Project

PRJNA195909:zebrafish embryo and larva development

Navigation
Downloads

Results for isl1+isl1l

Z-value: 0.92

Motif logo

logo of

Transcription factors associated with isl1+isl1l

Gene Symbol Gene ID Gene Info
isl1
ENSDARG00000004023 ISL LIM homeobox 1
isl1l
ENSDARG00000021055 islet1, like
isl1l
ENSDARG00000110204 islet1, like

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
isl1dr11_v1_chr5_-_40734045_407340450.703.7e-02Click!
isl1ldr11_v1_chr10_+_8680730_86807300.215.9e-01Click!

Activity profile of isl1+isl1l motif

Sorted Z-values of isl1+isl1l motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_25679339 1.24 ENSDART00000161703
ENSDART00000054230
fgg
fibrinogen gamma chain
chr1_+_44439661 1.11 ENSDART00000100309
crybb1l2
crystallin, beta B1, like 2
chr5_-_30615901 1.07 ENSDART00000147769
si:ch211-117m20.5
si:ch211-117m20.5
chr4_+_7508316 0.89 ENSDART00000170924
ENSDART00000170933
ENSDART00000164985
ENSDART00000167571
ENSDART00000158843
ENSDART00000158999
tnnt2e
troponin T2e, cardiac
chr23_+_36653376 0.87 ENSDART00000053189
gpr182
G protein-coupled receptor 182
chr19_+_10855158 0.85 ENSDART00000172219
ENSDART00000170826
apoea
apolipoprotein Ea
chr6_+_15268685 0.78 ENSDART00000128090
ENSDART00000154417
ecrg4b
esophageal cancer related gene 4b
chr21_+_28958471 0.77 ENSDART00000144331
ENSDART00000005929
ppp3ca
protein phosphatase 3, catalytic subunit, alpha isozyme
chr9_+_7548533 0.72 ENSDART00000081543
ptprna
protein tyrosine phosphatase, receptor type, Na
chr5_+_32345187 0.71 ENSDART00000147132
c9
complement component 9
chr3_+_15505275 0.69 ENSDART00000141714
nupr1
nuclear protein 1
chr13_-_36391496 0.67 ENSDART00000100217
ENSDART00000140243
actn1
actinin, alpha 1
chr22_-_14115292 0.64 ENSDART00000105717
ENSDART00000165670
aox5
aldehyde oxidase 5
chr14_-_17072736 0.63 ENSDART00000106333
phox2bb
paired-like homeobox 2bb
chr2_+_59527149 0.61 ENSDART00000168568
CU861477.1

chr23_+_36063599 0.60 ENSDART00000103147
hoxc12a
homeobox C12a
chr4_+_76705830 0.58 ENSDART00000064312
ms4a17a.7
membrane-spanning 4-domains, subfamily A, member 17A.7
chr14_-_17121676 0.58 ENSDART00000170154
ENSDART00000060479
smtnl1
smoothelin-like 1
chr6_+_2093206 0.56 ENSDART00000114314
tgm2b
transglutaminase 2b
chr20_+_572037 0.56 ENSDART00000028062
ENSDART00000152736
ENSDART00000031759
ENSDART00000162198
smyd2b
SET and MYND domain containing 2b
chr18_+_15132112 0.56 ENSDART00000099764
zgc:153031
zgc:153031
chr10_+_32104305 0.54 ENSDART00000099880
wnt11r
wingless-type MMTV integration site family, member 11, related
chr6_+_2093367 0.54 ENSDART00000148396
tgm2b
transglutaminase 2b
chr20_+_2281933 0.53 ENSDART00000137579
si:ch73-18b11.2
si:ch73-18b11.2
chr21_-_35853245 0.53 ENSDART00000172245
sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr25_-_27541621 0.52 ENSDART00000130678
spam1
sperm adhesion molecule 1
chr8_-_1051438 0.51 ENSDART00000067093
ENSDART00000170737
smyd1b
SET and MYND domain containing 1b
chr17_+_32343121 0.51 ENSDART00000156051
dhx32b
DEAH (Asp-Glu-Ala-His) box polypeptide 32b
chr24_+_36636208 0.50 ENSDART00000139211
si:ch73-334d15.4
si:ch73-334d15.4
chr4_+_15968483 0.50 ENSDART00000101575
si:dkey-117n7.5
si:dkey-117n7.5
chr15_-_24869826 0.50 ENSDART00000127047
tusc5a
tumor suppressor candidate 5a
chr3_-_58650057 0.49 ENSDART00000057640
dhrs7ca
dehydrogenase/reductase (SDR family) member 7Ca
chr23_-_31372639 0.48 ENSDART00000179908
ENSDART00000135620
ENSDART00000053367
hmgn3
high mobility group nucleosomal binding domain 3
chr8_+_23213320 0.46 ENSDART00000032996
ENSDART00000137536
ppdpfa
pancreatic progenitor cell differentiation and proliferation factor a
chr5_-_64203101 0.46 ENSDART00000029364
ak5l
adenylate kinase 5, like
chr7_+_8543317 0.45 ENSDART00000114998
jac8
jacalin 8
chr22_-_10121880 0.45 ENSDART00000002348
rdh5
retinol dehydrogenase 5 (11-cis/9-cis)
chr2_+_27010439 0.45 ENSDART00000030547
cdh7a
cadherin 7a
chr23_+_23020709 0.45 ENSDART00000146463
samd11
sterile alpha motif domain containing 11
chr10_+_21576909 0.44 ENSDART00000168604
ENSDART00000166533
pcdh1a3
protocadherin 1 alpha 3
chr16_+_24626448 0.44 ENSDART00000153591
si:dkey-56f14.7
si:dkey-56f14.7
chr14_+_11457500 0.44 ENSDART00000169202
si:ch211-153b23.5
si:ch211-153b23.5
chr6_-_21492752 0.44 ENSDART00000006843
ENSDART00000171479
cacng1a
calcium channel, voltage-dependent, gamma subunit 1a
chr24_-_32665283 0.42 ENSDART00000038364
ca2
carbonic anhydrase II
chr6_+_16031189 0.42 ENSDART00000015333
gbx2
gastrulation brain homeobox 2
chr4_+_5506952 0.41 ENSDART00000032857
ENSDART00000160222
mapk11
mitogen-activated protein kinase 11
chr5_-_41831646 0.41 ENSDART00000134326
si:dkey-65b12.6
si:dkey-65b12.6
chr6_+_16406723 0.40 ENSDART00000040035
ccdc80l1
coiled-coil domain containing 80 like 1
chr1_+_41588170 0.40 ENSDART00000139175
si:dkey-56e3.2
si:dkey-56e3.2
chr16_+_32059785 0.39 ENSDART00000134459
si:dkey-40m6.8
si:dkey-40m6.8
chr15_-_23529945 0.39 ENSDART00000152543
hmbsb
hydroxymethylbilane synthase, b
chr13_-_16222388 0.39 ENSDART00000182861
zgc:110045
zgc:110045
chr19_+_9786722 0.38 ENSDART00000138310
cacng6a
calcium channel, voltage-dependent, gamma subunit 6a
chr8_+_18830759 0.38 ENSDART00000089079
mpnd
MPN domain containing
chr5_-_42872712 0.38 ENSDART00000003947
flot2a
flotillin 2a
chr17_-_19535328 0.38 ENSDART00000077809
cyp26c1
cytochrome P450, family 26, subfamily C, polypeptide 1
chr10_+_21797276 0.38 ENSDART00000169105
pcdh1g29
protocadherin 1 gamma 29
chr7_+_69841017 0.38 ENSDART00000169107
FO818704.1

chr10_-_22845485 0.36 ENSDART00000079454
vamp2
vesicle-associated membrane protein 2
chr5_+_26795773 0.36 ENSDART00000145631
tcn2
transcobalamin II
chr6_-_19023468 0.36 ENSDART00000184729
sept9b
septin 9b
chr11_+_2172335 0.35 ENSDART00000170593
hoxc12b
homeobox C12b
chr1_-_19079957 0.34 ENSDART00000141795
phox2ba
paired-like homeobox 2ba
chr7_+_36035432 0.34 ENSDART00000179004
irx3a
iroquois homeobox 3a
chr5_-_55600689 0.34 ENSDART00000013229
gnaq
guanine nucleotide binding protein (G protein), q polypeptide
chr14_-_1454045 0.34 ENSDART00000161460
pmt
phosphoethanolamine methyltransferase
chr3_-_58116314 0.34 ENSDART00000154901
si:ch211-256e16.6
si:ch211-256e16.6
chr14_+_20893065 0.33 ENSDART00000079452
lygl1
lysozyme g-like 1
chr19_+_14921000 0.33 ENSDART00000144052
oprd1a
opioid receptor, delta 1a
chr4_+_2230701 0.32 ENSDART00000080439
cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr17_+_42274825 0.32 ENSDART00000020156
pax1a
paired box 1a
chr25_+_459901 0.32 ENSDART00000154895
prtgb
protogenin homolog b (Gallus gallus)
chr12_+_38556462 0.31 ENSDART00000021069
ENSDART00000145377
rpl38
ribosomal protein L38
chr16_+_53203370 0.31 ENSDART00000154669
si:ch211-269k10.2
si:ch211-269k10.2
chr20_-_22464250 0.31 ENSDART00000165904
pdgfra
platelet-derived growth factor receptor, alpha polypeptide
chr9_+_18716485 0.30 ENSDART00000135125
serp2
stress-associated endoplasmic reticulum protein family member 2
chr7_+_56098590 0.30 ENSDART00000098453
cdh15
cadherin 15, type 1, M-cadherin (myotubule)
chr4_+_15899668 0.30 ENSDART00000101592
col7a1l
collagen type VII alpha 1-like
chr4_-_24019711 0.29 ENSDART00000077926
celf2
cugbp, Elav-like family member 2
chr9_+_14152211 0.29 ENSDART00000148055
si:ch211-67e16.11
si:ch211-67e16.11
chr1_+_51475094 0.29 ENSDART00000146352
meis1a
Meis homeobox 1 a
chr11_-_1400507 0.28 ENSDART00000173029
ENSDART00000172953
ENSDART00000111140
rpl29
ribosomal protein L29
chr1_-_43727012 0.28 ENSDART00000181064
bdh2
3-hydroxybutyrate dehydrogenase, type 2
chr21_-_43606502 0.27 ENSDART00000151030
si:ch73-362m14.4
si:ch73-362m14.4
chr9_-_4506819 0.27 ENSDART00000113975
kcnj3a
potassium inwardly-rectifying channel, subfamily J, member 3a
chr22_-_36875264 0.27 ENSDART00000137548
kng1
kininogen 1
chr3_+_46457450 0.26 ENSDART00000127127
si:ch211-66e2.5
si:ch211-66e2.5
chr16_-_22192006 0.26 ENSDART00000163338
il6r
interleukin 6 receptor
chr21_-_22317920 0.26 ENSDART00000191083
ENSDART00000108701
gdpd4b
glycerophosphodiester phosphodiesterase domain containing 4b
chr22_-_13851297 0.26 ENSDART00000080306
s100b
S100 calcium binding protein, beta (neural)
chr1_-_43727418 0.25 ENSDART00000133715
ENSDART00000074597
ENSDART00000132542
ENSDART00000181792
bdh2
SLC9B2
3-hydroxybutyrate dehydrogenase, type 2
si:dkey-162b23.4
chr25_-_14398281 0.25 ENSDART00000046934
coq9
coenzyme Q9 homolog (S. cerevisiae)
chr8_-_6943155 0.24 ENSDART00000139545
ENSDART00000033294
wdr13
WD repeat domain 13
chr15_-_39969988 0.24 ENSDART00000146054
rps5
ribosomal protein S5
chr4_-_25485404 0.24 ENSDART00000041402
pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr6_-_27123327 0.23 ENSDART00000073881
agxta
alanine-glyoxylate aminotransferase a
chr7_-_6680622 0.23 ENSDART00000180437
ENSDART00000173270
ENSDART00000066450
dusp19b
dual specificity phosphatase 19b
chr16_+_52999778 0.23 ENSDART00000011506
nkd2a
naked cuticle homolog 2a
chr13_-_16191674 0.23 ENSDART00000147868
vwc2
von Willebrand factor C domain containing 2
chr21_-_20381481 0.22 ENSDART00000115236
atp5mea
ATP synthase membrane subunit ea
chr9_-_19161982 0.22 ENSDART00000081878
pou1f1
POU class 1 homeobox 1
chr7_+_36898850 0.22 ENSDART00000113342
tox3
TOX high mobility group box family member 3
chr15_+_36309070 0.22 ENSDART00000157034
gmnc
geminin coiled-coil domain containing
chr25_+_19489370 0.22 ENSDART00000091132
glsl
glutaminase like
chr7_+_38897836 0.22 ENSDART00000024330
creb3l1
cAMP responsive element binding protein 3-like 1
chr4_-_25485214 0.22 ENSDART00000159941
pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr11_+_16216909 0.21 ENSDART00000081035
ENSDART00000147190
slc25a26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr6_-_49898881 0.21 ENSDART00000150204
atp5f1e
ATP synthase F1 subunit epsilon
chr5_-_41838354 0.21 ENSDART00000146793
si:dkey-65b12.6
si:dkey-65b12.6
chr3_+_22377312 0.20 ENSDART00000155597
arhgap27l
Rho GTPase activating protein 27, like
chr17_-_25397558 0.20 ENSDART00000182052
fam167b
family with sequence similarity 167, member B
chr4_-_69189894 0.20 ENSDART00000169596
si:ch211-209j12.1
si:ch211-209j12.1
chr20_+_34770197 0.20 ENSDART00000018304
mcm3
minichromosome maintenance complex component 3
chr10_+_38708099 0.20 ENSDART00000172306
tmprss2
transmembrane protease, serine 2
chr1_+_50997156 0.20 ENSDART00000010449
ugp2a
UDP-glucose pyrophosphorylase 2a
chr6_-_436658 0.19 ENSDART00000191515
grap2b
GRB2-related adaptor protein 2b
chr17_-_38769781 0.19 ENSDART00000062067
dglucy
D-glutamate cyclase
chr18_-_14743659 0.19 ENSDART00000125979
tshz3a
teashirt zinc finger homeobox 3a
chr9_+_44430974 0.19 ENSDART00000056846
ppp1r1c
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr12_-_46959990 0.19 ENSDART00000084557
lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr25_+_35913614 0.19 ENSDART00000022437
gpia
glucose-6-phosphate isomerase a
chr16_-_46619967 0.18 ENSDART00000158341
tmem176l.3a
transmembrane protein 176l.3a
chr20_+_32406011 0.18 ENSDART00000018640
ENSDART00000137910
snx3
sorting nexin 3
chr7_+_53541173 0.18 ENSDART00000159449
gramd2aa
GRAM domain containing 2Aa
chr15_+_16387088 0.18 ENSDART00000101789
flot2b
flotillin 2b
chr8_-_49172418 0.17 ENSDART00000142437
ENSDART00000036157
fkbp1aa
FK506 binding protein 1Aa
chr15_-_1962326 0.17 ENSDART00000179669
dock10
dedicator of cytokinesis 10
chr4_+_14826299 0.17 ENSDART00000067035
shisal1a
shisa like 1a
chr7_-_18598661 0.17 ENSDART00000182109
DTX4
si:ch211-119e14.2
chr8_+_23009662 0.16 ENSDART00000030885
uckl1a
uridine-cytidine kinase 1-like 1a
chr20_-_39333657 0.16 ENSDART00000153720
ENSDART00000142164
ccl38.1
chemokine (C-C motif) ligand 38, duplicate 1
chr22_-_26852516 0.16 ENSDART00000005829
gde1
glycerophosphodiester phosphodiesterase 1
chr3_-_22212764 0.16 ENSDART00000155490
maptb
microtubule-associated protein tau b
chr7_+_15871156 0.16 ENSDART00000145946
pax6b
paired box 6b
chr17_-_46457622 0.16 ENSDART00000130215
TMEM179 (1 of many)
transmembrane protein 179
chr4_+_17280868 0.16 ENSDART00000145349
bcat1
branched chain amino-acid transaminase 1, cytosolic
chr10_-_13116337 0.16 ENSDART00000164568
musk
muscle, skeletal, receptor tyrosine kinase
chr21_-_39327223 0.15 ENSDART00000115097
aifm5
apoptosis-inducing factor, mitochondrion-associated, 5
chr16_+_9762261 0.15 ENSDART00000020654
psmd4b
proteasome 26S subunit, non-ATPase 4b
chr11_+_41459408 0.15 ENSDART00000182285
park7
parkinson protein 7
chr19_+_10331325 0.15 ENSDART00000143930
tmem238a
transmembrane protein 238a
chr7_+_756942 0.15 ENSDART00000152224
zgc:63470
zgc:63470
chr18_-_40509006 0.15 ENSDART00000021372
chrna5
cholinergic receptor, nicotinic, alpha 5
chr8_+_54055390 0.15 ENSDART00000102696
magi1a
membrane associated guanylate kinase, WW and PDZ domain containing 1a
chr4_-_5856200 0.14 ENSDART00000121936
slc5a8
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
chr22_-_36770649 0.14 ENSDART00000169442
acy1
aminoacylase 1
chr2_+_13056802 0.14 ENSDART00000142649
prkag2b
protein kinase, AMP-activated, gamma 2 non-catalytic subunit b
chr7_-_34192834 0.14 ENSDART00000125131
smad6a
SMAD family member 6a
chr24_+_744713 0.14 ENSDART00000067764
stk17a
serine/threonine kinase 17a
chr5_-_57528943 0.14 ENSDART00000130320
pisd
phosphatidylserine decarboxylase
chr21_+_723998 0.14 ENSDART00000160956
oaz1b
ornithine decarboxylase antizyme 1b
chr8_-_30338872 0.14 ENSDART00000137583
dock8
dedicator of cytokinesis 8
chr16_+_14029283 0.13 ENSDART00000146165
ENSDART00000132075
rusc1
RUN and SH3 domain containing 1
chr10_+_17875891 0.13 ENSDART00000191744
phf24
PHD finger protein 24
chr14_-_36799280 0.13 ENSDART00000168615
rnf130
ring finger protein 130
chr7_-_30174882 0.13 ENSDART00000110409
frmd5
FERM domain containing 5
chr15_+_9053059 0.13 ENSDART00000012039
ppm1na
protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative)
chr4_-_75707991 0.13 ENSDART00000166358
ENSDART00000160021
si:dkey-165o8.2
si:dkey-165o8.2
chr5_-_42083363 0.13 ENSDART00000162596
cxcl11.5
chemokine (C-X-C motif) ligand 11, duplicate 5
chr7_+_15871408 0.13 ENSDART00000014572
pax6b
paired box 6b
chr9_+_4250918 0.13 ENSDART00000164543
kalrna
kalirin RhoGEF kinase a
chr7_-_33949246 0.12 ENSDART00000173513
pias1a
protein inhibitor of activated STAT, 1a
chr23_+_4022620 0.12 ENSDART00000055099
b4galt5
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
chr1_-_35924495 0.12 ENSDART00000184424
smad1
SMAD family member 1
chr4_+_3980247 0.12 ENSDART00000049194
gpr37b
G protein-coupled receptor 37b
chr15_-_12011202 0.12 ENSDART00000160427
ENSDART00000168715
si:dkey-202l22.6
si:dkey-202l22.6
chr10_-_17587832 0.12 ENSDART00000113101
smarcad1b
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 b
chr1_+_38776294 0.12 ENSDART00000170546
wdr17
WD repeat domain 17
chr12_+_26706745 0.12 ENSDART00000141401
arhgap12b
Rho GTPase activating protein 12b
chr22_+_7486867 0.11 ENSDART00000034586
CELA1 (1 of many)
zgc:112302
chr12_-_48006835 0.11 ENSDART00000108989
adamts14
ADAM metallopeptidase with thrombospondin type 1 motif, 14
chr11_+_27347076 0.11 ENSDART00000173383
fbln2
fibulin 2
chr20_+_2039518 0.11 ENSDART00000043157
CABZ01088134.1

chr24_-_36802891 0.11 ENSDART00000088130
dcakd
dephospho-CoA kinase domain containing
chr23_+_309099 0.11 ENSDART00000134556
ENSDART00000055152
taf11
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr6_-_35738836 0.11 ENSDART00000111642
brinp3a.1
bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 1
chr8_-_25033681 0.11 ENSDART00000003493
nfyal
nuclear transcription factor Y, alpha, like
chr12_+_31735159 0.11 ENSDART00000185442
RNF157
si:dkey-49c17.3
chr3_-_23474416 0.10 ENSDART00000161672
si:dkey-225f5.5
si:dkey-225f5.5
chr13_+_44857087 0.10 ENSDART00000017770
zbtb8os
zinc finger and BTB domain containing 8 opposite strand
chr20_+_15982482 0.10 ENSDART00000020999
angptl1a
angiopoietin-like 1a
chr11_-_279328 0.10 ENSDART00000066179
npffl
neuropeptide FF-amide peptide precursor like
chr9_+_38624478 0.10 ENSDART00000077389
ENSDART00000114728
znf148
zinc finger protein 148
chr14_-_2196267 0.10 ENSDART00000161674
ENSDART00000125674
pcdh2ab8
pcdh2ab9
protocadherin 2 alpha b 8
protocadherin 2 alpha b 9
chr15_-_15983183 0.10 ENSDART00000154841
synrg
synergin, gamma
chr4_+_9478500 0.10 ENSDART00000030738
lmf2b
lipase maturation factor 2b
chr14_+_23709134 0.09 ENSDART00000191162
ENSDART00000179754
ENSDART00000054266
gnpda1
glucosamine-6-phosphate deaminase 1
chr2_+_1881334 0.09 ENSDART00000161420
adgrl2b.1
adhesion G protein-coupled receptor L2b, tandem duplicate 1
chr9_+_38684871 0.09 ENSDART00000147938
ENSDART00000004462
heg1
heart development protein with EGF-like domains 1
chr13_+_27314795 0.09 ENSDART00000128726
eef1a1a
eukaryotic translation elongation factor 1 alpha 1a
chr3_-_11008532 0.09 ENSDART00000165086
CR382337.3

chr3_-_17716322 0.09 ENSDART00000192664
CABZ01018956.1

chr1_+_9994811 0.09 ENSDART00000143719
ENSDART00000110749
si:dkeyp-75b4.10
si:dkeyp-75b4.10
chr15_+_1199407 0.09 ENSDART00000163827
mfsd1
major facilitator superfamily domain containing 1
chr6_-_40581376 0.09 ENSDART00000185412
tspo
translocator protein
chr14_+_21222287 0.09 ENSDART00000159905
si:ch211-175m2.4
si:ch211-175m2.4
chr6_-_18618106 0.08 ENSDART00000161562
znf207b
zinc finger protein 207, b
chr22_+_26853254 0.08 ENSDART00000182487
tmem186
transmembrane protein 186
chr2_-_44280061 0.08 ENSDART00000136818
mpz
myelin protein zero
chr9_-_7640692 0.08 ENSDART00000135616
dnajb2
DnaJ (Hsp40) homolog, subfamily B, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of isl1+isl1l

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0070314 G1 to G0 transition(GO:0070314)
0.2 0.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 0.8 GO:0051000 regulation of nitric-oxide synthase activity(GO:0050999) positive regulation of nitric-oxide synthase activity(GO:0051000) beta-amyloid clearance(GO:0097242) regulation of beta-amyloid clearance(GO:1900221)
0.2 0.8 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.2 0.5 GO:0035773 insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.2 0.6 GO:0061549 sympathetic ganglion development(GO:0061549)
0.1 0.6 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.1 0.4 GO:0006824 cobalt ion transport(GO:0006824) cobalamin transport(GO:0015889)
0.1 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 0.4 GO:0015670 carbon dioxide transport(GO:0015670)
0.1 0.5 GO:0019184 nonribosomal peptide biosynthetic process(GO:0019184)
0.1 1.2 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.1 0.3 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 0.6 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 0.4 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.1 1.1 GO:0018149 peptide cross-linking(GO:0018149)
0.1 0.4 GO:0003151 outflow tract morphogenesis(GO:0003151) atrial cardiac muscle cell development(GO:0055014)
0.1 0.3 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.1 0.3 GO:0003311 pancreatic D cell differentiation(GO:0003311) pancreatic epsilon cell differentiation(GO:0090104)
0.1 0.8 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 0.2 GO:2000378 negative regulation of reactive oxygen species metabolic process(GO:2000378)
0.0 0.5 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.0 0.4 GO:0021871 forebrain regionalization(GO:0021871)
0.0 0.3 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
0.0 0.5 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.2 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.0 0.4 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.5 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.2 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.2 GO:0009098 leucine biosynthetic process(GO:0009098)
0.0 0.3 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.2 GO:0006545 glycine biosynthetic process(GO:0006545)
0.0 0.7 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.4 GO:2000047 regulation of cell-cell adhesion mediated by cadherin(GO:2000047)
0.0 0.2 GO:1902292 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.0 0.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.2 GO:0006537 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.0 0.1 GO:1903358 regulation of Golgi organization(GO:1903358)
0.0 0.2 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.4 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.2 GO:0044211 CTP salvage(GO:0044211)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.2 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.5 GO:0060034 notochord cell differentiation(GO:0060034)
0.0 0.3 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.9 GO:0006937 regulation of muscle contraction(GO:0006937)
0.0 0.2 GO:0006536 glutamate metabolic process(GO:0006536)
0.0 0.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.2 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.3 GO:1901663 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:0032048 cardiolipin metabolic process(GO:0032048) phosphatidylglycerol metabolic process(GO:0046471)
0.0 0.1 GO:0035094 response to nicotine(GO:0035094)
0.0 0.5 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.1 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.1 GO:0051145 smooth muscle cell differentiation(GO:0051145) negative regulation of muscle cell differentiation(GO:0051148)
0.0 0.2 GO:0045661 regulation of myoblast differentiation(GO:0045661)
0.0 0.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.5 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0005577 fibrinogen complex(GO:0005577)
0.2 0.7 GO:0044279 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.2 0.8 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 0.6 GO:0016600 flotillin complex(GO:0016600)
0.1 0.8 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.5 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.2 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.1 0.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.5 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0090443 FAR/SIN/STRIPAK complex(GO:0090443)
0.0 0.5 GO:0031430 M band(GO:0031430)
0.0 0.2 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.9 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0030904 retromer complex(GO:0030904)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.7 GO:0016342 catenin complex(GO:0016342)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.6 GO:0031941 filamentous actin(GO:0031941)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0004031 aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.1 0.8 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.3 GO:0038046 enkephalin receptor activity(GO:0038046)
0.1 0.3 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.9 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1 0.3 GO:0048407 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.1 0.4 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.1 0.3 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.2 GO:0004427 inorganic diphosphatase activity(GO:0004427) protein histidine phosphatase activity(GO:0101006)
0.0 0.4 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.3 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.1 GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489)
0.0 0.5 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.2 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.0 0.2 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.3 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.2 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.6 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.5 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.1 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.2 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.5 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.2 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.6 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.2 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.5 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.0 GO:0042806 fucose binding(GO:0042806)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 0.8 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 0.3 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.2 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.0 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.1 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions