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PRJNA195909:zebrafish embryo and larva development

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Results for pou1f1

Z-value: 0.82

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Transcription factors associated with pou1f1

Gene Symbol Gene ID Gene Info
pou1f1
ENSDARG00000058924 POU class 1 homeobox 1
pou1f1
ENSDARG00000110816 POU class 1 homeobox 1
pou1f1
ENSDARG00000115109 POU class 1 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pou1f1dr11_v1_chr9_-_19161982_191619820.872.5e-03Click!

Activity profile of pou1f1 motif

Sorted Z-values of pou1f1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_22099536 3.72 ENSDART00000101923
CR391987.1

chr4_+_9669717 3.48 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr12_-_17712393 3.46 ENSDART00000143534
ENSDART00000010144
pvalb2
parvalbumin 2
chr3_+_28939759 2.65 ENSDART00000141904
lgals1l1
lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1
chr9_-_22213297 2.32 ENSDART00000110656
ENSDART00000133149
crygm2d20
crystallin, gamma M2d20
chr3_+_26145013 2.27 ENSDART00000162546
ENSDART00000129561
atp2a1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr13_+_24279021 2.24 ENSDART00000058629
acta1b
actin, alpha 1b, skeletal muscle
chr14_+_46313396 1.92 ENSDART00000047525
cryba1l1
crystallin, beta A1, like 1
chr2_-_7666021 1.60 ENSDART00000180007
CABZ01021592.1

chr6_-_58764672 1.59 ENSDART00000154322
soat2
sterol O-acyltransferase 2
chr21_+_25236297 1.34 ENSDART00000112783
tmem45b
transmembrane protein 45B
chr23_-_21453614 1.31 ENSDART00000079274
her4.1
hairy-related 4, tandem duplicate 1
chr21_-_43015383 1.27 ENSDART00000065097
dpysl3
dihydropyrimidinase-like 3
chr24_-_26328721 1.27 ENSDART00000125468
apodb
apolipoprotein Db
chr20_+_19512727 1.27 ENSDART00000063696
atraid
all-trans retinoic acid-induced differentiation factor
chr14_-_24761132 1.22 ENSDART00000146299
slit3
slit homolog 3 (Drosophila)
chr16_-_28856112 1.20 ENSDART00000078543
syt11b
synaptotagmin XIb
chr13_-_29420885 1.13 ENSDART00000024225
chata
choline O-acetyltransferase a
chr3_+_30922947 1.13 ENSDART00000184060
cldni
claudin i
chr14_-_413273 1.10 ENSDART00000163976
ENSDART00000179907
FAT4
FAT atypical cadherin 4
chr24_+_32176155 1.08 ENSDART00000003745
vim
vimentin
chr5_-_71705191 1.07 ENSDART00000187767
ak1
adenylate kinase 1
chr21_+_45841731 1.04 ENSDART00000038657
faxdc2
fatty acid hydroxylase domain containing 2
chr5_+_71802014 1.03 ENSDART00000124939
ENSDART00000097164
LHX3
LIM homeobox 3
chr9_-_42418470 1.03 ENSDART00000144353
calcrla
calcitonin receptor-like a
chr5_-_41494831 1.02 ENSDART00000051081
eef2l2
eukaryotic translation elongation factor 2, like 2
chr14_-_4145594 0.96 ENSDART00000077348
casp3b
caspase 3, apoptosis-related cysteine peptidase b
chr3_+_36424055 0.96 ENSDART00000170318
si:ch1073-443f11.2
si:ch1073-443f11.2
chr8_+_7359294 0.96 ENSDART00000121708
pcsk1nl
proprotein convertase subtilisin/kexin type 1 inhibitor, like
chr4_-_2545310 0.95 ENSDART00000150619
ENSDART00000140760
e2f7
E2F transcription factor 7
chr7_+_59020972 0.92 ENSDART00000157873
hacd1
3-hydroxyacyl-CoA dehydratase 1
chr15_+_9327252 0.92 ENSDART00000144381
sgcg
sarcoglycan, gamma
chr6_-_11768198 0.92 ENSDART00000183463
march7
membrane-associated ring finger (C3HC4) 7
chr7_+_19495379 0.91 ENSDART00000180514
si:ch211-212k18.8
si:ch211-212k18.8
chr12_+_27331324 0.90 ENSDART00000087208
sost
sclerostin
chr13_+_9432501 0.90 ENSDART00000058064
zgc:123321
zgc:123321
chr11_-_1509773 0.89 ENSDART00000050762
phactr3b
phosphatase and actin regulator 3b
chr10_-_43771447 0.87 ENSDART00000052307
arrdc3b
arrestin domain containing 3b
chr13_-_9886579 0.87 ENSDART00000101926
si:ch211-117n7.7
si:ch211-117n7.7
chr16_-_21140097 0.86 ENSDART00000145837
ENSDART00000146500
si:dkey-271j15.3
si:dkey-271j15.3
chr9_+_34641237 0.85 ENSDART00000133996
shox
short stature homeobox
chr19_+_12915498 0.85 ENSDART00000132892
cthrc1a
collagen triple helix repeat containing 1a
chr23_+_19813677 0.84 ENSDART00000139192
ENSDART00000142308
emd
emerin (Emery-Dreifuss muscular dystrophy)
chr2_+_2223837 0.83 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr19_+_43297546 0.82 ENSDART00000168002
laptm5
lysosomal protein transmembrane 5
chr17_-_30702411 0.81 ENSDART00000114358
zgc:194392
zgc:194392
chr23_-_21446985 0.81 ENSDART00000044080
her12
hairy-related 12
chr20_-_5291012 0.79 ENSDART00000122892
cyp46a1.3
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 3
chr5_-_44829719 0.79 ENSDART00000019104
fbp2
fructose-1,6-bisphosphatase 2
chr23_-_42232124 0.79 ENSDART00000149944
gpx7
glutathione peroxidase 7
chr7_+_71664624 0.78 ENSDART00000170273
emilin2b
elastin microfibril interfacer 2b
chr16_+_46111849 0.78 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr15_-_21014270 0.77 ENSDART00000154019
si:ch211-212c13.10
si:ch211-212c13.10
chr13_+_29770837 0.77 ENSDART00000076998
pax2a
paired box 2a
chr12_+_3022882 0.77 ENSDART00000122905
rac3b
Rac family small GTPase 3b
chr3_-_15999501 0.76 ENSDART00000160668
nme3
NME/NM23 nucleoside diphosphate kinase 3
chr1_-_42289704 0.73 ENSDART00000150124
si:ch211-71k14.1
si:ch211-71k14.1
chr10_-_14556978 0.73 ENSDART00000126643
zgc:153395
zgc:153395
chr24_+_21621654 0.73 ENSDART00000002595
rpl21
ribosomal protein L21
chr10_+_18952271 0.72 ENSDART00000146517
dpysl2b
dihydropyrimidinase-like 2b
chr23_-_23401305 0.71 ENSDART00000078936
her9
hairy-related 9
chr6_+_52350443 0.71 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
si:ch211-239j9.1
chr14_-_24391424 0.70 ENSDART00000113376
ENSDART00000126894
fam13b
family with sequence similarity 13, member B
chr7_+_26029672 0.69 ENSDART00000101126
alox12
arachidonate 12-lipoxygenase
chr23_+_31405497 0.69 ENSDART00000053546
sh3bgrl2
SH3 domain binding glutamate-rich protein like 2
chr2_+_16160906 0.69 ENSDART00000135783
selenoj
selenoprotein J
chr17_-_29224908 0.67 ENSDART00000156288
si:dkey-28g23.6
si:dkey-28g23.6
chr7_+_19495905 0.67 ENSDART00000125584
ENSDART00000173774
si:ch211-212k18.8
si:ch211-212k18.8
chr5_-_2282256 0.66 ENSDART00000064012
ca4a
carbonic anhydrase IV a
chr8_-_13574764 0.66 ENSDART00000076561
B3GNT3 (1 of many)
si:ch211-126g16.10
chr12_-_558201 0.65 ENSDART00000168586
ENSDART00000158355
bsk146
brain specific kinase 146
chr24_-_38657683 0.64 ENSDART00000154843
si:ch1073-164k15.3
si:ch1073-164k15.3
chr1_-_54063520 0.63 ENSDART00000171722
smdt1b
single-pass membrane protein with aspartate-rich tail 1b
chr9_+_18716485 0.63 ENSDART00000135125
serp2
stress-associated endoplasmic reticulum protein family member 2
chr12_+_13282797 0.62 ENSDART00000137757
ENSDART00000152397
irf9
interferon regulatory factor 9
chr13_-_31452516 0.61 ENSDART00000193268
rtn1a
reticulon 1a
chr20_+_7584211 0.61 ENSDART00000132481
ENSDART00000127975
ENSDART00000144551
bloc1s2
biogenesis of lysosomal organelles complex-1, subunit 2
chr19_+_43359075 0.61 ENSDART00000148287
ENSDART00000149856
ENSDART00000188236
ENSDART00000136695
ENSDART00000193859
yrk
Yes-related kinase
chr5_-_54672763 0.60 ENSDART00000159009
spag8
sperm associated antigen 8
chr19_+_43780970 0.60 ENSDART00000063870
rpl11
ribosomal protein L11
chr19_-_26869103 0.59 ENSDART00000089699
prrt1
proline-rich transmembrane protein 1
chr4_-_5302866 0.58 ENSDART00000138590
SNAP91 (1 of many)
si:ch211-214j24.9
chr8_+_26141680 0.58 ENSDART00000078334
celsr3
cadherin, EGF LAG seven-pass G-type receptor 3
chr16_+_28728347 0.57 ENSDART00000149240
si:dkey-24i24.3
si:dkey-24i24.3
chr15_-_20939579 0.57 ENSDART00000152371
usp2a
ubiquitin specific peptidase 2a
chr23_-_20051369 0.57 ENSDART00000049836
bgnb
biglycan b
chr22_-_13851297 0.56 ENSDART00000080306
s100b
S100 calcium binding protein, beta (neural)
chr23_-_6522099 0.56 ENSDART00000092214
ENSDART00000183380
ENSDART00000138020
bmp7b
bone morphogenetic protein 7b
chr7_+_26534131 0.56 ENSDART00000173980
si:dkey-62k3.5
si:dkey-62k3.5
chr6_-_54815886 0.55 ENSDART00000180793
ENSDART00000007498
tnni1b
troponin I type 1b (skeletal, slow)
chr8_+_28259347 0.54 ENSDART00000110857
fam212b
family with sequence similarity 212, member B
chr3_+_23092762 0.54 ENSDART00000142884
ENSDART00000024136
gngt2a
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2a
chr11_+_11974708 0.54 ENSDART00000125060
zgc:64002
zgc:64002
chr11_+_30057762 0.53 ENSDART00000164139
nhsb
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr11_+_40812590 0.53 ENSDART00000186690
errfi1a
ERBB receptor feedback inhibitor 1a
chr3_-_19368435 0.53 ENSDART00000132987
s1pr5a
sphingosine-1-phosphate receptor 5a
chr14_-_17072736 0.53 ENSDART00000106333
phox2bb
paired-like homeobox 2bb
chr16_+_28932038 0.53 ENSDART00000149480
npr1b
natriuretic peptide receptor 1b
chr4_+_22480169 0.52 ENSDART00000146272
ENSDART00000066904
ndufb2
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2
chr17_-_12336987 0.52 ENSDART00000172001
snap25b
synaptosomal-associated protein, 25b
chr20_+_4060839 0.52 ENSDART00000178565
TRIM67
tripartite motif containing 67
chr13_-_31622195 0.51 ENSDART00000057432
six1a
SIX homeobox 1a
chr22_-_10121880 0.50 ENSDART00000002348
rdh5
retinol dehydrogenase 5 (11-cis/9-cis)
chr16_-_12173554 0.50 ENSDART00000110567
ENSDART00000155935
clstn3
calsyntenin 3
chr1_+_51721851 0.50 ENSDART00000040397
prdx2
peroxiredoxin 2
chr1_+_5402476 0.50 ENSDART00000040204
tuba8l2
tubulin, alpha 8 like 2
chr21_-_20939488 0.50 ENSDART00000039043
rgs7bpb
regulator of G protein signaling 7 binding protein b
chr19_+_10339538 0.50 ENSDART00000151808
ENSDART00000151235
rcvrn3
recoverin 3
chr3_-_36839115 0.49 ENSDART00000154553
ramp2
receptor (G protein-coupled) activity modifying protein 2
chr8_+_24745041 0.48 ENSDART00000148872
slc16a4
solute carrier family 16, member 4
chr1_+_25801648 0.48 ENSDART00000129471
gucy1b1
guanylate cyclase 1 soluble subunit beta 1
chr25_+_31227747 0.48 ENSDART00000033872
tnni2a.1
troponin I type 2a (skeletal, fast), tandem duplicate 1
chr11_+_43419809 0.48 ENSDART00000172982
slc29a1b
solute carrier family 29 (equilibrative nucleoside transporter), member 1b
chr16_-_28878080 0.47 ENSDART00000149501
si:dkey-239n17.4
si:dkey-239n17.4
chr9_+_7724152 0.47 ENSDART00000061716
mnx2a
motor neuron and pancreas homeobox 2a
chr15_-_46779934 0.47 ENSDART00000085136
clcn2c
chloride channel 2c
chr8_-_2434282 0.47 ENSDART00000137262
ENSDART00000134044
vdac3
voltage-dependent anion channel 3
chr23_+_45512825 0.46 ENSDART00000064846
prelid1b
PRELI domain containing 1b
chr21_+_22840246 0.46 ENSDART00000151621
birc2
baculoviral IAP repeat containing 2
chr3_+_38540411 0.45 ENSDART00000154943
si:dkey-7f16.3
si:dkey-7f16.3
chr24_+_9475809 0.44 ENSDART00000132688
si:ch211-285f17.1
si:ch211-285f17.1
chr13_-_2010191 0.43 ENSDART00000161021
ENSDART00000124134
gfral
GDNF family receptor alpha like
chr22_+_30331414 0.43 ENSDART00000133482
BX649448.3

chr21_-_25522510 0.43 ENSDART00000162711
cnksr2b
connector enhancer of kinase suppressor of Ras 2b
chr4_+_25654686 0.43 ENSDART00000100714
acot16
acyl-CoA thioesterase 16
chr1_+_44127292 0.42 ENSDART00000160542
cabp2a
calcium binding protein 2a
chr18_+_24919614 0.42 ENSDART00000008638
rgma
repulsive guidance molecule family member a
chr16_+_11992498 0.41 ENSDART00000143442
p3h3
prolyl 3-hydroxylase 3
chr21_+_19635486 0.41 ENSDART00000185736
fgf10a
fibroblast growth factor 10a
chr1_-_9980765 0.41 ENSDART00000142906
si:dkeyp-75b4.7
si:dkeyp-75b4.7
chr16_+_12836143 0.41 ENSDART00000067741
cacng6b
calcium channel, voltage-dependent, gamma subunit 6b
chr1_-_31534089 0.41 ENSDART00000007770
lbx1b
ladybird homeobox 1b
chr10_-_33621739 0.41 ENSDART00000142655
ENSDART00000128049
hunk
hormonally up-regulated Neu-associated kinase
chr22_-_31060579 0.41 ENSDART00000182376
cand2
cullin-associated and neddylation-dissociated 2 (putative)
chr23_-_18913032 0.41 ENSDART00000136678
si:ch211-209j10.6
si:ch211-209j10.6
chr6_+_6797520 0.40 ENSDART00000150967
si:ch211-85n16.3
si:ch211-85n16.3
chr6_-_50704689 0.40 ENSDART00000074100
osgn1
oxidative stress induced growth inhibitor 1
chr2_+_20406399 0.40 ENSDART00000006817
ENSDART00000137848
palmda
palmdelphin a
chr8_+_8845932 0.39 ENSDART00000112028
si:ch211-180f4.1
si:ch211-180f4.1
chr1_+_13087797 0.39 ENSDART00000170314
si:dkey-5n7.2
si:dkey-5n7.2
chr3_-_19200571 0.39 ENSDART00000131503
ENSDART00000012335
rfx1a
regulatory factor X, 1a (influences HLA class II expression)
chr16_+_36671064 0.38 ENSDART00000109703
col6a4a
collagen, type VI, alpha 4a
chr5_-_42083363 0.37 ENSDART00000162596
cxcl11.5
chemokine (C-X-C motif) ligand 11, duplicate 5
chr2_-_59327299 0.37 ENSDART00000133734
ftr36
finTRIM family, member 36
chr20_+_25225112 0.37 ENSDART00000153088
ENSDART00000127291
ENSDART00000130494
moxd1
monooxygenase, DBH-like 1
chr1_-_22757145 0.37 ENSDART00000134719
prom1b
prominin 1 b
chr1_+_31638274 0.36 ENSDART00000057885
fgf8b
fibroblast growth factor 8 b
chr11_+_30663300 0.36 ENSDART00000161662
ttbk1a
tau tubulin kinase 1a
chr10_-_35236949 0.35 ENSDART00000145804
ypel2a
yippee-like 2a
chr12_+_1139690 0.35 ENSDART00000160442
CABZ01072885.1

chr20_-_44557037 0.35 ENSDART00000140995
mfsd2b
major facilitator superfamily domain containing 2B
chr4_+_5255041 0.34 ENSDART00000137966
ccdc167
coiled-coil domain containing 167
chr5_-_65000312 0.34 ENSDART00000192893
ANXA1 (1 of many)
zgc:110283
chr19_-_32150078 0.34 ENSDART00000134934
ENSDART00000186410
ENSDART00000181780
pag1
phosphoprotein membrane anchor with glycosphingolipid microdomains 1
chr16_+_46401576 0.34 ENSDART00000130264
rpz
rapunzel
chr16_+_5408748 0.34 ENSDART00000160008
ENSDART00000014024
plecb
plectin b
chr12_+_39203745 0.34 ENSDART00000153661
si:dkeyp-106c3.2
si:dkeyp-106c3.2
chr22_-_5529241 0.34 ENSDART00000157893
CABZ01064968.1

chr8_+_52637507 0.34 ENSDART00000163830
si:dkey-90l8.3
si:dkey-90l8.3
chr17_-_32413147 0.34 ENSDART00000149102
grhl1
grainyhead-like transcription factor 1
chr18_+_39937225 0.34 ENSDART00000141136
si:ch211-282k23.2
si:ch211-282k23.2
chr16_+_9540033 0.33 ENSDART00000149574
ca14
carbonic anhydrase XIV
chr11_-_29737088 0.33 ENSDART00000159828
si:ch211-218g23.6
si:ch211-218g23.6
chr9_+_34127005 0.33 ENSDART00000167384
ENSDART00000078065
f5
coagulation factor V
chr20_+_7180298 0.33 ENSDART00000143026
si:dkeyp-51f12.2
si:dkeyp-51f12.2
chr7_+_65876335 0.33 ENSDART00000150143
tead1b
TEA domain family member 1b
chr2_-_59157790 0.32 ENSDART00000192303
ENSDART00000159362
ftr32
finTRIM family, member 32
chr2_+_20496223 0.32 ENSDART00000157931
agla
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase a
chr24_-_1151334 0.32 ENSDART00000039700
ENSDART00000177356
itgb1a
integrin, beta 1a
chr6_+_25257728 0.32 ENSDART00000162581
kyat3
kynurenine aminotransferase 3
chr6_-_28980756 0.31 ENSDART00000014661
glmnb
glomulin, FKBP associated protein b
chr11_-_45141309 0.31 ENSDART00000181736
cant1b
calcium activated nucleotidase 1b
chr13_+_7442023 0.31 ENSDART00000080975
tnfaip2b
tumor necrosis factor, alpha-induced protein 2b
chr15_-_18162647 0.31 ENSDART00000012064
pih1d2
PIH1 domain containing 2
chr16_-_12173399 0.31 ENSDART00000142574
clstn3
calsyntenin 3
chr7_+_21859337 0.31 ENSDART00000159626
si:dkey-85k7.7
si:dkey-85k7.7
chr17_+_16564921 0.30 ENSDART00000151904
foxn3
forkhead box N3
chr14_-_24081929 0.30 ENSDART00000158576
msx2a
muscle segment homeobox 2a
chr15_-_40157165 0.30 ENSDART00000192991
si:ch211-281l24.3
si:ch211-281l24.3
chr22_-_26865361 0.29 ENSDART00000182504
hmox2a
heme oxygenase 2a
chr10_+_31248036 0.29 ENSDART00000193574
robo4
roundabout, axon guidance receptor, homolog 4 (Drosophila)
chr3_+_26342768 0.29 ENSDART00000163832
si:ch211-156b7.4
si:ch211-156b7.4
chr5_-_42904329 0.29 ENSDART00000112807
cxcl20
chemokine (C-X-C motif) ligand 20
chr17_-_21418340 0.29 ENSDART00000007021
atp6v1ba
ATPase, H+ transporting, lysosomal, V1 subunit B, member a
chr6_+_40714811 0.29 ENSDART00000153868
ccdc36
coiled-coil domain containing 36
chr6_+_58832323 0.29 ENSDART00000042595
dctn2
dynactin 2 (p50)
chr17_+_24851951 0.29 ENSDART00000180746
cx35.4
connexin 35.4
chr4_-_18309917 0.29 ENSDART00000189084
plxnc1
plexin C1
chr1_-_22512063 0.29 ENSDART00000031546
ENSDART00000190987
chrna6
cholinergic receptor, nicotinic, alpha 6
chr20_+_11731039 0.28 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
si:ch211-155o21.3
chr18_-_47662696 0.28 ENSDART00000184260
CABZ01073963.1

chr5_+_65536095 0.28 ENSDART00000189898
si:dkey-21e5.1
si:dkey-21e5.1
chr3_+_23029934 0.28 ENSDART00000110343
nags
N-acetylglutamate synthase
chr24_-_7995960 0.28 ENSDART00000186594
bloc1s5
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr9_+_55154414 0.28 ENSDART00000182924
ANOS1
anosmin 1
chr10_+_2742499 0.28 ENSDART00000122847
grk5
G protein-coupled receptor kinase 5
chr14_+_4807207 0.28 ENSDART00000167145
ap1ar
adaptor-related protein complex 1 associated regulatory protein
chr15_-_40157331 0.28 ENSDART00000187958
si:ch211-281l24.3
si:ch211-281l24.3
chr12_+_31735159 0.28 ENSDART00000185442
RNF157
si:dkey-49c17.3
chr13_+_24756486 0.27 ENSDART00000137074
col17a1b
collagen, type XVII, alpha 1b

Network of associatons between targets according to the STRING database.

First level regulatory network of pou1f1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0045988 regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
0.4 1.3 GO:0008292 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.3 1.3 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.3 0.8 GO:0005986 sucrose metabolic process(GO:0005985) sucrose biosynthetic process(GO:0005986) disaccharide biosynthetic process(GO:0046351)
0.2 0.9 GO:0032875 regulation of DNA endoreduplication(GO:0032875) positive regulation of DNA endoreduplication(GO:0032877) DNA endoreduplication(GO:0042023)
0.2 1.6 GO:0034434 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.2 0.9 GO:0052651 phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.2 1.1 GO:0009136 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.1 0.4 GO:0010265 SCF complex assembly(GO:0010265)
0.1 0.5 GO:0061549 sympathetic ganglion development(GO:0061549)
0.1 0.5 GO:0014856 skeletal muscle cell proliferation(GO:0014856) regulation of skeletal muscle cell proliferation(GO:0014857)
0.1 0.4 GO:0042420 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.1 0.5 GO:0099548 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
0.1 0.5 GO:0060547 negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.1 2.6 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 0.9 GO:0030279 negative regulation of ossification(GO:0030279)
0.1 0.4 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.4 GO:0061033 lung growth(GO:0060437) secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.1 1.8 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 0.3 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.1 0.8 GO:0021588 cerebellum formation(GO:0021588)
0.1 0.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 0.5 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
0.1 0.4 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 0.4 GO:1902514 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.1 0.5 GO:0015862 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.1 0.8 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.3 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.1 0.6 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.1 0.3 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.1 0.4 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.2 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.4 GO:0006788 heme oxidation(GO:0006788)
0.1 0.7 GO:0051121 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1 0.2 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.1 1.2 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.5 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.1 0.5 GO:1990748 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.5 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 1.3 GO:0000302 response to reactive oxygen species(GO:0000302)
0.0 1.0 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.5 GO:0036368 cone photoresponse recovery(GO:0036368)
0.0 0.8 GO:0021654 rhombomere boundary formation(GO:0021654)
0.0 0.7 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 0.3 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.8 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.8 GO:0006183 GTP biosynthetic process(GO:0006183)
0.0 0.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.6 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.9 GO:0030497 fatty acid elongation(GO:0030497)
0.0 4.8 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.3 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.1 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.0 0.1 GO:0051876 pigment granule dispersal(GO:0051876)
0.0 0.3 GO:0030719 P granule organization(GO:0030719)
0.0 0.3 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.0 0.3 GO:0051601 exocyst localization(GO:0051601)
0.0 0.2 GO:0048730 epidermis morphogenesis(GO:0048730)
0.0 1.2 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.3 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 2.2 GO:0014904 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0 0.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 0.6 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 0.6 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 0.3 GO:0042119 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0 0.5 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 1.0 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.3 GO:1903672 positive regulation of sprouting angiogenesis(GO:1903672)
0.0 0.1 GO:0070572 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.8 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.3 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.9 GO:0030282 bone mineralization(GO:0030282)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0046958 nonassociative learning(GO:0046958) habituation(GO:0046959)
0.0 1.0 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.2 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.8 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.0 GO:0071706 tumor necrosis factor production(GO:0032640) tumor necrosis factor superfamily cytokine production(GO:0071706)
0.0 0.3 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.8 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.0 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.0 0.6 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.3 GO:0035329 hippo signaling(GO:0035329)
0.0 0.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.4 GO:0044259 collagen metabolic process(GO:0032963) multicellular organismal macromolecule metabolic process(GO:0044259)
0.0 0.2 GO:1990798 pancreas regeneration(GO:1990798)
0.0 0.2 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0031673 H zone(GO:0031673)
0.2 2.5 GO:0005869 dynactin complex(GO:0005869)
0.1 0.9 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.5 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 0.3 GO:0097255 R2TP complex(GO:0097255)
0.1 0.9 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.6 GO:1990246 uniplex complex(GO:1990246)
0.0 0.4 GO:0071914 prominosome(GO:0071914)
0.0 0.2 GO:0030891 VCB complex(GO:0030891)
0.0 0.2 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 1.0 GO:0005861 troponin complex(GO:0005861)
0.0 1.3 GO:0030426 growth cone(GO:0030426)
0.0 1.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 0.5 GO:0046930 pore complex(GO:0046930)
0.0 0.3 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.4 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.1 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.0 0.5 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.5 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.1 GO:0005882 intermediate filament(GO:0005882)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.3 1.0 GO:0001605 adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635)
0.3 2.6 GO:0016936 galactoside binding(GO:0016936)
0.3 0.8 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.2 0.9 GO:0018812 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.2 2.0 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.4 GO:0034618 arginine binding(GO:0034618)
0.1 0.6 GO:0044548 S100 protein binding(GO:0044548)
0.1 2.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.8 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.1 0.4 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.1 0.9 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.1 0.9 GO:0036122 BMP binding(GO:0036122)
0.1 0.8 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.1 0.3 GO:0055105 ubiquitin-protein transferase inhibitor activity(GO:0055105)
0.1 0.4 GO:0031544 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.1 1.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.5 GO:0015288 porin activity(GO:0015288)
0.1 1.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 0.3 GO:0004135 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.1 1.2 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.3 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.1 0.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.5 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.5 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.5 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 0.8 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.3 GO:0098634 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.4 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.1 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.3 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.1 0.6 GO:0070700 BMP receptor binding(GO:0070700)
0.1 4.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.0 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.9 GO:0015026 coreceptor activity(GO:0015026)
0.0 1.0 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 0.1 GO:0019777 Atg12 transferase activity(GO:0019777)
0.0 0.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.1 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.0 0.8 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 1.0 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.5 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.3 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.1 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247) voltage-gated anion channel activity(GO:0008308)
0.0 0.3 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 1.0 GO:0043022 ribosome binding(GO:0043022)
0.0 0.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.2 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.4 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.3 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.1 GO:0008506 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.4 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.1 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 1.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.3 GO:0019894 kinesin binding(GO:0019894)
0.0 0.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.3 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.5 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 1.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 0.6 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 1.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.1 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.2 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER