Project

PRJNA195909:zebrafish embryo and larva development

Navigation
Downloads

Results for lhx1a+lhx1b

Z-value: 0.45

Motif logo

logo of

Transcription factors associated with lhx1a+lhx1b

Gene Symbol Gene ID Gene Info
lhx1b
ENSDARG00000007944 LIM homeobox 1b
lhx1a
ENSDARG00000014018 LIM homeobox 1a
lhx1b
ENSDARG00000111635 LIM homeobox 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lhx1bdr11_v1_chr5_+_56268436_562684360.655.9e-02Click!
lhx1adr11_v1_chr15_-_27710513_277105750.137.5e-01Click!

Activity profile of lhx1a+lhx1b motif

Sorted Z-values of lhx1a+lhx1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_32818607 1.30 ENSDART00000075465
mylpfa
myosin light chain, phosphorylatable, fast skeletal muscle a
chr17_+_15433518 0.85 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr24_-_26328721 0.85 ENSDART00000125468
apodb
apolipoprotein Db
chr4_+_9669717 0.84 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr12_-_17712393 0.84 ENSDART00000143534
ENSDART00000010144
pvalb2
parvalbumin 2
chr17_+_15433671 0.81 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr4_+_16885854 0.81 ENSDART00000017726
etnk1
ethanolamine kinase 1
chr3_-_19368435 0.79 ENSDART00000132987
s1pr5a
sphingosine-1-phosphate receptor 5a
chr12_-_35830625 0.67 ENSDART00000180028
CU459056.1

chr9_-_22147567 0.65 ENSDART00000110941
crygm2d14
crystallin, gamma M2d14
chr3_+_36424055 0.63 ENSDART00000170318
si:ch1073-443f11.2
si:ch1073-443f11.2
chr20_-_45812144 0.63 ENSDART00000147897
ENSDART00000147637
fermt1
fermitin family member 1
chr1_-_669717 0.62 ENSDART00000160564
cyyr1
cysteine/tyrosine-rich 1
chr9_-_14504834 0.61 ENSDART00000056103
nrp2b
neuropilin 2b
chr12_+_13118540 0.58 ENSDART00000077840
ENSDART00000127870
cmn
calymmin
chr19_+_43297546 0.53 ENSDART00000168002
laptm5
lysosomal protein transmembrane 5
chr18_+_46382484 0.52 ENSDART00000024202
ENSDART00000142790
daw1
dynein assembly factor with WDR repeat domains 1
chr2_-_30668580 0.50 ENSDART00000087270
ctnnd2b
catenin (cadherin-associated protein), delta 2b
chr3_-_15999501 0.50 ENSDART00000160668
nme3
NME/NM23 nucleoside diphosphate kinase 3
chr4_-_9891874 0.47 ENSDART00000067193
adm2a
adrenomedullin 2a
chr11_-_41853874 0.46 ENSDART00000002556
mrto4
MRT4 homolog, ribosome maturation factor
chr5_-_31901468 0.46 ENSDART00000147814
ENSDART00000141446
coro1cb
coronin, actin binding protein, 1Cb
chr19_-_5769728 0.46 ENSDART00000133106
si:ch211-264f5.6
si:ch211-264f5.6
chr16_-_28856112 0.46 ENSDART00000078543
syt11b
synaptotagmin XIb
chr22_-_24285432 0.45 ENSDART00000164083
si:ch211-117l17.4
si:ch211-117l17.4
chr24_-_38657683 0.45 ENSDART00000154843
si:ch1073-164k15.3
si:ch1073-164k15.3
chr3_+_45687266 0.44 ENSDART00000131652
gpr146
G protein-coupled receptor 146
chr19_-_5769553 0.44 ENSDART00000175003
si:ch211-264f5.6
si:ch211-264f5.6
chr1_+_6172786 0.43 ENSDART00000126468
prkag3a
protein kinase, AMP-activated, gamma 3a non-catalytic subunit
chr9_+_34641237 0.42 ENSDART00000133996
shox
short stature homeobox
chr7_+_20471315 0.39 ENSDART00000173714
si:dkey-19b23.13
si:dkey-19b23.13
chr4_+_57881965 0.39 ENSDART00000162234
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr2_+_2223837 0.38 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr23_+_4689626 0.38 ENSDART00000131532
gp9
glycoprotein IX (platelet)
chr6_-_21582444 0.33 ENSDART00000151339
si:dkey-43k4.3
si:dkey-43k4.3
chr7_-_38658411 0.33 ENSDART00000109463
ENSDART00000017155
npsn
nephrosin
chr22_-_12160283 0.33 ENSDART00000146785
ENSDART00000128176
tmem163b
transmembrane protein 163b
chr6_+_7444899 0.30 ENSDART00000053775
arf3b
ADP-ribosylation factor 3b
chr21_+_6151953 0.29 ENSDART00000131854
si:dkey-93m18.6
si:dkey-93m18.6
chr9_+_37152564 0.29 ENSDART00000189497
gli2a
GLI family zinc finger 2a
chr14_-_413273 0.29 ENSDART00000163976
ENSDART00000179907
FAT4
FAT atypical cadherin 4
chr20_+_11731039 0.28 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
si:ch211-155o21.3
chr15_+_9861973 0.27 ENSDART00000170945
si:dkey-13m3.2
si:dkey-13m3.2
chr23_-_16485190 0.27 ENSDART00000155038
si:dkeyp-100a5.4
si:dkeyp-100a5.4
chr22_-_19552796 0.26 ENSDART00000148088
ENSDART00000105485
si:dkey-78l4.14
si:dkey-78l4.14
chr14_-_451555 0.26 ENSDART00000190906
FAT4
FAT atypical cadherin 4
chr24_+_21540842 0.26 ENSDART00000091529
wasf3b
WAS protein family, member 3b
chr17_+_49281597 0.26 ENSDART00000155599
zgc:113176
zgc:113176
chr21_-_17482465 0.26 ENSDART00000004548
barhl1b
BarH-like homeobox 1b
chr1_+_51039558 0.26 ENSDART00000024743
dpy30
dpy-30 histone methyltransferase complex regulatory subunit
chr2_+_20406399 0.26 ENSDART00000006817
ENSDART00000137848
palmda
palmdelphin a
chr23_-_35649000 0.26 ENSDART00000053310
tmem18
transmembrane protein 18
chr3_-_56541723 0.25 ENSDART00000156398
ENSDART00000050576
ENSDART00000184874
si:ch211-189a21.1
cyth1a
si:ch211-189a21.1
cytohesin 1a
chr3_-_29941357 0.25 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
grna
granulin a
chr24_-_31425799 0.24 ENSDART00000157998
cngb3.1
cyclic nucleotide gated channel beta 3, tandem duplicate 1
chr8_+_43340995 0.24 ENSDART00000038566
rflna
refilin A
chr13_-_29420885 0.24 ENSDART00000024225
chata
choline O-acetyltransferase a
chr15_-_22074315 0.23 ENSDART00000149830
drd2a
dopamine receptor D2a
chr18_-_17485419 0.22 ENSDART00000018764
foxl1
forkhead box L1
chr8_-_16712111 0.22 ENSDART00000184147
ENSDART00000180419
ENSDART00000076600
rpe65c
retinal pigment epithelium-specific protein 65c
chr6_-_11768198 0.22 ENSDART00000183463
march7
membrane-associated ring finger (C3HC4) 7
chr16_-_12173554 0.22 ENSDART00000110567
ENSDART00000155935
clstn3
calsyntenin 3
chr3_+_3681116 0.21 ENSDART00000109618
art4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr11_-_40204621 0.21 ENSDART00000086287
znf362a
zinc finger protein 362a
chr15_-_17618800 0.20 ENSDART00000157185
adamts15b
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr8_-_12867434 0.20 ENSDART00000081657
slc2a6
solute carrier family 2 (facilitated glucose transporter), member 6
chr21_+_25802190 0.20 ENSDART00000128987
nf2b
neurofibromin 2b (merlin)
chr24_-_40860603 0.19 ENSDART00000188032
CU633479.7

chr5_+_38040407 0.18 ENSDART00000139936
si:dkey-111e8.4
si:dkey-111e8.4
chr1_+_21731382 0.18 ENSDART00000054395
pax5
paired box 5
chr8_-_45760087 0.17 ENSDART00000025620
ppiaa
peptidylprolyl isomerase Aa (cyclophilin A)
chr10_+_16584382 0.17 ENSDART00000112039
CR790388.1

chr6_-_40029423 0.17 ENSDART00000103230
pfkfb4b
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4b
chr5_+_2815021 0.16 ENSDART00000020472
hpda
4-hydroxyphenylpyruvate dioxygenase a
chr22_-_8725768 0.15 ENSDART00000189873
ENSDART00000181819
si:ch73-27e22.1
si:ch73-27e22.8
si:ch73-27e22.1
si:ch73-27e22.8
chr9_+_24159280 0.15 ENSDART00000184624
ENSDART00000178422
hecw2a
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr24_-_35767501 0.15 ENSDART00000105680
ENSDART00000042290
ENSDART00000166264
dtna
dystrobrevin, alpha
chr4_+_72723304 0.15 ENSDART00000186791
ENSDART00000158902
ENSDART00000191925
rab3ip
RAB3A interacting protein (rabin3)
chr23_-_16484383 0.15 ENSDART00000187839
si:dkeyp-100a5.4
si:dkeyp-100a5.4
chr4_+_5255041 0.15 ENSDART00000137966
ccdc167
coiled-coil domain containing 167
chr20_-_28642061 0.14 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr12_+_7497882 0.14 ENSDART00000134608
phyhiplb
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr16_-_12173399 0.14 ENSDART00000142574
clstn3
calsyntenin 3
chr15_-_17619306 0.14 ENSDART00000184011
adamts15b
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr17_-_10122204 0.13 ENSDART00000160751
BX088587.1

chr8_-_30979494 0.13 ENSDART00000138959
si:ch211-251j10.3
si:ch211-251j10.3
chr5_-_38094130 0.13 ENSDART00000131831
si:ch211-284e13.4
si:ch211-284e13.4
chr6_-_28980756 0.13 ENSDART00000014661
glmnb
glomulin, FKBP associated protein b
chr6_+_39905021 0.12 ENSDART00000064904
endou
endonuclease, polyU-specific
chr22_-_36530902 0.12 ENSDART00000056188
polr2h
info polymerase (RNA) II (DNA directed) polypeptide H
chr10_+_42423318 0.12 ENSDART00000134282
npy8ar
neuropeptide Y receptor Y8a
chr21_-_39327223 0.12 ENSDART00000115097
aifm5
apoptosis-inducing factor, mitochondrion-associated, 5
chr23_-_1660708 0.12 ENSDART00000175138
CU693481.1

chr9_+_28598577 0.11 ENSDART00000142623
ENSDART00000135947
si:ch73-7i4.1
si:ch73-7i4.1
chr21_-_35419486 0.11 ENSDART00000138529
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr15_-_14552101 0.11 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr4_+_12966640 0.11 ENSDART00000113357
vhll
von Hippel-Lindau tumor suppressor like
chr2_+_20605925 0.11 ENSDART00000191510
olfml2bb
olfactomedin-like 2Bb
chr4_+_69191065 0.11 ENSDART00000170595
znf1075
zinc finger protein 1075
chr20_+_6035427 0.10 ENSDART00000054086
tshr
thyroid stimulating hormone receptor
chr11_-_2838699 0.10 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr22_+_19553390 0.09 ENSDART00000061739
hsd11b1la
hydroxysteroid (11-beta) dehydrogenase 1-like a
chr9_+_24159725 0.09 ENSDART00000137756
hecw2a
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr10_+_45089820 0.09 ENSDART00000175481
camk2b2
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr4_+_52212057 0.09 ENSDART00000165627
znf1034
zinc finger protein 1034
chr17_+_31914877 0.08 ENSDART00000177801
FAM196A (1 of many)
family with sequence similarity 196 member A
chr2_+_38373272 0.08 ENSDART00000113111
psmb5
proteasome subunit beta 5
chr6_+_11989537 0.08 ENSDART00000190817
baz2ba
bromodomain adjacent to zinc finger domain, 2Ba
chr7_-_52388734 0.08 ENSDART00000174186
wdr93
WD repeat domain 93
chr3_+_26342768 0.07 ENSDART00000163832
si:ch211-156b7.4
si:ch211-156b7.4
chr8_+_19504011 0.07 ENSDART00000158859
ENSDART00000159044
sec22bb
SEC22 homolog B, vesicle trafficking protein b
chr8_-_12867128 0.07 ENSDART00000142201
slc2a6
solute carrier family 2 (facilitated glucose transporter), member 6
chr4_+_49266048 0.07 ENSDART00000127767
ENSDART00000186362
si:ch211-42i6.2
si:ch211-42i6.2
chr11_+_30663300 0.07 ENSDART00000161662
ttbk1a
tau tubulin kinase 1a
chr15_-_20939579 0.07 ENSDART00000152371
usp2a
ubiquitin specific peptidase 2a
chr12_+_16168342 0.06 ENSDART00000079326
ENSDART00000170024
lrp2b
low density lipoprotein receptor-related protein 2b
chr7_+_4474880 0.06 ENSDART00000143528
si:dkey-83f18.14
si:dkey-83f18.14
chr12_-_48006835 0.05 ENSDART00000108989
adamts14
ADAM metallopeptidase with thrombospondin type 1 motif, 14
chr24_+_2495197 0.05 ENSDART00000146887
f13a1a.1
coagulation factor XIII, A1 polypeptide a, tandem duplicate 1
chr23_-_4409668 0.05 ENSDART00000081823
si:ch73-142c19.1
si:ch73-142c19.1
chr20_-_40755614 0.05 ENSDART00000061247
cx32.3
connexin 32.3
chr22_+_19552987 0.04 ENSDART00000105315
hsd11b1la
hydroxysteroid (11-beta) dehydrogenase 1-like a
chr17_-_45040813 0.04 ENSDART00000075514
entpd5a
ectonucleoside triphosphate diphosphohydrolase 5a
chr13_-_29421331 0.04 ENSDART00000150228
chata
choline O-acetyltransferase a
chr10_+_11261576 0.04 ENSDART00000155333
hsdl2
hydroxysteroid dehydrogenase like 2
chr24_+_28953089 0.04 ENSDART00000153761
rnpc3
RNA-binding region (RNP1, RRM) containing 3
chr25_+_4751879 0.03 ENSDART00000169465
si:zfos-2372e4.1
si:zfos-2372e4.1
chr25_+_22296666 0.03 ENSDART00000138887
ENSDART00000193410
cyp11a2
cytochrome P450, family 11, subfamily A, polypeptide 2
chr16_+_54209504 0.03 ENSDART00000020033
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr7_+_22809905 0.03 ENSDART00000166900
ENSDART00000143455
ENSDART00000126037
sf1
splicing factor 1
chr24_+_13316737 0.03 ENSDART00000191658
SBSPON
somatomedin B and thrombospondin type 1 domain containing
chr13_-_12602920 0.02 ENSDART00000102311
lrit3b
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b
chr16_-_16761164 0.02 ENSDART00000135872
si:dkey-27n14.1
si:dkey-27n14.1
chr22_-_14247276 0.02 ENSDART00000033332
si:ch211-246m6.5
si:ch211-246m6.5
chr13_-_9450210 0.02 ENSDART00000133768
pimr152
Pim proto-oncogene, serine/threonine kinase, related 152
chr20_+_46202188 0.00 ENSDART00000100523
taar13c
trace amine associated receptor 13c
chr21_-_2415808 0.00 ENSDART00000171179
si:ch211-241b2.5
si:ch211-241b2.5
chr5_+_60590796 0.00 ENSDART00000159859
tmem132e
transmembrane protein 132E

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx1a+lhx1b

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008292 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.1 0.2 GO:1903011 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.1 0.3 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.1 0.2 GO:0016123 tetraterpenoid metabolic process(GO:0016108) tetraterpenoid biosynthetic process(GO:0016109) carotenoid metabolic process(GO:0016116) carotenoid biosynthetic process(GO:0016117) xanthophyll metabolic process(GO:0016122) xanthophyll biosynthetic process(GO:0016123) zeaxanthin metabolic process(GO:1901825) zeaxanthin biosynthetic process(GO:1901827)
0.1 0.6 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.0 0.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.5 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.2 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.0 0.2 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.9 GO:0007568 aging(GO:0007568)
0.0 0.2 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.5 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.0 0.2 GO:0018120 peptidyl-arginine ADP-ribosylation(GO:0018120)
0.0 0.4 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.2 GO:0060005 reflex(GO:0060004) vestibular reflex(GO:0060005) vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.0 0.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.3 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.2 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.5 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.4 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.3 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.3 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.0 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.1 GO:0030891 VCB complex(GO:0030891)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.8 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.2 GO:0031005 filamin binding(GO:0031005)
0.1 0.2 GO:0052885 retinol isomerase activity(GO:0050251) all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity(GO:0052885)
0.1 0.2 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.1 0.6 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0055105 ubiquitin-protein transferase inhibitor activity(GO:0055105)
0.0 0.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.2 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.2 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.5 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.4 GO:0016208 AMP binding(GO:0016208)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0008443 6-phosphofructo-2-kinase activity(GO:0003873) phosphofructokinase activity(GO:0008443)
0.0 0.1 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.6 GO:0005178 integrin binding(GO:0005178)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.4 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors