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PRJNA195909:zebrafish embryo and larva development

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Results for lhx6

Z-value: 0.83

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Transcription factors associated with lhx6

Gene Symbol Gene ID Gene Info
lhx6
ENSDARG00000006896 LIM homeobox 6
lhx6
ENSDARG00000112520 LIM homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lhx6dr11_v1_chr10_+_9372702_93727020.817.5e-03Click!

Activity profile of lhx6 motif

Sorted Z-values of lhx6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_15433518 2.22 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr17_+_15433671 2.16 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr3_-_61162750 1.52 ENSDART00000055064
pvalb8
parvalbumin 8
chr9_-_22099536 1.48 ENSDART00000101923
CR391987.1

chr4_-_9891874 1.32 ENSDART00000067193
adm2a
adrenomedullin 2a
chr20_-_9436521 1.29 ENSDART00000133000
zgc:101840
zgc:101840
chr5_-_64831207 1.17 ENSDART00000144816
lix1
limb and CNS expressed 1
chr3_-_46811611 1.12 ENSDART00000134092
elavl3
ELAV like neuron-specific RNA binding protein 3
chr20_+_26880668 1.11 ENSDART00000077769
serpinb1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr12_-_35830625 1.07 ENSDART00000180028
CU459056.1

chr8_+_16025554 1.05 ENSDART00000110171
elavl4
ELAV like neuron-specific RNA binding protein 4
chr20_-_48485354 1.04 ENSDART00000124040
ENSDART00000148437
insm1a
insulinoma-associated 1a
chr22_-_10121880 1.03 ENSDART00000002348
rdh5
retinol dehydrogenase 5 (11-cis/9-cis)
chr24_-_21923930 1.02 ENSDART00000131944
tagln3b
transgelin 3b
chr15_-_23376541 0.91 ENSDART00000078570
c1qtnf5
C1q and TNF related 5
chr15_+_9072821 0.88 ENSDART00000154463
si:dkey-202g17.3
si:dkey-202g17.3
chr5_-_41307550 0.88 ENSDART00000143446
npr3
natriuretic peptide receptor 3
chr5_+_64732270 0.88 ENSDART00000134241
olfm1a
olfactomedin 1a
chr5_+_64732036 0.87 ENSDART00000073950
olfm1a
olfactomedin 1a
chr16_+_31804590 0.87 ENSDART00000167321
wnt4b
wingless-type MMTV integration site family, member 4b
chr1_-_19845378 0.81 ENSDART00000139314
ENSDART00000132958
ENSDART00000147502
grhprb
glyoxylate reductase/hydroxypyruvate reductase b
chr11_+_38280454 0.75 ENSDART00000171496
CDK18
si:dkey-166c18.1
chr13_+_255067 0.73 ENSDART00000102505
foxg1d
forkhead box G1d
chr13_+_19322686 0.73 ENSDART00000058036
emx2
empty spiracles homeobox 2
chr15_+_47903864 0.72 ENSDART00000063835
otx5
orthodenticle homolog 5
chr21_-_22827548 0.71 ENSDART00000079161
angptl5
angiopoietin-like 5
chr4_+_21129752 0.71 ENSDART00000169764
syt1a
synaptotagmin Ia
chr5_-_51619742 0.70 ENSDART00000188537
otpb
orthopedia homeobox b
chr11_-_39044595 0.69 ENSDART00000065461
cldn19
claudin 19
chr22_-_15593824 0.68 ENSDART00000123125
tpm4a
tropomyosin 4a
chr16_+_46111849 0.66 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr7_+_30787903 0.65 ENSDART00000174000
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr21_+_28958471 0.65 ENSDART00000144331
ENSDART00000005929
ppp3ca
protein phosphatase 3, catalytic subunit, alpha isozyme
chr3_-_46817499 0.65 ENSDART00000013717
elavl3
ELAV like neuron-specific RNA binding protein 3
chr13_-_31622195 0.64 ENSDART00000057432
six1a
SIX homeobox 1a
chr7_-_35708450 0.63 ENSDART00000193886
irx5a
iroquois homeobox 5a
chr1_-_50859053 0.62 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
si:dkeyp-123h10.2
chr9_+_25776971 0.61 ENSDART00000146011
zeb2a
zinc finger E-box binding homeobox 2a
chr3_-_53533128 0.60 ENSDART00000183591
notch3
notch 3
chr14_+_14662116 0.60 ENSDART00000161693
cetn2
centrin, EF-hand protein, 2
chr12_+_20352400 0.60 ENSDART00000066383
hbae5
hemoglobin, alpha embryonic 5
chr5_+_56268436 0.60 ENSDART00000021159
lhx1b
LIM homeobox 1b
chr1_+_25801648 0.59 ENSDART00000129471
gucy1b1
guanylate cyclase 1 soluble subunit beta 1
chr13_+_35339182 0.59 ENSDART00000019323
jag1b
jagged 1b
chr13_-_31435137 0.59 ENSDART00000057441
rtn1a
reticulon 1a
chr18_+_30847237 0.59 ENSDART00000012374
foxf1
forkhead box F1
chr9_+_34641237 0.58 ENSDART00000133996
shox
short stature homeobox
chr22_-_13350240 0.58 ENSDART00000154095
ENSDART00000155118
si:ch211-227m13.1
si:ch211-227m13.1
chr18_+_9171778 0.58 ENSDART00000101192
sema3d
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr9_+_30108641 0.57 ENSDART00000060174
jagn1a
jagunal homolog 1a
chr3_-_50443607 0.57 ENSDART00000074036
rcvrna
recoverin a
chr3_-_43356082 0.56 ENSDART00000171213
uncx
UNC homeobox
chr12_-_4781801 0.56 ENSDART00000167490
ENSDART00000121718
mapta
microtubule-associated protein tau a
chr3_-_12930217 0.55 ENSDART00000166322
pdgfab
platelet-derived growth factor alpha polypeptide b
chr20_-_16171297 0.55 ENSDART00000012476
coa7
cytochrome c oxidase assembly factor 7
chr7_-_28148310 0.54 ENSDART00000044208
lmo1
LIM domain only 1
chr13_-_24311628 0.54 ENSDART00000004420
rab4a
RAB4a, member RAS oncogene family
chr2_-_32558795 0.54 ENSDART00000140026
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr3_+_32553714 0.53 ENSDART00000165638
pax10
paired box 10
chr18_+_16744307 0.51 ENSDART00000179872
ENSDART00000133490
lyve1b
lymphatic vessel endothelial hyaluronic receptor 1b
chr2_+_35728033 0.51 ENSDART00000002094
ankrd45
ankyrin repeat domain 45
chr2_+_50608099 0.51 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr11_-_42554290 0.51 ENSDART00000130573
atp6ap1la
ATPase H+ transporting accessory protein 1 like a
chr5_-_63515210 0.50 ENSDART00000022348
prdm12b
PR domain containing 12b
chr8_+_29986265 0.50 ENSDART00000148258
ptch1
patched 1
chr4_-_4834347 0.48 ENSDART00000141803
coa6
cytochrome c oxidase assembly factor 6
chr4_-_17629444 0.48 ENSDART00000108814
nrip2
nuclear receptor interacting protein 2
chr16_-_42894628 0.47 ENSDART00000045600
hfe2
hemochromatosis type 2
chr13_-_29420885 0.47 ENSDART00000024225
chata
choline O-acetyltransferase a
chr4_-_4834617 0.45 ENSDART00000141539
coa6
cytochrome c oxidase assembly factor 6
chr4_+_11384891 0.45 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
pcloa
piccolo presynaptic cytomatrix protein a
chr17_-_36896560 0.44 ENSDART00000045287
mapre3a
microtubule-associated protein, RP/EB family, member 3a
chr3_+_45687266 0.44 ENSDART00000131652
gpr146
G protein-coupled receptor 146
chr3_-_60175470 0.43 ENSDART00000156597
si:ch73-364h19.1
si:ch73-364h19.1
chr14_-_4145594 0.43 ENSDART00000077348
casp3b
caspase 3, apoptosis-related cysteine peptidase b
chr20_+_37294112 0.43 ENSDART00000076293
ENSDART00000140450
cx23
connexin 23
chr15_-_22074315 0.42 ENSDART00000149830
drd2a
dopamine receptor D2a
chr19_+_233143 0.41 ENSDART00000175273
syngap1a
synaptic Ras GTPase activating protein 1a
chr1_-_46981134 0.40 ENSDART00000130607
pknox1.2
pbx/knotted 1 homeobox 1.2
chr17_-_13007484 0.39 ENSDART00000156812
si:dkeyp-33b5.4
si:dkeyp-33b5.4
chr23_+_28582865 0.39 ENSDART00000020296
l1cama
L1 cell adhesion molecule, paralog a
chr10_+_21726853 0.39 ENSDART00000162869
pcdh1g14
protocadherin 1 gamma 14
chr19_+_19786117 0.39 ENSDART00000167757
ENSDART00000163546
hoxa1a
homeobox A1a
chr8_-_33381913 0.39 ENSDART00000076420
lmx1bb
LIM homeobox transcription factor 1, beta b
chr1_-_45049603 0.39 ENSDART00000023336
rps6
ribosomal protein S6
chr20_-_46362606 0.39 ENSDART00000153087
bmf2
BCL2 modifying factor 2
chr24_+_16547035 0.39 ENSDART00000164319
sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr14_+_17376940 0.38 ENSDART00000054590
ENSDART00000010148
spon2b
spondin 2b, extracellular matrix protein
chr7_-_49594995 0.38 ENSDART00000174161
ENSDART00000109147
brsk2b
BR serine/threonine kinase 2b
chr8_-_15129573 0.37 ENSDART00000142358
bcar3
BCAR3, NSP family adaptor protein
chr16_+_21330634 0.37 ENSDART00000191285
ENSDART00000183267
osbpl3b
oxysterol binding protein-like 3b
chr1_-_16665044 0.37 ENSDART00000040434
asah1b
N-acylsphingosine amidohydrolase (acid ceramidase) 1b
chr15_+_23799461 0.37 ENSDART00000154885
si:ch211-167j9.4
si:ch211-167j9.4
chr6_-_39270851 0.37 ENSDART00000148839
arhgef25b
Rho guanine nucleotide exchange factor (GEF) 25b
chr16_-_26296477 0.37 ENSDART00000157553
erfl1
Ets2 repressor factor like 1
chr1_-_31534089 0.35 ENSDART00000007770
lbx1b
ladybird homeobox 1b
chr21_+_30937690 0.35 ENSDART00000022562
rhogb
ras homolog family member Gb
chr2_-_30668580 0.35 ENSDART00000087270
ctnnd2b
catenin (cadherin-associated protein), delta 2b
chr6_+_39232245 0.35 ENSDART00000187351
b4galnt1b
beta-1,4-N-acetyl-galactosaminyl transferase 1b
chr14_-_33105434 0.35 ENSDART00000163795
dlg3
discs, large homolog 3 (Drosophila)
chr23_+_11285662 0.34 ENSDART00000111028
chl1a
cell adhesion molecule L1-like a
chr18_-_20869175 0.34 ENSDART00000090079
synm
synemin, intermediate filament protein
chr23_+_31107685 0.34 ENSDART00000103448
tbx18
T-box 18
chr3_+_56645710 0.33 ENSDART00000193978
CR759836.1

chr7_-_31759602 0.33 ENSDART00000113467
igdcc4
immunoglobulin superfamily, DCC subclass, member 4
chr24_+_6107901 0.33 ENSDART00000156419
si:ch211-37e10.2
si:ch211-37e10.2
chr5_-_69004007 0.33 ENSDART00000137443
ank1a
ankyrin 1, erythrocytic a
chr23_+_40460333 0.32 ENSDART00000184658
soga3b
SOGA family member 3b
chr20_+_539852 0.32 ENSDART00000185994
dse
dermatan sulfate epimerase
chr13_+_27232848 0.32 ENSDART00000138043
rin2
Ras and Rab interactor 2
chr5_-_48268049 0.32 ENSDART00000187454
mef2cb
myocyte enhancer factor 2cb
chr9_+_38372216 0.32 ENSDART00000141895
plcd4b
phospholipase C, delta 4b
chr19_+_22062202 0.31 ENSDART00000100181
sall3b
spalt-like transcription factor 3b
chr9_-_19161982 0.31 ENSDART00000081878
pou1f1
POU class 1 homeobox 1
chr3_-_56541723 0.31 ENSDART00000156398
ENSDART00000050576
ENSDART00000184874
si:ch211-189a21.1
cyth1a
si:ch211-189a21.1
cytohesin 1a
chr18_-_48547564 0.31 ENSDART00000138607
kcnj1a.1
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr3_-_23406964 0.31 ENSDART00000114723
rapgefl1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr14_-_858985 0.30 ENSDART00000148687
ENSDART00000149375
slc34a1a
solute carrier family 34 (type II sodium/phosphate cotransporter), member 1a
chr8_+_25902170 0.30 ENSDART00000193130
rhoab
ras homolog gene family, member Ab
chr24_+_17269849 0.30 ENSDART00000017605
spag6
sperm associated antigen 6
chr15_+_1796313 0.30 ENSDART00000126253
fam124b
family with sequence similarity 124B
chr22_+_5176255 0.30 ENSDART00000092647
cers1
ceramide synthase 1
chr20_-_22476255 0.30 ENSDART00000103510
pdgfra
platelet-derived growth factor receptor, alpha polypeptide
chr6_-_6487876 0.29 ENSDART00000137642
cep170ab
centrosomal protein 170Ab
chr8_-_25336589 0.29 ENSDART00000009682
atp5pb
ATP synthase peripheral stalk-membrane subunit b
chr18_+_27738349 0.29 ENSDART00000187816
tspan18b
tetraspanin 18b
chr24_+_19591893 0.29 ENSDART00000152026
slco5a1a
solute carrier organic anion transporter family member 5A1a
chr7_+_27834130 0.29 ENSDART00000052656
rras2
RAS related 2
chr12_+_20587179 0.28 ENSDART00000170127
arsg
arylsulfatase G
chr4_+_12612145 0.28 ENSDART00000181201
lmo3
LIM domain only 3
chr25_-_6049339 0.28 ENSDART00000075184
snx1a
sorting nexin 1a
chr7_-_30174882 0.27 ENSDART00000110409
frmd5
FERM domain containing 5
chr22_+_5176693 0.27 ENSDART00000160927
cers1
ceramide synthase 1
chr10_+_36026576 0.27 ENSDART00000193786
hmgb1a
high mobility group box 1a
chr10_-_27049170 0.27 ENSDART00000143451
cnih2
cornichon family AMPA receptor auxiliary protein 2
chr10_-_11385155 0.26 ENSDART00000064214
plac8.1
placenta-specific 8, tandem duplicate 1
chr4_+_3980247 0.26 ENSDART00000049194
gpr37b
G protein-coupled receptor 37b
chr4_-_5652030 0.26 ENSDART00000010903
rsph9
radial spoke head 9 homolog
chr12_+_22580579 0.26 ENSDART00000171725
ENSDART00000192290
capgb
capping protein (actin filament), gelsolin-like b
chr14_-_30587814 0.26 ENSDART00000144912
ENSDART00000149714
tmem265
transmembrane protein 265
chr15_-_9272328 0.25 ENSDART00000172114
calm2a
calmodulin 2a (phosphorylase kinase, delta)
chr12_+_41697664 0.25 ENSDART00000162302
bnip3
BCL2 interacting protein 3
chr4_+_12612723 0.24 ENSDART00000133767
lmo3
LIM domain only 3
chr2_+_20604775 0.24 ENSDART00000131501
olfml2bb
olfactomedin-like 2Bb
chr22_+_27090136 0.24 ENSDART00000136770
si:dkey-246e1.3
si:dkey-246e1.3
chr24_-_35767501 0.24 ENSDART00000105680
ENSDART00000042290
ENSDART00000166264
dtna
dystrobrevin, alpha
chr6_+_9870192 0.24 ENSDART00000150894
MPP4 (1 of many)
si:ch211-222n4.6
chr4_+_9400012 0.23 ENSDART00000191960
tmtc1
transmembrane and tetratricopeptide repeat containing 1
chr8_-_12867434 0.23 ENSDART00000081657
slc2a6
solute carrier family 2 (facilitated glucose transporter), member 6
chr16_-_51888952 0.23 ENSDART00000186407
ENSDART00000175435
rpl28
ribosomal protein L28
chr11_-_41853874 0.23 ENSDART00000002556
mrto4
MRT4 homolog, ribosome maturation factor
chr10_+_36178713 0.23 ENSDART00000140816
or108-3
odorant receptor, family D, subfamily 108, member 3
chr13_+_49175947 0.23 ENSDART00000056927
egln1a
egl-9 family hypoxia-inducible factor 1a
chr3_-_58798377 0.23 ENSDART00000161248
si:ch73-281f12.4
si:ch73-281f12.4
chr3_+_23092762 0.22 ENSDART00000142884
ENSDART00000024136
gngt2a
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2a
chr14_+_5385855 0.22 ENSDART00000031508
lbx2
ladybird homeobox 2
chr25_-_13842618 0.22 ENSDART00000160258
mapk8ip1a
mitogen-activated protein kinase 8 interacting protein 1a
chr21_+_15824182 0.22 ENSDART00000065779
gnrh2
gonadotropin-releasing hormone 2
chr13_+_22476742 0.21 ENSDART00000078759
ENSDART00000130101
ENSDART00000137220
ENSDART00000133065
ENSDART00000147348
ldb3a
LIM domain binding 3a
chr21_-_18993110 0.21 ENSDART00000144086
si:ch211-222n4.6
si:ch211-222n4.6
chr9_-_20372977 0.21 ENSDART00000113418
igsf3
immunoglobulin superfamily, member 3
chr22_-_19552796 0.21 ENSDART00000148088
ENSDART00000105485
si:dkey-78l4.14
si:dkey-78l4.14
chr16_-_22930925 0.21 ENSDART00000133819
si:dkey-246i14.3
si:dkey-246i14.3
chr1_-_5455498 0.21 ENSDART00000040368
ENSDART00000114035
mnx2b
motor neuron and pancreas homeobox 2b
chrM_+_8130 0.20 ENSDART00000093609
mt-co2
cytochrome c oxidase II, mitochondrial
chr3_+_17537352 0.20 ENSDART00000104549
hcrt
hypocretin (orexin) neuropeptide precursor
chr4_+_72723304 0.20 ENSDART00000186791
ENSDART00000158902
ENSDART00000191925
rab3ip
RAB3A interacting protein (rabin3)
chr20_-_28642061 0.19 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr8_-_23776399 0.19 ENSDART00000114800
INAVA
si:ch211-163l21.4
chr18_+_28106139 0.19 ENSDART00000089615
kiaa1549lb
KIAA1549-like b
chr1_+_21731382 0.19 ENSDART00000054395
pax5
paired box 5
chr15_-_4528326 0.19 ENSDART00000158122
ENSDART00000155619
ENSDART00000128602
tfdp2
transcription factor Dp-2
chr2_-_37140423 0.19 ENSDART00000144220
tspan37
tetraspanin 37
chr7_+_36898850 0.19 ENSDART00000113342
tox3
TOX high mobility group box family member 3
chr2_+_40294313 0.18 ENSDART00000037292
epha4b
eph receptor A4b
chr17_+_30545895 0.18 ENSDART00000076739
nhsl1a
NHS-like 1a
chr6_-_55585423 0.18 ENSDART00000157129
slc12a5a
solute carrier family 12 (potassium/chloride transporter), member 5a
chr1_-_44701313 0.18 ENSDART00000193926
si:dkey-28b4.8
si:dkey-28b4.8
chr11_-_40728380 0.18 ENSDART00000023745
ccdc114
coiled-coil domain containing 114
chr13_+_49175624 0.18 ENSDART00000193550
egln1a
egl-9 family hypoxia-inducible factor 1a
chr11_+_28476298 0.18 ENSDART00000122319
lrrc38b
leucine rich repeat containing 38b
chr23_-_42752550 0.18 ENSDART00000187059
si:ch73-217n20.1
si:ch73-217n20.1
chr3_-_29941357 0.18 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
grna
granulin a
chr7_-_31759394 0.17 ENSDART00000193040
igdcc4
immunoglobulin superfamily, DCC subclass, member 4
chr3_-_58798815 0.17 ENSDART00000082920
si:ch73-281f12.4
si:ch73-281f12.4
chr17_+_11675362 0.17 ENSDART00000157911
kif26ba
kinesin family member 26Ba
chr8_-_25034411 0.17 ENSDART00000135973
nfyal
nuclear transcription factor Y, alpha, like
chr17_+_13007307 0.17 ENSDART00000064554
ppp2r3c
protein phosphatase 2, regulatory subunit B'', gamma
chr10_-_5581487 0.17 ENSDART00000141943
syk
spleen tyrosine kinase
chr23_-_19230627 0.16 ENSDART00000007122
guca1b
guanylate cyclase activator 1B
chr21_-_26490186 0.16 ENSDART00000009889
zgc:110540
zgc:110540
chr12_-_46112892 0.16 ENSDART00000187128
ENSDART00000114268
zgc:153932
zgc:153932
chr8_+_49778486 0.16 ENSDART00000131732
ntrk2a
neurotrophic tyrosine kinase, receptor, type 2a
chr4_+_4849789 0.16 ENSDART00000130818
ENSDART00000127751
ptprz1b
protein tyrosine phosphatase, receptor-type, Z polypeptide 1b
chr16_-_30932533 0.16 ENSDART00000085761
slc45a4
solute carrier family 45, member 4
chr10_+_16584382 0.16 ENSDART00000112039
CR790388.1

chr14_-_30967284 0.16 ENSDART00000149435
il2rgb
interleukin 2 receptor, gamma b
chr20_-_48604199 0.16 ENSDART00000161762
ENSDART00000170894
mgst3a
microsomal glutathione S-transferase 3a
chr11_-_45138857 0.16 ENSDART00000166501
cant1b
calcium activated nucleotidase 1b
chr2_-_5505094 0.16 ENSDART00000145035
saga
S-antigen; retina and pineal gland (arrestin) a

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0035019 somatic stem cell population maintenance(GO:0035019) symmetric cell division(GO:0098725)
0.2 1.8 GO:1902868 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.2 0.6 GO:0038158 granulocyte colony-stimulating factor signaling pathway(GO:0038158)
0.2 1.0 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
0.2 0.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 0.6 GO:0014856 skeletal muscle cell proliferation(GO:0014856) regulation of skeletal muscle cell proliferation(GO:0014857)
0.2 0.5 GO:0008292 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.1 1.0 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.1 0.6 GO:0099543 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
0.1 1.2 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.1 0.4 GO:0097264 self proteolysis(GO:0097264)
0.1 0.7 GO:0021767 mammillary body development(GO:0021767)
0.1 0.3 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.1 0.9 GO:0060114 vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.1 0.3 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.1 0.3 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 0.3 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.6 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.1 0.3 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
0.1 0.6 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 0.5 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 0.5 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.1 0.6 GO:0036368 cone photoresponse recovery(GO:0036368)
0.1 0.2 GO:2000434 regulation of protein neddylation(GO:2000434)
0.1 0.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.2 GO:0042755 eating behavior(GO:0042755)
0.0 0.4 GO:1904825 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 0.9 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.5 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.0 0.2 GO:1904105 positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.0 0.3 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.0 0.7 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.2 GO:0097032 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.9 GO:0014855 striated muscle cell proliferation(GO:0014855)
0.0 0.6 GO:0030878 thyroid gland development(GO:0030878) face morphogenesis(GO:0060325)
0.0 0.2 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.5 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.4 GO:0021592 fourth ventricle development(GO:0021592)
0.0 0.1 GO:0071361 cellular response to ethanol(GO:0071361)
0.0 0.4 GO:0046902 regulation of mitochondrial membrane permeability(GO:0046902)
0.0 0.1 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.0 0.1 GO:0071423 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.0 0.1 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.1 GO:0097237 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.0 0.6 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 0.9 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 0.4 GO:0030216 keratinocyte differentiation(GO:0030216)
0.0 0.1 GO:0055107 Golgi to secretory granule transport(GO:0055107)
0.0 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.1 GO:0070317 G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.7 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.2 GO:0048681 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.0 0.1 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.0 0.2 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.4 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.2 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.6 GO:0007099 centriole replication(GO:0007099)
0.0 0.5 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.4 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.4 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.0 GO:1903441 receptor localization to nonmotile primary cilium(GO:0097500) protein localization to ciliary membrane(GO:1903441)
0.0 0.1 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.0 0.3 GO:0009409 response to cold(GO:0009409)
0.0 0.4 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 0.4 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.1 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 0.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.0 0.2 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.0 0.3 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.4 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.0 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.1 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.6 GO:0030282 bone mineralization(GO:0030282)
0.0 0.4 GO:0060037 pharyngeal system development(GO:0060037)
0.0 0.4 GO:0042149 cellular response to glucose starvation(GO:0042149)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.7 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.3 GO:0001534 radial spoke(GO:0001534)
0.1 0.5 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 0.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.2 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.0 0.5 GO:0098982 GABA-ergic synapse(GO:0098982)
0.0 0.4 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.1 GO:0043204 perikaryon(GO:0043204)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0030904 retromer complex(GO:0030904)
0.0 0.1 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.1 GO:0043034 costamere(GO:0043034)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.5 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.3 GO:0005903 brush border(GO:0005903)
0.0 0.5 GO:0051233 spindle midzone(GO:0051233)
0.0 0.5 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.2 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 0.2 GO:0045277 respiratory chain complex IV(GO:0045277)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.4 GO:0005504 fatty acid binding(GO:0005504)
0.3 0.8 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.2 0.5 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 0.5 GO:0097108 hedgehog family protein binding(GO:0097108)
0.1 0.7 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.3 GO:0060175 brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.1 0.4 GO:0017064 fatty acid amide hydrolase activity(GO:0017064)
0.1 0.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.3 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.1 0.2 GO:0005183 gonadotropin hormone-releasing hormone activity(GO:0005183) gonadotropin-releasing hormone receptor binding(GO:0031530)
0.1 0.3 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1 0.6 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 0.4 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 0.3 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.6 GO:0031720 haptoglobin binding(GO:0031720)
0.0 1.2 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0 0.2 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.0 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.5 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.5 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.6 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.1 GO:1904121 phosphatidylethanolamine transporter activity(GO:1904121)
0.0 0.1 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.0 0.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.5 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.0 0.2 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.1 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.3 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.4 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.4 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 1.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.4 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.5 GO:0051020 GTPase binding(GO:0051020)
0.0 0.3 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.2 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.3 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.1 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 0.0 GO:0072545 tyrosine binding(GO:0072545)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.2 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 0.5 PID BMP PATHWAY BMP receptor signaling
0.0 0.6 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 0.6 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 0.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.3 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.6 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.1 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins