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PRJNA195909:zebrafish embryo and larva development

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Results for pbx1a+pbx1b+pbx2+pbx3a+pbx3b

Z-value: 3.24

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Transcription factors associated with pbx1a+pbx1b+pbx2+pbx3a+pbx3b

Gene Symbol Gene ID Gene Info
pbx3b
ENSDARG00000013615 pre-B-cell leukemia homeobox 3b
pbx2
ENSDARG00000019717 pre-B-cell leukemia homeobox 2
pbx3a
ENSDARG00000089262 pre-B-cell leukemia homeobox 3a
pbx1a
ENSDARG00000100494 pre-B-cell leukemia homeobox 1a
pbx1b
ENSDARG00000101131 pre-B-cell leukemia homeobox 1b
pbx3b
ENSDARG00000110194 pre-B-cell leukemia homeobox 3b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pbx1adr11_v1_chr2_-_18830722_188307830.964.9e-05Click!
pbx2dr11_v1_chr16_+_48616220_48616297-0.933.5e-04Click!
pbx3bdr11_v1_chr8_-_34052019_340520190.781.3e-02Click!
pbx3adr11_v1_chr5_-_5326010_53260100.713.3e-02Click!
pbx1bdr11_v1_chr6_+_2271559_22715590.127.7e-01Click!

Activity profile of pbx1a+pbx1b+pbx2+pbx3a+pbx3b motif

Sorted Z-values of pbx1a+pbx1b+pbx2+pbx3a+pbx3b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_22232902 7.70 ENSDART00000101845
crygm2d5
crystallin, gamma M2d5
chr9_-_22135576 5.33 ENSDART00000101902
crygm2d8
crystallin, gamma M2d8
chr3_+_32526263 4.54 ENSDART00000150897
si:ch73-367p23.2
si:ch73-367p23.2
chr12_+_15008582 4.25 ENSDART00000003847
mylpfb
myosin light chain, phosphorylatable, fast skeletal muscle b
chr9_-_22205682 4.15 ENSDART00000101869
crygm2d12
crystallin, gamma M2d12
chr9_-_22240052 4.02 ENSDART00000111109
crygm2d9
crystallin, gamma M2d9
chr9_-_22318511 3.93 ENSDART00000129295
crygm2d2
crystallin, gamma M2d2
chr9_-_22099536 3.82 ENSDART00000101923
CR391987.1

chr9_-_22076368 3.60 ENSDART00000128486
crygm2a
crystallin, gamma M2a
chr9_-_22135420 3.53 ENSDART00000184959
crygm2d8
crystallin, gamma M2d8
chr9_-_22092089 3.53 ENSDART00000101928
crygm2d13
crystallin, gamma M2d13
chr9_-_22122590 3.46 ENSDART00000108748
ENSDART00000174614
crygm2d9
crystallin, gamma M2d9
chr9_-_22272181 3.40 ENSDART00000113174
crygm2d7
crystallin, gamma M2d7
chr22_+_20720808 3.39 ENSDART00000171321
si:dkey-211f22.5
si:dkey-211f22.5
chr9_-_22188117 3.35 ENSDART00000132890
crygm2d17
crystallin, gamma M2d17
chr9_-_44295071 3.34 ENSDART00000011837
neurod1
neuronal differentiation 1
chr20_-_20533865 3.34 ENSDART00000125039
six6b
SIX homeobox 6b
chr9_-_22129788 3.33 ENSDART00000124272
ENSDART00000175417
crygm2d8
crystallin, gamma M2d8
chr17_+_52822831 3.28 ENSDART00000193368
meis2a
Meis homeobox 2a
chr3_+_32526799 3.26 ENSDART00000185755
si:ch73-367p23.2
si:ch73-367p23.2
chr9_-_22069364 3.23 ENSDART00000101938
crygm2b
crystallin, gamma M2b
chr6_+_14949950 3.23 ENSDART00000149202
ENSDART00000149949
pou3f3b
POU class 3 homeobox 3b
chr6_+_52804267 3.23 ENSDART00000065681
matn4
matrilin 4
chr5_-_19400166 3.12 ENSDART00000008994
foxn4
forkhead box N4
chr9_-_22147567 3.11 ENSDART00000110941
crygm2d14
crystallin, gamma M2d14
chr9_-_22310919 3.08 ENSDART00000108719
crygm2d10
crystallin, gamma M2d10
chr12_-_20350629 3.04 ENSDART00000066384
hbbe2
hemoglobin beta embryonic-2
chr11_+_14622379 3.04 ENSDART00000112589
efna2b
ephrin-A2b
chr9_-_22023061 2.93 ENSDART00000101952
crygm2c
crystallin, gamma M2c
chr20_+_28434196 2.89 ENSDART00000034245
dpf3
D4, zinc and double PHD fingers, family 3
chr12_+_15002757 2.87 ENSDART00000135036
mylpfb
myosin light chain, phosphorylatable, fast skeletal muscle b
chr2_+_2737422 2.83 ENSDART00000032459
aqp1a.1
aquaporin 1a (Colton blood group), tandem duplicate 1
chr9_-_22245572 2.82 ENSDART00000114943
crygm2d4
crystallin, gamma M2d4
chr5_-_36837846 2.69 ENSDART00000032481
ckma
creatine kinase, muscle a
chr4_+_9669717 2.67 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr1_-_54947592 2.66 ENSDART00000129710
crtac1a
cartilage acidic protein 1a
chr12_-_4388704 2.63 ENSDART00000152168
si:ch211-173d10.1
si:ch211-173d10.1
chr15_+_47161917 2.61 ENSDART00000167860
gap43
growth associated protein 43
chr2_+_1487118 2.49 ENSDART00000147283
c8a
complement component 8, alpha polypeptide
chr2_-_44946094 2.48 ENSDART00000036997
camk2n1a
calcium/calmodulin-dependent protein kinase II inhibitor 1a
chr12_+_36971952 2.37 ENSDART00000125900
hs3st3b1b
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1b
chr25_+_18563476 2.36 ENSDART00000170841
cav1
caveolin 1
chr23_-_24263474 2.36 ENSDART00000160312
hspb7
heat shock protein family, member 7 (cardiovascular)
chr24_-_40667800 2.35 ENSDART00000169315
smyhc1
slow myosin heavy chain 1
chr20_+_29743904 2.34 ENSDART00000146366
ENSDART00000153154
kidins220b
kinase D-interacting substrate 220b
chr3_+_26144765 2.33 ENSDART00000146267
ENSDART00000043932
atp2a1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr21_+_30563115 2.32 ENSDART00000028566
si:ch211-200p22.4
si:ch211-200p22.4
chr3_-_62380146 2.31 ENSDART00000155853
gprc5ba
G protein-coupled receptor, class C, group 5, member Ba
chr7_-_69636502 2.31 ENSDART00000126739
tspan5a
tetraspanin 5a
chr21_+_5129513 2.31 ENSDART00000102572
thbs4b
thrombospondin 4b
chr17_+_52822422 2.26 ENSDART00000158273
ENSDART00000161414
meis2a
Meis homeobox 2a
chr22_-_23253481 2.23 ENSDART00000054807
lhx9
LIM homeobox 9
chr13_+_28417297 2.23 ENSDART00000043658
slc2a15a
solute carrier family 2 (facilitated glucose transporter), member 15a
chr13_-_5569562 2.20 ENSDART00000102576
meis1b
Meis homeobox 1 b
chr14_+_33458294 2.19 ENSDART00000075278
atp1b4
ATPase Na+/K+ transporting subunit beta 4
chr13_-_5568928 2.16 ENSDART00000192679
meis1b
Meis homeobox 1 b
chr9_-_30274412 2.15 ENSDART00000089526
otc
ornithine carbamoyltransferase
chr17_+_45577326 2.12 ENSDART00000074854
si:ch211-202f3.3
si:ch211-202f3.3
chr7_+_71683853 2.11 ENSDART00000163002
emilin2b
elastin microfibril interfacer 2b
chr21_+_10828828 2.10 ENSDART00000136449
oacyl
O-acyltransferase like
chr9_-_22345500 2.05 ENSDART00000101802
crygm2f
crystallin, gamma M2f
chr2_-_55861351 2.03 ENSDART00000059003
rx2
retinal homeobox gene 2
chr7_-_29571615 2.00 ENSDART00000019140
rorab
RAR-related orphan receptor A, paralog b
chr7_-_51102479 1.99 ENSDART00000174023
col4a6
collagen, type IV, alpha 6
chr15_-_23376541 1.89 ENSDART00000078570
c1qtnf5
C1q and TNF related 5
chr1_-_40911332 1.87 ENSDART00000027463
hmx4
H6 family homeobox 4
chr17_+_52823015 1.86 ENSDART00000160507
ENSDART00000186979
meis2a
Meis homeobox 2a
chr12_-_31103187 1.85 ENSDART00000005562
ENSDART00000031408
ENSDART00000125046
ENSDART00000009237
ENSDART00000122972
ENSDART00000153068
tcf7l2
transcription factor 7 like 2
chr24_+_3963684 1.84 ENSDART00000182959
ENSDART00000185926
ENSDART00000167043
ENSDART00000033394
pfkpa
phosphofructokinase, platelet a
chr21_-_35832548 1.82 ENSDART00000180840
sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr17_+_41463942 1.81 ENSDART00000075331
insm1b
insulinoma-associated 1b
chr5_-_20185665 1.79 ENSDART00000051612
dao.2
D-amino-acid oxidase, tandem duplicate 2
chr9_-_5046315 1.76 ENSDART00000179087
ENSDART00000109954
nr4a2a
nuclear receptor subfamily 4, group A, member 2a
chr1_-_46984142 1.75 ENSDART00000125032
pknox1.2
pbx/knotted 1 homeobox 1.2
chr2_-_24996441 1.75 ENSDART00000144795
slc35g2a
solute carrier family 35, member G2a
chr21_+_11468934 1.75 ENSDART00000126045
ENSDART00000129744
ENSDART00000102368
grin1a
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr4_-_17725008 1.73 ENSDART00000016658
chpt1
choline phosphotransferase 1
chr10_-_26512742 1.72 ENSDART00000135951
si:dkey-5g14.1
si:dkey-5g14.1
chr15_+_36115955 1.71 ENSDART00000032702
sst1.2
somatostatin 1, tandem duplicate 2
chr9_-_42873700 1.67 ENSDART00000125953
ttn.1
titin, tandem duplicate 1
chr8_+_23213320 1.66 ENSDART00000032996
ENSDART00000137536
ppdpfa
pancreatic progenitor cell differentiation and proliferation factor a
chr13_+_10232695 1.66 ENSDART00000080805
six2a
SIX homeobox 2a
chr10_+_9553935 1.66 ENSDART00000028855
si:ch211-243g18.2
si:ch211-243g18.2
chr11_-_101758 1.65 ENSDART00000173015
elmo2
engulfment and cell motility 2
chr3_-_1190132 1.63 ENSDART00000149709
smdt1a
single-pass membrane protein with aspartate-rich tail 1a
chr13_+_35635672 1.62 ENSDART00000148481
thbs2a
thrombospondin 2a
chr2_+_1486822 1.62 ENSDART00000132500
c8a
complement component 8, alpha polypeptide
chr20_+_37294112 1.61 ENSDART00000076293
ENSDART00000140450
cx23
connexin 23
chr24_-_38816725 1.60 ENSDART00000063231
nog2
noggin 2
chr22_-_13851297 1.60 ENSDART00000080306
s100b
S100 calcium binding protein, beta (neural)
chr22_+_34430310 1.58 ENSDART00000109860
amigo3
adhesion molecule with Ig-like domain 3
chr7_-_51032128 1.56 ENSDART00000182781
ENSDART00000121574
col4a6
collagen, type IV, alpha 6
chr13_+_22249636 1.55 ENSDART00000108472
ENSDART00000173123
synpo2la
synaptopodin 2-like a
chr7_+_27250186 1.53 ENSDART00000150068
sox6
SRY (sex determining region Y)-box 6
chr5_+_54501105 1.52 ENSDART00000165889
tprn
taperin
chr10_-_26512993 1.51 ENSDART00000188549
ENSDART00000193316
si:dkey-5g14.1
si:dkey-5g14.1
chr7_-_27038488 1.51 ENSDART00000052731
ENSDART00000191382
nucb2a
nucleobindin 2a
chr16_+_50100420 1.50 ENSDART00000128167
nr1d2a
nuclear receptor subfamily 1, group D, member 2a
chr20_+_26683933 1.50 ENSDART00000139852
ENSDART00000077751
foxq1b
forkhead box Q1b
chr7_+_56098590 1.50 ENSDART00000098453
cdh15
cadherin 15, type 1, M-cadherin (myotubule)
chr4_-_5291256 1.49 ENSDART00000150864
SNAP91 (1 of many)
si:ch211-214j24.9
chr11_-_7261717 1.48 ENSDART00000128959
zgc:113223
zgc:113223
chr10_+_43797130 1.47 ENSDART00000027242
nr2f1b
nuclear receptor subfamily 2, group F, member 1b
chr24_-_25691020 1.47 ENSDART00000015391
chrnd
cholinergic receptor, nicotinic, delta (muscle)
chr13_-_10261383 1.45 ENSDART00000080808
six3a
SIX homeobox 3a
chr5_+_23630384 1.45 ENSDART00000013745
cx39.9
connexin 39.9
chr15_+_7057050 1.44 ENSDART00000061828
foxl2a
forkhead box L2a
chr23_+_28582865 1.43 ENSDART00000020296
l1cama
L1 cell adhesion molecule, paralog a
chr18_-_16801033 1.43 ENSDART00000100100
admb
adrenomedullin b
chr20_-_47731768 1.43 ENSDART00000031167
tfap2d
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr20_-_53996193 1.41 ENSDART00000004756
hsp90aa1.1
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1
chr22_-_5006801 1.41 ENSDART00000106166
rx1
retinal homeobox gene 1
chr20_+_27646772 1.40 ENSDART00000141697
mthfd1a
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1a, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr24_-_2947393 1.39 ENSDART00000166661
ENSDART00000147110
tubb6
tubulin, beta 6 class V
chr7_-_58729894 1.38 ENSDART00000149347
chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr10_+_34426256 1.38 ENSDART00000102566
nbeaa
neurobeachin a
chr1_+_119960 1.37 ENSDART00000013209
f7
coagulation factor VII
chr10_+_20108557 1.37 ENSDART00000142708
dmtn
dematin actin binding protein
chr7_-_4036184 1.37 ENSDART00000019949
ndrg2
NDRG family member 2
chr11_-_42554290 1.36 ENSDART00000130573
atp6ap1la
ATPase H+ transporting accessory protein 1 like a
chr15_-_12545683 1.35 ENSDART00000162807
scn2b
sodium channel, voltage-gated, type II, beta
chr14_+_32022272 1.34 ENSDART00000105760
zic6
zic family member 6
chr10_+_22724059 1.34 ENSDART00000136123
kdm6bb
lysine (K)-specific demethylase 6B, b
chr24_+_29382109 1.33 ENSDART00000184620
ENSDART00000188414
ENSDART00000186132
ENSDART00000191489
ntng1a
netrin g1a
chr1_+_12763461 1.33 ENSDART00000159226
ENSDART00000180121
pcdh10a
protocadherin 10a
chr25_+_5039050 1.32 ENSDART00000154700
parvb
parvin, beta
chr12_+_34127573 1.31 ENSDART00000153413
cyth1b
cytohesin 1b
chr15_+_7086327 1.30 ENSDART00000114560
pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
chr10_-_35236949 1.30 ENSDART00000145804
ypel2a
yippee-like 2a
chr19_-_24443394 1.29 ENSDART00000090825
thbs3b
thrombospondin 3b
chr4_+_15942075 1.29 ENSDART00000147964
si:dkey-117n7.2
si:dkey-117n7.2
chr21_+_35215810 1.28 ENSDART00000135256
ubtd2
ubiquitin domain containing 2
chr3_+_23669267 1.28 ENSDART00000111227
hoxb10a
homeobox B10a
chr2_+_43469241 1.27 ENSDART00000142078
ENSDART00000098265
nrp1b
neuropilin 1b
chr11_+_7261981 1.27 ENSDART00000130400
ENSDART00000155427
reep6
receptor accessory protein 6
chr25_+_13191391 1.27 ENSDART00000109937
si:ch211-147m6.2
si:ch211-147m6.2
chr1_-_54063520 1.27 ENSDART00000171722
smdt1b
single-pass membrane protein with aspartate-rich tail 1b
chr19_-_9829965 1.26 ENSDART00000136842
ENSDART00000142766
cacng8a
calcium channel, voltage-dependent, gamma subunit 8a
chr9_+_27411502 1.26 ENSDART00000143994
si:dkey-193n17.9
si:dkey-193n17.9
chr5_+_36752943 1.26 ENSDART00000017138
exoc3l2a
exocyst complex component 3-like 2a
chr14_-_3381303 1.25 ENSDART00000171601
im:7150988
im:7150988
chr5_-_36949476 1.25 ENSDART00000047269
h3f3c
H3 histone, family 3C
chr5_+_19320554 1.24 ENSDART00000165119
rusc2
RUN and SH3 domain containing 2
chr14_-_52521460 1.24 ENSDART00000172110
GPR151
G protein-coupled receptor 151
chr25_-_36492779 1.24 ENSDART00000042271
irx3b
iroquois homeobox 3b
chr10_+_20128267 1.24 ENSDART00000064615
dmtn
dematin actin binding protein
chr15_-_19250543 1.24 ENSDART00000092705
ENSDART00000138895
igsf9ba
immunoglobulin superfamily, member 9Ba
chr5_+_11290851 1.23 ENSDART00000180408
CABZ01077124.1

chr19_-_31802296 1.23 ENSDART00000103640
hey1
hes-related family bHLH transcription factor with YRPW motif 1
chr21_-_23746916 1.22 ENSDART00000017229
ncam1a
neural cell adhesion molecule 1a
chr4_-_27301356 1.22 ENSDART00000100444
fam19a5a
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5a
chr16_-_50229193 1.21 ENSDART00000161782
ENSDART00000010081
etfb
electron-transfer-flavoprotein, beta polypeptide
chr12_-_16558106 1.20 ENSDART00000109033
si:dkey-269i1.4
si:dkey-269i1.4
chr19_+_26718074 1.20 ENSDART00000134455
zgc:100906
zgc:100906
chr22_-_15280638 1.19 ENSDART00000063008
mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr25_+_5044780 1.19 ENSDART00000153980
parvb
parvin, beta
chr15_-_2184638 1.18 ENSDART00000135460
shox2
short stature homeobox 2
chr25_+_13191615 1.18 ENSDART00000168849
si:ch211-147m6.2
si:ch211-147m6.2
chr1_+_55137943 1.18 ENSDART00000138070
ENSDART00000150510
ENSDART00000133472
ENSDART00000136378
mb
myoglobin
chr16_-_22192006 1.18 ENSDART00000163338
il6r
interleukin 6 receptor
chr2_-_7431590 1.17 ENSDART00000185699
asip2b
agouti signaling protein, nonagouti homolog (mouse) 2b
chr2_-_51719439 1.16 ENSDART00000170385
tgm1l1
transglutaminase 1 like 1
chr19_-_24443867 1.16 ENSDART00000163763
ENSDART00000043133
thbs3b
thrombospondin 3b
chr21_-_12119711 1.16 ENSDART00000131538
celf4
CUGBP, Elav-like family member 4
chr16_+_41873708 1.15 ENSDART00000084631
ENSDART00000084639
ENSDART00000058611
scn1ba
sodium channel, voltage-gated, type I, beta a
chr4_-_27398385 1.15 ENSDART00000142117
ENSDART00000150553
ENSDART00000182746
fam19a5a
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5a
chr18_-_45736 1.15 ENSDART00000148373
ENSDART00000148950
gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr20_-_24963038 1.13 ENSDART00000102788
ENSDART00000159122
epha7
eph receptor A7
chr8_-_1051438 1.12 ENSDART00000067093
ENSDART00000170737
smyd1b
SET and MYND domain containing 1b
chr7_-_68373495 1.12 ENSDART00000167440
zfhx3
zinc finger homeobox 3
chr8_+_7144066 1.11 ENSDART00000146306
slc6a6a
solute carrier family 6 (neurotransmitter transporter), member 6a
chr22_-_21392748 1.11 ENSDART00000144648
ankrd24
ankyrin repeat domain 24
chr1_-_46401385 1.10 ENSDART00000150029
atp11a
ATPase phospholipid transporting 11A
chr12_+_25600685 1.10 ENSDART00000077157
six3b
SIX homeobox 3b
chr9_-_21067971 1.09 ENSDART00000004333
tbx15
T-box 15
chr5_+_59278593 1.09 ENSDART00000097374
rasa4
RAS p21 protein activator 4
chr14_+_22591624 1.08 ENSDART00000108987
gfra4b
GDNF family receptor alpha 4b
chr2_-_50298337 1.07 ENSDART00000155125
cntnap2b
contactin associated protein like 2b
chr21_-_34658266 1.07 ENSDART00000023038
dacha
dachshund a
chr8_+_7033049 1.07 ENSDART00000064172
ENSDART00000134440
gpd1a
glycerol-3-phosphate dehydrogenase 1a
chr24_+_41931585 1.07 ENSDART00000130310
epb41l3a
erythrocyte membrane protein band 4.1-like 3a
chr16_-_563235 1.06 ENSDART00000016303
irx2a
iroquois homeobox 2a
chr10_-_27046639 1.06 ENSDART00000041841
cnih2
cornichon family AMPA receptor auxiliary protein 2
chr14_+_45883687 1.06 ENSDART00000114790
flrt1b
fibronectin leucine rich transmembrane protein 1b
chr4_-_18595525 1.06 ENSDART00000049061
cdkn1ba
cyclin-dependent kinase inhibitor 1Ba
chr3_-_22000986 1.06 ENSDART00000111103
BX547992.1

chr6_+_48618512 1.05 ENSDART00000111190
FAM19A3
si:dkey-238f9.1
chr4_-_16001118 1.05 ENSDART00000041070
ENSDART00000125389
mest
mesoderm specific transcript
chr16_+_5251768 1.04 ENSDART00000144558
plecb
plectin b
chr5_+_32791245 1.03 ENSDART00000077189
ier5l
immediate early response 5-like
chr6_+_4872883 1.03 ENSDART00000186730
ENSDART00000092290
ENSDART00000151674
pcdh9
protocadherin 9
chr15_-_34213898 1.02 ENSDART00000191945
ENSDART00000186089
etv1
ets variant 1
chr15_-_34214440 1.01 ENSDART00000167052
etv1
ets variant 1
chr7_-_27037990 1.00 ENSDART00000173561
nucb2a
nucleobindin 2a
chr16_-_13730152 0.99 ENSDART00000138772
ttyh1
tweety family member 1
chr6_+_43903209 0.98 ENSDART00000006435
gpr27
G protein-coupled receptor 27
chr16_+_7626535 0.98 ENSDART00000182670
ENSDART00000065514
ENSDART00000150212
stx12l
syntaxin 12, like
chr5_+_39087364 0.97 ENSDART00000004286
anxa3a
annexin A3a
chr8_-_25247284 0.97 ENSDART00000132697
gnat2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr2_+_40294313 0.97 ENSDART00000037292
epha4b
eph receptor A4b

Network of associatons between targets according to the STRING database.

First level regulatory network of pbx1a+pbx1b+pbx2+pbx3a+pbx3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0003097 renal water homeostasis(GO:0003091) renal water transport(GO:0003097)
0.7 2.2 GO:0097376 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.6 3.6 GO:0038065 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.6 2.3 GO:0031446 regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
0.5 2.2 GO:0006526 arginine biosynthetic process(GO:0006526)
0.5 3.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.5 2.5 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.5 1.4 GO:0048496 maintenance of organ identity(GO:0048496)
0.5 62.2 GO:0002088 lens development in camera-type eye(GO:0002088)
0.5 2.4 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.5 1.9 GO:0010226 response to lithium ion(GO:0010226)
0.4 1.8 GO:0006524 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.4 4.9 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.4 1.2 GO:0021961 posterior commissure morphogenesis(GO:0021961)
0.4 1.2 GO:0032369 negative regulation of lipid transport(GO:0032369)
0.4 2.3 GO:0035989 tendon development(GO:0035989)
0.4 1.1 GO:0006601 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
0.3 0.3 GO:0070587 regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
0.3 0.9 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.3 0.9 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.3 1.2 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.3 0.9 GO:0032290 peripheral nervous system myelin formation(GO:0032290) semicircular canal fusion(GO:0060879)
0.3 2.8 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.3 0.8 GO:0003156 regulation of organ formation(GO:0003156)
0.3 4.4 GO:0072554 endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.3 1.1 GO:0006116 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.3 2.5 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.2 1.0 GO:0090387 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.2 0.7 GO:0034035 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.2 2.9 GO:0006603 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.2 2.4 GO:0061718 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.2 1.1 GO:0071205 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
0.2 0.9 GO:0015871 choline transport(GO:0015871)
0.2 5.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 4.2 GO:0015671 oxygen transport(GO:0015671)
0.2 1.8 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.2 1.5 GO:0043090 amino acid import(GO:0043090) L-amino acid import(GO:0043092)
0.2 0.9 GO:0031652 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.2 0.9 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.2 0.7 GO:0060074 synapse maturation(GO:0060074)
0.2 1.2 GO:0048745 smooth muscle tissue development(GO:0048745)
0.2 2.9 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2 0.5 GO:0044650 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.2 3.0 GO:0072160 pronephric nephron tubule epithelial cell differentiation(GO:0035778) cell differentiation involved in pronephros development(GO:0039014) nephron tubule epithelial cell differentiation(GO:0072160)
0.2 1.6 GO:0060612 adipose tissue development(GO:0060612)
0.2 1.1 GO:0086091 regulation of heart rate by cardiac conduction(GO:0086091)
0.2 1.3 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.2 0.5 GO:0090113 regulation of COPII vesicle coating(GO:0003400) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.2 0.5 GO:0034382 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
0.2 2.5 GO:0016198 axon choice point recognition(GO:0016198)
0.2 0.8 GO:1902514 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.2 1.7 GO:0048769 sarcomerogenesis(GO:0048769)
0.2 1.8 GO:0007525 somatic muscle development(GO:0007525)
0.2 1.8 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.1 0.7 GO:1902019 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.1 3.8 GO:0019835 cytolysis(GO:0019835)
0.1 1.0 GO:0070571 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.1 0.8 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.5 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 1.9 GO:0048923 posterior lateral line neuromast hair cell differentiation(GO:0048923)
0.1 2.6 GO:0030316 osteoclast differentiation(GO:0030316)
0.1 0.9 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 1.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 0.8 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.6 GO:0021982 pineal gland development(GO:0021982)
0.1 0.8 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.1 0.4 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.1 0.6 GO:0021794 thalamus development(GO:0021794)
0.1 0.3 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.1 1.5 GO:0061074 regulation of neural retina development(GO:0061074)
0.1 1.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 1.1 GO:0051963 regulation of synapse assembly(GO:0051963)
0.1 3.7 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.1 3.0 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.1 1.0 GO:0050819 negative regulation of coagulation(GO:0050819)
0.1 0.5 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.1 2.5 GO:0070831 basement membrane assembly(GO:0070831)
0.1 1.2 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.1 1.0 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 0.4 GO:2000051 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 1.3 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1 1.5 GO:0035476 angioblast cell migration(GO:0035476)
0.1 2.3 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) synaptic vesicle budding(GO:0070142)
0.1 0.7 GO:0002082 regulation of oxidative phosphorylation(GO:0002082)
0.1 0.4 GO:0006574 valine catabolic process(GO:0006574)
0.1 0.2 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.5 GO:0007172 signal complex assembly(GO:0007172)
0.1 0.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 1.3 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 1.2 GO:0018149 peptide cross-linking(GO:0018149)
0.1 1.9 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.1 0.5 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 1.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 1.4 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 0.5 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.1 0.6 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 0.5 GO:1902262 apoptotic process involved in patterning of blood vessels(GO:1902262)
0.1 0.5 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 1.8 GO:0060037 pharyngeal system development(GO:0060037)
0.1 0.3 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 0.7 GO:0048932 myelination of lateral line nerve axons(GO:0048897) posterior lateral line nerve glial cell differentiation(GO:0048931) myelination of posterior lateral line nerve axons(GO:0048932) lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048938) posterior lateral line nerve glial cell development(GO:0048941) posterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048942)
0.1 0.8 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 1.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.6 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 0.3 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.1 1.1 GO:0039022 pronephric duct development(GO:0039022) nephric duct development(GO:0072176)
0.0 2.1 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.6 GO:0001649 osteoblast differentiation(GO:0001649)
0.0 6.3 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.0 0.8 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.0 0.9 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.4 GO:0051189 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 1.0 GO:0010883 regulation of lipid storage(GO:0010883)
0.0 0.3 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 1.6 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 0.7 GO:0007631 feeding behavior(GO:0007631)
0.0 0.2 GO:0016093 polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0 0.6 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 1.0 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 1.6 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 2.7 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 1.1 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.1 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.0 0.5 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.5 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.7 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 1.1 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.7 GO:0043049 otic placode formation(GO:0043049)
0.0 0.8 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.1 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.0 0.4 GO:0009251 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 1.1 GO:0048935 peripheral nervous system neuron development(GO:0048935)
0.0 1.9 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.5 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.0 1.0 GO:0042593 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
0.0 0.5 GO:0032438 melanosome organization(GO:0032438)
0.0 1.5 GO:0007416 synapse assembly(GO:0007416)
0.0 0.4 GO:0043687 post-translational protein modification(GO:0043687)
0.0 0.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.6 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 1.0 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.1 GO:0060584 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.2 GO:0098719 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 1.4 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 1.5 GO:0030239 myofibril assembly(GO:0030239)
0.0 0.2 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 0.6 GO:0055064 chloride ion homeostasis(GO:0055064)
0.0 1.1 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 3.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.9 GO:0051604 protein maturation(GO:0051604)
0.0 4.0 GO:0006813 potassium ion transport(GO:0006813)
0.0 0.2 GO:0010737 protein kinase A signaling(GO:0010737)
0.0 0.2 GO:1900052 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.0 0.4 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.7 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.4 GO:0030497 fatty acid elongation(GO:0030497)
0.0 1.5 GO:0006909 phagocytosis(GO:0006909)
0.0 0.7 GO:0007422 peripheral nervous system development(GO:0007422)
0.0 0.1 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.0 0.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 1.3 GO:0006906 vesicle fusion(GO:0006906)
0.0 0.2 GO:0033555 multicellular organismal response to stress(GO:0033555)
0.0 0.4 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.9 GO:0006821 chloride transport(GO:0006821)
0.0 0.5 GO:0000187 activation of MAPK activity(GO:0000187)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.6 GO:0032584 growth cone membrane(GO:0032584)
0.6 3.6 GO:0098651 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.6 2.3 GO:0031673 H zone(GO:0031673)
0.5 1.9 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.4 2.2 GO:0070062 extracellular exosome(GO:0070062)
0.3 0.9 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233) anchored component of external side of plasma membrane(GO:0031362)
0.3 2.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.3 4.1 GO:0005579 membrane attack complex(GO:0005579)
0.3 3.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 2.9 GO:1990246 uniplex complex(GO:1990246)
0.2 1.7 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.2 1.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 1.4 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.2 2.2 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.2 2.4 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.2 2.3 GO:0098894 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.2 1.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 0.5 GO:0030062 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.2 0.7 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.2 1.0 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 0.7 GO:0030314 junctional membrane complex(GO:0030314)
0.1 1.1 GO:0033010 paranodal junction(GO:0033010)
0.1 0.7 GO:0043034 costamere(GO:0043034)
0.1 1.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.4 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.5 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 2.9 GO:0071565 nBAF complex(GO:0071565)
0.1 0.9 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 2.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 2.5 GO:0031672 A band(GO:0031672)
0.1 0.8 GO:0061700 GATOR2 complex(GO:0061700)
0.1 2.0 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.1 1.0 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.4 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.1 0.8 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 1.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 3.8 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.6 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 5.2 GO:0030018 Z disc(GO:0030018)
0.1 0.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 3.0 GO:0042383 sarcolemma(GO:0042383)
0.0 1.3 GO:0000145 exocyst(GO:0000145)
0.0 1.0 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.7 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.3 GO:0030428 cell septum(GO:0030428)
0.0 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 2.3 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 1.3 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 1.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.2 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 1.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.6 GO:0016529 sarcoplasm(GO:0016528) sarcoplasmic reticulum(GO:0016529)
0.0 1.7 GO:0005882 intermediate filament(GO:0005882)
0.0 1.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 4.3 GO:0005911 cell-cell junction(GO:0005911)
0.0 0.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.0 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 0.2 GO:0035101 FACT complex(GO:0035101)
0.0 0.5 GO:0043679 axon terminus(GO:0043679)
0.0 0.6 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 3.9 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 62.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.7 2.2 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.5 2.6 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.4 1.8 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.4 2.5 GO:0010858 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.4 1.6 GO:0044548 S100 protein binding(GO:0044548)
0.4 2.8 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.3 1.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 1.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.3 1.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.3 2.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.3 3.0 GO:0031720 haptoglobin binding(GO:0031720)
0.2 1.2 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.2 0.7 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.2 2.9 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.2 2.4 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.2 0.9 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.2 1.4 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.2 0.6 GO:0031716 calcitonin receptor binding(GO:0031716)
0.2 3.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 2.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 2.6 GO:0005504 fatty acid binding(GO:0005504)
0.2 2.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 1.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 0.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 2.5 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.7 GO:0048763 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.1 0.7 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.2 GO:0005344 oxygen transporter activity(GO:0005344) oxygen binding(GO:0019825)
0.1 0.4 GO:0004394 heparan sulfate 2-O-sulfotransferase activity(GO:0004394)
0.1 1.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 1.2 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.1 1.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 0.8 GO:0070728 leucine binding(GO:0070728)
0.1 0.4 GO:0008442 3-hydroxyisobutyrate dehydrogenase activity(GO:0008442)
0.1 1.0 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.8 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.4 GO:0004135 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.1 0.4 GO:0102345 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.1 0.8 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 1.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.4 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.6 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 1.7 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.6 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.1 1.0 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.1 0.5 GO:0008126 acetylesterase activity(GO:0008126)
0.1 0.6 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 1.0 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.2 GO:0047777 (3S)-citramalyl-CoA lyase activity(GO:0047777)
0.1 1.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.3 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.1 2.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 11.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.2 GO:0000035 acyl binding(GO:0000035)
0.1 0.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.9 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 2.0 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 0.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 0.3 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 0.6 GO:0031628 opioid receptor binding(GO:0031628)
0.1 2.7 GO:0044325 ion channel binding(GO:0044325)
0.1 1.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 0.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.4 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.6 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 1.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.8 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.3 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.3 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.7 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.9 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 2.3 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 4.0 GO:0008201 heparin binding(GO:0008201)
0.0 3.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.3 GO:0004100 chitin synthase activity(GO:0004100)
0.0 0.9 GO:0043236 laminin binding(GO:0043236)
0.0 1.1 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.0 1.0 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:0009041 uridylate kinase activity(GO:0009041)
0.0 1.1 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.5 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 1.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.7 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.5 GO:0009055 electron carrier activity(GO:0009055)
0.0 3.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.1 GO:0017022 myosin binding(GO:0017022)
0.0 0.1 GO:0008117 sphinganine-1-phosphate aldolase activity(GO:0008117)
0.0 0.1 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0 3.4 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 21.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 33.8 GO:0001159 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.7 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.2 GO:0015386 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.3 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.1 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.4 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 2.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.7 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.0 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.0 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0 0.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.5 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.3 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.4 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 1.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.6 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 4.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 2.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 1.3 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 1.0 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.5 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 1.1 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.9 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.5 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 4.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 ST ADRENERGIC Adrenergic Pathway
0.0 0.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.4 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 2.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 3.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 2.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 1.6 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 1.5 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 4.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.2 0.5 REACTOME IMMUNE SYSTEM Genes involved in Immune System
0.2 1.4 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 2.3 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 1.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 3.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 1.6 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 0.8 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 0.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.2 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 1.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.2 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.7 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 1.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.5 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors