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PRJNA195909:zebrafish embryo and larva development

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Results for prox1a+prox2+prox3

Z-value: 0.64

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Transcription factors associated with prox1a+prox2+prox3

Gene Symbol Gene ID Gene Info
prox2
ENSDARG00000041952 prospero homeobox 2
prox1a
ENSDARG00000055158 prospero homeobox 1a
prox3
ENSDARG00000088810 prospero homeobox 3
prox3
ENSDARG00000113014 prospero homeobox 3
prox2
ENSDARG00000117137 prospero homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
prox2dr11_v1_chr17_-_52521002_525210020.363.5e-01Click!
prox1bdr11_v1_chr7_-_19940473_199404730.304.3e-01Click!
prox1adr11_v1_chr17_-_32865788_328657880.245.4e-01Click!

Activity profile of prox1a+prox2+prox3 motif

Sorted Z-values of prox1a+prox2+prox3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_29952169 1.02 ENSDART00000173540
ENSDART00000173940
ENSDART00000173906
ENSDART00000173772
ENSDART00000173506
ENSDART00000039657
tpma
alpha-tropomyosin
chr7_+_29951997 0.82 ENSDART00000173453
tpma
alpha-tropomyosin
chr10_-_31782616 0.63 ENSDART00000128839
fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr9_-_23033818 0.62 ENSDART00000022392
rnd3b
Rho family GTPase 3b
chr2_+_2470687 0.61 ENSDART00000184024
ENSDART00000061955
myl13
myosin, light chain 13
chr1_+_44442140 0.52 ENSDART00000190592
crybb1l2
crystallin, beta B1, like 2
chr15_+_32711663 0.45 ENSDART00000157854
ENSDART00000167515
postnb
periostin, osteoblast specific factor b
chr2_+_25658112 0.42 ENSDART00000051234
tnika
TRAF2 and NCK interacting kinase a
chr19_+_42886413 0.39 ENSDART00000151298
arpp21
cAMP-regulated phosphoprotein, 21
chr9_-_42696408 0.38 ENSDART00000144744
col5a2a
collagen, type V, alpha 2a
chr3_-_59981162 0.38 ENSDART00000128790
cdr2l
cerebellar degeneration-related protein 2-like
chr25_+_22587306 0.36 ENSDART00000067479
stra6
stimulated by retinoic acid 6
chr20_-_40717900 0.34 ENSDART00000181663
cx43
connexin 43
chr11_-_24681292 0.31 ENSDART00000089601
olfml3b
olfactomedin-like 3b
chr23_+_35672542 0.30 ENSDART00000046268
pmelb
premelanosome protein b
chr19_+_46372115 0.30 ENSDART00000163935
med30
mediator complex subunit 30
chr5_+_27440325 0.29 ENSDART00000185815
ENSDART00000144013
loxl2b
lysyl oxidase-like 2b
chr21_-_13972745 0.29 ENSDART00000143874
akna
AT-hook transcription factor
chr19_-_21766461 0.28 ENSDART00000104279
znf516
zinc finger protein 516
chr15_+_32249062 0.26 ENSDART00000133867
ENSDART00000152545
ENSDART00000082315
ENSDART00000152513
ENSDART00000152139
arfip2a
ADP-ribosylation factor interacting protein 2a
chr6_+_3934738 0.25 ENSDART00000159673
dync1i2b
dynein, cytoplasmic 1, intermediate chain 2b
chr11_-_23219367 0.25 ENSDART00000003646
optc
opticin
chr12_-_31422433 0.25 ENSDART00000186075
ENSDART00000153172
ENSDART00000066256
vti1a
vesicle transport through interaction with t-SNAREs 1A
chr17_-_5583345 0.24 ENSDART00000035944
clic5a
chloride intracellular channel 5a
chr12_-_23365737 0.24 ENSDART00000170376
mpp7a
membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7)
chr21_+_22124736 0.24 ENSDART00000130179
ENSDART00000172573
cul5b
cullin 5b
chr1_-_59065217 0.24 ENSDART00000188972
CABZ01080042.1

chr3_+_22578369 0.22 ENSDART00000187695
ENSDART00000182678
ENSDART00000112270
tanc2a
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2a
chr12_+_27117609 0.22 ENSDART00000076154
hoxb8b
homeobox B8b
chr23_+_36118738 0.22 ENSDART00000139319
hoxc5a
homeobox C5a
chr5_-_62306819 0.22 ENSDART00000168993
spata22
spermatogenesis associated 22
chr9_+_21401189 0.21 ENSDART00000062669
cx30.3
connexin 30.3
chr23_+_16889352 0.21 ENSDART00000145275
si:dkey-147f3.8
si:dkey-147f3.8
chr2_+_6885852 0.20 ENSDART00000016607
rgs5b
regulator of G protein signaling 5b
chr2_+_50722439 0.20 ENSDART00000188927
fyco1b
FYVE and coiled-coil domain containing 1b
chr15_-_23475051 0.19 ENSDART00000152460
nlrx1
NLR family member X1
chr17_+_15674052 0.18 ENSDART00000156726
bach2a
BTB and CNC homology 1, basic leucine zipper transcription factor 2a
chr23_+_13124085 0.18 ENSDART00000139475
samd10b
sterile alpha motif domain containing 10b
chr14_+_9287683 0.17 ENSDART00000122485
msnb
moesin b
chr3_+_21200763 0.15 ENSDART00000067841
zgc:112038
zgc:112038
chr8_-_47800754 0.15 ENSDART00000115050
ENSDART00000133669
kank3
KN motif and ankyrin repeat domains 3
chr19_-_13950231 0.15 ENSDART00000168665
sh3bgrl3
SH3 domain binding glutamate-rich protein like 3
chr1_-_9485939 0.15 ENSDART00000157814
micall2b
mical-like 2b
chr1_-_9486214 0.14 ENSDART00000137821
micall2b
mical-like 2b
chr23_+_216012 0.14 ENSDART00000181115
ENSDART00000004678
ENSDART00000190439
ENSDART00000189322
PDZD4
si:ch73-162j3.4
chr23_+_45845423 0.13 ENSDART00000183404
lmnl3
lamin L3
chr19_-_31042570 0.13 ENSDART00000144337
ENSDART00000136213
ENSDART00000133101
ENSDART00000190949
bzw2
basic leucine zipper and W2 domains 2
chr7_+_57866292 0.13 ENSDART00000138757
camk2d1
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr23_+_21663631 0.13 ENSDART00000066125
dhrs3a
dehydrogenase/reductase (SDR family) member 3a
chr10_+_43037064 0.11 ENSDART00000160159
atg10
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr16_+_39196727 0.10 ENSDART00000017017
zdhhc3a
zinc finger, DHHC-type containing 3a
chr19_-_22621811 0.10 ENSDART00000090669
pleca
plectin a
chr8_+_47219107 0.10 ENSDART00000146018
ENSDART00000075068
mthfr
methylenetetrahydrofolate reductase (NAD(P)H)
chr14_-_30971264 0.10 ENSDART00000010512
zgc:92907
zgc:92907
chr8_+_11325310 0.09 ENSDART00000142577
fxn
frataxin
chr5_+_13870340 0.08 ENSDART00000160690
hk2
hexokinase 2
chr23_-_13877898 0.07 ENSDART00000138696
g6pd
glucose-6-phosphate dehydrogenase
chr25_+_8407892 0.07 ENSDART00000153536
muc5.2
mucin 5.2
chr10_-_38316134 0.07 ENSDART00000149580
nrip1b
nuclear receptor interacting protein 1b
chr4_+_20177526 0.07 ENSDART00000017947
ENSDART00000135451
ccdc146
coiled-coil domain containing 146
chr6_+_11250033 0.07 ENSDART00000065411
ENSDART00000132677
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr5_+_22510639 0.07 ENSDART00000080919
rpl36a
ribosomal protein L36A
chr10_+_29431529 0.07 ENSDART00000158154
dlg2
discs, large homolog 2 (Drosophila)
chrM_+_9052 0.06 ENSDART00000093612
mt-atp6
ATP synthase 6, mitochondrial
chr7_-_44604540 0.06 ENSDART00000149186
tk2
thymidine kinase 2, mitochondrial
chr7_-_44605050 0.06 ENSDART00000148471
ENSDART00000149072
tk2
thymidine kinase 2, mitochondrial
chr7_+_19562045 0.06 ENSDART00000077545
slc7a7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr17_-_20979077 0.06 ENSDART00000006676
phyhipla
phytanoyl-CoA 2-hydroxylase interacting protein-like a
chr10_-_20637098 0.06 ENSDART00000080391
sprn2
shadow of prion protein 2
chr20_-_54014373 0.06 ENSDART00000152934
si:dkey-241l7.6
si:dkey-241l7.6
chr6_-_34006917 0.05 ENSDART00000190702
ENSDART00000184003
tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr20_+_38201644 0.05 ENSDART00000022694
ehd3
EH-domain containing 3
chr8_+_2773776 0.05 ENSDART00000156796
ENSDART00000154529
ENSDART00000155092
sh3glb2a
SH3-domain GRB2-like endophilin B2a
chr19_+_19989380 0.05 ENSDART00000142841
osbpl3a
oxysterol binding protein-like 3a
chr8_-_49345388 0.05 ENSDART00000053203
plp2
proteolipid protein 2
chr18_-_44611252 0.04 ENSDART00000173095
spred3
sprouty-related, EVH1 domain containing 3
chr5_+_37517800 0.04 ENSDART00000048107
FP102018.1
Danio rerio latent transforming growth factor beta binding protein 3 (ltbp3), mRNA.
chr19_-_22621991 0.04 ENSDART00000175106
pleca
plectin a
chr17_+_48164536 0.03 ENSDART00000161750
ENSDART00000156923
plekhd1
pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
chr5_+_42136359 0.03 ENSDART00000083731
trpv1
transient receptor potential cation channel, subfamily V, member 1
chr5_-_69707787 0.03 ENSDART00000108820
ENSDART00000149692
dguok
deoxyguanosine kinase
chr8_+_30600386 0.03 ENSDART00000164976
specc1la
sperm antigen with calponin homology and coiled-coil domains 1-like a
chr3_+_22335030 0.03 ENSDART00000055676
zgc:103564
zgc:103564
chr21_+_21791343 0.03 ENSDART00000151654
neu3.1
sialidase 3 (membrane sialidase), tandem duplicate 1
chr17_-_10059557 0.03 ENSDART00000092209
ENSDART00000161243
baz1a
bromodomain adjacent to zinc finger domain, 1A
chr18_+_16750080 0.03 ENSDART00000136320
rnf141
ring finger protein 141
chr24_-_18809433 0.03 ENSDART00000152009
arfgef1
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
chr1_-_37087966 0.02 ENSDART00000172111
ENSDART00000160056
nr3c2
nuclear receptor subfamily 3, group C, member 2
chr15_+_31735931 0.02 ENSDART00000185681
ENSDART00000149137
rxfp2b
relaxin/insulin-like family peptide receptor 2b
chr10_-_36254445 0.02 ENSDART00000123571
or110-2
odorant receptor, family D, subfamily 110, member 2
chr10_+_7719796 0.02 ENSDART00000191795
ggcx
gamma-glutamyl carboxylase
chr17_-_37195354 0.02 ENSDART00000190963
asxl2
additional sex combs like transcriptional regulator 2
chr22_+_17286841 0.01 ENSDART00000133176
FAM163A
si:dkey-171o17.8
chr7_+_7019911 0.01 ENSDART00000172421
rbm14b
RNA binding motif protein 14b
chr25_+_19947298 0.01 ENSDART00000067648
kcna6a
potassium voltage-gated channel, shaker-related, subfamily, member 6 a
chr17_+_5616826 0.00 ENSDART00000178720
fam167aa
family with sequence similarity 167, member Aa
chr15_-_31177324 0.00 ENSDART00000008854
wsb1
WD repeat and SOCS box containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of prox1a+prox2+prox3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.1 0.2 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.1 0.4 GO:0071939 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.0 0.2 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.5 GO:0016203 muscle attachment(GO:0016203)
0.0 1.9 GO:0061515 myeloid cell development(GO:0061515)
0.0 0.3 GO:0032438 melanosome organization(GO:0032438)
0.0 0.3 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.9 GO:0005884 actin filament(GO:0005884)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0034632 retinol transporter activity(GO:0034632)
0.0 0.1 GO:0019777 Atg12 transferase activity(GO:0019777)
0.0 0.1 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0 0.1 GO:0019107 myristoyltransferase activity(GO:0019107)
0.0 0.3 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.1 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 1.7 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.1 GO:0016530 metallochaperone activity(GO:0016530)