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PRJNA195909:zebrafish embryo and larva development

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Results for nr2c1

Z-value: 1.60

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Transcription factors associated with nr2c1

Gene Symbol Gene ID Gene Info
nr2c1
ENSDARG00000045527 nuclear receptor subfamily 2, group C, member 1
nr2c1
ENSDARG00000111803 nuclear receptor subfamily 2, group C, member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr2c1dr11_v1_chr4_-_25858620_25858620-0.941.8e-04Click!

Activity profile of nr2c1 motif

Sorted Z-values of nr2c1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_43866526 4.29 ENSDART00000111309
treh
trehalase (brush-border membrane glycoprotein)
chr21_+_1119046 4.23 ENSDART00000184678
CABZ01088049.1

chr6_+_154556 3.95 ENSDART00000193153
zglp1
zinc finger, GATA-like protein 1
chr10_-_21362071 3.81 ENSDART00000125167
avd
avidin
chr19_-_8798178 3.26 ENSDART00000188232
cers2a
ceramide synthase 2a
chr3_-_34724879 2.76 ENSDART00000177021
thraa
thyroid hormone receptor alpha a
chr18_+_27515640 2.47 ENSDART00000181593
tp53i11b
tumor protein p53 inducible protein 11b
chr18_-_43866001 2.46 ENSDART00000150218
treh
trehalase (brush-border membrane glycoprotein)
chr5_+_29851433 2.42 ENSDART00000143434
ubash3ba
ubiquitin associated and SH3 domain containing Ba
chr1_+_24387659 2.40 ENSDART00000130356
qdprb2
quinoid dihydropteridine reductase b2
chr9_-_32912638 2.36 ENSDART00000110582
fam160a2
family with sequence similarity 160, member A2
chr24_+_39137001 2.31 ENSDART00000181086
ENSDART00000183724
ENSDART00000193466
tbc1d24
TBC1 domain family, member 24
chr5_-_16472719 2.27 ENSDART00000162071
piwil2
piwi-like RNA-mediated gene silencing 2
chr20_-_32981053 2.26 ENSDART00000138708
nbas
neuroblastoma amplified sequence
chr17_-_6613458 2.24 ENSDART00000175024
si:ch211-189e2.3
si:ch211-189e2.3
chr12_+_48681601 2.13 ENSDART00000187831
uros
uroporphyrinogen III synthase
chr15_+_47386939 2.07 ENSDART00000128224
FO904873.1

chr3_-_58455289 1.93 ENSDART00000052179
cdr2a
cerebellar degeneration-related protein 2a
chr8_+_50534948 1.91 ENSDART00000174435
PEBP4
phosphatidylethanolamine binding protein 4
chr8_-_4097722 1.89 ENSDART00000135006
cux2b
cut-like homeobox 2b
chr20_-_36671660 1.78 ENSDART00000134819
slc5a6a
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6a
chr3_-_34561624 1.74 ENSDART00000129313
sept9a
septin 9a
chr19_-_27564458 1.72 ENSDART00000123155
si:dkeyp-46h3.6
si:dkeyp-46h3.6
chr21_-_1972236 1.72 ENSDART00000192858
ENSDART00000189962
ENSDART00000182461
ENSDART00000165547
WDR7
WD repeat domain 7
chr23_+_39346774 1.71 ENSDART00000190985
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr5_+_31049742 1.68 ENSDART00000173097
zzef1
zinc finger, ZZ-type with EF hand domain 1
chr10_+_36441124 1.68 ENSDART00000185626
uspl1
ubiquitin specific peptidase like 1
chr18_-_158541 1.62 ENSDART00000188914
ENSDART00000191052
trpm7
transient receptor potential cation channel, subfamily M, member 7
chr23_+_39346930 1.58 ENSDART00000102843
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr21_+_15883546 1.56 ENSDART00000186325
fam169ab
family with sequence similarity 169, member Ab
chr2_-_4787566 1.53 ENSDART00000160663
ENSDART00000157808
tnk2b
tyrosine kinase, non-receptor, 2b
chr3_+_1179601 1.51 ENSDART00000173378
triobpb
TRIO and F-actin binding protein b
chr17_+_654759 1.49 ENSDART00000193703
CABZ01079748.1

chr22_-_7050 1.48 ENSDART00000127829
atad3
ATPase family, AAA domain containing 3
chr21_+_13245302 1.45 ENSDART00000189498
specc1lb
sperm antigen with calponin homology and coiled-coil domains 1-like b
chr7_+_34296789 1.41 ENSDART00000052471
ENSDART00000173798
ENSDART00000173778
bbox1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr7_+_34297271 1.41 ENSDART00000180342
bbox1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr3_-_36419641 1.39 ENSDART00000173545
cog1
component of oligomeric golgi complex 1
chr11_+_24314148 1.38 ENSDART00000171491
rem1
RAS (RAD and GEM)-like GTP-binding 1
chr10_+_15340768 1.36 ENSDART00000046274
ENSDART00000168909
trappc13
trafficking protein particle complex 13
chr8_-_12468744 1.35 ENSDART00000135019
FIBCD1 (1 of many)
si:dkeyp-51b7.3
chr8_+_10862353 1.28 ENSDART00000140717
brpf3b
bromodomain and PHD finger containing, 3b
chr14_+_1719367 1.27 ENSDART00000157696
trpc7b
transient receptor potential cation channel, subfamily C, member 7b
chr2_-_57076687 1.26 ENSDART00000161523
slc25a42
solute carrier family 25, member 42
chr11_-_36020005 1.25 ENSDART00000031993
itpr1b
inositol 1,4,5-trisphosphate receptor, type 1b
chr10_-_40939706 1.24 ENSDART00000059795
ENSDART00000190510
bmp1b
bone morphogenetic protein 1b
chr7_+_14005111 1.23 ENSDART00000187365
furina
furin (paired basic amino acid cleaving enzyme) a
chr24_-_29586082 1.23 ENSDART00000136763
vav3a
vav 3 guanine nucleotide exchange factor a
chr13_+_7575563 1.21 ENSDART00000146592
gbf1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr1_-_58868306 1.20 ENSDART00000166615
dnm2b
dynamin 2b
chr5_-_3839285 1.19 ENSDART00000122292
mlxipl
MLX interacting protein like
chr6_+_40523370 1.18 ENSDART00000033819
prkcda
protein kinase C, delta a
chr4_-_2975461 1.18 ENSDART00000150794
plekha5
pleckstrin homology domain containing, family A member 5
chr6_+_40952031 1.15 ENSDART00000189219
patz1
POZ (BTB) and AT hook containing zinc finger 1
chr10_-_38443312 1.13 ENSDART00000141260
gdpd5a
glycerophosphodiester phosphodiesterase domain containing 5a
chr19_+_19652439 1.10 ENSDART00000165934
hibadha
3-hydroxyisobutyrate dehydrogenase a
chr25_-_35113891 1.10 ENSDART00000190724
zgc:165555
zgc:165555
chr11_+_24313931 1.09 ENSDART00000017599
ENSDART00000166045
rem1
RAS (RAD and GEM)-like GTP-binding 1
chr11_+_45343245 1.09 ENSDART00000160904
si:ch73-100l22.3
si:ch73-100l22.3
chr10_-_40939303 1.08 ENSDART00000134295
bmp1b
bone morphogenetic protein 1b
chr19_-_27564980 1.08 ENSDART00000171967
si:dkeyp-46h3.8
si:dkeyp-46h3.8
chr12_-_22509069 1.05 ENSDART00000179755
ENSDART00000109707
neurl4
neuralized E3 ubiquitin protein ligase 4
chr3_-_18805225 1.03 ENSDART00000133471
ENSDART00000131758
msrb1a
methionine sulfoxide reductase B1a
chr19_+_2631565 1.02 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr3_-_33494163 1.00 ENSDART00000020342
sgsm3
small G protein signaling modulator 3
chr13_-_36566260 0.97 ENSDART00000030133
synj2bp
synaptojanin 2 binding protein
chr9_+_38502524 0.95 ENSDART00000087229
lmln
leishmanolysin-like (metallopeptidase M8 family)
chr23_+_22597624 0.93 ENSDART00000054337
gpr157
G protein-coupled receptor 157
chr13_-_30143127 0.93 ENSDART00000146097
tysnd1
trypsin domain containing 1
chr25_+_22017182 0.92 ENSDART00000156517
si:dkey-217l24.1
si:dkey-217l24.1
chr9_+_38503233 0.92 ENSDART00000140331
lmln
leishmanolysin-like (metallopeptidase M8 family)
chr12_+_26670778 0.92 ENSDART00000144355
arhgap12b
Rho GTPase activating protein 12b
chr12_+_27096835 0.92 ENSDART00000149475
ttll6
tubulin tyrosine ligase-like family, member 6
chr10_-_7555326 0.91 ENSDART00000162191
ENSDART00000186945
wrn
Werner syndrome
chr10_-_8197049 0.91 ENSDART00000129467
dhx29
DEAH (Asp-Glu-Ala-His) box polypeptide 29
chr25_-_27665978 0.89 ENSDART00000123590
si:ch211-91p5.3
si:ch211-91p5.3
chr12_+_23866368 0.88 ENSDART00000188652
ENSDART00000192478
svila
supervillin a
chr13_+_13805385 0.88 ENSDART00000166859
slc4a11
solute carrier family 4, sodium borate transporter, member 11
chr16_+_30002605 0.88 ENSDART00000160555
sema6e
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E
chr19_+_3056450 0.87 ENSDART00000141324
ENSDART00000082353
hsf1
heat shock transcription factor 1
chr3_+_31680592 0.87 ENSDART00000172456
mylk5
myosin, light chain kinase 5
chr21_+_38089036 0.86 ENSDART00000147219
klf8
Kruppel-like factor 8
chr14_+_30413312 0.84 ENSDART00000186864
cnot7
CCR4-NOT transcription complex, subunit 7
chr1_+_54737353 0.82 ENSDART00000130675
ENSDART00000162075
pi4k2a
phosphatidylinositol 4-kinase type 2 alpha
chr3_+_40289418 0.79 ENSDART00000017304
cpsf4
cleavage and polyadenylation specific factor 4
chr10_-_7555660 0.77 ENSDART00000163689
wrn
Werner syndrome
chr24_-_1021318 0.76 ENSDART00000181403
ralaa
v-ral simian leukemia viral oncogene homolog Aa (ras related)
chr23_+_2914577 0.74 ENSDART00000184897
DHX35
zgc:158828
chr16_-_25680666 0.73 ENSDART00000132693
ENSDART00000140539
ENSDART00000015302
tomm40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr17_-_49407091 0.73 ENSDART00000021950
mthfd1b
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
chr11_+_24819324 0.72 ENSDART00000184549
kdm5ba
lysine (K)-specific demethylase 5Ba
chr7_+_13988075 0.72 ENSDART00000186812
furina
furin (paired basic amino acid cleaving enzyme) a
chr12_+_31783066 0.71 ENSDART00000105584
lrrc59
leucine rich repeat containing 59
chr15_-_28618502 0.71 ENSDART00000086902
slc6a4a
solute carrier family 6 (neurotransmitter transporter), member 4a
chr20_-_874807 0.70 ENSDART00000020506
snx14
sorting nexin 14
chr23_+_39970425 0.69 ENSDART00000165376
fyco1a
FYVE and coiled-coil domain containing 1a
chr23_+_37482727 0.68 ENSDART00000162737
agmat
agmatine ureohydrolase (agmatinase)
chr15_-_31213119 0.66 ENSDART00000182009
cuedc1b
CUE domain containing 1b
chr24_+_14240196 0.64 ENSDART00000124740
ncoa2
nuclear receptor coactivator 2
chr10_+_589501 0.63 ENSDART00000188415
LO018557.1

chr5_-_26330313 0.61 ENSDART00000148656
arvcfb
ARVCF, delta catenin family member b
chr11_+_3499111 0.60 ENSDART00000113096
ENSDART00000171621
pusl1
pseudouridylate synthase-like 1
chr23_-_45319592 0.60 ENSDART00000189861
ccdc171
coiled-coil domain containing 171
chr20_-_29499363 0.59 ENSDART00000152889
ENSDART00000153252
ENSDART00000170972
ENSDART00000166420
ENSDART00000163079
rrm2
ribonucleotide reductase M2 polypeptide
chr22_-_3595439 0.58 ENSDART00000083308
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr9_+_24936496 0.58 ENSDART00000157474
slc39a10
solute carrier family 39 (zinc transporter), member 10
chr15_+_28268135 0.58 ENSDART00000152536
ENSDART00000188550
myo1cb
myosin Ic, paralog b
chr11_+_24819624 0.57 ENSDART00000155514
kdm5ba
lysine (K)-specific demethylase 5Ba
chr2_-_15040345 0.56 ENSDART00000109657
si:dkey-10f21.4
si:dkey-10f21.4
chr19_-_24136233 0.55 ENSDART00000143365
thap7
THAP domain containing 7
chr22_-_7129631 0.54 ENSDART00000171359
asic1b
acid-sensing (proton-gated) ion channel 1b
chr15_+_28119284 0.54 ENSDART00000188366
unc119a
unc-119 homolog a (C. elegans)
chr1_+_58182400 0.54 ENSDART00000144784
si:ch211-15j1.1
si:ch211-15j1.1
chr8_-_11146924 0.53 ENSDART00000126824
asb13b
ankyrin repeat and SOCS box containing 13b
chr5_+_57328535 0.52 ENSDART00000149646
slc31a1
solute carrier family 31 (copper transporter), member 1
chr1_-_53750522 0.52 ENSDART00000190755
akt3b
v-akt murine thymoma viral oncogene homolog 3b
chr4_-_7875808 0.50 ENSDART00000162276
nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr3_+_54047342 0.50 ENSDART00000178486
olfm2a
olfactomedin 2a
chr7_-_42206720 0.49 ENSDART00000110907
itfg1
integrin alpha FG-GAP repeat containing 1
chr25_+_27410352 0.48 ENSDART00000154362
pot1
protection of telomeres 1 homolog
chr11_-_17713987 0.48 ENSDART00000090401
fam19a4b
family with sequence similarity 19 (chemokine (C-C motif)-like), member A4b
chr16_-_39131666 0.48 ENSDART00000075517
gdf6a
growth differentiation factor 6a
chr1_+_59328030 0.47 ENSDART00000172464
CABZ01052576.1

chr1_-_44581937 0.47 ENSDART00000009858
tmx2b
thioredoxin-related transmembrane protein 2b
chr1_+_57311901 0.47 ENSDART00000149397
mycbpap
mycbp associated protein
chr9_+_40546677 0.47 ENSDART00000132911
vwc2l
von Willebrand factor C domain containing protein 2-like
chr14_+_989733 0.46 ENSDART00000161487
ENSDART00000127317
si:ch73-308l14.2
si:ch73-308l14.2
chr6_-_39903393 0.46 ENSDART00000085945
tsfm
Ts translation elongation factor, mitochondrial
chr3_+_26035550 0.43 ENSDART00000078137
ankrd54
ankyrin repeat domain 54
chr6_-_51541488 0.43 ENSDART00000156336
si:dkey-6e2.2
si:dkey-6e2.2
chr7_+_7495034 0.43 ENSDART00000102629
ENSDART00000180475
nit1
nitrilase 1
chr21_-_43171249 0.43 ENSDART00000021037
ENSDART00000148630
hspa4a
heat shock protein 4a
chr15_+_21711671 0.40 ENSDART00000136151
NKAPD1
zgc:162339
chr3_+_27770110 0.40 ENSDART00000017962
eci1
enoyl-CoA delta isomerase 1
chr5_+_24156170 0.38 ENSDART00000136570
slc25a15b
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15b
chr6_-_18393476 0.37 ENSDART00000168309
trim25
tripartite motif containing 25
chr7_+_50109239 0.37 ENSDART00000021605
LRRC4C (1 of many)
si:dkey-6l15.1
chr13_+_713941 0.37 ENSDART00000109737
cox15
cytochrome c oxidase assembly homolog 15 (yeast)
chr19_-_47571456 0.37 ENSDART00000158071
ENSDART00000165841
rrm2
ribonucleotide reductase M2 polypeptide
chr21_+_43171013 0.36 ENSDART00000151362
zcchc10
zinc finger, CCHC domain containing 10
chr4_-_965267 0.36 ENSDART00000093289
atp23
ATP23 metallopeptidase and ATP synthase assembly factor homolog
chr7_-_30553588 0.36 ENSDART00000139546
sltm
SAFB-like, transcription modulator
chr18_+_38807239 0.34 ENSDART00000184332
fam214a
family with sequence similarity 214, member A
chr13_-_303137 0.33 ENSDART00000099131
chs1
chitin synthase 1
chr4_+_77993103 0.33 ENSDART00000174392
terfa
telomeric repeat binding factor a
chr13_+_42406883 0.33 ENSDART00000084354
cpeb3
cytoplasmic polyadenylation element binding protein 3
chr1_-_46859398 0.32 ENSDART00000135795
agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr1_+_58260886 0.31 ENSDART00000110453
si:dkey-222h21.8
si:dkey-222h21.8
chr25_+_18587338 0.30 ENSDART00000180287
met
MET proto-oncogene, receptor tyrosine kinase
chr7_+_42206847 0.30 ENSDART00000149250
phkb
phosphorylase kinase, beta
chr4_+_77993977 0.29 ENSDART00000174118
terfa
telomeric repeat binding factor a
chr1_+_58303892 0.28 ENSDART00000147678
CR769768.1

chr3_+_30257582 0.28 ENSDART00000159497
ENSDART00000103457
ENSDART00000121883
mybpc2a
myosin binding protein C, fast type a
chr7_+_41314862 0.28 ENSDART00000185198
zgc:165532
zgc:165532
chr23_+_44634187 0.27 ENSDART00000143688
si:ch73-265d7.2
si:ch73-265d7.2
chr3_+_34159192 0.27 ENSDART00000151119
carm1
coactivator-associated arginine methyltransferase 1
chr6_+_60036767 0.26 ENSDART00000155009
tgm8
transglutaminase 8
chr8_+_21159122 0.25 ENSDART00000033491
spryd4
SPRY domain containing 4
chr6_+_9872261 0.25 ENSDART00000045070
MPP4 (1 of many)
si:ch211-222n4.6
chr3_+_19336286 0.25 ENSDART00000111528
kri1
KRI1 homolog
chr8_-_11146687 0.24 ENSDART00000189626
asb13b
ankyrin repeat and SOCS box containing 13b
chr1_-_44314 0.24 ENSDART00000160050
tmem39a
transmembrane protein 39A
chr23_-_2448234 0.24 ENSDART00000082097
LO018513.1

chr2_+_6067371 0.23 ENSDART00000053868
ENSDART00000145244
aldh9a1b
aldehyde dehydrogenase 9 family, member A1b
chr8_+_8699085 0.21 ENSDART00000021209
uxt
ubiquitously-expressed, prefoldin-like chaperone
chr7_-_29231686 0.21 ENSDART00000173780
herc1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr15_-_1844048 0.21 ENSDART00000102410
taf15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr12_-_4176329 0.21 ENSDART00000092746
si:dkey-32n7.7
si:dkey-32n7.7
chr25_+_12012 0.20 ENSDART00000170348
cntn1a
contactin 1a
chr20_-_25877793 0.19 ENSDART00000177333
ENSDART00000184619
exoc1
exocyst complex component 1
chr11_+_36243774 0.19 ENSDART00000023323
zgc:172270
zgc:172270
chr2_+_21486529 0.18 ENSDART00000047468
inhbab
inhibin, beta Ab
chr20_-_26936887 0.17 ENSDART00000160827
ftr79
finTRIM family, member 79
chr22_+_17399124 0.15 ENSDART00000145769
rabgap1l
RAB GTPase activating protein 1-like
chr23_+_4583747 0.14 ENSDART00000160350
LO017700.1

chr17_-_46850299 0.13 ENSDART00000154430
pimr23
Pim proto-oncogene, serine/threonine kinase, related 23
chr2_-_56649883 0.13 ENSDART00000191786
gpx4b
glutathione peroxidase 4b
chr1_+_58353661 0.12 ENSDART00000140074
si:dkey-222h21.2
si:dkey-222h21.2
chr17_+_52524452 0.11 ENSDART00000016614
dlst
dihydrolipoamide S-succinyltransferase
chr8_+_2530065 0.11 ENSDART00000063943
mrpl40
mitochondrial ribosomal protein L40
chr13_-_31878043 0.09 ENSDART00000187720
syt14a
synaptotagmin XIVa
chr18_+_43183749 0.09 ENSDART00000151166
nectin1b
nectin cell adhesion molecule 1b
chr3_+_18424244 0.09 ENSDART00000127796
gaa
glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II)
chr9_+_34433053 0.08 ENSDART00000137416
si:ch211-269e2.1
si:ch211-269e2.1
chr2_+_43750899 0.07 ENSDART00000135836
arhgap12a
Rho GTPase activating protein 12a
chr20_+_36806398 0.06 ENSDART00000153317
abracl
ABRA C-terminal like
chr14_+_22293787 0.05 ENSDART00000157967
atp10b
ATPase phospholipid transporting 10B
chr19_-_3193443 0.04 ENSDART00000179855
si:ch211-133n4.6
si:ch211-133n4.6
chr4_-_20243021 0.03 ENSDART00000048023
cacna2d4a
calcium channel, voltage-dependent, alpha 2/delta subunit 4a
chr12_+_19138452 0.03 ENSDART00000141346
ENSDART00000066397
phf5a
PHD finger protein 5A
chr1_+_58221372 0.02 ENSDART00000138467
si:dkey-222h21.10
si:dkey-222h21.10
chr17_-_46933567 0.02 ENSDART00000157274
pimr25
Pim proto-oncogene, serine/threonine kinase, related 25
chr19_+_20274944 0.01 ENSDART00000151237
oxnad1
oxidoreductase NAD-binding domain containing 1
chr8_+_8893535 0.01 ENSDART00000139150
otud5a
OTU deubiquitinase 5a

Network of associatons between targets according to the STRING database.

First level regulatory network of nr2c1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.8 GO:0005991 trehalose metabolic process(GO:0005991)
1.1 3.3 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.6 2.3 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.6 2.3 GO:1902373 negative regulation of mRNA catabolic process(GO:1902373) regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.5 1.6 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.5 2.5 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.5 1.4 GO:0097095 frontonasal suture morphogenesis(GO:0097095)
0.4 1.8 GO:0015887 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.4 3.1 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.4 1.7 GO:0010259 multicellular organism aging(GO:0010259) G-quadruplex DNA unwinding(GO:0044806)
0.3 1.7 GO:0030575 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576) protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) protein localization to nucleoplasm(GO:1990173)
0.3 2.8 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.3 1.1 GO:1903723 negative regulation of centriole elongation(GO:1903723)
0.2 2.4 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.2 0.5 GO:0042671 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.2 0.6 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.2 1.5 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2 1.1 GO:0006574 valine catabolic process(GO:0006574)
0.2 0.7 GO:0051610 serotonin transport(GO:0006837) serotonin uptake(GO:0051610)
0.2 0.6 GO:0032208 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208)
0.2 0.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 1.9 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.1 0.7 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.1 2.1 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.1 0.4 GO:0000066 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.1 1.1 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.1 0.4 GO:0039529 RIG-I signaling pathway(GO:0039529) regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039531) regulation of RIG-I signaling pathway(GO:0039535)
0.1 0.4 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.1 1.2 GO:0021681 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 0.5 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 1.9 GO:0097324 melanocyte migration(GO:0097324)
0.1 0.6 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 0.5 GO:0051972 regulation of telomerase activity(GO:0051972)
0.1 0.9 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.1 1.3 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.1 0.9 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 0.5 GO:0071467 cellular response to pH(GO:0071467)
0.1 0.8 GO:0098789 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 1.0 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 3.9 GO:0048599 oocyte development(GO:0048599)
0.1 0.8 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 0.7 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.1 0.7 GO:0009446 putrescine biosynthetic process(GO:0009446)
0.1 0.5 GO:2001286 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1 0.3 GO:0006031 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.1 0.3 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 1.2 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.1 3.3 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.7 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.9 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 1.3 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.3 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.0 1.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.6 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988) synaptic membrane adhesion(GO:0099560)
0.0 0.2 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 0.8 GO:0007032 endosome organization(GO:0007032)
0.0 0.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.0 0.9 GO:0009408 response to heat(GO:0009408)
0.0 0.4 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.1 GO:0044406 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.0 0.9 GO:0051014 actin filament severing(GO:0051014)
0.0 1.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.2 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 1.0 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.2 GO:0044854 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 1.7 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.7 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579) positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.0 0.6 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 0.9 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 1.0 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.3 GO:0018149 peptide cross-linking(GO:0018149)
0.0 1.7 GO:0021782 glial cell development(GO:0021782)
0.0 1.1 GO:0006352 DNA-templated transcription, initiation(GO:0006352)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:1990072 TRAPPIII protein complex(GO:1990072)
0.5 2.3 GO:1990923 PET complex(GO:1990923)
0.1 1.2 GO:0001772 immunological synapse(GO:0001772)
0.1 1.4 GO:0017119 Golgi transport complex(GO:0017119)
0.1 1.7 GO:0015030 Cajal body(GO:0015030)
0.1 1.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 0.7 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.8 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 1.2 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 1.4 GO:0005921 gap junction(GO:0005921)
0.1 1.2 GO:0030667 secretory granule membrane(GO:0030667)
0.1 0.5 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.1 GO:0000784 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.0 1.7 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.3 GO:0030428 cell septum(GO:0030428)
0.0 0.8 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.4 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 4.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.3 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.5 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.9 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.1 GO:0005814 centriole(GO:0005814)
0.0 0.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.4 GO:0030496 midbody(GO:0030496)
0.0 0.1 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.8 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.9 2.8 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.8 3.8 GO:0009374 biotin binding(GO:0009374)
0.6 2.4 GO:0070404 6,7-dihydropteridine reductase activity(GO:0004155) NADH binding(GO:0070404)
0.4 1.8 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.4 1.3 GO:0080122 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.3 1.7 GO:0032183 SUMO binding(GO:0032183)
0.3 2.3 GO:0034584 piRNA binding(GO:0034584)
0.3 1.1 GO:0008442 3-hydroxyisobutyrate dehydrogenase activity(GO:0008442)
0.3 1.0 GO:0033745 L-methionine-(R)-S-oxide reductase activity(GO:0033745)
0.2 0.7 GO:0015222 serotonin:sodium symporter activity(GO:0005335) serotonin transmembrane transporter activity(GO:0015222)
0.2 3.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 1.7 GO:0009378 four-way junction helicase activity(GO:0009378)
0.2 2.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 1.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 1.1 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 1.0 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 1.3 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1 0.8 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.5 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 0.5 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 1.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.7 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 2.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 1.3 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.1 0.6 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 0.2 GO:0043878 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity(GO:0043878)
0.1 0.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.9 GO:0070739 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.1 4.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 1.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 0.3 GO:0008469 histone-arginine N-methyltransferase activity(GO:0008469)
0.1 0.9 GO:0030552 cAMP binding(GO:0030552)
0.1 0.4 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 0.7 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 1.2 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.4 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.3 GO:0004100 chitin synthase activity(GO:0004100)
0.0 0.9 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.1 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 2.1 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.6 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.4 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 4.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.1 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.0 1.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 2.8 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.3 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.5 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.0 2.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.9 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.9 GO:0060090 binding, bridging(GO:0060090)
0.0 2.8 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.3 ST STAT3 PATHWAY STAT3 Pathway
0.1 1.2 PID ARF 3PATHWAY Arf1 pathway
0.0 0.8 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 2.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.9 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.3 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.2 PID E2F PATHWAY E2F transcription factor network
0.0 0.9 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 6.8 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.4 3.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 2.1 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 0.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 0.8 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 1.1 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.0 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.5 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 2.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.3 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.2 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism