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PRJNA195909:zebrafish embryo and larva development

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Results for nkx3.3-1

Z-value: 0.76

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Transcription factors associated with nkx3.3-1

Gene Symbol Gene ID Gene Info
nkx3.3-1
ENSDARG00000110589 NK3 homeobox 3

Activity profile of nkx3.3-1 motif

Sorted Z-values of nkx3.3-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr24_-_33308045 1.19 ENSDART00000149711
slc4a2b
solute carrier family 4 (anion exchanger), member 2b
chr4_+_9467049 0.88 ENSDART00000012659
zgc:55888
zgc:55888
chr9_+_8380728 0.87 ENSDART00000133501
si:ch1073-75o15.4
si:ch1073-75o15.4
chr6_-_1820606 0.86 ENSDART00000183228
FO834857.1

chr19_-_6840506 0.81 ENSDART00000081568
tcf19l
transcription factor 19 (SC1), like
chr6_-_31987940 0.79 ENSDART00000132280
ror1
receptor tyrosine kinase-like orphan receptor 1
chr8_-_51507144 0.78 ENSDART00000024882
ENSDART00000135166
fgfr1a
fibroblast growth factor receptor 1a
chr5_+_57726425 0.77 ENSDART00000134684
fdxacb1
ferredoxin-fold anticodon binding domain containing 1
chr6_-_31739709 0.69 ENSDART00000087964
cachd1
cache domain containing 1
chr3_-_60886984 0.68 ENSDART00000170974
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr6_-_41135215 0.68 ENSDART00000001861
slc6a22.1
solute carrier family 6 member 22, tandem duplicate 1
chr2_-_57918314 0.64 ENSDART00000138265
si:dkeyp-68b7.7
si:dkeyp-68b7.7
chr13_-_50463938 0.63 ENSDART00000083857
ccnj
cyclin J
chr19_+_8612839 0.63 ENSDART00000144925
snx27a
sorting nexin family member 27a
chr21_+_4256291 0.61 ENSDART00000148138
lrrc8aa
leucine rich repeat containing 8 VRAC subunit Aa
chr23_-_29812667 0.61 ENSDART00000006120
pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
chr13_+_33462232 0.60 ENSDART00000177841
zgc:136302
zgc:136302
chr2_-_57900430 0.60 ENSDART00000132245
ENSDART00000140060
si:dkeyp-68b7.7
si:dkeyp-68b7.7
chr4_-_5077158 0.60 ENSDART00000155915
ahcyl2
adenosylhomocysteinase-like 2
chr20_+_23498255 0.59 ENSDART00000149922
palld
palladin, cytoskeletal associated protein
chr15_+_45595385 0.57 ENSDART00000161937
ENSDART00000170214
ENSDART00000157450
atg16l1
ATG16 autophagy related 16-like 1 (S. cerevisiae)
chr25_+_28282274 0.57 ENSDART00000164502
aass
aminoadipate-semialdehyde synthase
chr8_+_10869183 0.56 ENSDART00000188111
brpf3b
bromodomain and PHD finger containing, 3b
chr18_-_29977431 0.55 ENSDART00000135357
si:ch211-220f16.2
si:ch211-220f16.2
chr21_-_30026359 0.55 ENSDART00000153645
pwwp2a
PWWP domain containing 2A
chr5_+_13870340 0.54 ENSDART00000160690
hk2
hexokinase 2
chr7_+_36467796 0.53 ENSDART00000146202
aktip
akt interacting protein
chr11_+_31680513 0.52 ENSDART00000139900
ENSDART00000040305
diaph3
diaphanous-related formin 3
chr25_+_2361721 0.52 ENSDART00000172905
zmp:0000000932
zmp:0000000932
chr19_-_29302249 0.51 ENSDART00000188751
srfbp1
serum response factor binding protein 1
chr5_-_57204352 0.51 ENSDART00000171252
ENSDART00000180727
man2a1
mannosidase, alpha, class 2A, member 1
chr6_+_58622831 0.50 ENSDART00000128793
sp7
Sp7 transcription factor
chr5_-_54712159 0.50 ENSDART00000149207
ccnb1
cyclin B1
chr7_+_20260172 0.50 ENSDART00000012450
dvl2
dishevelled segment polarity protein 2
chr10_-_7472323 0.48 ENSDART00000163702
ENSDART00000167054
ENSDART00000167706
nrg1
neuregulin 1
chr12_+_29236274 0.48 ENSDART00000006505
mxtx2
mix-type homeobox gene 2
chr16_+_3982590 0.47 ENSDART00000149295
zc3h12a
zinc finger CCCH-type containing 12A
chr21_+_15435946 0.47 ENSDART00000137491
si:dkey-11o15.10
si:dkey-11o15.10
chr23_-_24542952 0.47 ENSDART00000088777
atp13a2
ATPase 13A2
chr17_-_25831569 0.46 ENSDART00000148743
hhat
hedgehog acyltransferase
chr22_-_16755885 0.46 ENSDART00000036467
patj
PATJ, crumbs cell polarity complex component
chr19_+_32321797 0.46 ENSDART00000167664
atxn1a
ataxin 1a
chr5_-_38248347 0.46 ENSDART00000084917
ENSDART00000139479
slc12a9
solute carrier family 12, member 9
chr8_-_51753604 0.45 ENSDART00000007090
tbx16
T-box 16
chr4_-_14642379 0.44 ENSDART00000114977
si:ch211-127b11.1
si:ch211-127b11.1
chr1_-_58887610 0.44 ENSDART00000180647
CABZ01084501.1
microfibril-associated glycoprotein 4-like precursor
chr16_-_22585289 0.44 ENSDART00000134239
ENSDART00000193959
ENSDART00000077998
si:dkey-238m4.3
cgna
si:dkey-238m4.3
cingulin a
chr7_-_23777445 0.44 ENSDART00000173527
si:ch211-200p22.4
si:ch211-200p22.4
chr6_-_12275836 0.43 ENSDART00000189980
pkp4
plakophilin 4
chr20_+_46741074 0.43 ENSDART00000145294
si:ch211-57i17.1
si:ch211-57i17.1
chr16_-_13612650 0.42 ENSDART00000080372
dbpb
D site albumin promoter binding protein b
chr23_+_25172976 0.41 ENSDART00000140789
si:dkey-151g10.3
si:dkey-151g10.3
chr7_-_70283372 0.41 ENSDART00000112969
adgra3
adhesion G protein-coupled receptor A3
chr11_+_27134116 0.41 ENSDART00000129736
hdac11
histone deacetylase 11
chr10_-_33343244 0.40 ENSDART00000164191
c2cd2
C2 calcium-dependent domain containing 2
chr23_-_26227805 0.40 ENSDART00000158082
BX927204.1

chr5_-_55848511 0.40 ENSDART00000183503
camk4
calcium/calmodulin-dependent protein kinase IV
chr5_-_5243079 0.39 ENSDART00000130576
ENSDART00000164377
mvb12ba
multivesicular body subunit 12Ba
chr6_+_515181 0.38 ENSDART00000171374
CACNA1I (1 of many)
si:ch73-379f7.5
chr16_+_27444098 0.37 ENSDART00000157690
invs
inversin
chr4_-_14649158 0.37 ENSDART00000145737
si:dkey-183c2.4
si:dkey-183c2.4
chr21_+_18925318 0.37 ENSDART00000136182
si:ch211-222n4.2
si:ch211-222n4.2
chr7_-_5487593 0.37 ENSDART00000136594
arhgef11
Rho guanine nucleotide exchange factor (GEF) 11
chr3_-_31069776 0.37 ENSDART00000167462
elob
elongin B
chr5_+_44846280 0.36 ENSDART00000084370
kank1a
KN motif and ankyrin repeat domains 1a
chr8_-_43689324 0.36 ENSDART00000159904
ep400
E1A binding protein p400
chr23_-_17003533 0.35 ENSDART00000080545
dnmt3bb.2
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2
chr16_+_38240027 0.35 ENSDART00000111081
prune
prune exopolyphosphatase
chr12_+_16087077 0.35 ENSDART00000141898
znf281b
zinc finger protein 281b
chr20_-_33675676 0.35 ENSDART00000147168
rock2b
rho-associated, coiled-coil containing protein kinase 2b
chr8_-_14554785 0.35 ENSDART00000057645
qsox1
quiescin Q6 sulfhydryl oxidase 1
chr10_+_37268854 0.34 ENSDART00000131897
nf1b
neurofibromin 1b
chr3_+_14581643 0.34 ENSDART00000182840
znf653
zinc finger protein 653
chr14_-_51014292 0.34 ENSDART00000029797
faf2
Fas associated factor family member 2
chr3_+_11926030 0.33 ENSDART00000081367
dnaja3a
DnaJ (Hsp40) homolog, subfamily A, member 3A
chr12_-_45304971 0.33 ENSDART00000186537
ENSDART00000126405
fdxr
ferredoxin reductase
chr4_-_8030583 0.32 ENSDART00000113628
si:ch211-240l19.8
si:ch211-240l19.8
chr8_-_4031121 0.32 ENSDART00000169474
ENSDART00000163754
mtmr3
myotubularin related protein 3
chr8_-_8446430 0.32 ENSDART00000137382
cdk16
cyclin-dependent kinase 16
chr16_+_6750289 0.31 ENSDART00000167736
znf236
zinc finger protein 236
chr13_+_23093743 0.31 ENSDART00000148034
pik3ap1
phosphoinositide-3-kinase adaptor protein 1
chr18_+_22174630 0.31 ENSDART00000089549
ripor1
RHO family interacting cell polarization regulator 1
chr16_-_12097558 0.31 ENSDART00000123142
pex5
peroxisomal biogenesis factor 5
chr22_-_27113332 0.31 ENSDART00000146951
ENSDART00000178855
xpnpep1
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
chr25_+_33033633 0.31 ENSDART00000192336
tln2b
talin 2b
chr11_-_5953636 0.30 ENSDART00000140960
ENSDART00000123601
dda1
DET1 and DDB1 associated 1
chr8_+_8712446 0.30 ENSDART00000158674
elk1
ELK1, member of ETS oncogene family
chr5_-_57820873 0.30 ENSDART00000089961
sik2a
salt-inducible kinase 2a
chr17_-_16069905 0.29 ENSDART00000110383
map7a
microtubule-associated protein 7a
chr17_+_21817859 0.29 ENSDART00000143832
ENSDART00000141462
ikzf5
IKAROS family zinc finger 5
chr24_-_41195068 0.29 ENSDART00000121592
acvr2ba
activin A receptor type 2Ba
chr5_+_29652198 0.29 ENSDART00000184083
tsc1a
TSC complex subunit 1a
chr5_-_8907819 0.29 ENSDART00000188523
adamts12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr16_-_26132122 0.29 ENSDART00000157787
lipeb
lipase, hormone-sensitive b
chr5_-_29122834 0.29 ENSDART00000087197
whrnb
whirlin b
chr22_+_7480465 0.29 ENSDART00000034545
CELA1 (1 of many)
zgc:92745
chr3_-_52899394 0.29 ENSDART00000128223
CHCHD5
coiled-coil-helix-coiled-coil-helix domain containing 5
chr19_-_43757568 0.29 ENSDART00000058491
ppt1
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr22_+_9922301 0.28 ENSDART00000105924
blf
bloody fingers
chr16_+_46725087 0.28 ENSDART00000008920
rab11al
RAB11a, member RAS oncogene family, like
chr14_-_36763302 0.28 ENSDART00000074786
ctso
cathepsin O
chr11_+_19370717 0.28 ENSDART00000165906
prickle2b
prickle homolog 2b
chr17_+_23554932 0.28 ENSDART00000135814
pank1a
pantothenate kinase 1a
chr20_-_53078607 0.28 ENSDART00000163494
ENSDART00000191730
CABZ01066813.1

chr5_-_23783739 0.28 ENSDART00000139502
GBGT1 (1 of many)
si:ch211-287c22.1
chr19_+_791538 0.28 ENSDART00000146554
ENSDART00000138406
tmem79a
transmembrane protein 79a
chr18_+_44566863 0.28 ENSDART00000176084
dhx34
DEAH (Asp-Glu-Ala-His) box polypeptide 34
chr20_-_28698172 0.28 ENSDART00000190635
sipa1l1
signal-induced proliferation-associated 1 like 1
chr22_+_32228882 0.27 ENSDART00000092082
manf
mesencephalic astrocyte-derived neurotrophic factor
chr24_-_25166720 0.27 ENSDART00000141601
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr11_+_19370447 0.26 ENSDART00000186154
prickle2b
prickle homolog 2b
chr1_-_26045560 0.26 ENSDART00000172737
ENSDART00000076120
ENSDART00000193593
gpank1
G patch domain and ankyrin repeats 1
chr11_-_2221159 0.26 ENSDART00000189292
smug1
single-strand-selective monofunctional uracil-DNA glycosylase 1
chr7_-_30272871 0.25 ENSDART00000099586
zgc:162945
zgc:162945
chr25_+_7299488 0.25 ENSDART00000184836
hmg20a
high mobility group 20A
chr22_-_31020690 0.25 ENSDART00000130604
ssuh2.4
ssu-2 homolog, tandem duplicate 4
chr1_+_55095314 0.24 ENSDART00000132727
aftpha
aftiphilin a
chr1_+_18863060 0.24 ENSDART00000139241
rnf38
ring finger protein 38
chr20_+_27298783 0.24 ENSDART00000013861
ppp4r4
protein phosphatase 4, regulatory subunit 4
chr11_+_19271557 0.23 ENSDART00000190559
prickle2b
prickle homolog 2b
chr19_+_40248697 0.23 ENSDART00000151269
cdk6
cyclin-dependent kinase 6
chr17_+_21818093 0.23 ENSDART00000125335
ikzf5
IKAROS family zinc finger 5
chr3_-_34753605 0.23 ENSDART00000000160
thraa
thyroid hormone receptor alpha a
chr5_-_29122615 0.23 ENSDART00000144802
whrnb
whirlin b
chr14_+_49152341 0.22 ENSDART00000084114
nsd1a
nuclear receptor binding SET domain protein 1a
chr10_-_38468847 0.22 ENSDART00000133914
gdpd5a
glycerophosphodiester phosphodiesterase domain containing 5a
chr9_+_51655636 0.22 ENSDART00000169908
RBMS1 (1 of many)
RNA binding motif single stranded interacting protein 1
chr19_-_35155722 0.22 ENSDART00000151924
macf1a
microtubule-actin crosslinking factor 1a
chr5_-_26765188 0.22 ENSDART00000029450
rnf181
ring finger protein 181
chr6_+_41808673 0.22 ENSDART00000038163
rad18
RAD18 E3 ubiquitin protein ligase
chr9_-_1604601 0.22 ENSDART00000143130
agps
alkylglycerone phosphate synthase
chr10_+_44641599 0.22 ENSDART00000172128
sez6l
seizure related 6 homolog (mouse)-like
chr18_+_26829362 0.22 ENSDART00000132728
slc28a1
solute carrier family 28 (concentrative nucleoside transporter), member 1
chr8_+_53051701 0.21 ENSDART00000131514
nadka
NAD kinase a
chr15_-_20709289 0.21 ENSDART00000136767
tpst1
tyrosylprotein sulfotransferase 1
chr23_-_18568522 0.21 ENSDART00000004655
sephs2
selenophosphate synthetase 2
chr22_-_34551568 0.21 ENSDART00000148147
rnf123
ring finger protein 123
chr1_-_524433 0.21 ENSDART00000147610
si:ch73-41e3.7
si:ch73-41e3.7
chr13_+_10023256 0.21 ENSDART00000110035
srbd1
S1 RNA binding domain 1
chr18_-_22094102 0.21 ENSDART00000100904
pard6a
par-6 family cell polarity regulator alpha
chr1_+_55643198 0.20 ENSDART00000060693
adgre7
adhesion G protein-coupled receptor E7
chr23_+_12840080 0.20 ENSDART00000081016
ENSDART00000121697
smc1al
structural maintenance of chromosomes 1A, like
chr5_-_12063381 0.20 ENSDART00000026749
nipsnap1
nipsnap homolog 1 (C. elegans)
chr23_-_21535040 0.20 ENSDART00000010647
rcc2
regulator of chromosome condensation 2
chr10_-_38456382 0.20 ENSDART00000182129
gdpd5a
glycerophosphodiester phosphodiesterase domain containing 5a
chr15_-_24676211 0.20 ENSDART00000153502
ENSDART00000100756
tmem199
transmembrane protein 199
chr14_-_31814149 0.19 ENSDART00000173393
arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr2_+_55916911 0.19 ENSDART00000189483
ENSDART00000183647
ENSDART00000083470
atcayb
ataxia, cerebellar, Cayman type b
chr9_-_34882516 0.19 ENSDART00000011163
asmtl
acetylserotonin O-methyltransferase-like
chr23_+_36601984 0.18 ENSDART00000128598
igfbp6b
insulin-like growth factor binding protein 6b
chr24_-_11057305 0.18 ENSDART00000186494
asap1b
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b
chr7_-_40578733 0.18 ENSDART00000173926
ENSDART00000010035
dnajb6b
DnaJ (Hsp40) homolog, subfamily B, member 6b
chr5_-_26764880 0.18 ENSDART00000140392
ENSDART00000134728
rnf181
ring finger protein 181
chr23_-_36418708 0.18 ENSDART00000132273
znf740b
zinc finger protein 740b
chr14_+_21722235 0.18 ENSDART00000183667
stx3a
syntaxin 3A
chr6_+_3280939 0.17 ENSDART00000151359
kdm4aa
lysine (K)-specific demethylase 4A, genome duplicate a
chr21_+_34814444 0.17 ENSDART00000161816
wdr55
WD repeat domain 55
chr25_+_11456696 0.17 ENSDART00000171408
AGBL1
si:ch73-141f14.1
chr25_-_37284370 0.17 ENSDART00000103222
nudt7
nudix (nucleoside diphosphate linked moiety X)-type motif 7
chr16_+_20934353 0.17 ENSDART00000052660
skap2
src kinase associated phosphoprotein 2
chr4_-_2059233 0.17 ENSDART00000188177
ENSDART00000129521
ENSDART00000082289
cpsf6
cleavage and polyadenylation specific factor 6
chr21_+_10021823 0.17 ENSDART00000163995
herc7
hect domain and RLD 7
chr5_+_26765275 0.17 ENSDART00000144169
si:ch211-102c2.8
si:ch211-102c2.8
chr15_+_20281305 0.16 ENSDART00000155065
plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr25_-_11016675 0.16 ENSDART00000099572
mespab
mesoderm posterior ab
chr1_-_30568225 0.16 ENSDART00000144297
ENSDART00000164204
ubac2
UBA domain containing 2
chr6_+_46431848 0.16 ENSDART00000181056
ENSDART00000144569
ENSDART00000064865
ENSDART00000133992
stau1
staufen double-stranded RNA binding protein 1
chr1_-_49950643 0.15 ENSDART00000138301
sgms2
sphingomyelin synthase 2
chr21_-_38031038 0.15 ENSDART00000179483
ENSDART00000076238
rbm41
RNA binding motif protein 41
chr1_-_54706039 0.15 ENSDART00000083633
exosc1
exosome component 1
chr15_+_42285643 0.15 ENSDART00000152731
scaf4b
SR-related CTD-associated factor 4b
chr15_+_15771418 0.15 ENSDART00000153831
si:ch211-33e4.3
si:ch211-33e4.3
chr4_-_10835620 0.14 ENSDART00000150739
ppfibp1a
PTPRF interacting protein, binding protein 1a (liprin beta 1)
chr3_-_18384501 0.14 ENSDART00000027630
kdelr2a
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2a
chr13_+_18371208 0.14 ENSDART00000138172
ccar1
cell division cycle and apoptosis regulator 1
chr21_+_26612777 0.14 ENSDART00000142667
esrra
estrogen-related receptor alpha
chr9_+_15893093 0.13 ENSDART00000099483
ENSDART00000134657
si:dkey-14o1.20
si:dkey-14o1.20
chr19_+_30990815 0.13 ENSDART00000134645
sync
syncoilin, intermediate filament protein
chr12_+_17754859 0.13 ENSDART00000112119
bhlha15
basic helix-loop-helix family, member a15
chr8_-_25814263 0.13 ENSDART00000143397
taf10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr13_-_35892051 0.12 ENSDART00000145884
tacc3
transforming, acidic coiled-coil containing protein 3
chr6_-_59381391 0.12 ENSDART00000157066
ppp1r16b
protein phosphatase 1, regulatory subunit 16B
chr16_+_14710436 0.12 ENSDART00000027982
col14a1a
collagen, type XIV, alpha 1a
chr17_-_51262430 0.11 ENSDART00000163222
trappc12
trafficking protein particle complex 12
chr8_-_18229169 0.11 ENSDART00000131764
ENSDART00000143036
ENSDART00000145986
si:ch211-241d21.5
si:ch211-241d21.5
chr15_-_43873005 0.11 ENSDART00000190326
NOX4
NADPH oxidase 4
chr7_-_59311165 0.11 ENSDART00000171105
m1ap
meiosis 1 associated protein
chr6_-_52235118 0.11 ENSDART00000191243
tomm34
translocase of outer mitochondrial membrane 34
chr22_+_724639 0.11 ENSDART00000105323
zgc:162255
zgc:162255
chr3_-_21010979 0.11 ENSDART00000109578
fam117aa
family with sequence similarity 117, member Aa
chr9_-_43073960 0.10 ENSDART00000059460
ttn.2
titin, tandem duplicate 2
chr10_+_40660772 0.10 ENSDART00000148007
taar19l
trace amine associated receptor 19l
chr21_-_2158298 0.10 ENSDART00000182199
gb:ai877918
expressed sequence AI877918
chr17_+_38447473 0.10 ENSDART00000149007
cdan1
codanin 1
chr21_-_21527983 0.10 ENSDART00000014254
diablob
diablo, IAP-binding mitochondrial protein b
chr22_+_1330477 0.10 ENSDART00000157567
CU207221.2

chr12_+_8074343 0.10 ENSDART00000124084
cabcoco1
ciliary associated calcium binding coiled-coil 1
chr8_+_25254435 0.10 ENSDART00000143554
ampd2b
adenosine monophosphate deaminase 2b
chr2_+_30463825 0.10 ENSDART00000092356
neto1
neuropilin (NRP) and tolloid (TLL)-like 1
chr22_-_36750589 0.10 ENSDART00000010824
acy1
aminoacylase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx3.3-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0010863 positive regulation of phospholipase C activity(GO:0010863) regulation of phospholipase C activity(GO:1900274)
0.2 0.6 GO:0033512 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878) L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.2 0.5 GO:0060959 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.2 0.5 GO:0048340 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341) intermediate mesoderm development(GO:0048389)
0.1 0.5 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 0.6 GO:0039689 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.1 0.5 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.1 0.5 GO:0097094 regulation of osteoblast proliferation(GO:0033688) craniofacial suture morphogenesis(GO:0097094)
0.1 0.4 GO:0019075 virion assembly(GO:0019068) virus maturation(GO:0019075) multi-organism membrane organization(GO:0044803) viral budding(GO:0046755) multi-organism organelle organization(GO:1902590) multi-organism membrane budding(GO:1902592)
0.1 0.4 GO:0072116 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.1 0.5 GO:0006013 mannose metabolic process(GO:0006013)
0.1 0.8 GO:0070475 rRNA base methylation(GO:0070475)
0.1 0.2 GO:0097384 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.1 0.5 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.1 0.4 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.1 0.3 GO:2000623 negative regulation of mRNA catabolic process(GO:1902373) regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 0.2 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.5 GO:0021588 cerebellum formation(GO:0021588)
0.1 0.3 GO:0060251 regulation of glial cell proliferation(GO:0060251)
0.1 0.2 GO:0046833 regulation of nucleobase-containing compound transport(GO:0032239) positive regulation of nucleobase-containing compound transport(GO:0032241) positive regulation of nucleocytoplasmic transport(GO:0046824) regulation of RNA export from nucleus(GO:0046831) positive regulation of RNA export from nucleus(GO:0046833) messenger ribonucleoprotein complex assembly(GO:1990120)
0.1 0.5 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.1 0.4 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.5 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.0 0.4 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.6 GO:0048669 collateral sprouting in absence of injury(GO:0048669) regulation of collateral sprouting in absence of injury(GO:0048696)
0.0 0.6 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.9 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.2 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
0.0 0.2 GO:1903573 negative regulation of response to endoplasmic reticulum stress(GO:1903573)
0.0 0.5 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.0 0.5 GO:0098927 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0 0.2 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0 0.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.3 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.8 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 0.2 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.0 0.2 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.6 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.1 GO:0060912 cardiac cell fate specification(GO:0060912)
0.0 0.5 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.2 GO:0043697 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.0 0.4 GO:0010765 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.2 GO:0060465 pharynx development(GO:0060465)
0.0 0.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.4 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.0 0.2 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.0 0.1 GO:0007060 male meiosis chromosome segregation(GO:0007060)
0.0 0.3 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.8 GO:0032402 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 0.3 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.0 0.1 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 0.3 GO:1901888 regulation of cell junction assembly(GO:1901888)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.3 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.5 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.3 GO:1901663 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.2 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.4 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.2 GO:0015858 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.0 0.1 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.3 GO:0009408 response to heat(GO:0009408)
0.0 0.6 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.4 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.0 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0 0.0 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.1 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.3 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.1 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 0.2 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.0 0.5 GO:0030490 maturation of SSU-rRNA(GO:0030490)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 0.5 GO:0070695 FHF complex(GO:0070695)
0.1 0.4 GO:0030891 VCB complex(GO:0030891)
0.1 0.3 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 0.5 GO:0032426 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142) stereocilium tip(GO:0032426)
0.1 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.4 GO:0098894 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.6 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.2 GO:0032019 mitochondrial cloud(GO:0032019)
0.0 0.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.3 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.5 GO:0030686 90S preribosome(GO:0030686)
0.0 0.2 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.6 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.0 GO:0098842 postsynaptic early endosome(GO:0098842)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 1.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.1 0.3 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 0.5 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.3 GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity(GO:0000703)
0.1 0.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 0.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.6 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 0.7 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.5 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.0 0.3 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.5 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.3 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.0 0.2 GO:0035197 siRNA binding(GO:0035197)
0.0 0.9 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.6 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 0.3 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.2 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.5 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.2 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.1 GO:0017020 myosin phosphatase regulator activity(GO:0017020)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.4 GO:0019870 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 0.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.1 GO:0008887 glycerate kinase activity(GO:0008887)
0.0 0.6 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.5 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.0 0.3 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 1.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.2 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.3 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.7 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.8 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.2 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.5 PID FOXO PATHWAY FoxO family signaling
0.0 0.2 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.4 ST GA13 PATHWAY G alpha 13 Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.5 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.6 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.4 REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS Genes involved in Activation of NMDA receptor upon glutamate binding and postsynaptic events
0.0 0.5 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.3 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport