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PRJNA195909:zebrafish embryo and larva development

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Results for nkx2.5

Z-value: 1.02

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Transcription factors associated with nkx2.5

Gene Symbol Gene ID Gene Info
nkx2.5
ENSDARG00000018004 NK2 homeobox 5
nkx2.5
ENSDARG00000116714 NK2 homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.5dr11_v1_chr14_+_24241241_24241241-0.771.5e-02Click!

Activity profile of nkx2.5 motif

Sorted Z-values of nkx2.5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_25236888 2.41 ENSDART00000037286
zgc:172218
zgc:172218
chr12_-_13729263 1.70 ENSDART00000078021
foxh1
forkhead box H1
chr4_-_77130289 1.68 ENSDART00000174380
CU467646.7

chr4_-_77125693 1.66 ENSDART00000174256
CU467646.3

chr4_-_77135076 1.56 ENSDART00000174184
zgc:173770
zgc:173770
chr22_+_25242322 1.51 ENSDART00000134628
si:ch211-226h8.8
si:ch211-226h8.8
chr9_+_8396755 1.41 ENSDART00000043067
zgc:171776
zgc:171776
chr1_-_6028876 1.23 ENSDART00000168117
si:ch1073-345a8.1
si:ch1073-345a8.1
chr6_+_515181 1.20 ENSDART00000171374
CACNA1I (1 of many)
si:ch73-379f7.5
chr22_+_25236657 1.17 ENSDART00000138012
zgc:172218
zgc:172218
chr6_-_1820606 1.17 ENSDART00000183228
FO834857.1

chr19_-_2115040 1.13 ENSDART00000020497
snx13
sorting nexin 13
chr3_+_32571929 1.08 ENSDART00000151025
si:ch73-248e21.1
si:ch73-248e21.1
chr16_+_26612401 1.01 ENSDART00000145571
epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr13_+_23093743 0.98 ENSDART00000148034
pik3ap1
phosphoinositide-3-kinase adaptor protein 1
chr6_-_24384654 0.96 ENSDART00000164723
brdt
bromodomain, testis-specific
chr8_+_3431671 0.96 ENSDART00000017850
ctu1
cytosolic thiouridylase subunit 1 homolog (S. pombe)
chr24_+_15655233 0.95 ENSDART00000143160
fbxo15
F-box protein 15
chr6_+_58622831 0.94 ENSDART00000128793
sp7
Sp7 transcription factor
chr16_-_22585289 0.89 ENSDART00000134239
ENSDART00000193959
ENSDART00000077998
si:dkey-238m4.3
cgna
si:dkey-238m4.3
cingulin a
chr24_+_10039165 0.89 ENSDART00000144186
pou6f2
POU class 6 homeobox 2
chr20_+_42918755 0.88 ENSDART00000134855
efr3bb
EFR3 homolog Bb (S. cerevisiae)
chr8_+_25893071 0.88 ENSDART00000078161
tmem115
transmembrane protein 115
chr10_-_38498072 0.84 ENSDART00000111234
gdpd5a
glycerophosphodiester phosphodiesterase domain containing 5a
chr12_+_33320884 0.83 ENSDART00000188988
csnk1db
casein kinase 1, delta b
chr5_+_24543862 0.81 ENSDART00000029699
atp6v0a2b
ATPase H+ transporting V0 subunit a2b
chr23_+_30736895 0.81 ENSDART00000042944
asxl1
additional sex combs like transcriptional regulator 1
chr6_-_12900154 0.79 ENSDART00000080408
ENSDART00000150887
ical1
islet cell autoantigen 1-like
chr15_-_26568278 0.76 ENSDART00000182609
wdr81
WD repeat domain 81
chr6_-_7726849 0.75 ENSDART00000151511
slc25a38b
solute carrier family 25, member 38b
chr3_-_10582384 0.75 ENSDART00000048095
ENSDART00000155152
elac2
elaC ribonuclease Z 2
chr14_+_31493306 0.71 ENSDART00000138341
phf6
PHD finger protein 6
chr18_+_17534627 0.71 ENSDART00000061007
mt2
metallothionein 2
chr8_-_4100365 0.70 ENSDART00000142846
cux2b
cut-like homeobox 2b
chr14_+_31493119 0.69 ENSDART00000006463
phf6
PHD finger protein 6
chr18_-_399554 0.69 ENSDART00000164374
ENSDART00000186311
ENSDART00000181816
ENSDART00000181892
si:ch211-79l17.1
si:ch211-79l17.1
chr3_+_14463941 0.66 ENSDART00000170927
cnn1b
calponin 1, basic, smooth muscle, b
chr18_-_29977431 0.66 ENSDART00000135357
si:ch211-220f16.2
si:ch211-220f16.2
chr3_+_22905341 0.66 ENSDART00000111435
hdac5
histone deacetylase 5
chr2_+_30513887 0.65 ENSDART00000137048
march6
membrane-associated ring finger (C3HC4) 6
chr17_+_6538733 0.64 ENSDART00000193712
slc5a6b
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr8_+_9715010 0.64 ENSDART00000139414
gripap1
GRIP1 associated protein 1
chr6_-_6673813 0.64 ENSDART00000150995
si:dkey-261j15.2
si:dkey-261j15.2
chr3_+_35812040 0.63 ENSDART00000075903
ENSDART00000147712
crlf3
cytokine receptor-like factor 3
chr22_+_15973122 0.62 ENSDART00000144545
rc3h1a
ring finger and CCCH-type domains 1a
chr1_+_44053641 0.60 ENSDART00000124873
si:ch73-109d9.4
si:ch73-109d9.4
chr8_-_22558773 0.60 ENSDART00000074309
porcnl
porcupine O-acyltransferase like
chr3_+_14581643 0.60 ENSDART00000182840
znf653
zinc finger protein 653
chr16_+_38240027 0.59 ENSDART00000111081
prune
prune exopolyphosphatase
chr12_+_32292564 0.58 ENSDART00000152945
ANKFN1
si:ch211-277e21.2
chr7_-_48733662 0.58 ENSDART00000191675
traf6
TNF receptor-associated factor 6
chr9_+_38737924 0.57 ENSDART00000147652
kansl1l
KAT8 regulatory NSL complex subunit 1-like
chr23_-_27479558 0.57 ENSDART00000013563
atf7a
activating transcription factor 7a
chr8_+_11471350 0.56 ENSDART00000092355
ENSDART00000136184
tjp2b
tight junction protein 2b (zona occludens 2)
chr7_-_23777445 0.56 ENSDART00000173527
si:ch211-200p22.4
si:ch211-200p22.4
chr13_-_28610965 0.55 ENSDART00000043156
cyp17a1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr23_+_7710721 0.55 ENSDART00000186852
ENSDART00000161193
kif3b
kinesin family member 3B
chr13_-_50614639 0.54 ENSDART00000170527
vent
ventral expressed homeobox
chr12_-_45304971 0.54 ENSDART00000186537
ENSDART00000126405
fdxr
ferredoxin reductase
chr18_+_3064237 0.54 ENSDART00000161848
ints4
integrator complex subunit 4
chr8_+_25962833 0.54 ENSDART00000086583
si:dkey-72l14.4
si:dkey-72l14.4
chr16_-_12097558 0.54 ENSDART00000123142
pex5
peroxisomal biogenesis factor 5
chr20_+_14789305 0.54 ENSDART00000002463
tmed5
transmembrane p24 trafficking protein 5
chr24_-_23839647 0.53 ENSDART00000125190
rrs1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr5_+_47975758 0.52 ENSDART00000097429
BX470189.1

chr12_+_5102670 0.52 ENSDART00000166600
cep55l
centrosomal protein 55 like
chr20_+_23498255 0.52 ENSDART00000149922
palld
palladin, cytoskeletal associated protein
chr20_-_25643667 0.52 ENSDART00000137457
si:dkeyp-117h8.4
si:dkeyp-117h8.4
chr23_+_7710447 0.51 ENSDART00000168199
kif3b
kinesin family member 3B
chr20_-_28698172 0.51 ENSDART00000190635
sipa1l1
signal-induced proliferation-associated 1 like 1
chr18_-_46183462 0.49 ENSDART00000021192
kcnk6
potassium channel, subfamily K, member 6
chr22_+_2229964 0.49 ENSDART00000112582
znf1161
zinc finger protein 1161
chr11_-_18017287 0.49 ENSDART00000155443
qrich1
glutamine-rich 1
chr4_-_39111612 0.48 ENSDART00000150394
si:dkey-122c11.8
si:dkey-122c11.8
chr3_-_26805455 0.48 ENSDART00000180648
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr8_+_21114338 0.48 ENSDART00000002186
uck2a
uridine-cytidine kinase 2a
chr23_-_14769523 0.48 ENSDART00000054909
gss
glutathione synthetase
chr5_-_29122834 0.47 ENSDART00000087197
whrnb
whirlin b
chr9_-_13871935 0.47 ENSDART00000146597
raph1a
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1a
chr16_-_8132742 0.47 ENSDART00000104323
snrka
SNF related kinase a
chr1_+_16621345 0.46 ENSDART00000149026
pcm1
pericentriolar material 1
chr13_-_32899322 0.46 ENSDART00000133882
rock2a
rho-associated, coiled-coil containing protein kinase 2a
chr21_+_34814444 0.46 ENSDART00000161816
wdr55
WD repeat domain 55
chr8_-_20243389 0.45 ENSDART00000184904
acer1
alkaline ceramidase 1
chr17_+_13088594 0.45 ENSDART00000193207
gemin2
gem (nuclear organelle) associated protein 2
chr15_-_36727462 0.45 ENSDART00000085971
nphs1
nephrosis 1, congenital, Finnish type (nephrin)
chr25_+_16194979 0.45 ENSDART00000185592
ENSDART00000158582
ENSDART00000161109
ENSDART00000139013
mical2b
microtubule associated monooxygenase, calponin and LIM domain containing 2b
chr15_-_17138640 0.44 ENSDART00000080777
mrpl28
mitochondrial ribosomal protein L28
chr15_+_24676905 0.44 ENSDART00000078014
ENSDART00000143137
poldip2
polymerase (DNA-directed), delta interacting protein 2
chr5_+_18047111 0.44 ENSDART00000132164
hira
histone cell cycle regulator a
chr11_-_27537593 0.43 ENSDART00000173444
ENSDART00000172895
ENSDART00000088177
ptpdc1a
protein tyrosine phosphatase domain containing 1a
chr24_-_26945390 0.43 ENSDART00000123354
msl2b
male-specific lethal 2 homolog b (Drosophila)
chr17_-_10043273 0.43 ENSDART00000156078
baz1a
bromodomain adjacent to zinc finger domain, 1A
chr5_-_8907819 0.42 ENSDART00000188523
adamts12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr16_-_41787421 0.42 ENSDART00000147210
si:dkey-199f5.8
si:dkey-199f5.8
chr1_+_46598502 0.42 ENSDART00000132861
cab39l
calcium binding protein 39-like
chr2_-_40890004 0.42 ENSDART00000191746
uggt1
UDP-glucose glycoprotein glucosyltransferase 1
chr12_+_5251647 0.42 ENSDART00000124097
plce1
phospholipase C, epsilon 1
chr20_+_34390196 0.42 ENSDART00000183596
trmt1l
tRNA methyltransferase 1-like
chr24_+_35183595 0.42 ENSDART00000075142
pcmtd1
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
chr5_-_29122615 0.42 ENSDART00000144802
whrnb
whirlin b
chr4_-_4795205 0.42 ENSDART00000039313
zgc:162331
zgc:162331
chr3_+_39600562 0.41 ENSDART00000134309
ENSDART00000007170
prpsap2
phosphoribosyl pyrophosphate synthetase-associated protein 2
chr22_+_1480988 0.41 ENSDART00000171122
si:ch211-255f4.2
si:ch211-255f4.2
chr5_+_2002804 0.41 ENSDART00000064088
vkorc1l1
vitamin K epoxide reductase complex, subunit 1-like 1
chr4_-_13255700 0.41 ENSDART00000162277
ENSDART00000026593
grip1
glutamate receptor interacting protein 1
chr22_-_27113332 0.40 ENSDART00000146951
ENSDART00000178855
xpnpep1
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
chr9_+_17862858 0.40 ENSDART00000166566
dgkh
diacylglycerol kinase, eta
chr25_-_34723937 0.39 ENSDART00000187286
ENSDART00000157021
nup160
nucleoporin 160
chr13_-_31346392 0.38 ENSDART00000134343
rrp12
ribosomal RNA processing 12 homolog
chr22_+_1421212 0.38 ENSDART00000161813
zgc:101130
zgc:101130
chr7_-_67248829 0.38 ENSDART00000192442
znf143a
zinc finger protein 143a
chr14_+_21828993 0.38 ENSDART00000144367
ctbp1
C-terminal binding protein 1
chr10_+_1052591 0.37 ENSDART00000123405
unc5c
unc-5 netrin receptor C
chr9_+_2452672 0.37 ENSDART00000193993
chn1
chimerin 1
chr11_-_29082175 0.37 ENSDART00000123245
igsf21a
immunoglobin superfamily, member 21a
chr11_-_34232906 0.36 ENSDART00000162150
lsg1
large 60S subunit nuclear export GTPase 1
chr20_-_26588736 0.36 ENSDART00000134337
exoc2
exocyst complex component 2
chr2_-_37280617 0.36 ENSDART00000190458
nadkb
NAD kinase b
chr5_-_24543526 0.35 ENSDART00000046384
trmt2a
tRNA methyltransferase 2 homolog A
chr2_-_3611960 0.35 ENSDART00000184579
pter
phosphotriesterase related
chr10_-_26218354 0.34 ENSDART00000180764
arfip2b
ADP-ribosylation factor interacting protein 2b
chr2_-_40890264 0.34 ENSDART00000123886
uggt1
UDP-glucose glycoprotein glucosyltransferase 1
chr4_+_33423119 0.33 ENSDART00000189413
znf1065
zinc finger protein 1065
chr17_-_608857 0.33 ENSDART00000163431
KLHL28
kelch like family member 28
chr11_-_36474306 0.33 ENSDART00000170678
ENSDART00000123591
usp48
ubiquitin specific peptidase 48
chr5_-_26765188 0.32 ENSDART00000029450
rnf181
ring finger protein 181
chr7_+_24390939 0.32 ENSDART00000087494
ENSDART00000125463
haus3
HAUS augmin-like complex, subunit 3
chr14_+_23874062 0.32 ENSDART00000172149
sh3rf2
SH3 domain containing ring finger 2
chr2_-_8609653 0.32 ENSDART00000193354
ENSDART00000189489
ENSDART00000186144
si:ch211-71m22.1
si:ch211-71m22.1
chr8_+_7756893 0.31 ENSDART00000191894
fgd1
FYVE, RhoGEF and PH domain containing 1
chr8_+_12930216 0.31 ENSDART00000115405
KIF2A
zgc:103670
chr5_+_51111766 0.31 ENSDART00000188552
pomt1
protein-O-mannosyltransferase 1
chr19_-_11966015 0.31 ENSDART00000123409
si:ch1073-296d18.1
si:ch1073-296d18.1
chr23_+_22291440 0.30 ENSDART00000185126
CR354612.1

chr2_+_37424261 0.30 ENSDART00000132427
phc3
polyhomeotic homolog 3 (Drosophila)
chr10_-_33265566 0.29 ENSDART00000063642
tbl2
transducin (beta)-like 2
chr8_-_13823091 0.29 ENSDART00000177174
ENSDART00000137021
cabp4
calcium binding protein 4
chr7_-_30560400 0.29 ENSDART00000142680
ENSDART00000142818
sltm
SAFB-like, transcription modulator
chr5_-_26764880 0.28 ENSDART00000140392
ENSDART00000134728
rnf181
ring finger protein 181
chr8_-_43834442 0.28 ENSDART00000191927
adgrd1
adhesion G protein-coupled receptor D1
chr7_-_59311165 0.28 ENSDART00000171105
m1ap
meiosis 1 associated protein
chr25_-_11016675 0.28 ENSDART00000099572
mespab
mesoderm posterior ab
chr1_+_47178529 0.28 ENSDART00000158432
ENSDART00000074450
ENSDART00000137448
morc3b
MORC family CW-type zinc finger 3b
chr16_+_13993285 0.27 ENSDART00000139130
ENSDART00000130353
si:dkey-85k15.7
fdps
si:dkey-85k15.7
farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
chr2_+_55916911 0.27 ENSDART00000189483
ENSDART00000183647
ENSDART00000083470
atcayb
ataxia, cerebellar, Cayman type b
chr20_+_25904199 0.27 ENSDART00000016864
slc35f6
solute carrier family 35, member F6
chr19_-_26923957 0.26 ENSDART00000182390
skiv2l
SKI2 homolog, superkiller viralicidic activity 2-like
chr17_+_50074372 0.26 ENSDART00000113644
vps39
vacuolar protein sorting 39 homolog (S. cerevisiae)
chr24_-_7587401 0.26 ENSDART00000093163
galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr21_+_27513859 0.25 ENSDART00000065420
pacs1a
phosphofurin acidic cluster sorting protein 1a
chr24_+_26017094 0.24 ENSDART00000137851
tfr1b
transferrin receptor 1b
chr12_-_19862912 0.24 ENSDART00000145788
shisa9a
shisa family member 9a
chr5_+_26765275 0.24 ENSDART00000144169
si:ch211-102c2.8
si:ch211-102c2.8
chr24_-_11057305 0.24 ENSDART00000186494
asap1b
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b
chr22_+_1481307 0.24 ENSDART00000177429
si:ch211-255f4.2
si:ch211-255f4.2
chr22_+_2598998 0.24 ENSDART00000176665
CU570894.1

chrM_+_4993 0.23 ENSDART00000093600
mt-nd2
NADH dehydrogenase 2, mitochondrial
chr3_+_48234445 0.23 ENSDART00000161419
tbcd
tubulin folding cofactor D
chr19_+_4062101 0.22 ENSDART00000166773
btr25
bloodthirsty-related gene family, member 25
chr20_-_5369105 0.22 ENSDART00000114316
sptlc2b
serine palmitoyltransferase, long chain base subunit 2b
chr4_+_45357558 0.21 ENSDART00000150769
si:ch211-162i8.5
si:ch211-162i8.5
chr6_+_11250316 0.21 ENSDART00000137122
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr7_-_38664947 0.21 ENSDART00000100546
ENSDART00000112405
c6ast1
six-cysteine containing astacin protease 1
chr11_-_8208464 0.21 ENSDART00000161283
pimr203
Pim proto-oncogene, serine/threonine kinase, related 203
chr1_+_46598764 0.20 ENSDART00000053240
cab39l
calcium binding protein 39-like
chr1_-_57129179 0.20 ENSDART00000157226
ENSDART00000152469
si:ch73-94k4.2
si:ch73-94k4.2
chr22_-_36934040 0.20 ENSDART00000151666
pimr206
Pim proto-oncogene, serine/threonine kinase, related 206
chr22_+_18389271 0.20 ENSDART00000088270
yjefn3
YjeF N-terminal domain containing 3
chr7_+_16352924 0.20 ENSDART00000158972
mpped2a
metallophosphoesterase domain containing 2a
chr2_-_37280028 0.20 ENSDART00000139459
nadkb
NAD kinase b
chr1_-_49950643 0.20 ENSDART00000138301
sgms2
sphingomyelin synthase 2
chr4_-_65036768 0.19 ENSDART00000184455
si:ch211-283l16.1
si:ch211-283l16.1
chr11_+_39928828 0.19 ENSDART00000137516
ENSDART00000134082
vamp3
vesicle-associated membrane protein 3 (cellubrevin)
chr3_-_15487111 0.19 ENSDART00000011320
nfatc2ip
nuclear factor of activated T cells 2 interacting protein
chr19_+_43885770 0.18 ENSDART00000135599
lypla2
lysophospholipase II
chr6_+_27991943 0.18 ENSDART00000143974
ENSDART00000141354
ENSDART00000088914
ENSDART00000139367
amotl2a
angiomotin like 2a
chr10_+_8550435 0.17 ENSDART00000185664
tbc1d10ab
TBC1 domain family, member 10Ab
chr22_+_1330477 0.17 ENSDART00000157567
CU207221.2

chr10_-_29831944 0.16 ENSDART00000063923
ENSDART00000136264
zpr1
ZPR1 zinc finger
chr22_+_39058269 0.16 ENSDART00000113362
ip6k1
inositol hexakisphosphate kinase 1
chr4_-_60049792 0.15 ENSDART00000158199
znf1033
zinc finger protein 1033
chr1_+_58470287 0.14 ENSDART00000160245
ENSDART00000169945
si:ch73-236c18.7
si:ch73-236c18.7
chr16_+_44906324 0.14 ENSDART00000074960
cd22
cd22 molecule
chr5_-_62317496 0.14 ENSDART00000180089
zgc:85789
zgc:85789
chr22_-_10470663 0.14 ENSDART00000143352
omd
osteomodulin
chr22_+_36914636 0.14 ENSDART00000150948
pimr205
Pim proto-oncogene, serine/threonine kinase, related 205
chr19_-_6873107 0.14 ENSDART00000124440
CABZ01029822.1

chr5_+_61843752 0.14 ENSDART00000130940
CR759879.1
Danio rerio interferon-induced protein with tetratricopeptide repeats 5 (LOC572297), mRNA.
chr11_-_29082429 0.14 ENSDART00000041443
igsf21a
immunoglobin superfamily, member 21a
chr14_+_36454087 0.14 ENSDART00000180247
TENM3
si:dkey-237h12.3
chr22_-_5663354 0.14 ENSDART00000081774
ccdc51
coiled-coil domain containing 51
chr3_-_111350 0.14 ENSDART00000171887
zgc:110249
zgc:110249
chr2_+_269781 0.13 ENSDART00000156019
phlpp1
PH domain and leucine rich repeat protein phosphatase 1
chr13_+_28702104 0.13 ENSDART00000135481
si:ch211-67n3.9
si:ch211-67n3.9
chr7_+_26167420 0.12 ENSDART00000173941
si:ch211-196f2.6
si:ch211-196f2.6
chr12_-_3453589 0.12 ENSDART00000175918
CABZ01063170.1

chr5_+_43782267 0.12 ENSDART00000130355
nos2a
nitric oxide synthase 2a, inducible
chr10_-_24319526 0.12 ENSDART00000148480
inpp5kb
inositol polyphosphate-5-phosphatase Kb
chr14_+_16036139 0.12 ENSDART00000190733
prelid1a
PRELI domain containing 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0060063 Spemann organizer formation at the embryonic shield(GO:0060063)
0.4 1.1 GO:0010658 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.3 1.0 GO:0051039 histone displacement(GO:0001207) regulation of transcription involved in meiotic cell cycle(GO:0051037) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.3 0.8 GO:0035973 aggrephagy(GO:0035973)
0.2 0.7 GO:1904983 transmembrane glycine transport from cytosol to mitochondrion(GO:1904983)
0.2 0.6 GO:0061355 Wnt protein secretion(GO:0061355)
0.2 0.9 GO:0033688 regulation of osteoblast proliferation(GO:0033688) craniofacial suture morphogenesis(GO:0097094)
0.2 0.7 GO:0042779 tRNA 3'-trailer cleavage(GO:0042779)
0.2 0.6 GO:0030237 female sex determination(GO:0030237) male sex determination(GO:0030238)
0.2 0.6 GO:0015887 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.2 0.6 GO:0099563 modification of synaptic structure(GO:0099563)
0.2 1.0 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.2 0.5 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) mediolateral intercalation(GO:0060031)
0.1 0.4 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.1 0.4 GO:0042373 vitamin K metabolic process(GO:0042373)
0.1 1.1 GO:0043584 nose development(GO:0043584)
0.1 0.5 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.1 0.4 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.4 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.8 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.1 0.5 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.1 0.4 GO:0021557 oculomotor nerve development(GO:0021557)
0.1 0.5 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.1 0.6 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.9 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.1 0.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.5 GO:0060465 pharynx development(GO:0060465)
0.1 0.6 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.1 0.7 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.1 0.2 GO:0072512 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.1 0.5 GO:0044211 CTP salvage(GO:0044211)
0.1 0.8 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.3 GO:0007060 male meiosis chromosome segregation(GO:0007060)
0.1 0.5 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.1 0.7 GO:0051597 response to methylmercury(GO:0051597)
0.1 0.2 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.0 0.8 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.9 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.5 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.5 GO:0042661 regulation of mesodermal cell fate specification(GO:0042661)
0.0 0.3 GO:0045337 farnesyl diphosphate biosynthetic process(GO:0045337)
0.0 0.4 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0002370 response to tumor cell(GO:0002347) natural killer cell cytokine production(GO:0002370) immune response to tumor cell(GO:0002418) natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of response to biotic stimulus(GO:0002833) regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.0 0.4 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 0.4 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.5 GO:0032418 lysosome localization(GO:0032418)
0.0 0.3 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.5 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 1.1 GO:2001236 regulation of extrinsic apoptotic signaling pathway(GO:2001236)
0.0 0.7 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.6 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.3 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.3 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.2 GO:0035909 establishment of cell polarity involved in ameboidal cell migration(GO:0003365) aorta morphogenesis(GO:0035909) dorsal aorta morphogenesis(GO:0035912)
0.0 0.2 GO:0044805 late nucleophagy(GO:0044805)
0.0 0.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0030823 regulation of cGMP metabolic process(GO:0030823) positive regulation of cGMP metabolic process(GO:0030825) regulation of cGMP biosynthetic process(GO:0030826) positive regulation of cGMP biosynthetic process(GO:0030828) regulation of guanylate cyclase activity(GO:0031282) positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.4 GO:0000054 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 0.5 GO:0016180 snRNA processing(GO:0016180)
0.0 0.3 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.1 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.0 0.5 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.0 0.1 GO:0097510 base-excision repair, AP site formation via deaminated base removal(GO:0097510)
0.0 0.1 GO:0035994 response to muscle stretch(GO:0035994)
0.0 0.6 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.8 GO:0042752 regulation of circadian rhythm(GO:0042752)
0.0 0.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.1 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.2 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.5 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.5 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 0.7 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0001836 release of cytochrome c from mitochondria(GO:0001836)
0.0 0.3 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 0.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.4 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.5 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.2 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.1 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway(GO:0002753)
0.0 1.0 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.2 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.4 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.6 GO:0042129 regulation of T cell proliferation(GO:0042129)
0.0 0.7 GO:0016575 histone deacetylation(GO:0016575)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.8 GO:0035517 PR-DUB complex(GO:0035517)
0.1 0.6 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 0.4 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 0.9 GO:0032426 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142) stereocilium tip(GO:0032426)
0.1 0.8 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.5 GO:0032797 SMN complex(GO:0032797)
0.1 0.4 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.4 GO:0072487 MSL complex(GO:0072487)
0.1 0.3 GO:0055087 Ski complex(GO:0055087)
0.1 0.6 GO:0098888 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.6 GO:0044545 NSL complex(GO:0044545)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.5 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.4 GO:0015030 Cajal body(GO:0015030)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.8 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.0 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.4 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0042781 3'-tRNA processing endoribonuclease activity(GO:0042781)
0.2 0.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.2 0.6 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.2 0.8 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.1 0.4 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 0.5 GO:0043295 glutathione binding(GO:0043295)
0.1 0.3 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 0.6 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 0.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 0.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.9 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.1 0.5 GO:0017040 ceramidase activity(GO:0017040)
0.1 1.0 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 0.4 GO:0043914 NADPH:sulfur oxidoreductase activity(GO:0043914)
0.1 1.0 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.4 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 0.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 0.2 GO:0004998 transferrin receptor activity(GO:0004998)
0.1 0.5 GO:0004849 uridine kinase activity(GO:0004849)
0.1 0.5 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.1 0.2 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 0.8 GO:0051117 ATPase binding(GO:0051117)
0.1 0.7 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.4 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.6 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.6 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 1.4 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 1.0 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 1.7 GO:0046332 SMAD binding(GO:0046332)
0.0 0.3 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 1.0 GO:0000049 tRNA binding(GO:0000049)
0.0 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.8 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.1 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.5 GO:0022841 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.0 0.4 GO:0048038 quinone binding(GO:0048038)
0.0 5.0 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.4 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0042936 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.2 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.3 GO:0005246 calcium channel regulator activity(GO:0005246)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.9 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.4 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.3 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 PID INSULIN PATHWAY Insulin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 0.5 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.4 REACTOME KINESINS Genes involved in Kinesins
0.1 0.6 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 0.6 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 0.6 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 0.9 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.7 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis