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PRJNA195909:zebrafish embryo and larva development

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Results for lhx6-1

Z-value: 1.91

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Transcription factors associated with lhx6-1

Gene Symbol Gene ID Gene Info
ENSDARG00000052165 si_ch211-236k19.2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
si:ch211-236k19.2dr11_v1_chr5_-_64900552_649005520.703.6e-02Click!

Activity profile of lhx6-1 motif

Sorted Z-values of lhx6-1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr24_+_1023839 4.03 ENSDART00000082526
zgc:111976
chr2_-_38284648 4.02 ENSDART00000148281
ENSDART00000132621
si:ch211-14a17.7
chr12_-_33354409 4.00 ENSDART00000178515
solute carrier family 16 (monocarboxylate transporter), member 3
chr6_+_28208973 3.76 ENSDART00000171216
ENSDART00000171377
ENSDART00000167389
ENSDART00000166988
si:ch73-14h10.2
chr2_+_6255434 3.73 ENSDART00000139429
zona pellucida glycoprotein 3b
chr10_-_34915886 3.63 ENSDART00000141201
ENSDART00000002166
cyclin A1
chr10_-_34916208 3.19 ENSDART00000187371
cyclin A1
chr12_-_33357655 3.14 ENSDART00000066233
ENSDART00000148165
solute carrier family 16 (monocarboxylate transporter), member 3
chr13_-_35808904 2.90 ENSDART00000171667
mitogen-activated protein kinase kinase kinase 4
chr24_-_9979342 2.79 ENSDART00000138576
ENSDART00000191206
zgc:171977
chr7_+_22313533 2.56 ENSDART00000123457
si:dkey-11f12.2
chr19_-_4793263 2.54 ENSDART00000147510
ENSDART00000141336
ENSDART00000110551
ENSDART00000146684
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr8_-_23780334 2.52 ENSDART00000145179
ENSDART00000145894
zgc:195245
chr9_+_44994214 2.50 ENSDART00000141434
retinol saturase (all-trans-retinol 13,14-reductase) like
chr16_+_47207691 2.45 ENSDART00000062507
islet cell autoantigen 1
chr9_+_18829360 2.39 ENSDART00000006514
general transcription factor IIF, polypeptide 2b
chr14_-_14659023 2.37 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
NAD(P) dependent steroid dehydrogenase-like
chr12_-_22238004 2.33 ENSDART00000038310
ORMDL sphingolipid biosynthesis regulator 3
chr24_-_33366188 2.16 ENSDART00000074161
solute carrier family 4 (anion exchanger), member 2b
chr4_+_9467049 2.12 ENSDART00000012659
zgc:55888
chr2_+_6253246 2.10 ENSDART00000058256
ENSDART00000076700
zona pellucida glycoprotein 3b
chr5_-_67241633 2.09 ENSDART00000114783
CAP-GLY domain containing linker protein 1a
chr5_-_30074332 2.05 ENSDART00000147963
beta-carotene oxygenase 2a
chr19_-_4785734 2.04 ENSDART00000113088
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr24_-_24724233 2.02 ENSDART00000127044
ENSDART00000012399
armadillo repeat containing 1
chr20_-_37813863 1.98 ENSDART00000147529
basic leucine zipper transcription factor, ATF-like 3
chr19_+_9231766 1.86 ENSDART00000190617
lysine (K)-specific methyltransferase 2Ba
chr8_+_11325310 1.83 ENSDART00000142577
frataxin
chr3_+_46559639 1.83 ENSDART00000146189
ENSDART00000127832
ENSDART00000151035
ribonucleoprotein, PTB-binding 1
chr12_+_47446158 1.82 ENSDART00000152857
formin 2b
chr22_-_21897203 1.80 ENSDART00000158501
ENSDART00000105566
ENSDART00000136795
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
chr16_+_39159752 1.78 ENSDART00000122081
syntabulin (syntaxin-interacting)
chr3_-_60711127 1.78 ENSDART00000184119
UBA-like domain containing 2
chr3_-_5067585 1.75 ENSDART00000169609
thyrotrophic embryonic factor b
chr21_-_13661631 1.72 ENSDART00000184408
patatin-like phospholipase domain containing 7a
chr25_-_1323623 1.72 ENSDART00000156532
ENSDART00000157163
ENSDART00000156062
ENSDART00000082447
ENSDART00000189175
calmodulin-like 4b
chr1_+_30723677 1.70 ENSDART00000177900
bora, aurora kinase A activator
chr4_-_837768 1.70 ENSDART00000185280
ENSDART00000135618
sine oculis binding protein homolog (Drosophila) b
chr1_+_30723380 1.69 ENSDART00000127943
ENSDART00000062628
ENSDART00000127670
bora, aurora kinase A activator
chr13_+_38817871 1.68 ENSDART00000187708
collagen, type XIX, alpha 1
chr7_-_33868903 1.67 ENSDART00000173500
ENSDART00000178746
uveal autoantigen with coiled-coil domains and ankyrin repeats b
chr16_-_28658341 1.66 ENSDART00000148456
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr13_-_24825691 1.63 ENSDART00000142745
STE20-like kinase a
chr7_+_69528850 1.61 ENSDART00000109507
Rap1 GTPase-GDP dissociation stimulator 1
chr10_-_32494499 1.60 ENSDART00000129395
UV radiation resistance associated gene
chr6_+_40922572 1.60 ENSDART00000133599
ENSDART00000002728
ENSDART00000145153
eukaryotic translation initiation factor 4E nuclear import factor 1
chr10_+_34001444 1.59 ENSDART00000149934
klotho
chr7_-_40630698 1.58 ENSDART00000134547
ubiquitin protein ligase E3C
chr5_-_67629263 1.57 ENSDART00000133753
zinc finger and BTB domain containing 20
chr11_+_5588122 1.56 ENSDART00000113281
zgc:172302
chr3_-_3366590 1.52 ENSDART00000109428
ENSDART00000175329
si:dkey-46g23.1
chr22_+_6727266 1.51 ENSDART00000142352

chr2_-_2957970 1.50 ENSDART00000162505
si:ch1073-82l19.1
chr21_-_13662237 1.50 ENSDART00000091647
ENSDART00000151547
patatin-like phospholipase domain containing 7a
chr7_+_51795667 1.50 ENSDART00000174201
ENSDART00000073839
solute carrier family 38, member 7
chr2_-_37462462 1.50 ENSDART00000145896
si:dkey-57k2.7
chr20_-_51831816 1.49 ENSDART00000060505
melanoma inhibitory activity family, member 3
chr11_-_16021424 1.49 ENSDART00000193291
ENSDART00000170731
ENSDART00000104107
zgc:173544
chr5_+_20257225 1.49 ENSDART00000127919
slingshot protein phosphatase 1a
chr3_-_21062706 1.47 ENSDART00000155605
ENSDART00000153686
ENSDART00000157168
ENSDART00000156614
ENSDART00000155743
ENSDART00000156275
family with sequence similarity 57, member Ba
chr7_+_69459759 1.46 ENSDART00000160500
CTD nuclear envelope phosphatase 1b
chr5_+_37903790 1.46 ENSDART00000162470
transmembrane protease, serine 4b
chr10_-_32494304 1.46 ENSDART00000028161
UV radiation resistance associated gene
chr19_-_5805923 1.40 ENSDART00000134340
si:ch211-264f5.8
chr22_-_37738203 1.36 ENSDART00000143190
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr3_-_30885250 1.34 ENSDART00000109104
lysine methyltransferase 5C
chr2_+_10006839 1.34 ENSDART00000160304
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr22_-_4439311 1.34 ENSDART00000169317
ubiquitin-like with PHD and ring finger domains 1
chr5_-_62925282 1.31 ENSDART00000188048
sperm antigen with calponin homology and coiled-coil domains 1
chr21_-_2042037 1.29 ENSDART00000171131
ENSDART00000160144
adducin 1 (alpha)
chr9_+_17983463 1.28 ENSDART00000182150
A kinase (PRKA) anchor protein 11
chr8_-_39822917 1.28 ENSDART00000067843
zgc:162025
chr12_+_5048044 1.26 ENSDART00000161548
ENSDART00000172607
kinesin family member 22
chr19_-_12648122 1.26 ENSDART00000151184
family with sequence similarity 210, member Aa
chr11_-_11791718 1.25 ENSDART00000180476
cell division cycle 6 homolog (S. cerevisiae)
chr9_+_56194410 1.25 ENSDART00000168530

chr2_+_24936766 1.24 ENSDART00000025962
glycogenin 1a
chr19_-_20430892 1.22 ENSDART00000111409
TBC1 domain family, member 5
chr3_-_27915270 1.21 ENSDART00000115370
methyltransferase like 22
chr5_+_61508418 1.19 ENSDART00000023676
branched chain ketoacid dehydrogenase kinase
chr2_+_21312972 1.19 ENSDART00000080495
zinc finger and BTB domain containing 47a
chr9_-_3934963 1.19 ENSDART00000062336
ubiquitin protein ligase E3 component n-recognin 3
chr19_-_46088429 1.18 ENSDART00000161385
phosphatidylserine synthase 1b
chr7_+_7151832 1.17 ENSDART00000109485
galactose-3-O-sulfotransferase 3
chr13_-_36663358 1.17 ENSDART00000085319
son of sevenless homolog 2 (Drosophila)
chr1_+_13930625 1.17 ENSDART00000111026
nocturnin b
chr4_-_77260727 1.17 ENSDART00000075770
zgc:162948
chr5_-_9625459 1.17 ENSDART00000143347
SH2B adaptor protein 3
chr3_-_10751491 1.16 ENSDART00000016351
zgc:112965
chr5_-_27993972 1.15 ENSDART00000175819
protein phosphatase 3, catalytic subunit, gamma isozyme, a
chr6_-_40922971 1.15 ENSDART00000155363
SFI1 centrin binding protein
chr19_+_2631565 1.15 ENSDART00000171487
family with sequence similarity 126, member A
chr10_+_44584614 1.15 ENSDART00000163523
seizure related 6 homolog (mouse)-like
chr4_+_77957611 1.14 ENSDART00000156692
ADP-ribosylation factor GTPase activating protein 3
chr5_-_40292299 1.14 ENSDART00000097525
sorting nexin 18a
chr23_+_38952529 1.13 ENSDART00000190076
ATPase phospholipid transporting 9A (putative)
chr24_+_17260001 1.13 ENSDART00000066765
bmi1 polycomb ring finger oncogene 1a
chr24_+_17260329 1.12 ENSDART00000129554
bmi1 polycomb ring finger oncogene 1a
chr20_+_23947004 1.11 ENSDART00000144195
caspase 8 associated protein 2
chr18_+_7611298 1.11 ENSDART00000062156
outer dense fiber of sperm tails 3B
chr12_+_36428052 1.10 ENSDART00000131300
unkempt family zinc finger
chr8_-_16464453 1.09 ENSDART00000098691
ring finger protein 11b
chr4_-_9191220 1.09 ENSDART00000156919
host cell factor C2
chr16_-_54498109 1.08 ENSDART00000083713
CDC-like kinase 2b
chr5_-_69571572 1.06 ENSDART00000145966
mitogen-activated protein kinase-activated protein kinase 5
chr5_-_25733745 1.05 ENSDART00000051566
zgc:101016
chr11_+_2855430 1.05 ENSDART00000172837
kinesin family member 21B
chr2_+_10007113 1.05 ENSDART00000155213
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr18_-_14274803 1.05 ENSDART00000166643
malonyl-CoA decarboxylase
chr5_+_22098591 1.05 ENSDART00000143676
zinc finger CCCH-type containing 12B
chr6_-_8360918 1.04 ENSDART00000004716
acid phosphatase 5a, tartrate resistant
chr22_-_20403194 1.04 ENSDART00000010048
mitogen-activated protein kinase kinase 2a
chr12_+_1469090 1.04 ENSDART00000183637
ubiquitin specific peptidase 22
chr6_+_3334710 1.04 ENSDART00000132848
ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
chr5_+_13394543 1.03 ENSDART00000051669
ENSDART00000135921
tectonic family member 2
chr1_-_29139141 1.03 ENSDART00000075546
ENSDART00000133246
heat shock transcription factor 2 binding protein
chr17_+_18031304 1.02 ENSDART00000127259
SET domain containing 3
chr3_-_40836081 1.02 ENSDART00000143135
WD repeat domain, phosphoinositide interacting 2
chr2_-_40890004 1.01 ENSDART00000191746
UDP-glucose glycoprotein glucosyltransferase 1
chr25_+_3759553 1.01 ENSDART00000180601
ENSDART00000055845
ENSDART00000157050
ENSDART00000153905
THO complex 5
chr16_+_42471455 1.00 ENSDART00000166640
si:ch211-215k15.5
chr2_-_21621878 0.98 ENSDART00000189540
zgc:55781
chr8_-_53044300 0.98 ENSDART00000191653
nuclear receptor subfamily 6, group A, member 1a
chr15_-_9593532 0.97 ENSDART00000169912
GRB2-associated binding protein 2
chr21_+_4410733 0.97 ENSDART00000136831
ENSDART00000131612
si:dkey-84o3.7
chr5_-_323712 0.97 ENSDART00000188793
hook microtubule tethering protein 3
chr9_-_12886108 0.95 ENSDART00000177283
ankyrin repeat and zinc finger domain containing 1
chr1_+_47335038 0.95 ENSDART00000188153
B cell CLL/lymphoma 9
chr1_-_23268013 0.95 ENSDART00000146575
replication factor C (activator 1) 1
chr7_+_50822465 0.94 ENSDART00000011082
period circadian clock 1b
chr15_-_18200358 0.94 ENSDART00000158569
si:ch211-247l8.8
chr6_-_12275836 0.94 ENSDART00000189980
plakophilin 4
chr7_+_15308219 0.94 ENSDART00000165683
mesoderm posterior ba
chr16_-_35329803 0.93 ENSDART00000161729
ENSDART00000157700
ENSDART00000184584
ENSDART00000174713
ENSDART00000162518
protein tyrosine phosphatase, receptor type, U, b
chr13_+_9468535 0.93 ENSDART00000135088
ENSDART00000164270
ENSDART00000099619
ENSDART00000164656
si:dkey-265c15.6
chr21_-_40398932 0.92 ENSDART00000162500
nucleoporin 98
chr20_-_9123296 0.92 ENSDART00000188495
Myb-like, SWIRM and MPN domains 1
chr25_-_2723902 0.90 ENSDART00000143721
ENSDART00000175224
ADP-dependent glucokinase
chr13_-_9045879 0.90 ENSDART00000155463
ENSDART00000140041
ENSDART00000137454
si:dkey-112g5.11
chr7_+_65398161 0.90 ENSDART00000166109
ENSDART00000157399
ubiquitin specific peptidase 47
chr17_+_8212477 0.89 ENSDART00000064665
solute carrier family 18, subfamily B, member 1
chr2_-_55298075 0.89 ENSDART00000186404
ENSDART00000149062
RAB8A, member RAS oncogene family
chr21_-_39177564 0.88 ENSDART00000065143
unc-119 homolog b (C. elegans)
chr13_-_9111927 0.88 ENSDART00000133815
ENSDART00000109783
ENSDART00000142540
ENSDART00000192613
si:dkey-19p15.4
si:dkey-112g5.12
chr19_-_6134802 0.87 ENSDART00000140051
capicua transcriptional repressor a
chr9_+_16241656 0.86 ENSDART00000154326
si:ch211-261p9.4
chr13_-_9091354 0.86 ENSDART00000140319
ENSDART00000142697
si:dkey-112g5.13
chr8_+_8947623 0.85 ENSDART00000131215
solute carrier family 35 (UDP-galactose transporter), member 2
chr13_-_9184132 0.85 ENSDART00000135289
ENSDART00000136309
ENSDART00000132630
si:dkey-33c12.10
chr24_-_18809433 0.85 ENSDART00000152009
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
chr24_-_32582378 0.84 ENSDART00000066590
retinol dehydrogenase 12, like
chr2_+_56168619 0.84 ENSDART00000021011
ENSDART00000180271
upf1 regulator of nonsense transcripts homolog (yeast)
chr8_-_45867358 0.82 ENSDART00000132810
ADAM metallopeptidase domain 9
chr10_+_34175476 0.82 ENSDART00000102123
zgc:174193
chr19_+_1673599 0.82 ENSDART00000163127
kelch-like family member 7
chr13_-_9236905 0.82 ENSDART00000142597
ENSDART00000147176
ENSDART00000181670
si:dkey-33c12.12
si:dkey-112g5.12
chr20_-_29532939 0.81 ENSDART00000049224
ENSDART00000062377
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B
chr17_-_37195354 0.81 ENSDART00000190963
additional sex combs like transcriptional regulator 2
chr6_+_40951227 0.81 ENSDART00000156660
POZ (BTB) and AT hook containing zinc finger 1
chr19_-_5103313 0.80 ENSDART00000037007
triosephosphate isomerase 1a
chr1_+_54199406 0.80 ENSDART00000176578
TSC complex subunit 2
chr2_-_15031858 0.79 ENSDART00000191478
holocytochrome c synthase a
chr13_+_9496748 0.78 ENSDART00000147050
ENSDART00000102120

chr19_-_12648408 0.78 ENSDART00000103692
family with sequence similarity 210, member Aa
chr5_+_25733774 0.78 ENSDART00000137088
ENSDART00000098467
abhydrolase domain containing 17B
chr13_+_12761707 0.77 ENSDART00000015127
zgc:100846
chr3_-_6519691 0.77 ENSDART00000165273
ENSDART00000179882
ENSDART00000172292
si:ch73-157i16.3
chr25_-_2723682 0.77 ENSDART00000113382
ADP-dependent glucokinase
chr2_+_36828746 0.76 ENSDART00000186638
nardilysin a (N-arginine dibasic convertase)
chr10_-_105100 0.75 ENSDART00000145716
tetratricopeptide repeat domain 3
chr22_-_7050 0.75 ENSDART00000127829
ATPase family, AAA domain containing 3
chr14_-_12020653 0.73 ENSDART00000106654
zinc finger protein 711
chr17_+_38030327 0.73 ENSDART00000085481
solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
chr24_+_14581864 0.73 ENSDART00000134536
thiamine triphosphatase
chr7_-_5431841 0.72 ENSDART00000173073
Rho guanine nucleotide exchange factor (GEF) 11
chr21_-_31013817 0.72 ENSDART00000065504
nuclear cap binding subunit 3
chr2_-_1622641 0.72 ENSDART00000082143
protein kinase, cAMP-dependent, catalytic, beta b
chr14_-_47815467 0.72 ENSDART00000166827
Rap guanine nucleotide exchange factor (GEF) 2
chr4_+_77943184 0.72 ENSDART00000159094
protein kinase C and casein kinase substrate in neurons 2
chr13_-_10730056 0.70 ENSDART00000126725
protein phosphatase, Mg2+/Mn2+ dependent, 1Ba
chr23_-_14766902 0.70 ENSDART00000168113
glutathione synthetase
chr19_+_12406583 0.70 ENSDART00000013865
ENSDART00000151535
SEH1-like (S. cerevisiae)
chr13_-_9257728 0.69 ENSDART00000145985
ENSDART00000169991
ENSDART00000132764
zgc:173425
chr13_-_9213207 0.68 ENSDART00000139861
ENSDART00000140524
si:dkey-33c12.11
chr12_-_32421046 0.68 ENSDART00000075567
ectonucleotide pyrophosphatase/phosphodiesterase 7, tandem duplicate 1
chr13_+_9521629 0.67 ENSDART00000149870
ENSDART00000137666
si:dkey-19p15.4
chr12_+_1469327 0.67 ENSDART00000059143
ubiquitin specific peptidase 22
chr3_-_13147310 0.67 ENSDART00000160840
protein kinase, cAMP-dependent, regulatory, type I, beta
chr5_-_22052852 0.67 ENSDART00000002938
myotubularin related protein 8
chr21_+_4328348 0.65 ENSDART00000131658
ENSDART00000143799
si:dkey-84o3.7
chr8_-_14080534 0.65 ENSDART00000042867
death effector domain containing
chr13_-_9159852 0.63 ENSDART00000170185
ENSDART00000158697
ENSDART00000143393
ENSDART00000164973
ENSDART00000159910
si:dkey-112g5.16
chr25_-_13490744 0.63 ENSDART00000056721
lactate dehydrogenase D
chr13_-_9070754 0.63 ENSDART00000143783
ENSDART00000102121
ENSDART00000140820
ENSDART00000184210
si:dkey-112g5.12
chr20_+_19006703 0.63 ENSDART00000128435
PIN2/TERF1 interacting, telomerase inhibitor 1
chr3_+_26813058 0.63 ENSDART00000055537
suppressor of cytokine signaling 1a
chr17_-_5426458 0.60 ENSDART00000157937
SPT3 homolog, SAGA and STAGA complex component
chr7_-_19642417 0.60 ENSDART00000160936
si:ch211-212k18.4
chr17_-_37195163 0.60 ENSDART00000108514
additional sex combs like transcriptional regulator 2
chr1_-_23268569 0.60 ENSDART00000143948
replication factor C (activator 1) 1

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx6-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.6 2.3 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.6 9.9 GO:0007339 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.6 1.7 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.4 1.3 GO:0034773 histone H4-K20 methylation(GO:0034770) histone H4-K20 trimethylation(GO:0034773)
0.4 1.8 GO:0060074 synapse maturation(GO:0060074)
0.4 1.3 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.4 1.1 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.3 2.1 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.3 1.5 GO:0010867 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.2 3.4 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.2 1.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.2 0.9 GO:0035522 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.2 2.0 GO:0016119 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.2 0.9 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.2 1.3 GO:0097065 anterior head development(GO:0097065)
0.2 0.6 GO:0006089 lactate metabolic process(GO:0006089)
0.2 1.0 GO:2001293 malonyl-CoA metabolic process(GO:2001293)
0.2 3.1 GO:0035493 SNARE complex assembly(GO:0035493)
0.2 0.8 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.2 1.2 GO:0097101 blood vessel endothelial cell fate specification(GO:0097101)
0.2 0.7 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.2 0.8 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.2 2.2 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.2 0.8 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.2 1.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.2 1.6 GO:0033700 phospholipid efflux(GO:0033700)
0.2 2.3 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 1.3 GO:0010390 histone monoubiquitination(GO:0010390)
0.1 0.9 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.1 0.7 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 7.2 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 1.0 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 0.7 GO:0006772 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.1 1.2 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 0.8 GO:0036268 swimming(GO:0036268)
0.1 0.9 GO:1900186 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1 0.9 GO:1905066 regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.1 1.0 GO:0061333 renal tubule morphogenesis(GO:0061333) nephron tubule morphogenesis(GO:0072078) nephron epithelium morphogenesis(GO:0072088)
0.1 0.7 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.1 0.5 GO:0070814 cysteine biosynthetic process from serine(GO:0006535) hydrogen sulfide biosynthetic process(GO:0070814)
0.1 1.5 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 1.0 GO:0045453 bone resorption(GO:0045453)
0.1 2.2 GO:0015701 bicarbonate transport(GO:0015701)
0.1 1.0 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 1.8 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 1.8 GO:0010737 protein kinase A signaling(GO:0010737)
0.1 1.8 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 7.1 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 1.5 GO:0035459 cargo loading into vesicle(GO:0035459)
0.1 0.8 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.1 0.5 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.1 1.6 GO:0050796 regulation of insulin secretion(GO:0050796)
0.1 1.9 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.1 1.0 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 0.2 GO:0003403 optic vesicle formation(GO:0003403)
0.1 0.4 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 0.7 GO:0070836 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.1 0.7 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.3 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 0.2 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.1 0.4 GO:0035264 multicellular organism growth(GO:0035264)
0.1 0.4 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1 0.7 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.1 2.1 GO:0009636 response to toxic substance(GO:0009636)
0.1 0.5 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.1 0.8 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 1.3 GO:0001966 thigmotaxis(GO:0001966)
0.1 2.2 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.1 0.2 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 0.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 0.3 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.4 GO:0070207 protein homotrimerization(GO:0070207)
0.0 1.2 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 2.1 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 1.0 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.0 2.1 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.9 GO:0007379 somite specification(GO:0001757) segment specification(GO:0007379)
0.0 0.3 GO:0006004 fucose metabolic process(GO:0006004)
0.0 1.0 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.3 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.1 GO:0070129 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.0 1.8 GO:0001508 action potential(GO:0001508)
0.0 1.1 GO:0001878 response to yeast(GO:0001878)
0.0 0.1 GO:0015677 copper ion import(GO:0015677)
0.0 0.7 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 1.4 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.2 GO:0010906 regulation of cellular carbohydrate metabolic process(GO:0010675) regulation of glucose metabolic process(GO:0010906)
0.0 0.6 GO:1990798 pancreas regeneration(GO:1990798)
0.0 0.8 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.7 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 1.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.5 GO:0070672 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
0.0 0.3 GO:0046902 regulation of mitochondrial membrane permeability(GO:0046902) necrotic cell death(GO:0070265) programmed necrotic cell death(GO:0097300)
0.0 0.8 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.3 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.0 1.2 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.7 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 2.6 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.5 GO:0010821 regulation of mitochondrion organization(GO:0010821)
0.0 1.2 GO:0009247 glycolipid biosynthetic process(GO:0009247)
0.0 0.1 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.6 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 1.6 GO:0034249 negative regulation of cellular amide metabolic process(GO:0034249)
0.0 1.1 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.2 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 1.2 GO:0008213 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.0 0.2 GO:0060325 face morphogenesis(GO:0060325)
0.0 1.0 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 4.5 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 1.3 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.0 1.0 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.4 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.9 GO:0051028 mRNA transport(GO:0051028)
0.0 0.1 GO:0034163 regulation of toll-like receptor 9 signaling pathway(GO:0034163) negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.0 0.4 GO:0050851 antigen receptor-mediated signaling pathway(GO:0050851) B cell receptor signaling pathway(GO:0050853)
0.0 0.2 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.0 GO:0036306 embryonic heart tube elongation(GO:0036306)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.8 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.6 2.3 GO:0035339 SPOTS complex(GO:0035339)
0.3 2.4 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.3 1.5 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.3 0.8 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.2 1.4 GO:0035517 PR-DUB complex(GO:0035517)
0.2 1.0 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 0.8 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 1.0 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 0.4 GO:0019815 B cell receptor complex(GO:0019815)
0.1 1.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 2.2 GO:0035102 PRC1 complex(GO:0035102)
0.1 1.3 GO:0000792 heterochromatin(GO:0000792)
0.1 0.9 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.6 GO:0030914 STAGA complex(GO:0030914)
0.1 1.8 GO:0030667 secretory granule membrane(GO:0030667)
0.1 4.1 GO:0016592 mediator complex(GO:0016592)
0.1 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.8 GO:0035371 microtubule plus-end(GO:0035371)
0.1 2.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.0 GO:0036038 MKS complex(GO:0036038)
0.1 0.7 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 1.1 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.1 GO:0005775 vacuolar lumen(GO:0005775) lysosomal lumen(GO:0043202)
0.0 0.3 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.9 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 3.2 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 1.9 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 0.9 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 1.1 GO:0016605 PML body(GO:0016605)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.9 GO:0005643 nuclear pore(GO:0005643)
0.0 0.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.0 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 0.3 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.8 GO:0005776 autophagosome(GO:0005776)
0.0 0.6 GO:0031941 filamentous actin(GO:0031941)
0.0 4.7 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.7 4.6 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.6 7.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.6 9.9 GO:0032190 acrosin binding(GO:0032190)
0.6 1.7 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462) efflux transmembrane transporter activity(GO:0015562)
0.5 1.5 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.4 1.3 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.4 1.1 GO:1990715 mRNA CDS binding(GO:1990715)
0.3 3.2 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.3 1.6 GO:0090556 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.3 1.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.3 0.8 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.3 2.4 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 2.9 GO:0008199 ferric iron binding(GO:0008199)
0.2 2.0 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.2 1.8 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.2 1.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 1.0 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.2 0.8 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.2 1.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 0.7 GO:0050333 thiamin-triphosphatase activity(GO:0050333)
0.2 0.8 GO:0004408 holocytochrome-c synthase activity(GO:0004408)
0.2 0.6 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.1 1.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 1.0 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.1 1.6 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 1.2 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 2.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 0.9 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 6.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.2 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 0.4 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.1 0.5 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
0.1 0.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 2.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.3 GO:0042806 fucose binding(GO:0042806)
0.1 1.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.8 GO:0019894 kinesin binding(GO:0019894)
0.1 1.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.5 GO:0019809 spermidine binding(GO:0019809)
0.1 0.2 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 1.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 1.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0033897 ribonuclease T2 activity(GO:0033897)
0.0 0.9 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 1.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 1.4 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.8 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 1.3 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 2.4 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.4 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 1.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 2.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.3 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.0 0.2 GO:0042287 MHC protein binding(GO:0042287)
0.0 1.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 4.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 1.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.8 GO:0019904 protein domain specific binding(GO:0019904)
0.0 1.2 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.2 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0005549 olfactory receptor activity(GO:0004984) odorant binding(GO:0005549)
0.0 0.7 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 1.2 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.1 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.0 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.0 0.9 GO:0045296 cadherin binding(GO:0045296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.8 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 0.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.0 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 3.4 PID PLK1 PATHWAY PLK1 signaling events
0.1 1.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 1.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 1.2 PID EPO PATHWAY EPO signaling pathway
0.1 1.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.6 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 1.2 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.5 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.9 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.3 PID ATR PATHWAY ATR signaling pathway
0.0 0.6 PID ATM PATHWAY ATM pathway
0.0 0.2 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.6 PID MYC PATHWAY C-MYC pathway
0.0 1.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.7 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.3 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.4 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.9 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.3 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.4 7.1 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.4 6.8 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 0.8 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 1.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 1.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 1.2 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.1 1.3 REACTOME KINESINS Genes involved in Kinesins
0.1 1.0 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 2.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.0 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.7 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.8 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.9 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.2 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 1.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.7 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 1.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.4 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.2 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors