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PRJNA195909:zebrafish embryo and larva development

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Results for nkx2.1

Z-value: 1.10

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Transcription factors associated with nkx2.1

Gene Symbol Gene ID Gene Info
nkx2.1
ENSDARG00000019835 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.1dr11_v1_chr17_+_38262408_38262408-0.959.6e-05Click!

Activity profile of nkx2.1 motif

Sorted Z-values of nkx2.1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_24597001 1.72 ENSDART00000191834
rlf
rearranged L-myc fusion
chr7_+_34602991 1.56 ENSDART00000073447
fhod1
formin homology 2 domain containing 1
chr6_+_38880166 1.51 ENSDART00000019939
ENSDART00000144286
bin2b
bridging integrator 2b
chr21_+_34132747 1.48 ENSDART00000148115
trpc5b
transient receptor potential cation channel, subfamily C, member 5b
chr8_-_44299247 1.48 ENSDART00000144497
piwil1
piwi-like RNA-mediated gene silencing 1
chr6_+_38879961 1.40 ENSDART00000184798
bin2b
bridging integrator 2b
chr4_-_14531687 1.37 ENSDART00000182093
ENSDART00000159447
plxnb2a
plexin b2a
chr3_-_23461954 1.35 ENSDART00000040065
casc3
cancer susceptibility candidate 3
chr22_+_8753092 1.31 ENSDART00000140720
si:dkey-182g1.2
si:dkey-182g1.2
chr14_-_33478963 1.30 ENSDART00000132813
lamp2
lysosomal-associated membrane protein 2
chr12_+_30788912 1.30 ENSDART00000160422
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr20_+_9128829 1.29 ENSDART00000064144
ENSDART00000137450
bpnt1
bisphosphate nucleotidase 1
chr5_-_54712159 1.26 ENSDART00000149207
ccnb1
cyclin B1
chr18_+_44631789 1.24 ENSDART00000144271
bicra
BRD4 interacting chromatin remodeling complex associated protein
chr11_-_36040549 1.10 ENSDART00000112684
setmar
SET domain and mariner transposase fusion gene
chr3_-_21166597 1.10 ENSDART00000175941
taok2a
TAO kinase 2a
chr7_-_24875421 1.08 ENSDART00000173920
adad2
adenosine deaminase domain containing 2
chr15_-_29012493 1.08 ENSDART00000060018
dharma
dharma
chr13_+_10023256 1.05 ENSDART00000110035
srbd1
S1 RNA binding domain 1
chr3_+_39600562 1.02 ENSDART00000134309
ENSDART00000007170
prpsap2
phosphoribosyl pyrophosphate synthetase-associated protein 2
chr7_-_59123066 0.98 ENSDART00000175438
dennd4c
DENN/MADD domain containing 4C
chr17_-_12249990 0.96 ENSDART00000177889
ENSDART00000155545
ahctf1
AT hook containing transcription factor 1
chr7_-_64770456 0.94 ENSDART00000192618
zdhhc21
zinc finger, DHHC-type containing 21
chr3_-_30888415 0.94 ENSDART00000124458
kmt5c
lysine methyltransferase 5C
chr1_+_16621345 0.93 ENSDART00000149026
pcm1
pericentriolar material 1
chr8_-_4100365 0.92 ENSDART00000142846
cux2b
cut-like homeobox 2b
chr1_+_27977297 0.91 ENSDART00000180692
ENSDART00000166819
sugt1
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr23_-_33558161 0.91 ENSDART00000018301
itga5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr4_-_8152746 0.83 ENSDART00000012928
ENSDART00000177482
wnk1b
WNK lysine deficient protein kinase 1b
chr3_+_17933132 0.80 ENSDART00000104299
ENSDART00000162144
ENSDART00000162242
ENSDART00000166289
ENSDART00000171101
ENSDART00000164853
cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr6_-_18531760 0.77 ENSDART00000167167
utp6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr3_+_22335030 0.77 ENSDART00000055676
zgc:103564
zgc:103564
chr25_-_17590971 0.77 ENSDART00000189942
mmp15a
matrix metallopeptidase 15a
chr11_+_25596038 0.74 ENSDART00000140856
ccdc120
coiled-coil domain containing 120
chr7_-_23777445 0.72 ENSDART00000173527
si:ch211-200p22.4
si:ch211-200p22.4
chr7_-_48733662 0.71 ENSDART00000191675
traf6
TNF receptor-associated factor 6
chr17_+_33999630 0.69 ENSDART00000167085
ENSDART00000155030
ENSDART00000168522
ENSDART00000191799
ENSDART00000189684
ENSDART00000153942
ENSDART00000187272
ENSDART00000127692
gphna
gephyrin a
chr15_-_434503 0.67 ENSDART00000122286
CABZ01056629.1

chr2_+_314249 0.65 ENSDART00000082086
zgc:113452
zgc:113452
chr21_+_45502621 0.65 ENSDART00000166719
si:dkey-223p19.2
si:dkey-223p19.2
chr25_-_20691075 0.65 ENSDART00000067373
edc3
enhancer of mRNA decapping 3 homolog (S. cerevisiae)
chr15_-_23482088 0.64 ENSDART00000185823
ENSDART00000185523
nlrx1
NLR family member X1
chr22_-_5724085 0.64 ENSDART00000110526
ENSDART00000140905
pgbd4
piggyBac transposable element derived 4
chr18_-_46020138 0.63 ENSDART00000027772
pcyt1ab
phosphate cytidylyltransferase 1, choline, alpha b
chr21_-_2348838 0.62 ENSDART00000160337
si:ch73-299h12.8
si:ch73-299h12.8
chr13_-_10727550 0.61 ENSDART00000190925
ppm1ba
protein phosphatase, Mg2+/Mn2+ dependent, 1Ba
chr2_-_37401600 0.61 ENSDART00000015723
prkci
protein kinase C, iota
chr22_+_39096911 0.58 ENSDART00000157127
ENSDART00000153841
lmcd1
LIM and cysteine-rich domains 1
chr20_-_38827623 0.57 ENSDART00000153310
cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr7_+_1442059 0.54 ENSDART00000173391
si:cabz01090193.1
si:cabz01090193.1
chr7_+_48555626 0.54 ENSDART00000125483
ENSDART00000083514
kcnq1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr3_+_17933553 0.53 ENSDART00000167731
ENSDART00000165644
cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr5_-_35456269 0.53 ENSDART00000051312
ttc33
tetratricopeptide repeat domain 33
chr7_+_25825667 0.48 ENSDART00000149835
mtm1
myotubularin 1
chr1_-_53756851 0.48 ENSDART00000122445
akt3b
v-akt murine thymoma viral oncogene homolog 3b
chr2_-_8609653 0.47 ENSDART00000193354
ENSDART00000189489
ENSDART00000186144
si:ch211-71m22.1
si:ch211-71m22.1
chr7_+_48675347 0.47 ENSDART00000157917
ENSDART00000185580
trpm5
transient receptor potential cation channel, subfamily M, member 5
chr24_+_39576071 0.46 ENSDART00000147137
si:dkey-161j23.6
si:dkey-161j23.6
chr7_+_24390939 0.45 ENSDART00000087494
ENSDART00000125463
haus3
HAUS augmin-like complex, subunit 3
chr21_+_34088377 0.45 ENSDART00000170070
mtmr1b
myotubularin related protein 1b
chr16_-_29397395 0.43 ENSDART00000130757
tlr18
toll-like receptor 18
chr4_-_9054947 0.43 ENSDART00000109764
si:dkey-48p11.3
si:dkey-48p11.3
chr13_+_46927350 0.43 ENSDART00000165041
ENSDART00000167931
mtrf1l
mitochondrial translational release factor 1-like
chr7_+_48555400 0.43 ENSDART00000174474
kcnq1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr11_-_24063196 0.43 ENSDART00000036513
trib3
tribbles pseudokinase 3
chr14_+_10656975 0.42 ENSDART00000127594
ENSDART00000125865
atrx
alpha thalassemia/mental retardation syndrome X-linked homolog (human)
chr8_-_20243389 0.42 ENSDART00000184904
acer1
alkaline ceramidase 1
chr2_+_26240339 0.42 ENSDART00000191006
palm1b
paralemmin 1b
chr20_+_46255057 0.40 ENSDART00000100536
taar14i
trace amine associated receptor 14i
chr2_+_19195841 0.39 ENSDART00000163137
ENSDART00000161095
elovl1a
ELOVL fatty acid elongase 1a
chr2_-_11119303 0.35 ENSDART00000135450
ENSDART00000131836
cryz
crystallin, zeta (quinone reductase)
chr12_-_19862912 0.32 ENSDART00000145788
shisa9a
shisa family member 9a
chr6_+_18531932 0.30 ENSDART00000165271
suz12b
SUZ12 polycomb repressive complex 2b subunit
chr14_-_10321851 0.29 ENSDART00000143382
il1rapl2
interleukin 1 receptor accessory protein-like 2
chr2_+_26237322 0.28 ENSDART00000030520
palm1b
paralemmin 1b
chr18_+_45504362 0.28 ENSDART00000140089
cngb1a
cyclic nucleotide gated channel beta 1a
chr12_+_34953038 0.27 ENSDART00000187022
ENSDART00000123988
ENSDART00000027034
qki2
QKI, KH domain containing, RNA binding 2
chr3_-_4455951 0.24 ENSDART00000193908
ENSDART00000074077
trim35-3
tripartite motif containing 35-3
chr22_+_28818291 0.23 ENSDART00000136032
tp53bp2b
tumor protein p53 binding protein, 2b
chr1_+_8304904 0.22 ENSDART00000168631
cacna1hb
calcium channel, voltage-dependent, T type, alpha 1H subunit b
chr3_-_7464250 0.22 ENSDART00000159873
znf1001
zinc finger protein 1001
chr4_-_50926767 0.21 ENSDART00000183430
si:ch211-208f21.3
si:ch211-208f21.3
chr19_-_6983002 0.21 ENSDART00000104891
znf384l
zinc finger protein 384 like
chr18_-_22701800 0.20 ENSDART00000135098
si:ch73-113g13.3
si:ch73-113g13.3
chr4_-_2052687 0.18 ENSDART00000138291
ENSDART00000150844
cpsf6
cleavage and polyadenylation specific factor 6
chr4_-_20314749 0.14 ENSDART00000066894
ENSDART00000188123
dcp1b
decapping mRNA 1B
chr1_-_23294753 0.13 ENSDART00000013263
ugdh
UDP-glucose 6-dehydrogenase
chr13_+_771403 0.11 ENSDART00000093166
nrxn1b
neurexin 1b
chr15_-_31357634 0.11 ENSDART00000127485
or111-2
odorant receptor, family D, subfamily 111, member 2
chr1_+_55662491 0.11 ENSDART00000152386
adgre8
adhesion G protein-coupled receptor E8
chr1_-_43862638 0.11 ENSDART00000145044
tacr3a
tachykinin receptor 3a
chr18_-_39321484 0.11 ENSDART00000077694
leo1
LEO1 homolog, Paf1/RNA polymerase II complex component
chr11_+_12879635 0.10 ENSDART00000182515
ENSDART00000081296
si:dkey-11m19.5
si:dkey-11m19.5
chr8_-_36469117 0.10 ENSDART00000111240
mhc2dab
major histocompatibility complex class II DAB gene
chr11_+_37909654 0.09 ENSDART00000172211
si:ch211-112f3.4
si:ch211-112f3.4
chr3_+_32118670 0.05 ENSDART00000055287
ENSDART00000111688
zgc:109934
zgc:109934
chr3_+_17846890 0.03 ENSDART00000193384
znf385c
zinc finger protein 385C
chr7_-_30639385 0.03 ENSDART00000173618
myo1ea
myosin IE, a
chr11_-_1956204 0.03 ENSDART00000185541
nr1d4b
nuclear receptor subfamily 1, group D, member 4b
chr2_-_36494308 0.02 ENSDART00000110378
BX901889.2

chr11_-_8271374 0.01 ENSDART00000168253
pimr202
Pim proto-oncogene, serine/threonine kinase, related 202

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.9 GO:0071800 podosome assembly(GO:0071800)
0.3 0.9 GO:0034770 histone H4-K20 methylation(GO:0034770) histone H4-K20 trimethylation(GO:0034773)
0.3 1.0 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.2 1.5 GO:0035093 spermatid nucleus differentiation(GO:0007289) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.2 0.7 GO:0018315 establishment of synaptic specificity at neuromuscular junction(GO:0007529) molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.2 1.1 GO:0048320 axial mesoderm formation(GO:0048320)
0.2 1.0 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.2 0.6 GO:0021563 glossopharyngeal nerve development(GO:0021563)
0.2 0.9 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.2 0.5 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.2 0.9 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.2 0.6 GO:0045217 establishment or maintenance of polarity of embryonic epithelium(GO:0016332) cell-cell junction maintenance(GO:0045217)
0.1 1.3 GO:0006561 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.1 0.4 GO:0070126 mitochondrial translational termination(GO:0070126)
0.1 1.3 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.1 0.8 GO:0031087 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 1.3 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 1.1 GO:0006382 adenosine to inosine editing(GO:0006382)
0.1 0.7 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.1 1.0 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.5 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.1 1.6 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.2 GO:1990120 regulation of nucleobase-containing compound transport(GO:0032239) positive regulation of nucleobase-containing compound transport(GO:0032241) positive regulation of nucleocytoplasmic transport(GO:0046824) regulation of RNA export from nucleus(GO:0046831) positive regulation of RNA export from nucleus(GO:0046833) messenger ribonucleoprotein complex assembly(GO:1990120)
0.1 1.3 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.1 1.5 GO:0006828 manganese ion transport(GO:0006828)
0.1 1.3 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 1.2 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.1 0.8 GO:0010765 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.1 1.3 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.0 0.5 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.2 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.4 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.9 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.9 GO:0050821 protein stabilization(GO:0050821)
0.0 0.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.7 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.8 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.4 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.1 GO:0003190 heart valve formation(GO:0003188) atrioventricular valve formation(GO:0003190)
0.0 0.4 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529)
0.0 1.1 GO:0034968 histone lysine methylation(GO:0034968)
0.0 0.1 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.0 0.5 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.4 1.3 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.4 2.9 GO:0001891 phagocytic cup(GO:0001891)
0.3 1.0 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.2 1.3 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 0.8 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.6 GO:0005915 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.1 0.9 GO:0034451 centriolar satellite(GO:0034451)
0.1 0.7 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.1 0.2 GO:0042382 paraspeckles(GO:0042382)
0.1 1.0 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.5 GO:0070652 HAUS complex(GO:0070652)
0.0 1.5 GO:0043186 P granule(GO:0043186)
0.0 1.2 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.9 GO:0008305 integrin complex(GO:0008305)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.1 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.4 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 0.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.3 0.9 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.3 1.3 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.3 1.0 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.2 0.7 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.2 0.6 GO:1990174 phosphodiesterase decapping endonuclease activity(GO:1990174)
0.2 0.6 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.2 1.5 GO:0034584 piRNA binding(GO:0034584)
0.1 0.4 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 0.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 0.3 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.1 1.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 0.9 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 0.4 GO:0017040 ceramidase activity(GO:0017040)
0.1 1.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 0.3 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.1 1.3 GO:0008252 nucleotidase activity(GO:0008252)
0.1 0.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.8 GO:0019870 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 0.9 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.4 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.8 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0003979 UDP-glucose 6-dehydrogenase activity(GO:0003979)
0.0 0.2 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.6 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.5 GO:0015377 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.3 GO:0005223 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.4 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 1.4 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 0.6 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0045309 protein phosphorylated amino acid binding(GO:0045309) phosphoprotein binding(GO:0051219)
0.0 0.5 GO:0099604 ligand-gated calcium channel activity(GO:0099604)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 1.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.3 PID FOXO PATHWAY FoxO family signaling
0.0 1.3 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.3 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.1 1.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 0.9 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 0.4 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.8 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.9 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 1.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.9 REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.0 1.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.3 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex