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PRJNA195909:zebrafish embryo and larva development

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Results for klf5l+klf6a+klf6b

Z-value: 1.51

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Transcription factors associated with klf5l+klf6a+klf6b

Gene Symbol Gene ID Gene Info
klf5l
ENSDARG00000018757 Kruppel-like factor 5 like
klf6a
ENSDARG00000029072 Kruppel-like factor 6a
klf6b
ENSDARG00000038561 Kruppel-like factor 6b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf6bdr11_v1_chr2_+_48073972_480739720.881.7e-03Click!
klf6adr11_v1_chr24_-_4148914_4148915-0.791.1e-02Click!
klf5ldr11_v1_chr21_-_38153824_38153824-0.343.7e-01Click!

Activity profile of klf5l+klf6a+klf6b motif

Sorted Z-values of klf5l+klf6a+klf6b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_-_30293224 4.86 ENSDART00000101051
slbp2
stem-loop binding protein 2
chr6_-_60104628 3.74 ENSDART00000057463
ENSDART00000169188
pmepa1
prostate transmembrane protein, androgen induced 1
chr6_-_9952103 3.72 ENSDART00000065475
zp2l2
zona pellucida glycoprotein 2, like 2
chr17_-_2584423 3.50 ENSDART00000013506
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr18_-_127558 3.44 ENSDART00000149556
trpm7
transient receptor potential cation channel, subfamily M, member 7
chr3_-_21118969 3.10 ENSDART00000129016
maza
MYC-associated zinc finger protein a (purine-binding transcription factor)
chr20_-_49889111 2.64 ENSDART00000058858
kif13bb
kinesin family member 13Bb
chr15_-_25613114 2.58 ENSDART00000182431
ENSDART00000187405
taok1a
TAO kinase 1a
chr7_+_25126629 2.28 ENSDART00000077217
zgc:101765
zgc:101765
chr4_+_3438510 2.24 ENSDART00000155320
atxn7l1
ataxin 7-like 1
chr19_+_7636941 2.16 ENSDART00000081611
ENSDART00000163805
ENSDART00000112404
cgnb
cingulin b
chr7_-_45852270 1.95 ENSDART00000170224
shcbp1
SHC SH2-domain binding protein 1
chr18_-_127873 1.86 ENSDART00000148490
trpm7
transient receptor potential cation channel, subfamily M, member 7
chr19_+_24324967 1.80 ENSDART00000090081
sema4ab
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ab
chr13_-_12021566 1.78 ENSDART00000125430
pprc1
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr22_+_1006573 1.76 ENSDART00000123458
pparda
peroxisome proliferator-activated receptor delta a
chr24_-_41180149 1.76 ENSDART00000019975
acvr2ba
activin A receptor type 2Ba
chr20_-_1268863 1.72 ENSDART00000109321
ENSDART00000027119
lats1
large tumor suppressor kinase 1
chr15_-_45538773 1.69 ENSDART00000113494
MB21D2
Mab-21 domain containing 2
chr2_+_59015878 1.63 ENSDART00000148816
ENSDART00000122795
si:ch1073-391i24.1
si:ch1073-391i24.1
chr13_+_23093743 1.60 ENSDART00000148034
pik3ap1
phosphoinositide-3-kinase adaptor protein 1
chr5_-_23800376 1.60 ENSDART00000134184
gbgt1l4
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4
chr11_-_11965033 1.56 ENSDART00000193683
abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr24_+_36452927 1.51 ENSDART00000168181
zgc:114120
zgc:114120
chr9_+_17787864 1.49 ENSDART00000013111
dgkh
diacylglycerol kinase, eta
chr24_+_24726956 1.47 ENSDART00000144574
ENSDART00000066628
mtfr1
mitochondrial fission regulator 1
chr8_-_4100365 1.44 ENSDART00000142846
cux2b
cut-like homeobox 2b
chr18_+_660578 1.35 ENSDART00000161203
CELF6
si:dkey-205h23.2
chr18_+_6641542 1.32 ENSDART00000160379
c2cd5
C2 calcium-dependent domain containing 5
chr22_+_35089031 1.31 ENSDART00000076040
srfa
serum response factor a
chr22_+_1786230 1.30 ENSDART00000169318
ENSDART00000164948
znf1154
zinc finger protein 1154
chr24_-_28381404 1.27 ENSDART00000148406
prkag2a
protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
chr22_+_12366516 1.22 ENSDART00000157802
r3hdm1
R3H domain containing 1
chr21_-_5056812 1.12 ENSDART00000139713
ENSDART00000140859
zgc:77838
zgc:77838
chr6_+_12503849 1.10 ENSDART00000149529
stk24b
serine/threonine kinase 24b (STE20 homolog, yeast)
chr16_-_7793457 1.09 ENSDART00000113483
trim71
tripartite motif containing 71, E3 ubiquitin protein ligase
chr7_-_46019756 1.09 ENSDART00000162583
zgc:162297
zgc:162297
chr17_+_6793001 1.06 ENSDART00000030773
foxo3a
forkhead box O3A
chr6_-_7109063 1.03 ENSDART00000148548
nhej1
nonhomologous end-joining factor 1
chr3_+_17634952 1.02 ENSDART00000191833
rab5c
RAB5C, member RAS oncogene family
chr4_+_15006217 1.00 ENSDART00000090837
zc3hc1
zinc finger, C3HC-type containing 1
chr21_+_43253538 1.00 ENSDART00000179940
ENSDART00000164806
ENSDART00000147026
shroom1
shroom family member 1
chr19_+_4892281 1.00 ENSDART00000150969
cdk12
cyclin-dependent kinase 12
chr17_+_37253706 0.95 ENSDART00000076004
tmem62
transmembrane protein 62
chr2_+_24867534 0.89 ENSDART00000158050
rab3aa
RAB3A, member RAS oncogene family, a
chr25_+_2229301 0.88 ENSDART00000180198
pparab
peroxisome proliferator-activated receptor alpha b
chr13_+_33688474 0.88 ENSDART00000161465
CABZ01087953.1

chr7_-_23768234 0.87 ENSDART00000173981
si:ch211-200p22.4
si:ch211-200p22.4
chr10_-_38456382 0.86 ENSDART00000182129
gdpd5a
glycerophosphodiester phosphodiesterase domain containing 5a
chr20_-_7176809 0.83 ENSDART00000012247
ENSDART00000125019
dhcr24
24-dehydrocholesterol reductase
chr15_-_47956388 0.77 ENSDART00000116506
si:ch1073-111c8.3
si:ch1073-111c8.3
chr14_-_237130 0.76 ENSDART00000164988
bod1l1
biorientation of chromosomes in cell division 1-like 1
chr11_-_12158412 0.73 ENSDART00000147670
npepps
aminopeptidase puromycin sensitive
chr22_-_26558166 0.71 ENSDART00000111125
glis2a
GLIS family zinc finger 2a
chr6_-_10788065 0.68 ENSDART00000190968
wipf1b
WAS/WASL interacting protein family, member 1b
chr2_+_24868010 0.64 ENSDART00000078838
rab3aa
RAB3A, member RAS oncogene family, a
chr13_-_23611960 0.62 ENSDART00000146216
prim2
DNA primase subunit 2
chr21_-_24865217 0.60 ENSDART00000101136
igsf9bb
immunoglobulin superfamily, member 9Bb
chr19_-_20106486 0.57 ENSDART00000043924
mpp6b
membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)
chr4_+_357810 0.55 ENSDART00000163436
ENSDART00000103645
tmem181
transmembrane protein 181
chr2_-_38225388 0.50 ENSDART00000146485
ENSDART00000128043
acin1a
apoptotic chromatin condensation inducer 1a
chr7_-_32980017 0.49 ENSDART00000113744
pkp3b
plakophilin 3b
chr16_+_34111919 0.47 ENSDART00000134037
ENSDART00000006061
ENSDART00000140552
tcea3
transcription elongation factor A (SII), 3
chr11_+_45461853 0.47 ENSDART00000173409
sos1
son of sevenless homolog 1 (Drosophila)
chr1_-_59232267 0.43 ENSDART00000169658
ENSDART00000163257
akap8l
A kinase (PRKA) anchor protein 8-like
chr6_+_27514465 0.41 ENSDART00000128985
ENSDART00000079397
ryk
receptor-like tyrosine kinase
chr3_-_33941319 0.41 ENSDART00000026090
ENSDART00000111878
gtf2f1
general transcription factor IIF, polypeptide 1
chr6_-_13891727 0.38 ENSDART00000065356
desmb
desmin b
chr9_-_34842414 0.35 ENSDART00000126348
BX601644.1
Danio rerio cytokine receptor-like factor 2 (crlf2), mRNA.
chr9_-_3496548 0.32 ENSDART00000102876
cybrd1
cytochrome b reductase 1
chr20_+_26940178 0.31 ENSDART00000190888
cdca4
cell division cycle associated 4
chr20_+_700616 0.29 ENSDART00000168166
senp6a
SUMO1/sentrin specific peptidase 6a
chr3_-_30909487 0.28 ENSDART00000025046
ppp1caa
protein phosphatase 1, catalytic subunit, alpha isozyme a
chr15_+_20543770 0.28 ENSDART00000092357
sgsm2
small G protein signaling modulator 2
chr21_-_24865454 0.25 ENSDART00000142907
igsf9bb
immunoglobulin superfamily, member 9Bb
chr6_+_22025806 0.24 ENSDART00000151240
ZXDC
si:dkey-156n14.3
chr7_-_25126212 0.22 ENSDART00000173588
MAJIN
si:dkey-23i12.11
chr9_+_44722205 0.12 ENSDART00000086176
ENSDART00000145271
ENSDART00000132696
nckap1
NCK-associated protein 1
chr13_-_50200042 0.06 ENSDART00000074230
pkz
protein kinase containing Z-DNA binding domains

Network of associatons between targets according to the STRING database.

First level regulatory network of klf5l+klf6a+klf6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.7 4.9 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) embryonic cleavage(GO:0040016)
0.5 3.7 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.5 1.5 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.4 2.6 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.3 0.9 GO:0070417 cellular response to cold(GO:0070417)
0.3 1.3 GO:0010828 positive regulation of glucose transport(GO:0010828)
0.3 1.8 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.2 1.1 GO:0010586 miRNA metabolic process(GO:0010586)
0.2 3.5 GO:0060046 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.2 0.6 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 1.7 GO:0003139 secondary heart field specification(GO:0003139) regulation of organ growth(GO:0046620)
0.1 1.5 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.1 0.8 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 0.9 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.1 1.6 GO:0030259 lipid glycosylation(GO:0030259)
0.1 2.6 GO:0097194 execution phase of apoptosis(GO:0097194)
0.1 0.9 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 0.3 GO:0010039 response to iron ion(GO:0010039)
0.1 0.3 GO:0090234 regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234)
0.1 1.4 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.1 1.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.4 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0 1.5 GO:0000266 mitochondrial fission(GO:0000266)
0.0 1.8 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.0 1.0 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 1.3 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 1.8 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 1.8 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.7 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.8 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 1.1 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.0 1.9 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 2.0 GO:0021782 glial cell development(GO:0021782)
0.0 1.0 GO:0030100 regulation of endocytosis(GO:0030100)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0032807 DNA ligase IV complex(GO:0032807)
0.2 0.6 GO:1990077 primosome complex(GO:1990077)
0.1 1.8 GO:0048179 activin receptor complex(GO:0048179)
0.1 1.0 GO:0019908 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.1 1.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.9 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.1 0.4 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 3.7 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:0031526 brush border membrane(GO:0031526)
0.0 2.6 GO:0005871 kinesin complex(GO:0005871)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.0 1.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 3.2 GO:0043296 apical junction complex(GO:0043296)
0.0 0.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.0 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.5 GO:0014069 postsynaptic density(GO:0014069)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.7 GO:0070412 R-SMAD binding(GO:0070412)
0.4 5.3 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.3 3.5 GO:0035804 structural constituent of egg coat(GO:0035804)
0.2 4.9 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 1.6 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 1.8 GO:0017002 activin-activated receptor activity(GO:0017002)
0.1 1.1 GO:0035198 miRNA binding(GO:0035198)
0.1 0.3 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 0.4 GO:0001096 RNA polymerase II basal transcription factor binding(GO:0001091) TFIIF-class transcription factor binding(GO:0001096)
0.1 2.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 1.0 GO:0030332 cyclin binding(GO:0030332)
0.1 0.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.8 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 1.3 GO:0016208 AMP binding(GO:0016208)
0.0 0.3 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.8 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.8 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 1.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 2.6 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.2 GO:0003774 motor activity(GO:0003774)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 2.1 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 1.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 1.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.1 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.6 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.3 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport