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PRJNA195909:zebrafish embryo and larva development

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Results for phox2ba

Z-value: 0.95

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Transcription factors associated with phox2ba

Gene Symbol Gene ID Gene Info
phox2ba
ENSDARG00000075330 paired like homeobox 2Ba

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
phox2badr11_v1_chr1_-_19079957_19079957-0.412.7e-01Click!

Activity profile of phox2ba motif

Sorted Z-values of phox2ba motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_77551860 2.40 ENSDART00000188176
AL935186.6

chr3_-_40054615 1.30 ENSDART00000003511
ENSDART00000102540
ENSDART00000146121
llgl1
lethal giant larvae homolog 1 (Drosophila)
chr2_+_44512324 1.20 ENSDART00000155017
ENSDART00000156310
ENSDART00000156686
pask
PAS domain containing serine/threonine kinase
chr21_+_18910502 1.20 ENSDART00000147567
smpd4
sphingomyelin phosphodiesterase 4
chr12_+_32368574 1.19 ENSDART00000086389
ANKFN1
si:ch211-277e21.2
chr24_+_39227519 1.15 ENSDART00000184611
ENSDART00000193494
ENSDART00000190728
ENSDART00000168705
MPRIP
si:ch73-103b11.2
chr9_+_22634073 1.09 ENSDART00000181822
etv5a
ets variant 5a
chr18_-_12612699 1.08 ENSDART00000090335
hipk2
homeodomain interacting protein kinase 2
chr9_+_55321322 0.98 ENSDART00000111111
ENSDART00000191579
nlgn4b
neuroligin 4b
chr18_+_27598755 0.96 ENSDART00000193808
cd82b
CD82 molecule b
chr17_-_20202725 0.93 ENSDART00000133650
ecd
ecdysoneless homolog (Drosophila)
chr3_+_23247325 0.91 ENSDART00000114190
ppp1r9ba
protein phosphatase 1, regulatory subunit 9Ba
chr8_+_10862353 0.89 ENSDART00000140717
brpf3b
bromodomain and PHD finger containing, 3b
chr15_-_23908605 0.82 ENSDART00000185578
usp32
ubiquitin specific peptidase 32
chr5_+_61941610 0.81 ENSDART00000168808
si:dkeyp-117b8.4
si:dkeyp-117b8.4
chr16_-_25519762 0.81 ENSDART00000146479
ENSDART00000142062
dtnbp1a
dystrobrevin binding protein 1a
chr13_-_34862452 0.80 ENSDART00000134573
ENSDART00000047552
sptlc3
serine palmitoyltransferase, long chain base subunit 3
chr16_+_53387085 0.80 ENSDART00000154223
ENSDART00000101404
kif13a
kinesin family member 13A
chr15_+_25681044 0.78 ENSDART00000077853
hic1
hypermethylated in cancer 1
chr1_+_26677406 0.75 ENSDART00000183427
ENSDART00000180366
ENSDART00000181997
si:dkey-25o16.4
si:dkey-25o16.4
chr5_-_25236340 0.73 ENSDART00000162774
abca2
ATP-binding cassette, sub-family A (ABC1), member 2
chr7_-_41746427 0.73 ENSDART00000174232
arl8
ADP-ribosylation factor-like 8
chr8_-_11835607 0.71 ENSDART00000183601
rapgef1a
Rap guanine nucleotide exchange factor (GEF) 1a
chr13_-_12021566 0.68 ENSDART00000125430
pprc1
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr12_-_30043809 0.65 ENSDART00000150220
ENSDART00000075889
ENSDART00000148847
trub1
TruB pseudouridine (psi) synthase family member 1
chr1_+_26676758 0.64 ENSDART00000152299
si:dkey-25o16.4
si:dkey-25o16.4
chr8_-_38355268 0.63 ENSDART00000129597
sorbs3
sorbin and SH3 domain containing 3
chr14_+_31493306 0.62 ENSDART00000138341
phf6
PHD finger protein 6
chr2_-_9971609 0.61 ENSDART00000137924
ENSDART00000048655
ENSDART00000131613
zgc:55943
zgc:55943
chr8_+_10835456 0.61 ENSDART00000151388
mapk13
mitogen-activated protein kinase 13
chr13_+_42858228 0.61 ENSDART00000179763
cdh23
cadherin-related 23
chr8_-_11832771 0.59 ENSDART00000193412
ENSDART00000184720
ENSDART00000139947
rapgef1a
Rap guanine nucleotide exchange factor (GEF) 1a
chr2_-_26590628 0.57 ENSDART00000025120
ndc1
NDC1 transmembrane nucleoporin
chr17_+_27134806 0.56 ENSDART00000151901
rps6ka1
ribosomal protein S6 kinase a, polypeptide 1
chr11_+_24800156 0.56 ENSDART00000131976
adipor1a
adiponectin receptor 1a
chr16_+_1471 0.55 ENSDART00000181972
CABZ01090785.1

chr14_+_45702521 0.54 ENSDART00000112470
ccdc88b
coiled-coil domain containing 88B
chr8_+_7854130 0.51 ENSDART00000165575
cxxc1a
CXXC finger protein 1a
chr18_+_27001115 0.48 ENSDART00000133547
pik3c2a
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
chr18_+_27000850 0.46 ENSDART00000188906
ENSDART00000086131
pik3c2a
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
chr24_+_19542323 0.44 ENSDART00000140379
ENSDART00000142830
sulf1
sulfatase 1
chr11_-_23459779 0.43 ENSDART00000183935
ENSDART00000184125
ENSDART00000193284
plekha6
pleckstrin homology domain containing, family A member 6
chr6_+_33537267 0.40 ENSDART00000040334
pik3r3b
phosphoinositide-3-kinase, regulatory subunit 3b (gamma)
chr24_-_25574967 0.38 ENSDART00000189828
cnksr2a
connector enhancer of kinase suppressor of Ras 2a
chr14_-_47314011 0.36 ENSDART00000178523
fstl5
follistatin-like 5
chr19_+_42047427 0.35 ENSDART00000180225
ENSDART00000145356
si:ch211-13c6.2
si:ch211-13c6.2
chr21_+_44300689 0.34 ENSDART00000186298
ENSDART00000142810
gabra3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr1_+_10074601 0.33 ENSDART00000168473
si:ch73-132f6.5
si:ch73-132f6.5
chr21_+_27189490 0.31 ENSDART00000125349
bada
BCL2 associated agonist of cell death a
chr22_+_2533514 0.31 ENSDART00000147967
si:ch73-92e7.4
si:ch73-92e7.4
chr6_-_11800427 0.31 ENSDART00000126243
march7
membrane-associated ring finger (C3HC4) 7
chr12_-_28956921 0.30 ENSDART00000142933
znf646
zinc finger protein 646
chr14_-_45702721 0.23 ENSDART00000165727
si:dkey-226n24.1
si:dkey-226n24.1
chr7_+_72460911 0.21 ENSDART00000160682
ENSDART00000168532
HECTD4
HECT domain E3 ubiquitin protein ligase 4
chr6_+_16493755 0.21 ENSDART00000126318
si:ch73-193c12.2
si:ch73-193c12.2
chr19_+_10799929 0.20 ENSDART00000159152
lipea
lipase, hormone-sensitive a
chr25_+_32530976 0.19 ENSDART00000156190
ENSDART00000103324
scaper
S-phase cyclin A-associated protein in the ER
chr13_+_47623916 0.19 ENSDART00000109266
mertka
c-mer proto-oncogene tyrosine kinase a
chr20_-_38801981 0.18 ENSDART00000125333
cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr15_+_2500510 0.14 ENSDART00000180329
wdr53
WD repeat domain 53
chr11_+_13223625 0.14 ENSDART00000161275
abcb11b
ATP-binding cassette, sub-family B (MDR/TAP), member 11b
chr14_+_32839535 0.12 ENSDART00000168975
arr3b
arrestin 3b, retinal (X-arrestin)
chr10_+_26645953 0.12 ENSDART00000131482
adgrg4b
adhesion G protein-coupled receptor G4b
chr1_+_33390286 0.11 ENSDART00000139004
dhrsx
dehydrogenase/reductase (SDR family) X-linked
chr2_-_51223658 0.06 ENSDART00000171770
pigrl4.2
polymeric immunoglobulin receptor-like 4.2
chr1_+_58205904 0.02 ENSDART00000147324
si:dkey-222h21.12
si:dkey-222h21.12
chr10_+_26646104 0.01 ENSDART00000187685
adgrg4b
adhesion G protein-coupled receptor G4b
chr20_-_18736281 0.01 ENSDART00000142837
enpp5
ectonucleotide pyrophosphatase/phosphodiesterase 5
chr8_+_16758304 0.01 ENSDART00000133514
elovl7a
ELOVL fatty acid elongase 7a

Network of associatons between targets according to the STRING database.

First level regulatory network of phox2ba

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.2 0.8 GO:0033363 secretory granule organization(GO:0033363) platelet dense granule organization(GO:0060155)
0.2 0.7 GO:1903292 protein localization to Golgi membrane(GO:1903292)
0.2 1.2 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.7 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.1 0.6 GO:0035678 neuromast hair cell morphogenesis(GO:0035678)
0.1 1.1 GO:0045634 regulation of melanocyte differentiation(GO:0045634)
0.1 1.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 1.3 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.1 1.1 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.1 0.8 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 0.8 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.1 0.9 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.1 0.2 GO:0021563 glossopharyngeal nerve development(GO:0021563)
0.1 0.6 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 0.4 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.0 0.9 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.6 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.1 GO:0032782 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0 0.4 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.3 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.0 0.8 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.0 0.2 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.7 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 0.1 GO:0002031 G-protein coupled receptor internalization(GO:0002031)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.8 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.9 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.6 GO:0032420 stereocilium(GO:0032420)
0.0 1.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 1.1 GO:0016605 PML body(GO:0016605)
0.0 1.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 1.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.3 GO:0045159 myosin II binding(GO:0045159)
0.1 0.9 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.1 0.2 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1 0.9 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.6 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.7 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0015126 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.2 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.3 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.5 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.5 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.6 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.1 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.8 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 0.8 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 0.9 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 0.7 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.6 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 1.2 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis