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PRJNA195909:zebrafish embryo and larva development

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Results for nfe2

Z-value: 0.67

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Transcription factors associated with nfe2

Gene Symbol Gene ID Gene Info
nfe2
ENSDARG00000020606 nuclear factor, erythroid 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nfe2dr11_v1_chr23_-_36313431_363134310.235.5e-01Click!

Activity profile of nfe2 motif

Sorted Z-values of nfe2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_55139127 1.69 ENSDART00000115324
hbae1.3
hemoglobin, alpha embryonic 1.3
chr5_-_30615901 0.93 ENSDART00000147769
si:ch211-117m20.5
si:ch211-117m20.5
chr13_-_23007813 0.93 ENSDART00000057638
hk1
hexokinase 1
chr3_-_26017592 0.83 ENSDART00000030890
hmox1a
heme oxygenase 1a
chr3_-_26017831 0.82 ENSDART00000179982
hmox1a
heme oxygenase 1a
chr5_-_67471375 0.80 ENSDART00000147009
si:dkey-251i10.2
si:dkey-251i10.2
chr20_-_16906623 0.76 ENSDART00000012859
ENSDART00000171628
psma6b
proteasome subunit alpha 6b
chr10_+_29265463 0.71 ENSDART00000155390
crebzf
CREB/ATF bZIP transcription factor
chr1_-_52498146 0.70 ENSDART00000122217
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr3_-_53533128 0.67 ENSDART00000183591
notch3
notch 3
chr15_-_21877726 0.65 ENSDART00000127819
ENSDART00000145646
ENSDART00000100897
ENSDART00000144739
zgc:162608
zgc:162608
chr23_-_44546124 0.64 ENSDART00000126779
ENSDART00000024082
psmb6
proteasome subunit beta 6
chr14_-_25985698 0.62 ENSDART00000172909
ENSDART00000123053
atox1
antioxidant 1 copper chaperone
chr9_+_41103127 0.57 ENSDART00000000250
slc40a1
solute carrier family 40 (iron-regulated transporter), member 1
chr9_-_33328948 0.56 ENSDART00000006948
rpl8
ribosomal protein L8
chr20_-_16972351 0.50 ENSDART00000148312
ENSDART00000186702
si:ch73-74h11.1
si:ch73-74h11.1
chr23_+_9560797 0.48 ENSDART00000180014
adrm1
adhesion regulating molecule 1
chr1_-_52497834 0.47 ENSDART00000136469
ENSDART00000004233
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr8_-_50979047 0.47 ENSDART00000184788
ENSDART00000180906
zgc:91909
zgc:91909
chr11_+_13630107 0.47 ENSDART00000172220
si:ch211-1a19.3
si:ch211-1a19.3
chr23_+_9560991 0.47 ENSDART00000081433
ENSDART00000131594
ENSDART00000130069
ENSDART00000138601
adrm1
adhesion regulating molecule 1
chr12_+_20587179 0.47 ENSDART00000170127
arsg
arylsulfatase G
chr2_+_4207209 0.44 ENSDART00000157903
ENSDART00000166476
gata6
GATA binding protein 6
chr12_-_1951233 0.44 ENSDART00000005676
ENSDART00000127937
sox9a
SRY (sex determining region Y)-box 9a
chr19_-_41404870 0.44 ENSDART00000167772
sem1
SEM1, 26S proteasome complex subunit
chr7_+_57109214 0.43 ENSDART00000135068
ENSDART00000098412
enosf1
enolase superfamily member 1
chr16_+_9762261 0.43 ENSDART00000020654
psmd4b
proteasome 26S subunit, non-ATPase 4b
chr19_+_43119698 0.41 ENSDART00000167847
ENSDART00000186962
ENSDART00000187305
eef1a1l1
eukaryotic translation elongation factor 1 alpha 1, like 1
chr14_-_17588345 0.41 ENSDART00000143486
selenot2
selenoprotein T, 2
chr14_+_34780886 0.40 ENSDART00000130469
ENSDART00000188806
ENSDART00000172924
ENSDART00000173266
ENSDART00000166377
ENSDART00000173371
sh3tc2
SH3 domain and tetratricopeptide repeats 2
chr21_+_8341774 0.40 ENSDART00000129749
ENSDART00000055325
ENSDART00000133804
psmb7
proteasome subunit beta 7
chr14_+_30279391 0.40 ENSDART00000172794
fgl1
fibrinogen-like 1
chr5_-_44843738 0.40 ENSDART00000003926
fbp1a
fructose-1,6-bisphosphatase 1a
chr19_-_6385594 0.40 ENSDART00000104950
atp1a3a
ATPase Na+/K+ transporting subunit alpha 3a
chr11_+_2198831 0.39 ENSDART00000160515
hoxc6b
homeobox C6b
chr8_+_39511932 0.35 ENSDART00000113511
lzts1
leucine zipper, putative tumor suppressor 1
chr22_+_16535575 0.35 ENSDART00000083063
tal1
T-cell acute lymphocytic leukemia 1
chr11_+_13629528 0.35 ENSDART00000186509
si:ch211-1a19.3
si:ch211-1a19.3
chr21_-_23110841 0.35 ENSDART00000147896
ENSDART00000003076
ENSDART00000184925
ENSDART00000190386
usp28
ubiquitin specific peptidase 28
chr18_+_2222447 0.34 ENSDART00000185927
pigbos1
PIGB opposite strand 1
chr20_-_39103119 0.32 ENSDART00000143379
rcan2
regulator of calcineurin 2
chr7_+_1045637 0.32 ENSDART00000111531
epdl1
ependymin-like 1
chr5_+_44805028 0.31 ENSDART00000141198
ctsla
cathepsin La
chr5_+_44805269 0.31 ENSDART00000136965
ctsla
cathepsin La
chr12_+_48216662 0.30 ENSDART00000187369
lrrc20
leucine rich repeat containing 20
chr7_+_756942 0.28 ENSDART00000152224
zgc:63470
zgc:63470
chr18_-_28938912 0.28 ENSDART00000136201
si:ch211-174j14.2
si:ch211-174j14.2
chr4_+_25630555 0.27 ENSDART00000133425
acot15
acyl-CoA thioesterase 15
chr21_-_929293 0.26 ENSDART00000006419
txnl1
thioredoxin-like 1
chr2_-_3038904 0.26 ENSDART00000186795
guk1a
guanylate kinase 1a
chr21_-_25756119 0.26 ENSDART00000002341
cldnc
claudin c
chr17_+_53424415 0.25 ENSDART00000157022
slc9a1b
solute carrier family 9 member A1b
chr20_-_19422496 0.25 ENSDART00000143658
si:ch211-278j3.3
si:ch211-278j3.3
chr10_+_31222433 0.25 ENSDART00000185080
tmem218
transmembrane protein 218
chr1_+_54655160 0.24 ENSDART00000190319
si:ch211-202h22.7
si:ch211-202h22.7
chr21_-_5393125 0.22 ENSDART00000146061
psmd5
proteasome 26S subunit, non-ATPase 5
chr13_-_40302710 0.22 ENSDART00000144360
pyroxd2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr23_+_44546319 0.22 ENSDART00000139088
ENSDART00000056935
trappc1
trafficking protein particle complex 1
chr14_+_923522 0.21 ENSDART00000185878
myoz3a
myozenin 3a
chr5_+_44804791 0.21 ENSDART00000122288
ctsla
cathepsin La
chr15_-_26552652 0.21 ENSDART00000152336
serpinf2b
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr17_-_12966907 0.21 ENSDART00000022874
psma6a
proteasome subunit alpha 6a
chr4_-_70308067 0.20 ENSDART00000165967
ENSDART00000134334
si:dkey-3h2.3
si:ch211-11p18.6
si:dkey-3h2.3
si:ch211-11p18.6
chr25_-_35182347 0.19 ENSDART00000115210
ano9a
anoctamin 9a
chr1_+_51039558 0.19 ENSDART00000024743
dpy30
dpy-30 histone methyltransferase complex regulatory subunit
chr6_-_32349153 0.19 ENSDART00000140004
angptl3
angiopoietin-like 3
chr2_-_24962002 0.19 ENSDART00000132050
hltf
helicase-like transcription factor
chr10_-_4375190 0.19 ENSDART00000016102
CABZ01073795.1

chr21_+_45316330 0.18 ENSDART00000056474
ENSDART00000149314
ENSDART00000149272
ENSDART00000149156
ENSDART00000099497
tcf7
transcription factor 7
chr16_+_13883872 0.18 ENSDART00000101304
ENSDART00000136005
atg12
ATG12 autophagy related 12 homolog (S. cerevisiae)
chr6_+_9421279 0.17 ENSDART00000161036
kalrnb
kalirin RhoGEF kinase b
chr7_+_57108823 0.17 ENSDART00000184943
ENSDART00000055956
enosf1
enolase superfamily member 1
chr23_+_25291891 0.17 ENSDART00000016248
pa2g4b
proliferation-associated 2G4, b
chr15_-_28677725 0.17 ENSDART00000060255
blmh
bleomycin hydrolase
chr4_-_36033377 0.16 ENSDART00000164348
ENSDART00000187058
zgc:174180
zgc:174180
chr17_-_23673864 0.16 ENSDART00000104738
ENSDART00000128958
ptena
phosphatase and tensin homolog A
chr4_-_20292821 0.14 ENSDART00000136069
ENSDART00000192504
cacna2d4a
calcium channel, voltage-dependent, alpha 2/delta subunit 4a
chr4_-_36476889 0.14 ENSDART00000163956
si:ch211-263l8.1
si:ch211-263l8.1
chr22_-_13857729 0.14 ENSDART00000177971
s100b
S100 calcium binding protein, beta (neural)
chr14_-_38873095 0.14 ENSDART00000047050
ENSDART00000173285
ENSDART00000147521
gsr
glutathione reductase
chr20_-_15090862 0.14 ENSDART00000063892
ENSDART00000122592
si:dkey-239i20.2
si:dkey-239i20.2
chr8_+_24747865 0.14 ENSDART00000078656
slc16a4
solute carrier family 16, member 4
chr7_+_17992640 0.14 ENSDART00000173679
ehbp1l1a
EH domain binding protein 1-like 1a
chr21_-_929448 0.14 ENSDART00000133976
txnl1
thioredoxin-like 1
chr9_-_23253870 0.13 ENSDART00000143657
ENSDART00000169911
acmsd
aminocarboxymuconate semialdehyde decarboxylase
chr17_-_7861219 0.13 ENSDART00000148604
syne1b
spectrin repeat containing, nuclear envelope 1b
chr20_-_48604199 0.13 ENSDART00000161762
ENSDART00000170894
mgst3a
microsomal glutathione S-transferase 3a
chr9_-_34509997 0.13 ENSDART00000169114
ppp2r3b
protein phosphatase 2, regulatory subunit B'', beta
chr23_-_29376859 0.12 ENSDART00000146411
sst6
somatostatin 6
chr21_-_45349548 0.12 ENSDART00000008454
skp1
S-phase kinase-associated protein 1
chr4_+_35189063 0.12 ENSDART00000185091
si:dkey-269p2.1
si:dkey-269p2.1
chr17_-_11439815 0.12 ENSDART00000130105
psma3
proteasome subunit alpha 3
chr20_-_39271844 0.11 ENSDART00000192708
clu
clusterin
chr5_-_31035198 0.11 ENSDART00000086534
cyb5d2
cytochrome b5 domain containing 2
chr15_+_37559570 0.11 ENSDART00000085522
hspb6
heat shock protein, alpha-crystallin-related, b6
chr23_+_25292147 0.11 ENSDART00000131486
pa2g4b
proliferation-associated 2G4, b
chr4_-_60780423 0.11 ENSDART00000162632
si:dkey-254e13.6
si:dkey-254e13.6
chr15_-_1590858 0.10 ENSDART00000081875
nnr
nanor
chr22_+_19528851 0.10 ENSDART00000145079
si:dkey-78l4.13
si:dkey-78l4.13
chr7_-_2116512 0.10 ENSDART00000098148
si:cabz01007802.1
si:cabz01007802.1
chr14_-_38872536 0.10 ENSDART00000184315
ENSDART00000127479
gsr
glutathione reductase
chr16_+_24721914 0.10 ENSDART00000109459
smg9
smg9 nonsense mediated mRNA decay factor
chr4_+_1757462 0.10 ENSDART00000032460
med21
mediator complex subunit 21
chr19_+_24872159 0.09 ENSDART00000158490
si:ch211-195b13.1
si:ch211-195b13.1
chr4_-_71708855 0.09 ENSDART00000158819
si:dkeyp-4f2.1
si:dkeyp-4f2.1
chr10_+_26747755 0.09 ENSDART00000100329
f9b
coagulation factor IXb
chr17_-_23674065 0.09 ENSDART00000104735
ENSDART00000182952
ptena
phosphatase and tensin homolog A
chr7_-_19043401 0.08 ENSDART00000158796
fcer1g
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr3_+_26064091 0.08 ENSDART00000143697
si:dkeyp-69e1.8
si:dkeyp-69e1.8
chr4_-_50930346 0.08 ENSDART00000184245
si:ch211-208f21.3
si:ch211-208f21.3
chr11_-_29936755 0.07 ENSDART00000145251
pir
pirin
chr4_+_42878556 0.07 ENSDART00000171047
si:zfos-451d2.2
si:zfos-451d2.2
chr25_+_10410620 0.07 ENSDART00000151886
ehf
ets homologous factor
chr2_-_36494308 0.07 ENSDART00000110378
BX901889.2

chr18_+_33009828 0.07 ENSDART00000160100
olfcj1
olfactory receptor C family, j1
chr4_+_54645654 0.07 ENSDART00000192864
si:ch211-227e10.1
si:ch211-227e10.1
chr13_-_51973562 0.07 ENSDART00000166701
slc30a10
solute carrier family 30, member 10
chr20_-_35557902 0.06 ENSDART00000134753
adgrf7
adhesion G protein-coupled receptor F7
chr19_-_32600823 0.05 ENSDART00000134149
ENSDART00000187858
zgc:91944
zgc:91944
chr2_-_6115389 0.05 ENSDART00000134921
prdx1
peroxiredoxin 1
chr20_-_48604621 0.05 ENSDART00000161769
ENSDART00000157871
mgst3a
microsomal glutathione S-transferase 3a
chr16_-_7692568 0.05 ENSDART00000148980
pimr209
Pim proto-oncogene, serine/threonine kinase, related 209
chr19_-_10478229 0.05 ENSDART00000142937
si:ch211-171h4.5
si:ch211-171h4.5
chr15_-_8191841 0.05 ENSDART00000156663
bach1a
BTB and CNC homology 1, basic leucine zipper transcription factor 1 a
chr4_-_36032930 0.05 ENSDART00000191414
zgc:174180
zgc:174180
chr3_+_23063718 0.05 ENSDART00000140225
ENSDART00000184431
b4galnt2.1
beta-1,4-N-acetyl-galactosaminyl transferase 2, tandem duplicate 1
chr8_+_4434422 0.04 ENSDART00000145184
srrd
SRR1 domain containing
chr6_+_53288018 0.04 ENSDART00000170319
cysltr3
cysteinyl leukotriene receptor 3
chr17_+_7524389 0.04 ENSDART00000067579
klhl10b.2
kelch-like family member 10b, tandem duplicate 2
chr2_-_6115688 0.04 ENSDART00000081663
prdx1
peroxiredoxin 1
chr2_-_26642831 0.04 ENSDART00000132854
ENSDART00000087714
ENSDART00000132651
u2surp
U2 snRNP-associated SURP domain containing
chr16_-_27640995 0.04 ENSDART00000019658
nacad
NAC alpha domain containing
chr17_-_31044803 0.04 ENSDART00000185941
ENSDART00000152016
eml1
echinoderm microtubule associated protein like 1
chr22_+_9027884 0.04 ENSDART00000171839
si:ch211-213a13.2
si:ch211-213a13.2
chr22_+_1110855 0.03 ENSDART00000168251
si:ch1073-181h11.1
si:ch1073-181h11.1
chr21_-_3826706 0.03 ENSDART00000053607
st6galnac6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr2_-_9544161 0.03 ENSDART00000124425
slc25a24l
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, like
chr23_-_37432459 0.03 ENSDART00000188916
zmp:0000001088
zmp:0000001088
chr9_+_11202552 0.03 ENSDART00000151931
asic4a
acid-sensing (proton-gated) ion channel family member 4a
chr4_-_71913556 0.03 ENSDART00000167608
si:dkey-92c21.1
si:dkey-92c21.1
chr20_-_19532531 0.03 ENSDART00000125830
ENSDART00000179566
ENSDART00000184193
eif2b4
BX276101.2
eukaryotic translation initiation factor 2B, subunit 4 delta

chr13_+_7241170 0.02 ENSDART00000109434
aifm2
apoptosis-inducing factor, mitochondrion-associated, 2
chr5_+_42064144 0.02 ENSDART00000035235
si:ch211-202a12.4
si:ch211-202a12.4
chr10_-_7974155 0.02 ENSDART00000147368
ENSDART00000075524
osbp2
oxysterol binding protein 2
chr4_+_76442674 0.02 ENSDART00000164825
si:dkey-16p6.1
si:dkey-16p6.1
chr3_+_58092212 0.02 ENSDART00000156059
si:ch211-256e16.7
si:ch211-256e16.7
chr25_+_3549401 0.02 ENSDART00000166312
ccdc77
coiled-coil domain containing 77
chr13_-_41546779 0.02 ENSDART00000163331
pcdh15a
protocadherin-related 15a
chr7_+_17992455 0.02 ENSDART00000089211
ENSDART00000190881
ehbp1l1a
EH domain binding protein 1-like 1a
chr4_-_71708567 0.01 ENSDART00000182645
si:dkeyp-4f2.1
si:dkeyp-4f2.1
chr24_-_23998897 0.01 ENSDART00000130053
zmp:0000000991
zmp:0000000991
chr4_-_39448829 0.01 ENSDART00000168526
si:dkey-261o4.9
si:dkey-261o4.9
chr14_-_7207961 0.00 ENSDART00000167994
ENSDART00000166532
stox2b
storkhead box 2b

Network of associatons between targets according to the STRING database.

First level regulatory network of nfe2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0043576 respiratory gaseous exchange(GO:0007585) regulation of respiratory gaseous exchange(GO:0043576)
0.2 0.7 GO:0098725 somatic stem cell population maintenance(GO:0035019) symmetric cell division(GO:0098725)
0.1 0.6 GO:0010039 response to iron ion(GO:0010039)
0.1 0.4 GO:0046351 sucrose metabolic process(GO:0005985) sucrose biosynthetic process(GO:0005986) disaccharide biosynthetic process(GO:0046351)
0.1 2.0 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.7 GO:0010873 regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
0.1 0.3 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.1 0.4 GO:0001773 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
0.1 1.7 GO:0015671 oxygen transport(GO:0015671)
0.1 0.6 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.1 2.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.2 GO:0031174 lifelong otolith mineralization(GO:0031174)
0.0 0.2 GO:0055091 phospholipid homeostasis(GO:0055091)
0.0 0.2 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0 0.6 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.0 0.4 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.0 0.2 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.2 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.3 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.1 GO:0046874 quinolinate biosynthetic process(GO:0019805) quinolinate metabolic process(GO:0046874)
0.0 0.1 GO:1990359 detoxification of zinc ion(GO:0010312) stress response to zinc ion(GO:1990359)
0.0 0.2 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.4 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 0.2 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.0 0.1 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.3 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.0 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.4 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.0 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 1.0 GO:0005839 proteasome core complex(GO:0005839)
0.1 0.7 GO:0042627 chylomicron(GO:0042627)
0.0 0.1 GO:0032998 Fc receptor complex(GO:0032997) Fc-epsilon receptor I complex(GO:0032998)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.2 0.9 GO:0061133 endopeptidase activator activity(GO:0061133)
0.2 0.9 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 1.7 GO:0031720 haptoglobin binding(GO:0031720)
0.1 0.4 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.1 0.7 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 0.6 GO:0016531 copper chaperone activity(GO:0016531)
0.1 1.2 GO:0004046 aminoacylase activity(GO:0004046)
0.1 0.2 GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.1 1.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.2 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.0 0.4 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.4 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.1 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.3 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0019767 immunoglobulin receptor activity(GO:0019763) IgE receptor activity(GO:0019767)
0.0 0.7 GO:0005112 Notch binding(GO:0005112)
0.0 0.3 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.0 0.5 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.6 GO:0019843 rRNA binding(GO:0019843)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.8 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.6 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.0 1.2 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.9 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.1 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism