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PRJNA195909:zebrafish embryo and larva development

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Results for mef2aa+mef2ab

Z-value: 2.59

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Transcription factors associated with mef2aa+mef2ab

Gene Symbol Gene ID Gene Info
ENSDARG00000031756 myocyte enhancer factor 2aa
ENSDARG00000057527 myocyte enhancer factor 2ab
ENSDARG00000110771 myocyte enhancer factor 2ab

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mef2abdr11_v1_chr7_+_15677196_156771960.674.7e-02Click!
mef2aadr11_v1_chr18_+_23193820_231938200.481.9e-01Click!

Activity profile of mef2aa+mef2ab motif

Sorted Z-values of mef2aa+mef2ab motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_61205711 7.32 ENSDART00000055062
parvalbumin 1
chr9_-_22205682 5.36 ENSDART00000101869
crystallin, gamma M2d12
chr3_+_32526263 4.95 ENSDART00000150897
si:ch73-367p23.2
chr3_+_28939759 4.93 ENSDART00000141904
lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1
chr19_-_7450796 4.64 ENSDART00000104750
MLLT11, transcription factor 7 cofactor
chr12_-_26064105 4.56 ENSDART00000168825
LIM domain binding 3b
chr9_-_22188117 4.26 ENSDART00000132890
crystallin, gamma M2d17
chr12_-_17712393 4.20 ENSDART00000143534
ENSDART00000010144
parvalbumin 2
chr12_-_5120339 4.12 ENSDART00000168759
retinol binding protein 4, plasma
chr5_-_72125551 3.98 ENSDART00000149412
SET and MYND domain containing 1a
chr1_+_7546259 3.95 ENSDART00000015732
myosin, light polypeptide 3, skeletal muscle
chr21_+_20383837 3.56 ENSDART00000026430
heat shock protein, alpha-crystallin-related, b11
chr7_-_27686021 3.45 ENSDART00000079112
ENSDART00000100989
calcitonin/calcitonin-related polypeptide, alpha
chr16_+_29663809 3.42 ENSDART00000191336
tropomodulin 4 (muscle)
chr12_-_4781801 3.41 ENSDART00000167490
ENSDART00000121718
microtubule-associated protein tau a
chr23_+_20110086 3.25 ENSDART00000054664
troponin C type 1b (slow)
chr12_-_26064480 3.18 ENSDART00000158215
ENSDART00000171206
ENSDART00000171212
ENSDART00000182956
ENSDART00000186779
LIM domain binding 3b
chr8_+_22930627 3.11 ENSDART00000187860
synaptophysin a
chr5_+_51597677 3.08 ENSDART00000048210
ENSDART00000184797
creatine kinase, mitochondrial 2b (sarcomeric)
chr15_+_19652807 2.98 ENSDART00000134321
ENSDART00000054426
lens intrinsic membrane protein 2.3
chr12_-_20340543 2.95 ENSDART00000055623
hemoglobin beta embryonic-3
chr5_+_36932718 2.94 ENSDART00000037879
cone-rod homeobox
chr20_-_40717900 2.84 ENSDART00000181663
connexin 43
chr8_+_34731982 2.80 ENSDART00000066050
4-hydroxyphenylpyruvate dioxygenase b
chr5_-_36948586 2.71 ENSDART00000193606
H3 histone, family 3C
chr7_+_7048245 2.65 ENSDART00000001649
actinin alpha 3b
chr16_-_36798783 2.62 ENSDART00000145697
calbindin 1
chr20_-_26001288 2.58 ENSDART00000136518
ENSDART00000063177
calpain 3b
chr10_-_8032885 2.53 ENSDART00000188619
ATPase H+ transporting V0 subunit a2a
chr8_-_11112058 2.50 ENSDART00000042755
adenosine monophosphate deaminase 1 (isoform M)
chr21_-_32487061 2.34 ENSDART00000114359
ENSDART00000131591
ENSDART00000131477
si:dkeyp-72g9.4
chr10_-_8033468 2.32 ENSDART00000140476
ATPase H+ transporting V0 subunit a2a
chr3_+_28953274 2.31 ENSDART00000133528
ENSDART00000103602
lectin, galactoside-binding, soluble, 2a
chr12_+_6041575 2.27 ENSDART00000091868
glucose-6-phosphatase a, catalytic subunit, tandem duplicate 2
chr1_-_13271085 2.26 ENSDART00000193663
protocadherin 18a
chr25_-_15040369 2.19 ENSDART00000159342
ENSDART00000166490
paired box 6a
chr5_+_67390645 2.18 ENSDART00000014822
early B cell factor 2
chr23_-_7797207 2.14 ENSDART00000181611
myelin transcription factor 1b
chr10_+_21776911 2.13 ENSDART00000163077
ENSDART00000186093
protocadherin 1 gamma 22
chr3_+_59051503 2.02 ENSDART00000160767
rasd family member 4
chr7_+_6969909 2.00 ENSDART00000189886
actinin alpha 3b
chr11_+_11200550 1.98 ENSDART00000181339
ENSDART00000187116
myomesin 2a
chr23_-_27633730 1.96 ENSDART00000103639
ADP-ribosylation factor 3a
chr3_+_40170216 1.95 ENSDART00000011568
synaptogyrin 3a
chr24_+_20960216 1.95 ENSDART00000133008
si:ch211-161h7.8
chr15_+_5923851 1.91 ENSDART00000152520
ENSDART00000145827
ENSDART00000121529
SH3 domain binding glutamate-rich protein
chr5_+_64732270 1.89 ENSDART00000134241
olfactomedin 1a
chr20_-_47732703 1.86 ENSDART00000193975
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr11_-_33960318 1.86 ENSDART00000087597
collagen, type VI, alpha 2
chr14_-_11430566 1.80 ENSDART00000137154
ENSDART00000091158
immunoresponsive gene 1, like
chr20_+_15552657 1.78 ENSDART00000063912
Jun proto-oncogene, AP-1 transcription factor subunit
chr17_-_5583345 1.77 ENSDART00000035944
chloride intracellular channel 5a
chr14_-_46451249 1.77 ENSDART00000058466
fibroblast growth factor binding protein 2a
chr10_-_22845485 1.73 ENSDART00000079454
vesicle-associated membrane protein 2
chr17_-_12336987 1.71 ENSDART00000172001
synaptosomal-associated protein, 25b
chr9_-_42873700 1.70 ENSDART00000125953
titin, tandem duplicate 1
chr12_+_6002715 1.66 ENSDART00000114961
si:ch211-131k2.3
chr25_+_19105804 1.65 ENSDART00000104414
retinaldehyde binding protein 1b
chr8_-_32497815 1.63 ENSDART00000122359
si:dkey-164f24.2
chr23_+_24926407 1.62 ENSDART00000137486
kelch-like family member 21
chr3_+_29445473 1.62 ENSDART00000020381
GRB2-related adaptor protein 2a
chr16_+_5774977 1.59 ENSDART00000134202
cholecystokinin a
chr5_-_57635664 1.59 ENSDART00000074306
heat shock protein, alpha-crystallin-related, b2
chr21_-_39253647 1.58 ENSDART00000133034
tumor suppressor candidate 5b
chr7_+_59649399 1.58 ENSDART00000123520
ENSDART00000040771
ribosomal protein L34
chr6_+_12462079 1.57 ENSDART00000192029
ENSDART00000065385
nuclear receptor subfamily 4, group A, member 2b
chr7_+_26716321 1.54 ENSDART00000189750
CD82 molecule a
chr25_-_23745765 1.53 ENSDART00000089278
si:ch211-236l14.4
chr5_+_64368770 1.52 ENSDART00000162246
phospholipid phosphatase 7 (inactive)
chr25_+_3677650 1.51 ENSDART00000154348
prion protein, related sequence 3
chr19_+_15571290 1.51 ENSDART00000131134
forkhead box O6 b
chr1_-_42778510 1.51 ENSDART00000190172
leucine rich repeat transmembrane neuronal 1
chr1_+_8601935 1.49 ENSDART00000152367
si:ch211-160d14.6
chr11_-_18253111 1.46 ENSDART00000125984
musculoskeletal, embryonic nuclear protein 1b
chr11_-_39202915 1.45 ENSDART00000105133
wingless-type MMTV integration site family, member 4a
chr6_-_20875111 1.43 ENSDART00000115118
ENSDART00000159916
tensin 1a
chr25_-_28384954 1.42 ENSDART00000073500
protein tyrosine phosphatase, receptor-type, Z polypeptide 1a
chr20_+_34455645 1.41 ENSDART00000135789
methyltransferase like 11B
chr1_+_6171585 1.40 ENSDART00000024358
protein kinase, AMP-activated, gamma 3a non-catalytic subunit
chr8_+_10304981 1.40 ENSDART00000160766
Pim-1 proto-oncogene, serine/threonine kinase
chr12_-_30338779 1.38 ENSDART00000192511
von Willebrand factor A domain containing 2
chr18_-_38087875 1.38 ENSDART00000111301
leucine zipper protein 2
chr10_-_24371312 1.36 ENSDART00000149362
phosphatidylinositol transfer protein, alpha b
chr10_-_10607118 1.35 ENSDART00000101089
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr19_-_10394931 1.35 ENSDART00000191549
zgc:194578
chr5_+_69808763 1.33 ENSDART00000143482
fibronectin type III and SPRY domain containing 1-like
chr13_-_2215213 1.32 ENSDART00000129773
muscular LMNA-interacting protein
chr8_-_27687095 1.31 ENSDART00000086946
Moloney leukemia virus 10b, tandem duplicate 1
chr23_-_19953089 1.31 ENSDART00000153828
ATPase plasma membrane Ca2+ transporting 3b
chr8_-_32497581 1.31 ENSDART00000176298
ENSDART00000183340
si:dkey-164f24.2
chr1_-_13271569 1.30 ENSDART00000127838
protocadherin 18a
chr20_+_16881883 1.30 ENSDART00000130107
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
chr6_+_57541776 1.28 ENSDART00000157330
N-terminal EF-hand calcium binding protein 3
chr14_+_22113331 1.27 ENSDART00000109759
thioredoxin-related transmembrane protein 2a
chr12_-_5663189 1.23 ENSDART00000105884
integrin, alpha 3b
chr22_-_7006974 1.22 ENSDART00000133143
glycerol-3-phosphate dehydrogenase 1b
chr25_+_20077225 1.22 ENSDART00000136543
troponin I4b, tandem duplicate 1
chr8_-_25002182 1.17 ENSDART00000078792
adenosylhomocysteinase-like 1
chr5_-_48260145 1.17 ENSDART00000044083
ENSDART00000163250
ENSDART00000135911
myocyte enhancer factor 2cb
chr10_-_26512742 1.16 ENSDART00000135951
si:dkey-5g14.1
chr13_+_22480857 1.15 ENSDART00000078721
ENSDART00000044719
ENSDART00000130957
ENSDART00000078757
ENSDART00000130424
ENSDART00000078747
LIM domain binding 3a
chr9_+_54644626 1.14 ENSDART00000190609
EGF-like-domain, multiple 6
chr4_-_16853464 1.12 ENSDART00000125743
ENSDART00000164570
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3a
chr16_-_16590489 1.11 ENSDART00000190021
si:ch211-257p13.3
chr7_+_69841017 1.09 ENSDART00000169107

chr14_+_49296052 1.07 ENSDART00000006073
ENSDART00000105346
annexin A6
chr21_-_5799122 1.06 ENSDART00000129351
ENSDART00000151202
cyclin I
chr7_-_22956889 1.06 ENSDART00000101447
TNF superfamily member 10, like
chr16_+_26777473 1.06 ENSDART00000188870
cadherin 17, LI cadherin (liver-intestine)
chr8_-_17516448 1.06 ENSDART00000100667
v-ski avian sarcoma viral oncogene homolog a
chr10_-_26512993 1.04 ENSDART00000188549
ENSDART00000193316
si:dkey-5g14.1
chr9_-_24209083 1.04 ENSDART00000134599
zgc:153521
chr19_+_25476228 1.04 ENSDART00000112808
collagen, type XXVIII, alpha 1a
chr15_-_22139566 1.02 ENSDART00000149017
sodium channel, voltage-gated, type III, beta
chr9_-_23990416 1.02 ENSDART00000113176
collagen, type VI, alpha 3
chr25_-_18140537 1.01 ENSDART00000113581
kit ligand a
chr25_+_10793478 1.00 ENSDART00000058339
ENSDART00000134923
adaptor-related protein complex 3, sigma 2 subunit
chr13_+_28821841 0.99 ENSDART00000179900

chr1_-_22678471 0.98 ENSDART00000128918
fibroblast growth factor binding protein 1b
chr16_-_28878080 0.98 ENSDART00000149501
si:dkey-239n17.4
chr14_-_32405387 0.98 ENSDART00000184647
fibroblast growth factor 13a
chr16_-_23797570 0.97 ENSDART00000077834
ribosomal protein S27, isoform 2
chr21_-_131236 0.95 ENSDART00000160005
si:ch1073-398f15.1
chr10_-_17232372 0.95 ENSDART00000135679
RAB36, member RAS oncogene family
chr2_-_16254782 0.92 ENSDART00000133708
Rho guanine nucleotide exchange factor (GEF) 4
chr18_+_45792035 0.91 ENSDART00000135045
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr20_-_26066020 0.91 ENSDART00000078559
myc target 1a
chr14_-_24332786 0.91 ENSDART00000173164
family with sequence similarity 13, member B
chr1_+_33969015 0.91 ENSDART00000042984
ENSDART00000146530
eph receptor A6
chr6_-_18698456 0.91 ENSDART00000166587
rhomboid, veinlet-like 3 (Drosophila)
chr10_+_36458563 0.90 ENSDART00000077008
arachidonate 5-lipoxygenase-activating protein
chr3_-_50046004 0.89 ENSDART00000109544
si:ch1073-100f3.2
chr16_+_20161805 0.88 ENSDART00000192146
chromosome 16 C2orf66 homolog
chr2_+_22495274 0.88 ENSDART00000167915
leucine rich repeat containing 8 VRAC subunit Da
chr24_+_25471196 0.88 ENSDART00000066625
small muscle protein, X-linked
chr8_+_52637507 0.87 ENSDART00000163830
si:dkey-90l8.3
chr14_+_11430796 0.87 ENSDART00000165275
si:ch211-153b23.3
chr21_+_12010505 0.86 ENSDART00000123522
aquaporin 7
chr3_+_32403758 0.86 ENSDART00000156982
si:ch211-195b15.8
chr15_+_7064819 0.86 ENSDART00000155268
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
chr23_-_39849155 0.85 ENSDART00000115330
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr24_-_6647275 0.80 ENSDART00000161494
Rho GTPase activating protein 21a
chr15_-_14375452 0.78 ENSDART00000160675
ENSDART00000164028
ENSDART00000171642
D4, zinc and double PHD fingers family 1
chr7_-_7420301 0.77 ENSDART00000102620
SIX homeobox 7
chr7_-_22956716 0.77 ENSDART00000122113
TNF superfamily member 10, like
chr3_-_52614747 0.76 ENSDART00000154365
tripartite motif containing 35-13
chr7_-_23745984 0.75 ENSDART00000048050
zgc:92429
chr17_-_39886628 0.73 ENSDART00000002217
zmp:0000000545
chr13_-_50139916 0.73 ENSDART00000099475
nidogen 1a
chr2_+_27403300 0.71 ENSDART00000099180
ELOVL fatty acid elongase 8a
chr14_+_23518110 0.70 ENSDART00000112930
si:ch211-221f10.2
chr7_+_57677120 0.70 ENSDART00000110623
arylsulfatase family, member J
chr19_+_24394560 0.70 ENSDART00000142506
si:dkey-81h8.1
chr2_-_5356686 0.70 ENSDART00000124290
mitofusin 1
chr13_+_25853757 0.69 ENSDART00000132521
B cell CLL/lymphoma 11Aa
chr4_+_47445318 0.69 ENSDART00000183819
si:dkey-124l13.1
chr17_+_8184649 0.68 ENSDART00000091818
tubby like protein 4b
chr14_-_36799280 0.67 ENSDART00000168615
ring finger protein 130
chr21_+_11685009 0.67 ENSDART00000014668
proprotein convertase subtilisin/kexin type 1
chr10_+_32561317 0.66 ENSDART00000109029
microtubule-associated protein 6a
chr25_-_6557854 0.65 ENSDART00000181740
chondroitin sulfate proteoglycan 4
chr25_+_31264155 0.65 ENSDART00000012256
troponin I type 2a (skeletal, fast), tandem duplicate 3
chr10_+_23511816 0.64 ENSDART00000127255
zmp:0000000924
chr24_+_34089977 0.64 ENSDART00000157466
ankyrin repeat and SOCS box containing 10
chr1_-_45662774 0.62 ENSDART00000042158
serine hydrolase-like
chr3_-_42981739 0.60 ENSDART00000167844
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
chr21_+_11684830 0.59 ENSDART00000147473
proprotein convertase subtilisin/kexin type 1
chr8_-_42238543 0.58 ENSDART00000062697
GDNF family receptor alpha 2a
chr7_-_19614916 0.58 ENSDART00000169029
zgc:194655
chr12_-_36740781 0.58 ENSDART00000105484
si:ch211-216b21.2
chr21_-_40083432 0.58 ENSDART00000141160
ENSDART00000191195
info solute carrier family 13 (sodium-dependent citrate transporter), member 5a
chr14_-_8795081 0.57 ENSDART00000106671
transforming growth factor, beta 2, like
chr16_-_17200120 0.55 ENSDART00000147739
glyceraldehyde-3-phosphate dehydrogenase
chr6_-_894006 0.54 ENSDART00000171091
zinc finger E-box binding homeobox 2b
chr20_-_51100669 0.53 ENSDART00000023488
ATPase H+ transporting V1 subunit D
chr2_-_30200206 0.53 ENSDART00000130142
ubiquitin-conjugating enzyme E2W (putative)
chr8_-_12264486 0.52 ENSDART00000091612
ENSDART00000135812
DAB2 interacting protein a
chr1_+_20084389 0.52 ENSDART00000140263
protease, serine, 12 (neurotrypsin, motopsin)
chr6_-_38816500 0.52 ENSDART00000190866
ENSDART00000104124
cyclic nucleotide gated channel alpha 3a
chr7_-_52334840 0.51 ENSDART00000174173

chr20_-_2134620 0.51 ENSDART00000064375
transmembrane protein 244
chr1_-_37383539 0.51 ENSDART00000127579
secretory calcium-binding phosphoprotein 1
chr20_+_33532296 0.50 ENSDART00000153153
potassium voltage-gated channel, subfamily F, member 1a
chr3_-_56889052 0.50 ENSDART00000188412
Usher syndrome 1Ga (autosomal recessive)
chr21_-_27507786 0.50 ENSDART00000077657
ENSDART00000191284
ENSDART00000178229
ENSDART00000186153
si:dkeyp-50d11.2
chr1_-_37383741 0.49 ENSDART00000193155
ENSDART00000191887
ENSDART00000189077
secretory calcium-binding phosphoprotein 1
chr2_-_3678029 0.45 ENSDART00000146861
matrix metallopeptidase 16b (membrane-inserted)
chr18_+_23193567 0.45 ENSDART00000190072
ENSDART00000171594
ENSDART00000181762
myocyte enhancer factor 2aa
chr24_+_38155830 0.45 ENSDART00000152019
si:ch211-234p6.5
chr16_+_32029090 0.45 ENSDART00000041054
transmembrane channel-like 4
chr18_+_7264961 0.44 ENSDART00000188461

chr2_-_28102264 0.44 ENSDART00000013638
cadherin 6
chr3_-_17871846 0.43 ENSDART00000074478
ENSDART00000187941
NFKB inhibitor interacting Ras-like 2
chr14_+_23520986 0.43 ENSDART00000170473
ENSDART00000175970
si:ch211-221f10.2
chr14_-_2318590 0.42 ENSDART00000192735
protocadherin 2 alpha b 8
chr23_+_33907899 0.41 ENSDART00000159445
citrate synthase
chr19_-_31035155 0.41 ENSDART00000161882
basic leucine zipper and W2 domains 2
chr3_+_31953145 0.41 ENSDART00000148861
potassium voltage-gated channel, Shaw-related subfamily, member 3a
chr1_-_35653560 0.40 ENSDART00000142154
Fras1 related extracellular matrix 3
chr9_-_28399071 0.40 ENSDART00000104317
ENSDART00000064343
Kruppel-like factor 7b

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2aa+mef2ab

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.6 GO:0090199 regulation of mitochondrial membrane potential(GO:0051881) regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.9 2.6 GO:0097264 self proteolysis(GO:0097264)
0.7 2.6 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.6 4.1 GO:0034633 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.5 2.1 GO:0003322 pancreatic A cell development(GO:0003322)
0.5 2.8 GO:0006572 tyrosine catabolic process(GO:0006572)
0.4 1.3 GO:0046333 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.4 1.3 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.4 8.8 GO:0031033 myosin filament organization(GO:0031033)
0.3 4.8 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.3 3.0 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.3 2.2 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.3 1.2 GO:0006116 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.3 1.5 GO:0035988 chondrocyte proliferation(GO:0035988)
0.3 1.1 GO:0003418 plasma membrane repair(GO:0001778) chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418)
0.3 1.3 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.3 1.0 GO:0086005 ventricular cardiac muscle cell action potential(GO:0086005)
0.3 1.3 GO:0021731 trigeminal motor nucleus development(GO:0021731)
0.2 3.1 GO:0006599 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.2 1.8 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.2 1.8 GO:0090594 inflammatory response to wounding(GO:0090594)
0.2 1.9 GO:1902868 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.2 1.3 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.2 0.9 GO:0019370 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.2 0.9 GO:0015744 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.2 2.3 GO:0090303 positive regulation of wound healing(GO:0090303)
0.2 1.6 GO:0071376 neutrophil homeostasis(GO:0001780) response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.2 0.7 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.2 2.4 GO:0032264 IMP salvage(GO:0032264)
0.1 3.0 GO:0015671 oxygen transport(GO:0015671)
0.1 1.8 GO:0051597 response to methylmercury(GO:0051597)
0.1 4.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.7 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 1.7 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 3.5 GO:0055064 chloride ion homeostasis(GO:0055064)
0.1 1.7 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 1.1 GO:0061337 cardiac conduction(GO:0061337)
0.1 1.5 GO:1901642 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.1 4.7 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 1.6 GO:0034629 cellular protein complex localization(GO:0034629)
0.1 0.4 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.1 0.9 GO:0006450 regulation of translational fidelity(GO:0006450)
0.1 1.3 GO:0016486 peptide hormone processing(GO:0016486)
0.1 1.7 GO:0007634 optokinetic behavior(GO:0007634)
0.1 9.7 GO:0002088 lens development in camera-type eye(GO:0002088)
0.1 0.1 GO:0055014 atrial cardiac muscle cell development(GO:0055014)
0.1 1.0 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.5 GO:0038026 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) reelin-mediated signaling pathway(GO:0038026)
0.1 1.1 GO:1903672 positive regulation of sprouting angiogenesis(GO:1903672)
0.1 1.4 GO:0010669 epithelial structure maintenance(GO:0010669)
0.1 0.9 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.6 GO:0015746 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.1 1.0 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 0.5 GO:0050957 equilibrioception(GO:0050957)
0.1 0.4 GO:0021570 rhombomere 4 development(GO:0021570) rhombomere 4 morphogenesis(GO:0021661)
0.1 0.4 GO:0021634 optic nerve formation(GO:0021634)
0.0 0.8 GO:0046549 retinal cone cell development(GO:0046549)
0.0 1.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.9 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.2 GO:0090113 regulation of COPII vesicle coating(GO:0003400) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.0 1.6 GO:0007586 digestion(GO:0007586)
0.0 1.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 2.9 GO:2000027 regulation of organ morphogenesis(GO:2000027)
0.0 0.7 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.3 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 1.2 GO:0060914 heart formation(GO:0060914)
0.0 0.4 GO:0014823 response to activity(GO:0014823)
0.0 0.5 GO:0060030 dorsal convergence(GO:0060030)
0.0 0.3 GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) G-protein coupled receptor internalization(GO:0002031) negative adaptation of signaling pathway(GO:0022401) adaptation of signaling pathway(GO:0023058)
0.0 1.4 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 1.1 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.2 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 1.2 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 9.8 GO:0061061 muscle structure development(GO:0061061)
0.0 1.4 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 1.2 GO:0033334 fin morphogenesis(GO:0033334)
0.0 0.6 GO:0050821 protein stabilization(GO:0050821)
0.0 1.0 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 0.4 GO:0032526 response to retinoic acid(GO:0032526)
0.0 0.4 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 1.3 GO:0031101 fin regeneration(GO:0031101)
0.0 0.9 GO:0006936 muscle contraction(GO:0006936)
0.0 1.4 GO:0006821 chloride transport(GO:0006821)
0.0 0.1 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.0 1.1 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.4 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.6 GO:0048484 enteric nervous system development(GO:0048484)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.8 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.3 6.8 GO:0031430 M band(GO:0031430)
0.3 1.7 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.2 3.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 1.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 8.9 GO:0031941 filamentous actin(GO:0031941)
0.1 7.7 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.1 1.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 2.8 GO:0043195 terminal bouton(GO:0043195)
0.1 1.3 GO:0030667 secretory granule membrane(GO:0030667)
0.1 5.1 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.3 GO:0043186 P granule(GO:0043186)
0.0 0.7 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.3 GO:0016605 PML body(GO:0016605)
0.0 1.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.8 GO:0071565 nBAF complex(GO:0071565)
0.0 1.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.2 GO:0008305 integrin complex(GO:0008305)
0.0 1.1 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 1.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.4 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 1.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.3 GO:0030175 filopodium(GO:0030175)
0.0 2.1 GO:0005581 collagen trimer(GO:0005581)
0.0 0.5 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.0 1.1 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.3 GO:0031985 Golgi cisterna(GO:0031985)
0.0 1.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0031672 A band(GO:0031672)
0.0 5.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.0 GO:0005604 basement membrane(GO:0005604)
0.0 14.6 GO:0005615 extracellular space(GO:0005615)
0.0 6.5 GO:0005576 extracellular region(GO:0005576)
0.0 3.9 GO:0005874 microtubule(GO:0005874)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0031716 calcitonin receptor binding(GO:0031716)
0.9 2.8 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.9 2.8 GO:0005499 vitamin D binding(GO:0005499)
0.7 7.2 GO:0016936 galactoside binding(GO:0016936)
0.6 4.1 GO:0034632 retinol transporter activity(GO:0034632)
0.4 1.3 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.4 8.9 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.4 1.3 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.4 1.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.3 1.3 GO:0005521 lamin binding(GO:0005521)
0.3 4.8 GO:0051117 ATPase binding(GO:0051117)
0.3 1.2 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.3 1.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 3.0 GO:0031720 haptoglobin binding(GO:0031720)
0.2 3.1 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.2 0.9 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.2 2.4 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.2 0.6 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
0.2 1.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.2 1.5 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.2 0.9 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.2 6.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 12.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.6 GO:0015141 succinate transmembrane transporter activity(GO:0015141)
0.1 1.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.6 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 1.0 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 1.8 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 2.6 GO:0005523 tropomyosin binding(GO:0005523)
0.1 3.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.9 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.1 0.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.8 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 2.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.9 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 1.0 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 0.6 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.9 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 4.0 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 0.9 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 1.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.4 GO:0016208 AMP binding(GO:0016208)
0.0 0.7 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.5 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 1.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0051430 mu-type opioid receptor binding(GO:0031852) dopamine receptor binding(GO:0050780) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.3 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.6 GO:0031386 protein tag(GO:0031386)
0.0 1.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.7 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 1.0 GO:0030165 PDZ domain binding(GO:0030165)
0.0 33.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.2 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 3.0 GO:0019838 growth factor binding(GO:0019838)
0.0 0.3 GO:0048495 Roundabout binding(GO:0048495)
0.0 1.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.3 GO:0002039 p53 binding(GO:0002039)
0.0 1.7 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 2.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.9 GO:0000049 tRNA binding(GO:0000049)
0.0 1.1 GO:0046332 SMAD binding(GO:0046332)
0.0 1.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.4 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.1 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.0 0.1 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.0 1.4 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.2 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 2.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.6 GO:0016831 carboxy-lyase activity(GO:0016831)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 2.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 1.4 PID IL5 PATHWAY IL5-mediated signaling events
0.1 2.9 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.9 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.9 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 2.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.5 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.3 0.9 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.3 2.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.2 1.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 3.5 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 1.3 REACTOME PEPTIDE HORMONE BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.1 2.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.7 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 0.9 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 0.7 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 0.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.8 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.4 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 1.3 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.3 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors