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PRJNA195909:zebrafish embryo and larva development

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Results for lhx8a+lhx8b

Z-value: 1.16

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Transcription factors associated with lhx8a+lhx8b

Gene Symbol Gene ID Gene Info
lhx8a
ENSDARG00000002330 LIM homeobox 8a
lhx8b
ENSDARG00000042145 LIM homeobox 8b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lhx8bdr11_v1_chr8_-_17926814_179268140.608.6e-02Click!
lhx8adr11_v1_chr2_+_11206317_11206317-0.265.0e-01Click!

Activity profile of lhx8a+lhx8b motif

Sorted Z-values of lhx8a+lhx8b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_7546259 2.46 ENSDART00000015732
mylz3
myosin, light polypeptide 3, skeletal muscle
chr9_-_22318511 2.11 ENSDART00000129295
crygm2d2
crystallin, gamma M2d2
chr25_+_31405266 1.93 ENSDART00000103395
tnnt3a
troponin T type 3a (skeletal, fast)
chr18_-_8877077 1.86 ENSDART00000137266
si:dkey-95h12.2
si:dkey-95h12.2
chr9_-_22310919 1.78 ENSDART00000108719
crygm2d10
crystallin, gamma M2d10
chr15_-_23645810 1.63 ENSDART00000168845
ckmb
creatine kinase, muscle b
chr5_-_46505691 1.56 ENSDART00000111589
ENSDART00000122966
ENSDART00000166907
hapln1a
hyaluronan and proteoglycan link protein 1a
chr10_+_21804772 1.54 ENSDART00000162194
pcdh1g31
protocadherin 1 gamma 31
chr5_+_32247310 1.48 ENSDART00000182649
myha
myosin, heavy chain a
chr14_-_25577094 1.24 ENSDART00000163669
cplx2
complexin 2
chr1_-_58064738 1.23 ENSDART00000073778
caspb
caspase b
chr12_+_42574148 1.18 ENSDART00000157855
ebf3a
early B cell factor 3a
chr12_-_4756478 1.11 ENSDART00000152181
mapta
microtubule-associated protein tau a
chr13_+_23988442 1.01 ENSDART00000010918
agt
angiotensinogen
chr3_+_25154078 0.99 ENSDART00000156973
si:ch211-256m1.8
si:ch211-256m1.8
chr16_+_20926673 0.98 ENSDART00000009827
hoxa2b
homeobox A2b
chr21_+_13861589 0.96 ENSDART00000015629
ENSDART00000171306
stxbp1a
syntaxin binding protein 1a
chr6_-_58764672 0.96 ENSDART00000154322
soat2
sterol O-acyltransferase 2
chr15_+_33991928 0.95 ENSDART00000170177
vwde
von Willebrand factor D and EGF domains
chr17_-_6730247 0.95 ENSDART00000031091
vsnl1b
visinin-like 1b
chr1_+_56274613 0.95 ENSDART00000052683
c3a.3
complement component c3a, duplicate 3
chr6_+_40661703 0.94 ENSDART00000142492
eno1b
enolase 1b, (alpha)
chr10_-_43568239 0.90 ENSDART00000131731
ENSDART00000097433
ENSDART00000131309
mef2ca
myocyte enhancer factor 2ca
chr9_-_1978090 0.89 ENSDART00000082344
hoxd11a
homeobox D11a
chr11_-_22599584 0.88 ENSDART00000014062
myog
myogenin
chr21_-_8153165 0.88 ENSDART00000182580
CABZ01074363.1

chr22_-_15602593 0.83 ENSDART00000036075
tpm4a
tropomyosin 4a
chr13_+_30912117 0.83 ENSDART00000133138
drgx
dorsal root ganglia homeobox
chr3_-_28428198 0.83 ENSDART00000151546
rbfox1
RNA binding fox-1 homolog 1
chr24_+_38306010 0.82 ENSDART00000143184
mybpc2b
myosin binding protein C, fast type b
chr20_-_10120442 0.80 ENSDART00000144970
meis2b
Meis homeobox 2b
chr6_-_57938043 0.80 ENSDART00000171073
tox2
TOX high mobility group box family member 2
chr22_-_15602760 0.78 ENSDART00000009054
tpm4a
tropomyosin 4a
chr19_-_47452874 0.74 ENSDART00000025931
tfap2e
transcription factor AP-2 epsilon
chr7_-_31441420 0.73 ENSDART00000075398
cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr22_-_910926 0.71 ENSDART00000180075
FP016205.1

chr19_+_10339538 0.70 ENSDART00000151808
ENSDART00000151235
rcvrn3
recoverin 3
chr21_-_36972127 0.68 ENSDART00000100310
dbn1
drebrin 1
chr1_-_38195012 0.66 ENSDART00000020409
hand2
heart and neural crest derivatives expressed 2
chr19_-_6303099 0.66 ENSDART00000133371
pou2f2a
POU class 2 homeobox 2a
chr7_+_26224211 0.65 ENSDART00000173999
vgf
VGF nerve growth factor inducible
chr5_+_57320113 0.64 ENSDART00000036331
atp6v1g1
ATPase H+ transporting V1 subunit G1
chr20_+_28434196 0.64 ENSDART00000034245
dpf3
D4, zinc and double PHD fingers, family 3
chr22_-_23706771 0.63 ENSDART00000159771
cfhl1
complement factor H like 1
chr9_-_33329700 0.63 ENSDART00000147265
ENSDART00000140039
rpl8
ribosomal protein L8
chr10_+_21656654 0.62 ENSDART00000160464
pcdh1g2
protocadherin 1 gamma 2
chr6_+_12865137 0.62 ENSDART00000090065
fam117ba
family with sequence similarity 117, member Ba
chr15_-_34567370 0.61 ENSDART00000099793
sostdc1a
sclerostin domain containing 1a
chr8_+_25351863 0.61 ENSDART00000034092
dnase1l1l
deoxyribonuclease I-like 1-like
chr3_-_15264698 0.59 ENSDART00000111948
ENSDART00000142594
sez6l2
seizure related 6 homolog (mouse)-like 2
chr13_-_9598320 0.59 ENSDART00000184613
cpxm1a
carboxypeptidase X (M14 family), member 1a
chr3_-_32603191 0.58 ENSDART00000150997
si:ch73-248e21.7
si:ch73-248e21.7
chr11_+_21050326 0.58 ENSDART00000065984
zgc:113307
zgc:113307
chr7_+_27253063 0.58 ENSDART00000191138
sox6
SRY (sex determining region Y)-box 6
chr20_-_49681850 0.58 ENSDART00000025926
col12a1b
collagen, type XII, alpha 1b
chr11_-_4175773 0.58 ENSDART00000042221
ccdc3b
coiled-coil domain containing 3b
chr16_-_45209684 0.57 ENSDART00000184595
fxyd1
FXYD domain containing ion transport regulator 1 (phospholemman)
chr18_+_17583479 0.57 ENSDART00000186977
ENSDART00000010998
slc12a3
solute carrier family 12 (sodium/chloride transporter), member 3
chr4_-_22311610 0.55 ENSDART00000137814
hcls1
hematopoietic cell-specific Lyn substrate 1
chr1_+_52929185 0.54 ENSDART00000147683
inpp4b
inositol polyphosphate-4-phosphatase type II B
chr23_+_45282858 0.53 ENSDART00000162353
CABZ01073265.1

chr9_-_18568927 0.53 ENSDART00000084668
enox1
ecto-NOX disulfide-thiol exchanger 1
chr13_+_30912385 0.53 ENSDART00000182642
drgx
dorsal root ganglia homeobox
chr4_-_23963838 0.52 ENSDART00000133433
ENSDART00000132615
ENSDART00000135942
ENSDART00000139439
celf2
cugbp, Elav-like family member 2
chr7_+_69653981 0.51 ENSDART00000090165
frem1a
Fras1 related extracellular matrix 1a
chr18_+_8340886 0.51 ENSDART00000081132
cpt1b
carnitine palmitoyltransferase 1B (muscle)
chr5_-_20205075 0.49 ENSDART00000051611
dao.3
D-amino-acid oxidase, tandem duplicate 3
chr9_+_25776971 0.49 ENSDART00000146011
zeb2a
zinc finger E-box binding homeobox 2a
chr16_+_25535993 0.49 ENSDART00000077436
mylipb
myosin regulatory light chain interacting protein b
chr16_-_12319822 0.48 ENSDART00000127453
ENSDART00000184526
trpv6
transient receptor potential cation channel, subfamily V, member 6
chr9_+_25775816 0.48 ENSDART00000127834
ENSDART00000189994
zeb2a
zinc finger E-box binding homeobox 2a
chr13_+_29771463 0.48 ENSDART00000134424
ENSDART00000138332
ENSDART00000134330
ENSDART00000160944
ENSDART00000076992
ENSDART00000160921
pax2a
paired box 2a
chr13_-_1085961 0.47 ENSDART00000171872
ENSDART00000166598
plek
pleckstrin
chr24_+_792429 0.46 ENSDART00000082523
impa2
inositol(myo)-1(or 4)-monophosphatase 2
chr15_-_21014015 0.46 ENSDART00000144991
si:ch211-212c13.10
si:ch211-212c13.10
chr18_+_924949 0.46 ENSDART00000170888
ENSDART00000193163
pkma
pyruvate kinase M1/2a
chr11_+_37201483 0.45 ENSDART00000160930
ENSDART00000173439
ENSDART00000171273
zgc:112265
zgc:112265
chr23_+_36095260 0.45 ENSDART00000127384
hoxc9a
homeobox C9a
chr7_+_20512419 0.45 ENSDART00000173907
si:dkey-19b23.14
si:dkey-19b23.14
chr2_+_37227011 0.45 ENSDART00000126587
ENSDART00000084958
samd7
sterile alpha motif domain containing 7
chr3_-_19899914 0.43 ENSDART00000134969
rnd2
Rho family GTPase 2
chr18_-_898870 0.43 ENSDART00000151777
ENSDART00000062654
parp6a
poly (ADP-ribose) polymerase family, member 6a
chr21_-_26918901 0.43 ENSDART00000100685
lrfn4a
leucine rich repeat and fibronectin type III domain containing 4a
chr13_-_30161684 0.43 ENSDART00000040409
ppa1b
pyrophosphatase (inorganic) 1b
chr11_+_6650966 0.43 ENSDART00000131236
si:dkey-246j7.1
si:dkey-246j7.1
chr22_-_11623063 0.42 ENSDART00000145653
gcga
glucagon a
chr2_-_34555945 0.42 ENSDART00000056671
brinp2
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr14_-_33105434 0.41 ENSDART00000163795
dlg3
discs, large homolog 3 (Drosophila)
chr18_+_31410652 0.41 ENSDART00000098504
def8
differentially expressed in FDCP 8 homolog (mouse)
chr15_+_32268790 0.41 ENSDART00000154457
fhdc4
FH2 domain containing 4
chr9_-_23383131 0.40 ENSDART00000101685
sh3bp4
SH3-domain binding protein 4
chr10_-_7974155 0.40 ENSDART00000147368
ENSDART00000075524
osbp2
oxysterol binding protein 2
chr8_+_6967108 0.39 ENSDART00000004588
asic1a
acid-sensing (proton-gated) ion channel 1a
chr13_+_23162447 0.39 ENSDART00000180209
sorbs1
sorbin and SH3 domain containing 1
chr4_-_5595237 0.39 ENSDART00000109854
vegfab
vascular endothelial growth factor Ab
chr5_-_22882210 0.38 ENSDART00000182232
si:ch211-26b3.4
si:ch211-26b3.4
chr4_+_11479705 0.38 ENSDART00000019458
ENSDART00000150587
ENSDART00000139370
ENSDART00000135826
asb13a.1
ankyrin repeat and SOCS box containing 13a, tandem duplicate 1
chr11_-_10828539 0.37 ENSDART00000040180
tbr1a
T-box, brain, 1a
chr14_+_19258702 0.37 ENSDART00000187087
ENSDART00000005738
slitrk2
SLIT and NTRK-like family, member 2
chr20_+_34151670 0.37 ENSDART00000152870
ENSDART00000010329
ENSDART00000145852
arpc5b
actin related protein 2/3 complex, subunit 5B
chr6_-_32093830 0.37 ENSDART00000017695
foxd3
forkhead box D3
chr22_-_23000815 0.36 ENSDART00000137111
ptprc
protein tyrosine phosphatase, receptor type, C
chr1_+_14073891 0.35 ENSDART00000021693
ank2a
ankyrin 2a, neuronal
chr20_+_23173710 0.35 ENSDART00000074172
sgcb
sarcoglycan, beta (dystrophin-associated glycoprotein)
chr13_-_33667922 0.35 ENSDART00000141631
si:dkey-76k16.5
si:dkey-76k16.5
chr8_-_53198154 0.34 ENSDART00000083416
gabrd
gamma-aminobutyric acid (GABA) A receptor, delta
chr20_-_38610360 0.33 ENSDART00000168783
ENSDART00000164638
slc30a2
solute carrier family 30 (zinc transporter), member 2
chr4_+_14727018 0.32 ENSDART00000124189
cmasa
cytidine monophosphate N-acetylneuraminic acid synthetase a
chr22_-_29586608 0.32 ENSDART00000059869
adra2a
adrenoceptor alpha 2A
chr20_-_22476255 0.32 ENSDART00000103510
pdgfra
platelet-derived growth factor receptor, alpha polypeptide
chr20_+_25225112 0.32 ENSDART00000153088
ENSDART00000127291
ENSDART00000130494
moxd1
monooxygenase, DBH-like 1
chr4_+_612363 0.31 ENSDART00000049154
pthlha
parathyroid hormone-like hormone a
chr18_+_7286788 0.30 ENSDART00000022998
ANO2 (1 of many)
si:ch73-86n2.1
chr9_-_16853462 0.29 ENSDART00000160273
CT573248.2

chr5_+_36654817 0.29 ENSDART00000131339
capns1a
calpain, small subunit 1 a
chr18_+_30028637 0.28 ENSDART00000139750
si:ch211-220f16.1
si:ch211-220f16.1
chr18_+_26899316 0.28 ENSDART00000050230
tspan3a
tetraspanin 3a
chr2_-_45027754 0.27 ENSDART00000168469
vwa5b2
von Willebrand factor A domain containing 5B2
chr8_+_25352268 0.27 ENSDART00000187829
dnase1l1l
deoxyribonuclease I-like 1-like
chr8_-_19216180 0.27 ENSDART00000146162
si:ch73-222f22.2
si:ch73-222f22.2
chr4_-_21652812 0.26 ENSDART00000174400
rps16
ribosomal protein S16
chr13_+_17702522 0.26 ENSDART00000057913
si:dkey-27m7.4
si:dkey-27m7.4
chr6_+_20647155 0.26 ENSDART00000193477
slc19a1
solute carrier family 19 (folate transporter), member 1
chr4_+_14727212 0.26 ENSDART00000158094
cmasa
cytidine monophosphate N-acetylneuraminic acid synthetase a
chr1_-_58036509 0.25 ENSDART00000081122
COLGALT1
si:ch211-114l13.7
chr20_-_39273987 0.25 ENSDART00000127173
clu
clusterin
chr5_+_33339762 0.25 ENSDART00000026085
ptges
prostaglandin E synthase
chr1_-_59077650 0.24 ENSDART00000043516
MFAP4 (1 of many)
si:zfos-2330d3.1
chr16_+_45739193 0.24 ENSDART00000184852
ENSDART00000156851
ENSDART00000154704
paqr6
progestin and adipoQ receptor family member VI
chr6_-_957830 0.24 ENSDART00000090019
ENSDART00000184286
zeb2b
zinc finger E-box binding homeobox 2b
chr24_+_119680 0.24 ENSDART00000061973
tgfbr1b
transforming growth factor, beta receptor 1 b
chr2_-_34483597 0.24 ENSDART00000133224
brinp2
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr3_-_32169754 0.24 ENSDART00000179010
tnnt1
troponin T type 1 (skeletal, slow)
chr20_+_46183505 0.23 ENSDART00000060799
taar13b
trace amine associated receptor 13b
chr17_-_22552678 0.23 ENSDART00000079401
si:ch211-125o16.4
si:ch211-125o16.4
chr6_+_11249706 0.23 ENSDART00000186547
ENSDART00000193287
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr10_-_42131408 0.23 ENSDART00000076693
stambpa
STAM binding protein a
chr20_-_39273505 0.22 ENSDART00000153114
clu
clusterin
chr5_-_69548986 0.22 ENSDART00000097250
ENSDART00000163390
ENSDART00000166117
ENSDART00000167625
ENSDART00000191777
kiss1rb
KISS1 receptor b
chr14_+_46274611 0.22 ENSDART00000134363
cabp2b
calcium binding protein 2b
chr3_+_25166805 0.22 ENSDART00000077493
TST
zgc:162544
chr14_+_17197132 0.22 ENSDART00000054598
rtn4rl2b
reticulon 4 receptor-like 2b
chr19_+_19511394 0.22 ENSDART00000172410
jazf1a
JAZF zinc finger 1a
chr10_+_14210667 0.22 ENSDART00000138854
si:dkey-286h21.1
si:dkey-286h21.1
chr5_-_65000312 0.21 ENSDART00000192893
ANXA1 (1 of many)
zgc:110283
chr1_-_23598657 0.21 ENSDART00000144348
ENSDART00000142641
ENSDART00000143588
si:dkeyp-26a9.7
si:dkeyp-26a9.7
chr12_+_9551667 0.21 ENSDART00000048493
ENSDART00000166178
p4ha1a
prolyl 4-hydroxylase, alpha polypeptide I a
chr4_+_31405646 0.21 ENSDART00000128732
si:rp71-5o12.3
si:rp71-5o12.3
chr2_-_32551178 0.20 ENSDART00000145603
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr24_-_21819010 0.20 ENSDART00000091096
CR352265.1

chr23_-_44916800 0.20 ENSDART00000150076
fhdc5
FH2 domain containing 5
chr5_-_54197084 0.20 ENSDART00000163640
grk1b
G protein-coupled receptor kinase 1 b
chr18_-_48558420 0.20 ENSDART00000058987
kcnj1a.1
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr15_+_36966369 0.20 ENSDART00000163622
kirrel3l
kirre like nephrin family adhesion molecule 3, like
chr8_-_2289264 0.20 ENSDART00000189397
plat
plasminogen activator, tissue
chr22_+_38164486 0.19 ENSDART00000137521
tm4sf18
transmembrane 4 L six family member 18
chr24_+_20920563 0.19 ENSDART00000037224
cst14a.2
cystatin 14a, tandem duplicate 2
chr11_+_30981777 0.19 ENSDART00000148949
cacna1ab
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b
chr17_-_2386569 0.19 ENSDART00000121614
PLCB2
phospholipase C beta 2
chr7_+_72469724 0.19 ENSDART00000187629
HECTD4
HECT domain E3 ubiquitin protein ligase 4
chr20_-_25436389 0.18 ENSDART00000153266
itsn2a
intersectin 2a
chr9_-_21918963 0.18 ENSDART00000090782
lmo7a
LIM domain 7a
chr9_-_41277347 0.18 ENSDART00000181213
glsb
glutaminase b
chr23_-_21797517 0.18 ENSDART00000110041
lrrc38a
leucine rich repeat containing 38a
chr2_-_14387335 0.18 ENSDART00000189332
ENSDART00000164786
ENSDART00000188572
sgip1b
SH3-domain GRB2-like (endophilin) interacting protein 1b
chr5_-_52921532 0.17 ENSDART00000160566
CU695117.1

chr2_+_45548890 0.17 ENSDART00000113994
fndc7a
fibronectin type III domain containing 7a
chr7_-_5316901 0.16 ENSDART00000181505
ENSDART00000124367
si:cabz01074946.1
si:cabz01074946.1
chr6_+_11250033 0.16 ENSDART00000065411
ENSDART00000132677
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr15_-_4094888 0.16 ENSDART00000166307
TM4SF19
si:dkey-83h2.3
chr1_-_44638058 0.16 ENSDART00000081835
slc43a1b
solute carrier family 43 (amino acid system L transporter), member 1b
chr7_+_2228276 0.16 ENSDART00000064294
si:dkey-187j14.4
si:dkey-187j14.4
chr7_+_48870496 0.16 ENSDART00000009642
igf2a
insulin-like growth factor 2a
chr1_-_28831848 0.15 ENSDART00000148536
GK3P
zgc:172295
chr17_-_8173380 0.15 ENSDART00000148520
syne1b
spectrin repeat containing, nuclear envelope 1b
chr15_+_16343073 0.15 ENSDART00000029063
p2rx8
purinergic receptor P2X, ligand-gated ion channel, 8
chr3_-_34180364 0.15 ENSDART00000151819
ENSDART00000003133
yipf2
Yip1 domain family, member 2
chr24_+_9003998 0.15 ENSDART00000179656
ENSDART00000191314
CR318624.2

chr20_+_18551657 0.15 ENSDART00000147001
si:dkeyp-72h1.1
si:dkeyp-72h1.1
chr3_-_55197881 0.14 ENSDART00000179903
kank2
KN motif and ankyrin repeat domains 2
chr1_-_40086978 0.14 ENSDART00000136990
si:dkey-117m1.4
si:dkey-117m1.4
chr23_-_43393589 0.14 ENSDART00000183592
zgc:174862
zgc:174862
chr5_+_51026563 0.14 ENSDART00000050988
gcnt4a
glucosaminyl (N-acetyl) transferase 4, core 2, a
chr3_+_34180835 0.13 ENSDART00000055252
timm29
translocase of inner mitochondrial membrane 29
chr9_+_25776194 0.13 ENSDART00000144499
zeb2a
zinc finger E-box binding homeobox 2a
chr19_+_816208 0.13 ENSDART00000093304
nrm
nurim
chr24_+_26887487 0.13 ENSDART00000189425
CR376848.1

chr25_+_28893615 0.13 ENSDART00000156994
ENSDART00000075151
amn1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr15_-_31364729 0.12 ENSDART00000185386
or111-2
odorant receptor, family D, subfamily 111, member 2
chr4_-_287425 0.12 ENSDART00000159128
echdc3
enoyl CoA hydratase domain containing 3
chr3_+_30968176 0.12 ENSDART00000186266
prf1.9
perforin 1.9
chr13_+_32148338 0.12 ENSDART00000188591
osr1
odd-skipped related transciption factor 1
chr14_-_8625845 0.11 ENSDART00000054760
zgc:162144
zgc:162144
chr3_-_17716322 0.11 ENSDART00000192664
CABZ01018956.1

chr7_+_26326462 0.11 ENSDART00000173515
zanl
zonadhesin, like
chr25_-_28768489 0.11 ENSDART00000088315
washc4
WASH complex subunit 4
chr22_+_10010292 0.10 ENSDART00000180096
BX324216.4

chr24_-_32025637 0.10 ENSDART00000180448
ENSDART00000159034
rsu1
Ras suppressor protein 1
chr9_+_49712868 0.10 ENSDART00000192969
ENSDART00000183310
CSRNP3
cysteine and serine rich nuclear protein 3
chr2_+_20332044 0.10 ENSDART00000112131
plppr4a
phospholipid phosphatase related 4a

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx8a+lhx8b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.3 0.9 GO:0036076 ligamentous ossification(GO:0036076)
0.2 0.9 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.2 1.1 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.1 0.7 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.1 0.7 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.1 1.7 GO:0006603 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 0.5 GO:0046436 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.1 0.5 GO:0045023 G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
0.1 0.9 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.1 0.5 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.1 0.3 GO:0046333 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.1 1.0 GO:0034434 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.1 0.5 GO:0007624 ultradian rhythm(GO:0007624)
0.1 0.3 GO:0002076 osteoblast development(GO:0002076)
0.1 0.3 GO:0098838 folic acid transport(GO:0015884) drug transport(GO:0015893) methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.1 0.3 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 0.9 GO:0036368 cone photoresponse recovery(GO:0036368)
0.1 1.9 GO:0006942 regulation of striated muscle contraction(GO:0006942)
0.1 0.4 GO:0097066 response to thyroid hormone(GO:0097066)
0.1 1.0 GO:0016540 protein autoprocessing(GO:0016540)
0.1 0.7 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 0.3 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.1 0.3 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.1 0.4 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.1 0.8 GO:0003209 cardiac atrium morphogenesis(GO:0003209)
0.1 0.5 GO:0021588 cerebellum formation(GO:0021588)
0.1 0.6 GO:0060612 adipose tissue development(GO:0060612)
0.1 0.1 GO:0048389 intermediate mesoderm development(GO:0048389)
0.1 0.6 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 1.0 GO:0001990 regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.1 0.4 GO:0070207 protein homotrimerization(GO:0070207)
0.1 1.6 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.1 0.6 GO:0039023 pronephric duct morphogenesis(GO:0039023)
0.1 0.9 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.0 0.2 GO:0014909 smooth muscle cell migration(GO:0014909)
0.0 0.2 GO:0003010 voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721) slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 3.7 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 1.0 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.0 0.1 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0 0.5 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 0.6 GO:0048679 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 0.6 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.0 0.3 GO:0097531 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.5 GO:0071545 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.0 0.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.2 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.2 GO:0006537 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.0 1.0 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:1901207 regulation of heart looping(GO:1901207)
0.0 0.8 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.2 GO:0039022 pronephric duct development(GO:0039022)
0.0 0.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.9 GO:0006956 complement activation(GO:0006956)
0.0 0.1 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0 0.2 GO:0046626 regulation of insulin receptor signaling pathway(GO:0046626)
0.0 0.2 GO:0033198 response to ATP(GO:0033198)
0.0 0.1 GO:0019483 beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
0.0 0.2 GO:0060030 dorsal convergence(GO:0060030)
0.0 1.3 GO:0031101 fin regeneration(GO:0031101)
0.0 0.4 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.1 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 0.6 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.2 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 1.0 GO:0016079 synaptic vesicle exocytosis(GO:0016079)
0.0 0.4 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 1.3 GO:0021782 glial cell development(GO:0021782)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0061702 inflammasome complex(GO:0061702)
0.2 1.9 GO:0001772 immunological synapse(GO:0001772)
0.1 0.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 2.2 GO:0005861 troponin complex(GO:0005861)
0.0 1.2 GO:0043195 terminal bouton(GO:0043195)
0.0 0.5 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.0 0.8 GO:0071565 nBAF complex(GO:0071565)
0.0 0.6 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.8 GO:0005884 actin filament(GO:0005884)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.3 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.0 0.7 GO:0030141 secretory granule(GO:0030141)
0.0 0.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0019863 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.2 1.0 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.2 1.0 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.2 1.9 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.2 0.5 GO:0052834 inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.1 1.7 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 0.5 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.1 0.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.3 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.1 0.4 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 0.3 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.1 1.2 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 0.4 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.9 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.1 0.3 GO:0008518 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
0.1 0.4 GO:0031769 glucagon receptor binding(GO:0031769)
0.1 0.3 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.1 0.4 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 0.6 GO:0036122 BMP binding(GO:0036122)
0.1 0.5 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 0.5 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.5 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.6 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.1 0.3 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.1 2.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.6 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 3.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0050254 rhodopsin kinase activity(GO:0050254)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.0 0.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.9 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.5 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.4 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 2.5 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.0 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.6 GO:0019843 rRNA binding(GO:0019843)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 4.2 GO:0051015 actin filament binding(GO:0051015)
0.0 0.8 GO:0031490 chromatin DNA binding(GO:0031490)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.4 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.0 0.5 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.4 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 2.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.9 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.5 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors