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PRJNA195909:zebrafish embryo and larva development

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Results for pou5f3

Z-value: 0.52

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Transcription factors associated with pou5f3

Gene Symbol Gene ID Gene Info
pou5f3
ENSDARG00000044774 POU domain, class 5, transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pou5f3dr11_v1_chr21_-_13690712_136907120.665.3e-02Click!

Activity profile of pou5f3 motif

Sorted Z-values of pou5f3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_41038141 1.47 ENSDART00000075620
gpat2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr8_+_41037541 1.28 ENSDART00000129344
gpat2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr1_-_55068941 1.06 ENSDART00000152143
ENSDART00000152590
peli1a
pellino E3 ubiquitin protein ligase 1a
chr5_-_30074332 1.06 ENSDART00000147963
bco2a
beta-carotene oxygenase 2a
chr7_+_33424044 0.99 ENSDART00000180260
glceb
glucuronic acid epimerase b
chr10_-_44560165 0.96 ENSDART00000181217
ENSDART00000076084
npm2b
nucleophosmin/nucleoplasmin, 2b
chr9_-_2945008 0.88 ENSDART00000183452
zak
sterile alpha motif and leucine zipper containing kinase AZK
chr24_-_20641000 0.83 ENSDART00000166135
zbtb47b
zinc finger and BTB domain containing 47b
chr8_-_44238526 0.68 ENSDART00000061115
ENSDART00000132473
ENSDART00000138019
ENSDART00000133021
piwil1
piwi-like RNA-mediated gene silencing 1
chr23_-_33709964 0.59 ENSDART00000143333
ENSDART00000130338
pou6f1
POU class 6 homeobox 1
chr8_+_7740004 0.54 ENSDART00000170184
ENSDART00000187811
fgd1
FYVE, RhoGEF and PH domain containing 1
chr7_-_24644893 0.53 ENSDART00000048921
rgp1
GP1 homolog, RAB6A GEF complex partner 1
chr4_+_6869847 0.53 ENSDART00000036646
dock4b
dedicator of cytokinesis 4b
chr11_-_36001495 0.51 ENSDART00000190330
itpr1b
inositol 1,4,5-trisphosphate receptor, type 1b
chr16_-_31351419 0.49 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1
chr7_-_72155022 0.46 ENSDART00000187984
zmp:0000001168
zmp:0000001168
chr17_+_28670132 0.40 ENSDART00000076344
ENSDART00000164981
ENSDART00000182851
hectd1
HECT domain containing 1
chr24_+_7322116 0.36 ENSDART00000005804
XRCC2
X-ray repair cross complementing 2
chr18_-_8030073 0.35 ENSDART00000151490
shank3a
SH3 and multiple ankyrin repeat domains 3a
chr8_-_22698651 0.35 ENSDART00000181411
iqsec2a
IQ motif and Sec7 domain 2a
chr7_+_58843700 0.30 ENSDART00000159500
ENSDART00000158436
lypla1
lysophospholipase I
chr4_-_8903240 0.29 ENSDART00000129983
mpped1
metallophosphoesterase domain containing 1
chr6_-_55399214 0.29 ENSDART00000168367
ctsa
cathepsin A
chr9_+_12444494 0.28 ENSDART00000102430
tmem41aa
transmembrane protein 41aa
chr18_+_20838786 0.23 ENSDART00000138692
ttc23
tetratricopeptide repeat domain 23
chr2_-_20120904 0.16 ENSDART00000186002
ENSDART00000124724
dpydb
dihydropyrimidine dehydrogenase b
chr25_+_26923193 0.13 ENSDART00000187364
grm8b
glutamate receptor, metabotropic 8b
chr13_+_31172833 0.10 ENSDART00000176378
CR931802.3

chr5_+_29715040 0.09 ENSDART00000192563
ddx31
DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
chr20_-_34868814 0.08 ENSDART00000153049
stmn4
stathmin-like 4

Network of associatons between targets according to the STRING database.

First level regulatory network of pou5f3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.8 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.2 1.1 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.1 1.1 GO:0016121 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.1 0.7 GO:0035093 spermatid nucleus differentiation(GO:0007289) regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 1.0 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1 1.0 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.1 0.2 GO:0046125 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.0 0.3 GO:2000463 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.3 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.5 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.5 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 0.5 GO:0046847 filopodium assembly(GO:0046847)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.5 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.7 GO:0043186 P granule(GO:0043186)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.8 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.2 1.0 GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity(GO:0047464)
0.1 1.1 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.1 0.7 GO:0034584 piRNA binding(GO:0034584)
0.1 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0002061 uracil binding(GO:0002058) pyrimidine nucleobase binding(GO:0002061) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
0.0 0.1 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.0 0.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.3 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK