00000162350
FBXO46
si:dkey-114g7.4
chr11_-_11791718 0.87 ENSDART00000180476
cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr16_+_26439939 0.87 ENSDART00000143073
trim35-28
tripartite motif containing 35-28
chr24_+_39027481 0.86 ENSDART00000085565
capn15
calpain 15
chr15_-_14083028 0.86 ENSDART00000147796
ENSDART00000043492
ENSDART00000133080
trappc6bl
trafficking protein particle complex 6b-like
chr17_+_25871304 0.85 ENSDART00000185143
wapla
WAPL cohesin release factor a
chr17_+_50798484 0.85 ENSDART00000125787
stxbp6
syntaxin binding protein 6 (amisyn)
chr19_+_15485287 0.85 ENSDART00000182797
pdik1l
PDLIM1 interacting kinase 1 like
chr15_-_15227541 0.85 ENSDART00000184787
rrp8
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr15_+_17100697 0.85 ENSDART00000183565
ENSDART00000123197
relb
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr8_-_49499457 0.84 ENSDART00000098326
opn7d
opsin 7, group member d
chr17_-_7218481 0.84 ENSDART00000181967
SAMD5
sterile alpha motif domain containing 5
chr1_-_12397258 0.84 ENSDART00000144596
sclt1
sodium channel and clathrin linker 1
chr22_-_6941098 0.84 ENSDART00000105864
zgc:171500
zgc:171500
chr15_-_16384184 0.83 ENSDART00000154504
fam222bb
family with sequence similarity 222, member Bb
chr5_+_36768674 0.83 ENSDART00000146854
mark4a
MAP/microtubule affinity-regulating kinase 4a
chr14_-_33328031 0.83 ENSDART00000137997
sept6
septin 6
chr20_+_44582318 0.82 ENSDART00000149000
ENSDART00000149775
ENSDART00000085416
atad2b
ATPase family, AAA domain containing 2B
chr19_+_4856351 0.81 ENSDART00000093402
cdk12
cyclin-dependent kinase 12
chr11_-_20096018 0.81 ENSDART00000030420
ogfrl2
opioid growth factor receptor-like 2
chr6_-_57539141 0.81 ENSDART00000156967
itcha
itchy E3 ubiquitin protein ligase a
chr25_-_27665978 0.81 ENSDART00000123590
si:ch211-91p5.3
si:ch211-91p5.3
chr20_-_26588736 0.80 ENSDART00000134337
exoc2
exocyst complex component 2
chr21_-_43428040 0.80 ENSDART00000148325
stk26
serine/threonine protein kinase 26
chr22_+_1440702 0.80 ENSDART00000165677
si:dkeyp-53d3.3
si:dkeyp-53d3.3
chr6_+_9793495 0.80 ENSDART00000108524
als2b
amyotrophic lateral sclerosis 2b (juvenile)
chr19_+_7115223 0.80 ENSDART00000001359
psmb12
proteasome subunit beta 12
chr4_+_59061652 0.80 ENSDART00000150447
znf1127
zinc finger protein 1127
chr6_+_13045885 0.80 ENSDART00000104757
casp8
caspase 8, apoptosis-related cysteine peptidase
chr6_+_30430591 0.80 ENSDART00000108943
shroom2a
shroom family member 2a
chr8_-_11067079 0.79 ENSDART00000181986
dennd2c
DENN/MADD domain containing 2C
chr16_-_40459104 0.79 ENSDART00000032389
plekhf2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr20_-_23254876 0.79 ENSDART00000141510
ociad1
OCIA domain containing 1
chr19_+_20178978 0.79 ENSDART00000145115
ENSDART00000151175
tra2a
transformer 2 alpha homolog
chr3_+_51684963 0.79 ENSDART00000091180
ENSDART00000183711
ENSDART00000159493
baiap2a
BAI1-associated protein 2a
chr15_+_44228917 0.78 ENSDART00000159630
CU929391.3

chr1_+_39865748 0.77 ENSDART00000131954
ENSDART00000130270
irf2a
interferon regulatory factor 2a
chr4_+_20486041 0.77 ENSDART00000017572
ints13
integrator complex subunit 13
chr5_+_22406672 0.76 ENSDART00000141385
si:dkey-27p18.3
si:dkey-27p18.3
chr22_-_7461603 0.76 ENSDART00000170630
BX511034.6

chr14_-_25078569 0.75 ENSDART00000172802
ENSDART00000173345
ENSDART00000135004
matr3l1.1
matrin 3-like 1.1
chr7_+_44593756 0.75 ENSDART00000125365
si:ch211-189a15.5
si:ch211-189a15.5
chr1_-_45584407 0.74 ENSDART00000149155
atf7ip
activating transcription factor 7 interacting protein
chr2_+_42005475 0.74 ENSDART00000056461
gbp2
guanylate binding protein 2
chr11_+_2596667 0.73 ENSDART00000175330
dnajc14
DnaJ (Hsp40) homolog, subfamily C, member 14
chr18_+_14684115 0.73 ENSDART00000108469
spata2l
spermatogenesis associated 2-like
chr23_+_2825940 0.73 ENSDART00000135781
plcg1
phospholipase C, gamma 1
chr5_+_17780475 0.72 ENSDART00000110783
ENSDART00000115227
chfr
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
chr10_+_35152928 0.72 ENSDART00000063418
nsun5
NOP2/Sun domain family, member 5
chr16_+_26439518 0.71 ENSDART00000041787
trim35-28
tripartite motif containing 35-28
chr1_-_524433 0.71 ENSDART00000147610
si:ch73-41e3.7
si:ch73-41e3.7
chr21_+_19319804 0.71 ENSDART00000063621
abraxas2a
abraxas 2a, BRISC complex subunit
chr13_+_11550454 0.70 ENSDART00000034935
ENSDART00000166908
desi2
desumoylating isopeptidase 2
chr8_-_14080534 0.70 ENSDART00000042867
dedd
death effector domain containing
chr7_-_40656148 0.70 ENSDART00000142315
nom1
nucleolar protein with MIF4G domain 1
chr6_-_1566186 0.69 ENSDART00000156305
trim107
tripartite motif containing 107
chr16_-_50952266 0.69 ENSDART00000165408
si:dkeyp-97a10.3
si:dkeyp-97a10.3
chr5_+_45895791 0.68 ENSDART00000141039
polk
polymerase (DNA directed) kappa
chr6_-_42949184 0.67 ENSDART00000147208
edem1
ER degradation enhancer, mannosidase alpha-like 1
chr13_-_31938512 0.67 ENSDART00000026726
ENSDART00000182666
diexf
digestive organ expansion factor homolog
chr15_-_36249087 0.67 ENSDART00000157190
ostn
osteocrin
chr11_-_45385803 0.67 ENSDART00000173329
trappc10
trafficking protein particle complex 10
chr23_-_36449111 0.66 ENSDART00000110478
zgc:174906
zgc:174906
chr14_+_31618982 0.66 ENSDART00000026195
slc9a6a
solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6a
chr10_+_7718156 0.65 ENSDART00000189101
ggcx
gamma-glutamyl carboxylase
chr22_+_1786230 0.65 ENSDART00000169318
ENSDART00000164948
znf1154
zinc finger protein 1154
chr14_-_25095808 0.65 ENSDART00000184244
matr3l1.1
matrin 3-like 1.1
chr22_-_8006342 0.65 ENSDART00000162028
sc:d217
sc:d217
chr18_-_44935174 0.64 ENSDART00000081025
pex16
peroxisomal biogenesis factor 16
chr4_-_9191220 0.64 ENSDART00000156919
hcfc2
host cell factor C2
chr19_+_9111550 0.64 ENSDART00000088336
setdb1a
SET domain, bifurcated 1a
chr21_+_25120546 0.63 ENSDART00000149507
ddx10
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr22_+_2512154 0.63 ENSDART00000097363
zgc:173726
zgc:173726
chr21_-_1644414 0.63 ENSDART00000105736
ENSDART00000124904
zgc:152948
zgc:152948
chr22_+_29990448 0.63 ENSDART00000165313
si:dkey-286j15.3
si:dkey-286j15.3
chr20_-_4793450 0.63 ENSDART00000053870
galca
galactosylceramidase a
chr20_+_32481348 0.63 ENSDART00000185018
ostm1
osteopetrosis associated transmembrane protein 1
chr5_+_52625975 0.62 ENSDART00000170341
ENSDART00000168317
apba1a
amyloid beta (A4) precursor protein-binding, family A, member 1a
chr7_-_19613388 0.62 ENSDART00000173664
si:ch211-212k18.13
si:ch211-212k18.13
chr6_+_29861288 0.62 ENSDART00000166782
dlg1
discs, large homolog 1 (Drosophila)
chr19_+_38168006 0.62 ENSDART00000087662
ENSDART00000177759
phf14
PHD finger protein 14
chr24_-_10828560 0.62 ENSDART00000132282
fam49bb
family with sequence similarity 49, member Bb
chr5_+_38612134 0.62 ENSDART00000135600
ENSDART00000181144
si:ch211-271e10.2
si:ch211-271e10.2
chr25_-_19574146 0.62 ENSDART00000156811
si:ch211-59o9.10
si:ch211-59o9.10
chr23_-_36884012 0.62 ENSDART00000137282
ube2j2
ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast)
chr16_+_30117798 0.61 ENSDART00000135723
ENSDART00000000198
sema6e
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E
chr24_+_12945803 0.61 ENSDART00000005105
psme1
proteasome activator subunit 1
chr20_-_38525467 0.61 ENSDART00000061417
si:ch211-245h14.1
si:ch211-245h14.1
chr13_-_33321058 0.61 ENSDART00000112084
si:dkey-71p21.13
si:dkey-71p21.13
chr6_+_9793791 0.60 ENSDART00000149896
als2b
amyotrophic lateral sclerosis 2b (juvenile)
chr11_-_19775182 0.60 ENSDART00000037894
namptb
nicotinamide phosphoribosyltransferase b
chr19_-_5865766 0.60 ENSDART00000191007
LO018585.1

chr15_-_15965456 0.59 ENSDART00000154579
synrg
synergin, gamma
chr17_-_15149192 0.59 ENSDART00000180511
ENSDART00000103405
gch1
GTP cyclohydrolase 1
chr13_-_33227411 0.59 ENSDART00000057386
golga5
golgin A5
chr5_-_4923473 0.59 ENSDART00000134585
zbtb43
zinc finger and BTB domain containing 43
chr7_+_39416336 0.58 ENSDART00000171783
CT030188.1

chr9_+_22375331 0.58 ENSDART00000090907
dgkg
diacylglycerol kinase, gamma
chr15_-_17169935 0.58 ENSDART00000110111
cul5a
cullin 5a

Network of associatons between targets according to the STRING database.

First level regulatory network of irf1b+irf2+irf2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.1 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.6 1.8 GO:1901836 regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901836)
0.4 1.6 GO:0048308 organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
0.3 1.5 GO:0030576 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576)
0.3 0.9 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.3 2.8 GO:0015886 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.3 0.8 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism(GO:0043903)
0.2 1.0 GO:0006526 arginine biosynthetic process(GO:0006526)
0.2 0.7 GO:0035477 regulation of angioblast cell migration involved in selective angioblast sprouting(GO:0035477)
0.2 2.3 GO:0019883 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.2 1.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.2 1.2 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.2 0.9 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.2 1.0 GO:0001919 regulation of receptor recycling(GO:0001919)
0.2 1.7 GO:0070475 rRNA base methylation(GO:0070475)
0.2 0.8 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.2 0.9 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 0.6 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.1 0.9 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.1 1.2 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 2.0 GO:0000076 DNA replication checkpoint(GO:0000076)
0.1 0.5 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.1 0.5 GO:0071788 endoplasmic reticulum tubular network maintenance(GO:0071788)
0.1 1.4 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.1 0.6 GO:0014005 microglia development(GO:0014005)
0.1 0.7 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1 1.4 GO:0090309 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 0.7 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.1 0.9 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.1 0.6 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 0.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 0.4 GO:0070587 regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
0.1 0.8 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.3 GO:1903292 protein localization to Golgi membrane(GO:1903292)
0.1 0.4 GO:1903573 negative regulation of response to endoplasmic reticulum stress(GO:1903573)
0.1 0.5 GO:0045337 farnesyl diphosphate biosynthetic process(GO:0045337)
0.1 1.2 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.1 0.9 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 1.1 GO:0036230 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.1 1.7 GO:0034453 microtubule anchoring(GO:0034453)
0.1 0.9 GO:1902042 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.1 0.2 GO:0051793 medium-chain fatty acid metabolic process(GO:0051791) medium-chain fatty acid catabolic process(GO:0051793)
0.1 0.6 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 0.2 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.1 0.7 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 0.7 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.1 0.3 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.1 0.7 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 0.4 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.1 0.3 GO:0044819 mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819)
0.1 1.8 GO:0019835 cytolysis(GO:0019835)
0.1 0.2 GO:0071514 genetic imprinting(GO:0071514)
0.1 0.3 GO:0098535 de novo centriole assembly(GO:0098535)
0.1 0.4 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 0.8 GO:0045176 asymmetric protein localization(GO:0008105) apical protein localization(GO:0045176)
0.1 0.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.7 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.9 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 0.8 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.3 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 0.9 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 1.4 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.1 1.7 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.1 0.2 GO:0019884 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.0 0.8 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.2 GO:0071267 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0 1.1 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 2.8 GO:0071166 ribonucleoprotein complex localization(GO:0071166)
0.0 1.4 GO:0007286 spermatid development(GO:0007286)
0.0 0.5 GO:0007020 microtubule nucleation(GO:0007020)
0.0 2.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.3 GO:0097340 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.0 0.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.2 GO:0043703 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.0 0.8 GO:0051642 centrosome localization(GO:0051642)
0.0 0.3 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.0 0.4 GO:0035479 angioblast cell migration from lateral mesoderm to midline(GO:0035479)
0.0 0.6 GO:1902807 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.3 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter in response to calcium ion(GO:0061400) positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 1.4 GO:0009225 nucleotide-sugar metabolic process(GO:0009225)
0.0 0.4 GO:0031269 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 1.6 GO:0006289 nucleotide-excision repair(GO:0006289)
0.0 2.0 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.4 GO:0051601 exocyst localization(GO:0051601)
0.0 1.0 GO:0071910 determination of liver left/right asymmetry(GO:0071910)
0.0 0.2 GO:0086013 membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.0 0.8 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 3.6 GO:0017148 negative regulation of translation(GO:0017148)
0.0 1.0 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.2 GO:0048662 regulation of smooth muscle cell proliferation(GO:0048660) negative regulation of smooth muscle cell proliferation(GO:0048662)
0.0 0.8 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 1.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.5 GO:0043486 histone exchange(GO:0043486)
0.0 1.2 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.3 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.6 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.0 0.2 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.3 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.6 GO:0034112 positive regulation of homotypic cell-cell adhesion(GO:0034112) positive regulation of T cell activation(GO:0050870) positive regulation of leukocyte cell-cell adhesion(GO:1903039)
0.0 0.9 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.5 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.4 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.7 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.3 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.3 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.1 GO:0031179 peptide modification(GO:0031179)
0.0 0.2 GO:1904356 regulation of telomere maintenance via telomere lengthening(GO:1904356)
0.0 0.1 GO:0005997 xylulose metabolic process(GO:0005997)
0.0 0.3 GO:0043550 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.5 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 3.1 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.0 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0 0.5 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 1.9 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 9.7 GO:0016567 protein ubiquitination(GO:0016567)
0.0 2.3 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.9 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 1.2 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.4 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.6 GO:0007031 peroxisome organization(GO:0007031)
0.0 0.2 GO:0070307 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.0 0.2 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.6 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.0 0.1 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.0 0.4 GO:0008272 sulfate transport(GO:0008272)
0.0 1.3 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.4 GO:0051084 'de novo' protein folding(GO:0006458) 'de novo' posttranslational protein folding(GO:0051084) chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.4 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 0.2 GO:0060034 notochord cell differentiation(GO:0060034)
0.0 1.4 GO:0000819 sister chromatid segregation(GO:0000819)
0.0 0.7 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 1.0 GO:0001894 tissue homeostasis(GO:0001894)
0.0 0.3 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.9 GO:0007283 spermatogenesis(GO:0007283)
0.0 0.7 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.0 0.2 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.0 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.0 0.2 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.4 GO:0051028 mRNA transport(GO:0051028)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0044326 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.2 1.2 GO:1990071 TRAPPII protein complex(GO:1990071)
0.2 0.6 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 0.9 GO:0033553 rDNA heterochromatin(GO:0033553)
0.2 1.0 GO:0071986 Ragulator complex(GO:0071986)
0.2 0.9 GO:0000938 GARP complex(GO:0000938)
0.2 0.6 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.9 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.7 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.1 1.4 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.6 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 0.9 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 0.5 GO:0008274 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.1 1.8 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.9 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 1.1 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 0.8 GO:0019908 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.1 0.4 GO:0097224 sperm connecting piece(GO:0097224)
0.1 1.5 GO:0015030 Cajal body(GO:0015030)
0.1 0.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.3 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 2.0 GO:0000145 exocyst(GO:0000145)
0.1 0.9 GO:0030008 TRAPP complex(GO:0030008)
0.1 1.4 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.9 GO:0000815 ESCRT III complex(GO:0000815)
0.1 1.2 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 0.4 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 2.1 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 1.0 GO:0030057 desmosome(GO:0030057)
0.1 0.3 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.5 GO:0000812 Swr1 complex(GO:0000812)
0.0 1.8 GO:0030496 midbody(GO:0030496)
0.0 0.9 GO:0032039 integrator complex(GO:0032039)
0.0 0.3 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.3 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.6 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.6 GO:0030130 trans-Golgi network transport vesicle membrane(GO:0012510) clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.0 0.6 GO:0000784 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.0 0.2 GO:0043194 axon initial segment(GO:0043194)
0.0 1.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.6 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.3 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)
0.0 3.0 GO:0043296 apical junction complex(GO:0043296)
0.0 1.3 GO:0000922 spindle pole(GO:0000922)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.6 GO:0016605 PML body(GO:0016605)
0.0 1.3 GO:0005871 kinesin complex(GO:0005871)
0.0 1.6 GO:0016607 nuclear speck(GO:0016607)
0.0 1.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.8 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.2 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.1 GO:0005795 Golgi stack(GO:0005795)
0.0 1.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.5 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.6 GO:0055037 recycling endosome(GO:0055037)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0004649 poly(ADP-ribose) glycohydrolase activity(GO:0004649)
0.4 2.8 GO:0015232 heme transporter activity(GO:0015232)
0.3 1.0 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.3 5.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.3 1.0 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.3 1.5 GO:0030620 U2 snRNA binding(GO:0030620)
0.3 1.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 1.0 GO:0016842 amidine-lyase activity(GO:0016842)
0.2 1.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.2 1.4 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.2 0.9 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 0.9 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.2 0.5 GO:0046978 TAP1 binding(GO:0046978)
0.2 0.5 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.2 0.7 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.2 0.8 GO:0051748 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.2 0.5 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.9 GO:1900750 oligopeptide binding(GO:1900750)
0.1 0.7 GO:0035197 siRNA binding(GO:0035197)
0.1 0.4 GO:0032027 myosin light chain binding(GO:0032027)
0.1 0.6 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.1 1.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 0.4 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.1 0.4 GO:0004061 arylformamidase activity(GO:0004061)
0.1 1.2 GO:0030332 cyclin binding(GO:0030332)
0.1 0.3 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462)
0.1 0.3 GO:0047760 medium-chain fatty acid-CoA ligase activity(GO:0031956) butyrate-CoA ligase activity(GO:0047760)
0.1 1.6 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 1.6 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.1 0.2 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) peptide-transporting ATPase activity(GO:0015440) TAP binding(GO:0046977)
0.1 0.6 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.6 GO:0005549 olfactory receptor activity(GO:0004984) odorant binding(GO:0005549)
0.1 4.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.3 GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902945)
0.1 0.5 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 1.2 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.1 1.0 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.3 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 0.6 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 2.0 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.3 GO:0004470 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.1 0.5 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.7 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1 0.3 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.1 0.5 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 0.4 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 1.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 2.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 1.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.6 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.4 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.3 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.3 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 1.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.4 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.4 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 1.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.8 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.3 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 1.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.5 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 4.0 GO:0060090 binding, bridging(GO:0060090)
0.0 1.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.1 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.2 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.9 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.0 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.7 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0036374 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.0 1.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.6 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.5 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.4 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 7.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.4 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.4 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 1.8 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 2.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.4 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.8 GO:0042393 histone binding(GO:0042393)
0.0 2.0 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.2 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 0.9 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.1 0.6 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 1.8 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 1.2 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.9 PID ARF 3PATHWAY Arf1 pathway
0.0 0.7 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.3 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.3 PID ATR PATHWAY ATR signaling pathway
0.0 1.2 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.8 PID P73PATHWAY p73 transcription factor network
0.0 0.9 PID AURORA B PATHWAY Aurora B signaling
0.0 0.4 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.8 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.6 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.3 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.2 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.2 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.2 2.0 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.0 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 1.6 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 0.9 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 0.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 0.7 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 0.5 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 2.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.5 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.6 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.9 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.5 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 0.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.8 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 1.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.5 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.4 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.2 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.3 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.9 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.3 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D