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PRJNA195909:zebrafish embryo and larva development

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Results for nfkb1_rela

Z-value: 1.10

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Transcription factors associated with nfkb1_rela

Gene Symbol Gene ID Gene Info
nfkb1
ENSDARG00000105261 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
rela
ENSDARG00000098696 v-rel avian reticuloendotheliosis viral oncogene homolog A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
reladr11_v1_chr7_-_804515_804515-0.901.0e-03Click!
nfkb1dr11_v1_chr14_-_49859747_49859823-0.751.9e-02Click!

Activity profile of nfkb1_rela motif

Sorted Z-values of nfkb1_rela motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_55131289 3.42 ENSDART00000111585
AL935210.1

chr3_+_55114097 2.70 ENSDART00000121686
hbbe1.1
hemoglobin beta embryonic-1.1
chr2_+_42191592 2.50 ENSDART00000144716
cavin4a
caveolae associated protein 4a
chr10_-_39011514 1.80 ENSDART00000075123
pcp4a
Purkinje cell protein 4a
chr21_+_28958471 1.72 ENSDART00000144331
ENSDART00000005929
ppp3ca
protein phosphatase 3, catalytic subunit, alpha isozyme
chr16_-_50175069 1.66 ENSDART00000192979
lim2.5
lens intrinsic membrane protein 2.5
chr15_+_32727848 1.58 ENSDART00000161361
postnb
periostin, osteoblast specific factor b
chr24_-_33703504 1.55 ENSDART00000079292
cavin4b
caveolae associated protein 4b
chr11_-_5865744 1.36 ENSDART00000104360
gamt
guanidinoacetate N-methyltransferase
chr20_+_28434196 1.35 ENSDART00000034245
dpf3
D4, zinc and double PHD fingers, family 3
chr19_+_19767567 1.35 ENSDART00000169074
hoxa3a
homeobox A3a
chr3_+_55122662 1.35 ENSDART00000128380
hbbe1.2
hemoglobin beta embryonic-1.2
chr22_-_651719 1.34 ENSDART00000148692
apobec2a
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a
chr23_+_31815423 1.25 ENSDART00000075730
ENSDART00000075726
myb
v-myb avian myeloblastosis viral oncogene homolog
chr25_+_37397031 1.24 ENSDART00000193643
ENSDART00000169132
slc1a2b
solute carrier family 1 (glial high affinity glutamate transporter), member 2b
chr23_+_36115541 1.22 ENSDART00000130090
hoxc6a
homeobox C6a
chr2_+_2737422 1.20 ENSDART00000032459
aqp1a.1
aquaporin 1a (Colton blood group), tandem duplicate 1
chr15_-_24869826 1.15 ENSDART00000127047
tusc5a
tumor suppressor candidate 5a
chr20_-_20533865 1.13 ENSDART00000125039
six6b
SIX homeobox 6b
chr7_-_28696556 1.12 ENSDART00000148822
adgrg1
adhesion G protein-coupled receptor G1
chr3_-_28120092 1.04 ENSDART00000151143
rbfox1
RNA binding fox-1 homolog 1
chr12_+_7445595 1.03 ENSDART00000103536
ENSDART00000152524
phyhiplb
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr2_+_16780643 1.02 ENSDART00000125647
ENSDART00000108611
ENSDART00000181245
ENSDART00000163194
tfa
transferrin-a
chr25_-_27843066 1.01 ENSDART00000179684
ENSDART00000186000
ENSDART00000190065
asb15a
ankyrin repeat and SOCS box containing 15a
chr1_+_18716 1.00 ENSDART00000172454
ENSDART00000161190
nfkbiz
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr6_-_58757131 1.00 ENSDART00000083582
soat2
sterol O-acyltransferase 2
chr3_+_46459540 0.99 ENSDART00000188150
si:ch211-66e2.5
si:ch211-66e2.5
chr15_+_27364394 0.96 ENSDART00000122101
tbx2b
T-box 2b
chr6_-_10305918 0.95 ENSDART00000090994
scn1lab
sodium channel, voltage-gated, type I like, alpha b
chr6_-_54815886 0.94 ENSDART00000180793
ENSDART00000007498
tnni1b
troponin I type 1b (skeletal, slow)
chr22_-_16180467 0.93 ENSDART00000171331
ENSDART00000185607
vcam1b
vascular cell adhesion molecule 1b
chr13_-_2010191 0.91 ENSDART00000161021
ENSDART00000124134
gfral
GDNF family receptor alpha like
chr13_+_51579851 0.91 ENSDART00000163847
nkx6.2
NK6 homeobox 2
chr6_-_607063 0.90 ENSDART00000189900
lgals2b
lectin, galactoside-binding, soluble, 2b
chr7_-_34262080 0.89 ENSDART00000183246
si:ch211-98n17.5
si:ch211-98n17.5
chr9_-_98982 0.86 ENSDART00000147882
lims2
LIM and senescent cell antigen-like domains 2
chr13_+_15004398 0.86 ENSDART00000057810
emx1
empty spiracles homeobox 1
chr4_-_25485404 0.86 ENSDART00000041402
pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr9_+_993477 0.86 ENSDART00000182045
CABZ01066921.1

chr12_+_26471712 0.83 ENSDART00000162115
ndel1a
nudE neurodevelopment protein 1-like 1a
chr21_+_30937690 0.83 ENSDART00000022562
rhogb
ras homolog family member Gb
chr16_+_23403602 0.82 ENSDART00000159848
s100w
S100 calcium binding protein W
chr1_+_16397063 0.80 ENSDART00000159794
micu3a
mitochondrial calcium uptake family, member 3a
chr18_+_27738349 0.80 ENSDART00000187816
tspan18b
tetraspanin 18b
chr20_+_16881883 0.80 ENSDART00000130107
nfkbiaa
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
chr8_+_25302172 0.78 ENSDART00000046182
ENSDART00000145316
gstm.3
glutathione S-transferase mu tandem duplicate 3
chr1_+_16396870 0.76 ENSDART00000189245
ENSDART00000113266
micu3a
mitochondrial calcium uptake family, member 3a
chr4_-_22311610 0.76 ENSDART00000137814
hcls1
hematopoietic cell-specific Lyn substrate 1
chr14_+_36885524 0.73 ENSDART00000032547
lect2l
leukocyte cell-derived chemotaxin 2 like
chr16_-_16590780 0.73 ENSDART00000059841
si:ch211-257p13.3
si:ch211-257p13.3
chr16_+_32995882 0.72 ENSDART00000170157
prss35
protease, serine, 35
chr11_-_35763323 0.72 ENSDART00000026017
bhlhe40
basic helix-loop-helix family, member e40
chr4_-_149334 0.72 ENSDART00000163280
tbk1
TANK-binding kinase 1
chr17_+_8175998 0.71 ENSDART00000131200
myct1b
myc target 1b
chr1_+_33328857 0.71 ENSDART00000137151
mxra5a
matrix-remodelling associated 5a
chr5_-_66702479 0.71 ENSDART00000129197
mn1b
meningioma 1b
chr2_-_42234484 0.71 ENSDART00000132617
ENSDART00000136690
ENSDART00000141358
apom
apolipoprotein M
chr14_-_4121052 0.70 ENSDART00000167074
irf2
interferon regulatory factor 2
chr3_-_21242460 0.69 ENSDART00000007293
tcap
titin-cap (telethonin)
chr8_-_38477817 0.69 ENSDART00000075989
inpp5l
inositol polyphosphate-5-phosphatase L
chr10_-_27196093 0.69 ENSDART00000185282
auts2a
autism susceptibility candidate 2a
chr11_+_8129536 0.67 ENSDART00000158112
ENSDART00000011183
prkacba
protein kinase, cAMP-dependent, catalytic, beta a
chr25_-_35960229 0.67 ENSDART00000073434
snx20
sorting nexin 20
chr12_+_34732262 0.67 ENSDART00000169634
si:dkey-21c1.8
si:dkey-21c1.8
chr4_-_25485214 0.67 ENSDART00000159941
pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr1_+_33322555 0.67 ENSDART00000113486
mxra5a
matrix-remodelling associated 5a
chr12_+_22576404 0.65 ENSDART00000172053
capgb
capping protein (actin filament), gelsolin-like b
chr8_+_42998944 0.65 ENSDART00000048819
rassf2a
Ras association (RalGDS/AF-6) domain family member 2a
chr12_-_30760971 0.65 ENSDART00000066257
entpd1
ectonucleoside triphosphate diphosphohydrolase 1
chr16_+_13855039 0.64 ENSDART00000113764
ENSDART00000143983
zgc:174888
zgc:174888
chr25_+_5288665 0.64 ENSDART00000169540
CABZ01039861.1

chr2_-_30200206 0.64 ENSDART00000130142
ube2w
ubiquitin-conjugating enzyme E2W (putative)
chr19_+_19412692 0.62 ENSDART00000113580
wu:fc38h03
wu:fc38h03
chr6_-_436658 0.62 ENSDART00000191515
grap2b
GRB2-related adaptor protein 2b
chr9_-_18716 0.59 ENSDART00000164763
CABZ01078737.1

chr5_+_37032038 0.58 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr17_-_51195651 0.57 ENSDART00000191205
ENSDART00000088185
paplna
papilin a, proteoglycan-like sulfated glycoprotein
chr6_+_2030703 0.57 ENSDART00000109679
ENSDART00000187502
ENSDART00000191165
ENSDART00000187544
quo
quattro
chr23_-_12423778 0.57 ENSDART00000124091
wfdc2
WAP four-disulfide core domain 2
chr24_-_4973765 0.56 ENSDART00000127597
zic1
zic family member 1 (odd-paired homolog, Drosophila)
chr23_-_43609595 0.56 ENSDART00000172222
CABZ01117603.1

chr8_-_13029297 0.56 ENSDART00000144305
dennd2da
DENN/MADD domain containing 2Da
chr11_-_396724 0.55 ENSDART00000184375
CR855375.3

chr11_+_2156430 0.55 ENSDART00000182896
hoxc13b
homeobox C13b
chr25_+_10458990 0.54 ENSDART00000130354
ENSDART00000044738
ric8a
RIC8 guanine nucleotide exchange factor A
chr8_+_24281512 0.53 ENSDART00000062845
mmp9
matrix metallopeptidase 9
chr11_-_32723851 0.53 ENSDART00000155592
pcdh17
protocadherin 17
chr23_-_37835794 0.53 ENSDART00000137358
cd40
CD40 molecule, TNF receptor superfamily member 5
chr14_+_33722950 0.52 ENSDART00000075312
apln
apelin
chr18_-_18543358 0.52 ENSDART00000126460
il34
interleukin 34
chr5_+_21100356 0.51 ENSDART00000051586
hs3st1l2
heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like 2
chr3_-_58733718 0.51 ENSDART00000154603
si:ch73-281f12.4
si:ch73-281f12.4
chr2_+_6963296 0.50 ENSDART00000147146
ddr2b
discoidin domain receptor tyrosine kinase 2b
chr13_-_31452516 0.50 ENSDART00000193268
rtn1a
reticulon 1a
chr10_+_7029664 0.50 ENSDART00000166206
psd3l
pleckstrin and Sec7 domain containing 3, like
chr14_-_7888748 0.49 ENSDART00000166293
ppp3cb
protein phosphatase 3, catalytic subunit, beta isozyme
chr16_-_35975254 0.49 ENSDART00000167537
eva1ba
eva-1 homolog Ba (C. elegans)
chr14_-_30967284 0.48 ENSDART00000149435
il2rgb
interleukin 2 receptor, gamma b
chr12_+_5081759 0.48 ENSDART00000164178
prrt2
proline-rich transmembrane protein 2
chr9_+_26103814 0.48 ENSDART00000026011
efnb2a
ephrin-B2a
chr13_-_45795722 0.48 ENSDART00000141779
fndc5a
fibronectin type III domain containing 5a
chr9_-_6380653 0.47 ENSDART00000078523
ecrg4a
esophageal cancer related gene 4a
chr14_-_31080183 0.47 ENSDART00000173282
mbnl3
muscleblind-like splicing regulator 3
chr13_+_12739283 0.47 ENSDART00000102279
lingo2b
leucine rich repeat and Ig domain containing 2b
chr25_-_6557854 0.46 ENSDART00000181740
cspg4
chondroitin sulfate proteoglycan 4
chr13_-_22843562 0.46 ENSDART00000142738
pbld
phenazine biosynthesis like protein domain containing
chr12_+_27462225 0.46 ENSDART00000105661
meox1
mesenchyme homeobox 1
chr7_+_39634873 0.46 ENSDART00000114774
ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr7_+_57677120 0.46 ENSDART00000110623
arsj
arylsulfatase family, member J
chr5_-_64168415 0.44 ENSDART00000048395
cmlc1
cardiac myosin light chain-1
chr21_+_5862476 0.44 ENSDART00000065848
wdr38
WD repeat domain 38
chr13_-_39947335 0.44 ENSDART00000056996
sfrp5
secreted frizzled-related protein 5
chr20_+_218886 0.43 ENSDART00000002661
lama4
laminin, alpha 4
chr7_-_20338048 0.43 ENSDART00000125594
zgc:194312
zgc:194312
chr23_+_42819221 0.43 ENSDART00000180495
myl9a
myosin, light chain 9a, regulatory
chr4_+_3389866 0.42 ENSDART00000153834
sypl1
synaptophysin-like 1
chr24_+_22731228 0.42 ENSDART00000146733
si:dkey-225k4.1
si:dkey-225k4.1
chr13_+_32148338 0.42 ENSDART00000188591
osr1
odd-skipped related transciption factor 1
chr20_+_22045089 0.42 ENSDART00000063564
ENSDART00000187013
ENSDART00000161552
ENSDART00000174478
ENSDART00000063568
ENSDART00000152247
nmu
neuromedin U
chr17_+_20205185 0.42 ENSDART00000167007
gnrh3
gonadotropin-releasing hormone 3
chr15_-_33640890 0.41 ENSDART00000167705
stard13b
StAR-related lipid transfer (START) domain containing 13b
chr12_+_2381213 0.41 ENSDART00000188007
LO018238.1

chr14_-_4120636 0.41 ENSDART00000059230
irf2
interferon regulatory factor 2
chr7_+_39758714 0.41 ENSDART00000111278
sorcs2
sortilin-related VPS10 domain containing receptor 2
chr25_+_19489370 0.41 ENSDART00000091132
glsl
glutaminase like
chr13_+_27316934 0.41 ENSDART00000164533
eef1a1a
eukaryotic translation elongation factor 1 alpha 1a
chr8_+_22355909 0.41 ENSDART00000146457
ENSDART00000142883
zgc:153631
zgc:153631
chr2_-_9857932 0.41 ENSDART00000154490
si:ch211-252f13.5
si:ch211-252f13.5
chr13_-_33822550 0.41 ENSDART00000143703
flrt3
fibronectin leucine rich transmembrane 3
chr9_+_31752628 0.40 ENSDART00000060054
itgbl1
integrin, beta-like 1
chr4_-_12914163 0.40 ENSDART00000140002
ENSDART00000145917
ENSDART00000141355
ENSDART00000067135
msrb3
methionine sulfoxide reductase B3
chr14_+_36889893 0.40 ENSDART00000124159
si:ch211-132p1.3
si:ch211-132p1.3
chr16_+_24681177 0.40 ENSDART00000058956
ENSDART00000189335
ywhabl
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like
chr7_+_22585447 0.40 ENSDART00000149144
chrnb1l
cholinergic receptor, nicotinic, beta 1 (muscle) like
chr13_-_24311628 0.40 ENSDART00000004420
rab4a
RAB4a, member RAS oncogene family
chr14_+_36246726 0.39 ENSDART00000105602
elovl6
ELOVL fatty acid elongase 6
chr3_-_58650057 0.39 ENSDART00000057640
dhrs7ca
dehydrogenase/reductase (SDR family) member 7Ca
chr11_-_236984 0.38 ENSDART00000170778
dusp7
dual specificity phosphatase 7
chr10_+_31244619 0.38 ENSDART00000145562
ENSDART00000184412
robo4
roundabout, axon guidance receptor, homolog 4 (Drosophila)
chr19_-_43659779 0.38 ENSDART00000144058
si:ch211-193k19.2
si:ch211-193k19.2
chr11_-_42106310 0.37 ENSDART00000164635
si:ch211-193l2.10
si:ch211-193l2.10
chr9_-_12624622 0.37 ENSDART00000146535
tspearb
thrombospondin-type laminin G domain and EAR repeats b
chr24_-_12689571 0.37 ENSDART00000015517
pdcd6
programmed cell death 6
chr6_-_18992896 0.37 ENSDART00000170228
sept9b
septin 9b
chr7_-_46781614 0.36 ENSDART00000173891
tshz3b
teashirt zinc finger homeobox 3b
chr23_+_3591690 0.36 ENSDART00000180822
si:dkey-9l20.3
si:dkey-9l20.3
chr5_-_41841675 0.36 ENSDART00000141683
si:dkey-65b12.6
si:dkey-65b12.6
chr7_-_15413019 0.36 ENSDART00000172147
si:ch211-106j24.1
si:ch211-106j24.1
chr24_+_80653 0.35 ENSDART00000158473
ENSDART00000129135
reck
reversion-inducing-cysteine-rich protein with kazal motifs
chr25_+_3347461 0.35 ENSDART00000104888
slc35b4
solute carrier family 35, member B4
chr7_-_35083585 0.35 ENSDART00000192732
agrp
agouti related neuropeptide
chr1_+_44919221 0.35 ENSDART00000140402
wu:fc21g02
wu:fc21g02
chr6_+_48664275 0.35 ENSDART00000161184
FAM19A3
si:dkey-238f9.1
chr3_-_39695856 0.35 ENSDART00000148247
b9d1
B9 protein domain 1
chr3_-_49815223 0.34 ENSDART00000181208
gcgra
glucagon receptor a
chr14_+_49382180 0.33 ENSDART00000158329
tnip1
TNFAIP3 interacting protein 1
chr9_+_56103173 0.33 ENSDART00000172063
edar
ectodysplasin A receptor
chr11_+_8565828 0.33 ENSDART00000126523
tbl1xr1a
transducin (beta)-like 1 X-linked receptor 1a
chr21_-_44009169 0.33 ENSDART00000028960
ndufa2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2
chr24_-_38816725 0.32 ENSDART00000063231
nog2
noggin 2
chr4_+_13810811 0.32 ENSDART00000067168
pdzrn4
PDZ domain containing ring finger 4
chr25_+_8955530 0.32 ENSDART00000156444
si:ch211-256a21.4
si:ch211-256a21.4
chr1_-_30039331 0.32 ENSDART00000086935
ENSDART00000143800
MARCH4 (1 of many)
zgc:153256
chr1_+_32528097 0.32 ENSDART00000128317
nlgn4a
neuroligin 4a
chr21_+_22845317 0.31 ENSDART00000065555
birc2
baculoviral IAP repeat containing 2
chr22_+_110158 0.31 ENSDART00000143698
prkar2ab
protein kinase, cAMP-dependent, regulatory, type II, alpha, B
chr6_+_58915889 0.31 ENSDART00000083628
ddit3
DNA-damage-inducible transcript 3
chr12_+_48634927 0.30 ENSDART00000168441
zgc:165653
zgc:165653
chr3_-_52644737 0.30 ENSDART00000126180
si:dkey-210j14.3
si:dkey-210j14.3
chr10_-_14536399 0.30 ENSDART00000186501
hdhd2
haloacid dehalogenase-like hydrolase domain containing 2
chr7_-_32833153 0.30 ENSDART00000099871
ENSDART00000099872
slc17a6b
solute carrier family 17 (vesicular glutamate transporter), member 6b
chr15_-_1962326 0.30 ENSDART00000179669
dock10
dedicator of cytokinesis 10
chr23_+_45579497 0.29 ENSDART00000110381
egr4
early growth response 4
chr13_-_9318891 0.29 ENSDART00000137364
si:dkey-33c12.3
si:dkey-33c12.3
chr13_+_35339182 0.29 ENSDART00000019323
jag1b
jagged 1b
chr5_+_9246018 0.29 ENSDART00000081769
ENSDART00000183189
susd1
sushi domain containing 1
chr17_+_38262408 0.29 ENSDART00000017493
nkx2.1
NK2 homeobox 1
chr23_+_3616224 0.29 ENSDART00000190917
si:dkey-9l20.3
si:dkey-9l20.3
chr4_+_73672430 0.29 ENSDART00000174310
ENSDART00000150505
si:dkey-262g12.7
si:dkey-262g12.7
chr13_-_27916439 0.28 ENSDART00000139081
ENSDART00000087097
ogfrl1
opioid growth factor receptor-like 1
chr18_+_2563756 0.28 ENSDART00000164147
p2ry2.1
purinergic receptor P2Y2, tandem duplicate 1
chr17_+_1063988 0.28 ENSDART00000160400
gchfr
GTP cyclohydrolase I feedback regulator
chr1_+_12135129 0.28 ENSDART00000126020
spink4
serine peptidase inhibitor, Kazal type 4
chr16_+_50006872 0.28 ENSDART00000157100
ube2e2
ubiquitin-conjugating enzyme E2E 2
chr1_-_37377509 0.28 ENSDART00000113542
tnip2
TNFAIP3 interacting protein 2
chr15_+_32821392 0.28 ENSDART00000158272
dclk1b
doublecortin-like kinase 1b
chr23_+_10347851 0.27 ENSDART00000127667
krt18
keratin 18
chr23_-_437467 0.27 ENSDART00000192106
tspan2b
tetraspanin 2b
chr1_-_36152131 0.27 ENSDART00000182113
ENSDART00000182904
znf827
zinc finger protein 827
chr5_+_30608057 0.27 ENSDART00000133583
si:ch211-117m20.4
si:ch211-117m20.4
chr9_-_32604414 0.27 ENSDART00000088876
ENSDART00000166502
satb2
SATB homeobox 2
chr22_+_661711 0.26 ENSDART00000113795
elf3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr20_-_8321280 0.26 ENSDART00000083906
ENSDART00000186477
dab1a
Dab, reelin signal transducer, homolog 1a (Drosophila)
chr9_+_41156818 0.25 ENSDART00000105764
ENSDART00000147052
stat4
signal transducer and activator of transcription 4
chr17_+_42027969 0.25 ENSDART00000147563
kiz
kizuna centrosomal protein
chr7_+_15871408 0.25 ENSDART00000014572
pax6b
paired box 6b
chr19_+_22216778 0.25 ENSDART00000052521
nfatc1
nuclear factor of activated T cells 1
chr4_+_20263097 0.25 ENSDART00000138820
lrtm2a
leucine-rich repeats and transmembrane domains 2a
chr4_+_7888047 0.25 ENSDART00000104676
camk1da
calcium/calmodulin-dependent protein kinase 1Da
chr16_+_26766423 0.25 ENSDART00000048036
gem
GTP binding protein overexpressed in skeletal muscle

Network of associatons between targets according to the STRING database.

First level regulatory network of nfkb1_rela

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0006600 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
0.4 1.3 GO:0043388 positive regulation of DNA binding(GO:0043388)
0.4 1.2 GO:0003091 renal water homeostasis(GO:0003091) renal water transport(GO:0003097)
0.3 1.0 GO:0072025 distal convoluted tubule development(GO:0072025) late distal convoluted tubule development(GO:0072068)
0.3 1.0 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.3 2.2 GO:0033292 T-tubule organization(GO:0033292)
0.3 0.8 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.3 0.5 GO:0045649 regulation of macrophage differentiation(GO:0045649)
0.2 1.1 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.2 1.2 GO:0030852 regulation of granulocyte differentiation(GO:0030852) regulation of neutrophil differentiation(GO:0045658)
0.2 3.1 GO:0048016 inositol phosphate-mediated signaling(GO:0048016)
0.2 1.3 GO:0060017 parathyroid gland development(GO:0060017)
0.2 1.3 GO:0035777 pronephric distal tubule development(GO:0035777)
0.2 0.7 GO:0045475 locomotor rhythm(GO:0045475)
0.2 0.5 GO:0002631 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.2 0.5 GO:0045191 response to protozoan(GO:0001562) TRIF-dependent toll-like receptor signaling pathway(GO:0035666) defense response to protozoan(GO:0042832) regulation of isotype switching(GO:0045191) positive regulation of isotype switching(GO:0045830)
0.2 0.5 GO:0070314 G1 to G0 transition(GO:0070314)
0.1 0.4 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.1 1.6 GO:0019731 antibacterial humoral response(GO:0019731)
0.1 0.8 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 2.7 GO:0015671 oxygen transport(GO:0015671)
0.1 0.8 GO:0090133 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.1 2.0 GO:0016203 muscle attachment(GO:0016203)
0.1 0.4 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.1 0.4 GO:1905048 regulation of metallopeptidase activity(GO:1905048)
0.1 1.0 GO:0034433 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.1 0.9 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.6 GO:0033986 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
0.1 0.4 GO:0030091 protein repair(GO:0030091)
0.1 0.5 GO:0007412 axon target recognition(GO:0007412)
0.1 1.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.6 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.3 GO:0034134 toll-like receptor 2 signaling pathway(GO:0034134)
0.1 1.4 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.1 0.2 GO:0035971 peptidyl-histidine dephosphorylation(GO:0035971)
0.1 0.6 GO:0021534 cell proliferation in hindbrain(GO:0021534)
0.1 0.3 GO:0060546 negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.1 0.3 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.1 0.2 GO:0032290 peripheral nervous system myelin formation(GO:0032290) semicircular canal fusion(GO:0060879)
0.1 0.4 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.1 0.3 GO:0070255 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.1 0.4 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 0.2 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.1 0.4 GO:0006543 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.0 0.2 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 1.2 GO:0008345 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.0 0.5 GO:0061056 sclerotome development(GO:0061056)
0.0 1.0 GO:0010737 protein kinase A signaling(GO:0010737)
0.0 0.4 GO:2000253 adult feeding behavior(GO:0008343) positive regulation of feeding behavior(GO:2000253)
0.0 0.1 GO:0072679 thymocyte migration(GO:0072679)
0.0 0.2 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.0 0.2 GO:0048939 anterior lateral line nerve glial cell differentiation(GO:0048913) myelination of anterior lateral line nerve axons(GO:0048914) anterior lateral line nerve glial cell development(GO:0048939) anterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048940)
0.0 0.7 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.3 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.3 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.0 1.1 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.0 0.2 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.0 0.1 GO:0006867 asparagine transport(GO:0006867)
0.0 0.4 GO:2000406 positive regulation of lymphocyte migration(GO:2000403) positive regulation of T cell migration(GO:2000406)
0.0 0.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.4 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.0 0.8 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 1.3 GO:0021854 hypothalamus development(GO:0021854)
0.0 2.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 0.4 GO:1901222 regulation of NIK/NF-kappaB signaling(GO:1901222)
0.0 0.2 GO:0031639 plasminogen activation(GO:0031639)
0.0 0.7 GO:0051014 actin filament severing(GO:0051014)
0.0 0.4 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.3 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.4 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.2 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.0 0.2 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.9 GO:0060048 cardiac muscle contraction(GO:0060048)
0.0 0.1 GO:0090467 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.0 0.3 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 0.2 GO:0042119 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0 0.5 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.1 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.4 GO:0001649 osteoblast differentiation(GO:0001649)
0.0 0.2 GO:1990798 pancreas regeneration(GO:1990798)
0.0 0.7 GO:0006414 translational elongation(GO:0006414)
0.0 0.2 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.0 0.5 GO:0007259 JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696)
0.0 0.1 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0005955 calcineurin complex(GO:0005955)
0.2 2.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.6 GO:1990246 uniplex complex(GO:1990246)
0.1 4.1 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 0.4 GO:1990909 Wnt signalosome(GO:1990909)
0.1 1.3 GO:0071565 nBAF complex(GO:0071565)
0.0 0.2 GO:0030314 junctional membrane complex(GO:0030314)
0.0 1.0 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0060171 stereocilium membrane(GO:0060171)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.2 GO:0070062 extracellular exosome(GO:0070062)
0.0 0.1 GO:0070743 interleukin-12 complex(GO:0043514) interleukin-23 complex(GO:0070743)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 1.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.7 GO:0005861 troponin complex(GO:0005861)
0.0 1.0 GO:0055037 recycling endosome(GO:0055037)
0.0 0.7 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.9 GO:0001726 ruffle(GO:0001726)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.3 0.8 GO:0031704 apelin receptor binding(GO:0031704)
0.2 1.0 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.2 2.7 GO:0031720 haptoglobin binding(GO:0031720)
0.2 1.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 0.7 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.2 1.2 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.1 0.4 GO:0031530 gonadotropin hormone-releasing hormone activity(GO:0005183) gonadotropin-releasing hormone receptor binding(GO:0031530)
0.1 0.7 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 1.5 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 0.9 GO:0016936 galactoside binding(GO:0016936)
0.1 0.4 GO:0031782 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1 0.7 GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.1 0.4 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.1 0.3 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.1 0.4 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984) odorant binding(GO:0005549)
0.1 0.2 GO:0101006 protein histidine phosphatase activity(GO:0101006)
0.1 0.3 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 0.5 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 0.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.4 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 1.0 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.2 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.0 0.6 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.3 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.2 GO:0038132 neuregulin receptor activity(GO:0038131) neuregulin binding(GO:0038132)
0.0 0.5 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.3 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.2 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.1 GO:0042164 interleukin-12 binding(GO:0019972) interleukin-12 alpha subunit binding(GO:0042164)
0.0 0.3 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.0 0.1 GO:0015182 L-histidine transmembrane transporter activity(GO:0005290) L-asparagine transmembrane transporter activity(GO:0015182)
0.0 0.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 1.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.4 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.2 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.5 GO:0051020 GTPase binding(GO:0051020)
0.0 0.5 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.5 GO:0003823 antigen binding(GO:0003823)
0.0 0.2 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.2 GO:0043236 laminin binding(GO:0043236)
0.0 0.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)
0.0 0.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 0.5 PID CD40 PATHWAY CD40/CD40L signaling
0.2 2.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.2 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.9 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.4 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.6 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.3 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 1.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.5 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.1 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB