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PRJNA195909:zebrafish embryo and larva development

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Results for meis3

Z-value: 1.27

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Transcription factors associated with meis3

Gene Symbol Gene ID Gene Info
meis3
ENSDARG00000002795 myeloid ecotropic viral integration site 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
meis3dr11_v1_chr15_-_6863317_68633170.571.1e-01Click!

Activity profile of meis3 motif

Sorted Z-values of meis3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_22310919 2.48 ENSDART00000108719
crygm2d10
crystallin, gamma M2d10
chr16_-_16152199 2.33 ENSDART00000012718
fabp11b
fatty acid binding protein 11b
chr10_-_39011514 2.30 ENSDART00000075123
pcp4a
Purkinje cell protein 4a
chr9_-_22205682 2.22 ENSDART00000101869
crygm2d12
crystallin, gamma M2d12
chr9_-_22232902 2.16 ENSDART00000101845
crygm2d5
crystallin, gamma M2d5
chr9_-_22240052 2.10 ENSDART00000111109
crygm2d9
crystallin, gamma M2d9
chr23_+_23658474 2.04 ENSDART00000162838
agrn
agrin
chr1_-_26026956 1.99 ENSDART00000102346
si:ch211-145b13.6
si:ch211-145b13.6
chr6_-_14146979 1.98 ENSDART00000089564
cacnb4b
calcium channel, voltage-dependent, beta 4b subunit
chr1_-_40911332 1.91 ENSDART00000027463
hmx4
H6 family homeobox 4
chr6_+_3827751 1.67 ENSDART00000003008
ENSDART00000122348
gad1b
glutamate decarboxylase 1b
chr11_-_41966854 1.60 ENSDART00000055709
her2
hairy-related 2
chr17_+_7595356 1.55 ENSDART00000130625
si:dkeyp-110a12.4
si:dkeyp-110a12.4
chr21_+_30351256 1.55 ENSDART00000078341
foxi3a
forkhead box I3a
chr7_-_26306546 1.52 ENSDART00000140817
zgc:77439
zgc:77439
chr16_-_26537103 1.46 ENSDART00000134908
ENSDART00000008152
sgk2b
serum/glucocorticoid regulated kinase 2b
chr21_+_45733871 1.41 ENSDART00000187285
ENSDART00000193018
zgc:77058
zgc:77058
chr2_-_32558795 1.40 ENSDART00000140026
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr15_-_29598679 1.40 ENSDART00000155153
si:ch211-207n23.2
si:ch211-207n23.2
chr10_+_26667475 1.38 ENSDART00000133281
ENSDART00000147013
si:ch73-52f15.5
si:ch73-52f15.5
chr8_+_8291492 1.35 ENSDART00000151314
srpk3
SRSF protein kinase 3
chr5_-_46980651 1.29 ENSDART00000181022
ENSDART00000168038
edil3a
EGF-like repeats and discoidin I-like domains 3a
chr22_-_5006119 1.28 ENSDART00000187998
rx1
retinal homeobox gene 1
chr2_+_6127593 1.23 ENSDART00000184007
fzr1b
fizzy/cell division cycle 20 related 1b
chr5_+_38913621 1.23 ENSDART00000137112
fras1
Fraser extracellular matrix complex subunit 1
chr20_+_51104367 1.22 ENSDART00000073981
eif2s1b
eukaryotic translation initiation factor 2, subunit 1 alpha b
chr23_+_21663631 1.21 ENSDART00000066125
dhrs3a
dehydrogenase/reductase (SDR family) member 3a
chr11_-_17981421 1.16 ENSDART00000005999
ENSDART00000104046
twf2b
twinfilin actin-binding protein 2b
chr20_-_26001288 1.12 ENSDART00000136518
ENSDART00000063177
capn3b
calpain 3b
chr23_-_15216654 1.12 ENSDART00000131649
sulf2b
sulfatase 2b
chr16_-_7239457 1.08 ENSDART00000148992
ENSDART00000149260
nt5c3a
5'-nucleotidase, cytosolic IIIA
chr13_-_7031033 1.07 ENSDART00000193211
CABZ01061524.1

chr2_+_45081489 1.06 ENSDART00000123966
chrng
cholinergic receptor, nicotinic, gamma
chr5_+_36752943 0.99 ENSDART00000017138
exoc3l2a
exocyst complex component 3-like 2a
chr22_-_34872533 0.98 ENSDART00000167176
slit1b
slit homolog 1b (Drosophila)
chr17_-_5583345 0.90 ENSDART00000035944
clic5a
chloride intracellular channel 5a
chr2_-_44183451 0.88 ENSDART00000111246
cadm3
cell adhesion molecule 3
chr12_-_45876387 0.87 ENSDART00000043210
ENSDART00000149044
pax2b
paired box 2b
chr2_-_44183613 0.86 ENSDART00000079596
cadm3
cell adhesion molecule 3
chr12_+_47122104 0.84 ENSDART00000184248
CABZ01088982.1

chr5_+_37091626 0.83 ENSDART00000161054
tagln2
transgelin 2
chr23_-_10177442 0.80 ENSDART00000144280
ENSDART00000129044
krt5
keratin 5
chr2_+_47623202 0.77 ENSDART00000154465
si:ch211-165b10.3
si:ch211-165b10.3
chr1_+_1805294 0.76 ENSDART00000103850
atp1a1a.3
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 3
chr20_+_32406011 0.73 ENSDART00000018640
ENSDART00000137910
snx3
sorting nexin 3
chr3_+_32557615 0.72 ENSDART00000151608
pax10
paired box 10
chr7_+_65673885 0.70 ENSDART00000169182
parvab
parvin, alpha b
chr3_+_26734162 0.70 ENSDART00000114552
si:dkey-202l16.5
si:dkey-202l16.5
chr1_+_34496855 0.69 ENSDART00000012873
klf12a
Kruppel-like factor 12a
chr7_-_67214972 0.68 ENSDART00000156861
swap70a
switching B cell complex subunit SWAP70a
chr10_+_406146 0.60 ENSDART00000145124
dact3a
dishevelled-binding antagonist of beta-catenin 3a
chr8_-_32506569 0.59 ENSDART00000061792
RFESD (1 of many)
Rieske Fe-S domain containing
chr9_-_25181137 0.58 ENSDART00000192624
esd
esterase D/formylglutathione hydrolase
chr16_-_1502699 0.55 ENSDART00000187189
sim1a
single-minded family bHLH transcription factor 1a
chr21_+_25231160 0.55 ENSDART00000063089
ENSDART00000139127
gng8
guanine nucleotide binding protein (G protein), gamma 8
chr8_-_7444390 0.53 ENSDART00000149671
hdac6
histone deacetylase 6
chr20_+_44311448 0.52 ENSDART00000114660
opn8b
opsin 8, group member b
chr7_-_30174882 0.50 ENSDART00000110409
frmd5
FERM domain containing 5
chr5_+_23118470 0.50 ENSDART00000149893
nexmifa
neurite extension and migration factor a
chr5_+_24245682 0.50 ENSDART00000049003
atp6v1aa
ATPase H+ transporting V1 subunit Aa
chr25_-_22191983 0.49 ENSDART00000191181
pkp3a
plakophilin 3a
chr16_+_24971717 0.49 ENSDART00000156958
fpr1
formyl peptide receptor 1
chr12_-_45875946 0.47 ENSDART00000149970
pax2b
paired box 2b
chr5_-_23118290 0.46 ENSDART00000132857
uprt
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
chr15_-_34056733 0.43 ENSDART00000170130
ENSDART00000188272
VWDE
si:dkey-30e9.7
chr8_-_26609259 0.43 ENSDART00000027301
sema3b
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr15_-_29598444 0.41 ENSDART00000154847
si:ch211-207n23.2
si:ch211-207n23.2
chr19_-_35596207 0.41 ENSDART00000136811
col8a2
collagen, type VIII, alpha 2
chr8_-_7444155 0.37 ENSDART00000148993
hdac6
histone deacetylase 6
chr14_-_17305657 0.37 ENSDART00000168853
jakmip1
janus kinase and microtubule interacting protein 1
chr5_-_21030934 0.34 ENSDART00000133461
ENSDART00000098667
camk2b1
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1
chr25_+_32525131 0.34 ENSDART00000156145
scaper
S-phase cyclin A-associated protein in the ER
chr3_-_45308394 0.34 ENSDART00000155324
pdpk1a
3-phosphoinositide dependent protein kinase 1a
chr25_-_22191733 0.32 ENSDART00000067478
pkp3a
plakophilin 3a
chr6_+_33537267 0.32 ENSDART00000040334
pik3r3b
phosphoinositide-3-kinase, regulatory subunit 3b (gamma)
chr17_-_30839338 0.32 ENSDART00000139707
gdf7
growth differentiation factor 7
chr9_-_28399071 0.26 ENSDART00000104317
ENSDART00000064343
klf7b
Kruppel-like factor 7b
chr17_-_15667198 0.26 ENSDART00000142972
ENSDART00000132571
ENSDART00000189936
manea
mannosidase, endo-alpha
chr19_-_30565122 0.26 ENSDART00000185650
hpcal4
hippocalcin like 4
chr25_-_28600433 0.26 ENSDART00000138980
agbl2
ATP/GTP binding protein-like 2
chr8_-_11229523 0.26 ENSDART00000002164
unc45b
unc-45 myosin chaperone B
chr1_-_10347198 0.25 ENSDART00000109141
ENSDART00000152565
si:ch211-243g6.3
si:ch211-243g6.3
chr24_+_34806822 0.25 ENSDART00000148407
ENSDART00000188328
mchr2
melanin-concentrating hormone receptor 2
chr12_+_36413886 0.24 ENSDART00000126325
si:ch211-250n8.1
si:ch211-250n8.1
chr20_-_23171430 0.24 ENSDART00000109234
spata18
spermatogenesis associated 18
chr1_-_44084071 0.23 ENSDART00000166912
vwa11
von Willebrand factor A domain containing 11
chr22_+_30335936 0.20 ENSDART00000059923
mxi1
max interactor 1, dimerization protein
chr8_-_4508248 0.20 ENSDART00000141915
si:ch211-166a6.5
si:ch211-166a6.5
chr2_+_9918678 0.20 ENSDART00000081253
acbd5b
acyl-CoA binding domain containing 5b
chr2_+_9918935 0.19 ENSDART00000140434
acbd5b
acyl-CoA binding domain containing 5b
chr24_-_30091937 0.18 ENSDART00000148249
plppr4b
phospholipid phosphatase related 4b
chr15_-_4415917 0.16 ENSDART00000062874
atp1b3b
ATPase Na+/K+ transporting subunit beta 3b
chr17_+_35362851 0.16 ENSDART00000137659
cmpk2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr6_+_9107063 0.15 ENSDART00000083820
vps16
vacuolar protein sorting protein 16
chr6_+_9952678 0.15 ENSDART00000019325
cyp20a1
cytochrome P450, family 20, subfamily A, polypeptide 1
chr6_-_13408680 0.14 ENSDART00000151566
fmnl2b
formin-like 2b
chr18_+_36769758 0.13 ENSDART00000180375
ENSDART00000136463
ENSDART00000133487
ENSDART00000130206
fosb
FBJ murine osteosarcoma viral oncogene homolog B
chr25_-_3139805 0.10 ENSDART00000166625
epx
eosinophil peroxidase
chr19_+_24872159 0.09 ENSDART00000158490
si:ch211-195b13.1
si:ch211-195b13.1
chr23_-_764135 0.09 ENSDART00000010248
ENSDART00000183978
mitfb
microphthalmia-associated transcription factor b
chr20_-_26467307 0.07 ENSDART00000078072
ENSDART00000158213
akap12b
A kinase (PRKA) anchor protein 12b
chr24_+_12989727 0.07 ENSDART00000126842
ENSDART00000129309
flj11011l
hypothetical protein FLJ11011-like (H. sapiens)
chr8_-_8698607 0.07 ENSDART00000046712
zgc:86609
zgc:86609
chr2_+_15128418 0.05 ENSDART00000141921
arhgap29b
Rho GTPase activating protein 29b
chr14_-_26436951 0.05 ENSDART00000140173
si:dkeyp-110e4.6
si:dkeyp-110e4.6
chr6_+_48041759 0.05 ENSDART00000140086
si:dkey-92f12.2
si:dkey-92f12.2
chr8_-_27515540 0.05 ENSDART00000146132
si:ch211-254n4.3
si:ch211-254n4.3
chr19_-_42588510 0.04 ENSDART00000102583
sytl1
synaptotagmin-like 1
chr6_+_15762647 0.04 ENSDART00000127133
ENSDART00000128939
iqca1
IQ motif containing with AAA domain 1
chr23_+_23182037 0.04 ENSDART00000137353
klhl17
kelch-like family member 17
chr13_+_30169681 0.03 ENSDART00000138326
pald1b
phosphatase domain containing, paladin 1b
chr21_+_30194904 0.03 ENSDART00000137023
ENSDART00000078403
BRD8
si:ch211-59d17.3

Network of associatons between targets according to the STRING database.

First level regulatory network of meis3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.6 1.7 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.4 1.5 GO:0009957 epidermal cell fate specification(GO:0009957)
0.4 1.1 GO:0097264 self proteolysis(GO:0097264)
0.3 1.6 GO:0007405 neuroblast proliferation(GO:0007405)
0.2 1.2 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.2 1.2 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.2 2.0 GO:0018120 peptidyl-arginine ADP-ribosylation(GO:0018120)
0.2 0.6 GO:0072020 proximal straight tubule development(GO:0072020)
0.2 1.9 GO:1900052 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.2 1.4 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 0.5 GO:2000048 negative regulation of cell-substrate adhesion(GO:0010812) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 1.2 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.6 GO:0046292 formaldehyde metabolic process(GO:0046292) formaldehyde catabolic process(GO:0046294)
0.1 0.5 GO:0002283 neutrophil activation involved in immune response(GO:0002283)
0.1 1.1 GO:0035860 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 1.4 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 9.2 GO:0002088 lens development in camera-type eye(GO:0002088)
0.1 0.3 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 1.1 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.1 0.2 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.0 2.0 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 1.2 GO:0010669 epithelial structure maintenance(GO:0010669)
0.0 1.2 GO:0021602 cranial nerve morphogenesis(GO:0021602)
0.0 1.3 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.7 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 1.3 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.3 GO:0043550 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.2 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 1.5 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 1.6 GO:1990266 neutrophil migration(GO:1990266)
0.0 0.9 GO:0006476 protein deacetylation(GO:0006476)
0.0 0.5 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 1.2 GO:0006413 translational initiation(GO:0006413)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0043614 multi-eIF complex(GO:0043614)
0.1 1.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.4 GO:0071564 npBAF complex(GO:0071564)
0.1 0.8 GO:0045095 keratin filament(GO:0045095)
0.1 0.6 GO:0030904 retromer complex(GO:0030904)
0.0 1.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.8 GO:0030057 desmosome(GO:0030057)
0.0 1.0 GO:0000145 exocyst(GO:0000145)
0.0 0.6 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.9 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.6 GO:0016324 apical plasma membrane(GO:0016324)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.2 1.2 GO:0010997 anaphase-promoting complex binding(GO:0010997) ubiquitin ligase activator activity(GO:1990757)
0.2 0.9 GO:0047611 tubulin deacetylase activity(GO:0042903) acetylspermidine deacetylase activity(GO:0047611)
0.2 2.0 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.2 1.5 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 1.2 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 8.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 2.0 GO:0043236 laminin binding(GO:0043236)
0.1 0.8 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 2.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 1.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.2 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.2 GO:0009041 uridylate kinase activity(GO:0009041)
0.0 1.0 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 1.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.5 GO:0004875 complement receptor activity(GO:0004875)
0.0 1.3 GO:0005178 integrin binding(GO:0005178)
0.0 1.2 GO:0043022 ribosome binding(GO:0043022)
0.0 0.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.3 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 2.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.5 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.6 GO:0016790 thiolester hydrolase activity(GO:0016790)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.9 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.1 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.6 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.0 0.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription