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PRJNA195909:zebrafish embryo and larva development

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Results for osr2

Z-value: 0.79

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Transcription factors associated with osr2

Gene Symbol Gene ID Gene Info
osr2
ENSDARG00000038006 odd-skipped related transciption factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
osr2dr11_v1_chr16_-_54405976_544059760.752.0e-02Click!

Activity profile of osr2 motif

Sorted Z-values of osr2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_46010 2.65 ENSDART00000052641
gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr18_-_45736 2.53 ENSDART00000148373
ENSDART00000148950
gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr13_+_29778610 1.77 ENSDART00000132004
pax2a
paired box 2a
chr14_+_36246726 1.76 ENSDART00000105602
elovl6
ELOVL fatty acid elongase 6
chr15_-_39848822 1.66 ENSDART00000155230
si:dkey-263j23.1
si:dkey-263j23.1
chr23_-_46040618 1.30 ENSDART00000161415
CABZ01080918.1

chr22_-_5006801 1.27 ENSDART00000106166
rx1
retinal homeobox gene 1
chr23_+_36095260 1.19 ENSDART00000127384
hoxc9a
homeobox C9a
chr12_-_38548299 1.07 ENSDART00000153374
si:dkey-1f1.3
si:dkey-1f1.3
chr18_-_977075 0.89 ENSDART00000032392
dhdhl
dihydrodiol dehydrogenase (dimeric), like
chr22_-_11626014 0.86 ENSDART00000063133
ENSDART00000160085
gcga
glucagon a
chr22_-_28871787 0.82 ENSDART00000104828
gtpbp2b
GTP binding protein 2b
chr10_+_38512270 0.77 ENSDART00000109752
serpinh1a
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a
chr20_-_29418620 0.73 ENSDART00000172634
ryr3
ryanodine receptor 3
chr5_-_48307804 0.73 ENSDART00000182831
ENSDART00000186920
ENSDART00000183585
mef2cb
myocyte enhancer factor 2cb
chr23_+_7379728 0.70 ENSDART00000012194
gata5
GATA binding protein 5
chr11_+_31285127 0.65 ENSDART00000160154
si:dkey-238i5.2
si:dkey-238i5.2
chr13_+_30696286 0.63 ENSDART00000192411
cxcl18a.1
chemokine (C-X-C motif) ligand 18a, duplicate 1
chr23_-_9925568 0.60 ENSDART00000081268
si:ch211-220i18.4
si:ch211-220i18.4
chr10_-_13239367 0.59 ENSDART00000001253
si:busm1-57f23.1
si:busm1-57f23.1
chr16_+_35344031 0.53 ENSDART00000167140
si:dkey-34d22.1
si:dkey-34d22.1
chr3_-_28120092 0.45 ENSDART00000151143
rbfox1
RNA binding fox-1 homolog 1
chr19_-_25519310 0.40 ENSDART00000089882
C1GALT1 (1 of many)
si:dkey-202e17.1
chr20_+_30490682 0.36 ENSDART00000184871
myt1la
myelin transcription factor 1-like, a
chr14_+_5383060 0.30 ENSDART00000187825
lbx2
ladybird homeobox 2
chr21_-_40834413 0.30 ENSDART00000148513
limk1b
LIM domain kinase 1b
chr19_-_25519612 0.28 ENSDART00000133150
C1GALT1 (1 of many)
si:dkey-202e17.1
chr2_+_3986083 0.26 ENSDART00000188979
mkxb
mohawk homeobox b
chr2_+_5446882 0.24 ENSDART00000083260
dusp28
dual specificity phosphatase 28
chr3_-_32958505 0.23 ENSDART00000147374
ENSDART00000136919
casp6l1
caspase 6, apoptosis-related cysteine peptidase, like 1
chr6_-_40884453 0.21 ENSDART00000017968
ENSDART00000154100
sirt4
sirtuin 4
chr23_-_4704938 0.19 ENSDART00000067293
cnbpa
CCHC-type zinc finger, nucleic acid binding protein a
chr8_+_48858132 0.15 ENSDART00000124737
ENSDART00000079644
tp73
tumor protein p73
chr2_-_48497175 0.13 ENSDART00000158839
CR391991.5

chr12_+_28856151 0.11 ENSDART00000152969
nfe2l1b
nuclear factor, erythroid 2-like 1b
chr2_-_48512450 0.06 ENSDART00000160132
CR391991.1

chr5_-_61787969 0.05 ENSDART00000112744
gas2l2
growth arrest specific 2 like 2
chr21_+_21679086 0.05 ENSDART00000146225
or125-5
odorant receptor, family E, subfamily 125, member 5
chr1_+_44826593 0.04 ENSDART00000162200
STX3
zgc:165520
chr3_-_30384353 0.04 ENSDART00000186832
lrrc4ba
leucine rich repeat containing 4Ba
chr7_+_42206543 0.03 ENSDART00000112543
phkb
phosphorylase kinase, beta

Network of associatons between targets according to the STRING database.

First level regulatory network of osr2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:0006600 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
0.3 1.2 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.2 1.8 GO:0021588 cerebellum formation(GO:0021588)
0.2 0.7 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.1 1.8 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.3 GO:1904105 positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.0 0.2 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.0 1.3 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.9 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.7 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.8 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.3 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.7 GO:0060914 heart formation(GO:0060914)
0.0 0.8 GO:0006414 translational elongation(GO:0006414)
0.0 0.6 GO:0000245 spliceosomal complex assembly(GO:0000245)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 5.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0031769 glucagon receptor binding(GO:0031769)
0.2 5.2 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.7 GO:0048763 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.1 1.8 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.8 GO:0005518 collagen binding(GO:0005518)
0.0 0.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.7 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.2 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.2 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 5.2 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives