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PRJNA195909:zebrafish embryo and larva development

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Results for rest

Z-value: 6.93

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Transcription factors associated with rest

Gene Symbol Gene ID Gene Info
rest
ENSDARG00000103046 Danio rerio RE1-silencing transcription factor (rest), mRNA.

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
restdr11_v1_chr14_-_52433292_52433292-0.932.7e-04Click!

Activity profile of rest motif

Sorted Z-values of rest motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_17676745 22.01 ENSDART00000030665
slc25a4
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr25_-_22639133 19.10 ENSDART00000073583
islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr20_+_34913069 17.55 ENSDART00000007584
snap25a
synaptosomal-associated protein, 25a
chr21_+_6751405 15.73 ENSDART00000037265
ENSDART00000146371
olfm1b
olfactomedin 1b
chr21_+_6751760 15.55 ENSDART00000135914
olfm1b
olfactomedin 1b
chr17_-_12385308 14.31 ENSDART00000080927
snap25b
synaptosomal-associated protein, 25b
chr1_+_10720294 13.29 ENSDART00000139387
atp1b1b
ATPase Na+/K+ transporting subunit beta 1b
chr21_+_11468934 13.00 ENSDART00000126045
ENSDART00000129744
ENSDART00000102368
grin1a
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr7_+_23907692 12.70 ENSDART00000045479
syt4
synaptotagmin IV
chr19_-_19339285 12.23 ENSDART00000158413
ENSDART00000170479
cspg5b
chondroitin sulfate proteoglycan 5b
chr25_+_5035343 11.91 ENSDART00000011751
parvb
parvin, beta
chr7_+_40228422 11.10 ENSDART00000052222
ptprn2
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr3_+_33341640 11.06 ENSDART00000186352
pyya
peptide YYa
chr3_+_33340939 10.47 ENSDART00000128786
pyya
peptide YYa
chr15_+_36156986 10.05 ENSDART00000059791
sst1.1
somatostatin 1, tandem duplicate 1
chr13_+_23282549 10.03 ENSDART00000101134
khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr4_-_5302162 9.50 ENSDART00000177099
SNAP91 (1 of many)
si:ch211-214j24.9
chr7_-_32833153 9.25 ENSDART00000099871
ENSDART00000099872
slc17a6b
solute carrier family 17 (vesicular glutamate transporter), member 6b
chr22_-_25033105 9.16 ENSDART00000124220
nptxrb
neuronal pentraxin receptor b
chr10_+_21588002 8.90 ENSDART00000100596
pcdh1a6
protocadherin 1 alpha 6
chr7_+_26224211 8.87 ENSDART00000173999
vgf
VGF nerve growth factor inducible
chr5_-_26093945 8.73 ENSDART00000010199
ENSDART00000145096
fam219ab
family with sequence similarity 219, member Ab
chr4_-_5302866 8.73 ENSDART00000138590
SNAP91 (1 of many)
si:ch211-214j24.9
chr19_+_26718074 8.29 ENSDART00000134455
zgc:100906
zgc:100906
chr9_-_34915351 8.25 ENSDART00000100728
ENSDART00000139608
upf3a
UPF3A, regulator of nonsense mediated mRNA decay
chr12_+_24342303 8.24 ENSDART00000111239
nrxn1a
neurexin 1a
chr23_-_30785382 8.20 ENSDART00000136156
ENSDART00000131285
myt1a
myelin transcription factor 1a
chr15_-_22147860 8.17 ENSDART00000149784
scn3b
sodium channel, voltage-gated, type III, beta
chr21_+_11468642 8.12 ENSDART00000041869
grin1a
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr25_-_31863374 8.08 ENSDART00000028338
scamp5a
secretory carrier membrane protein 5a
chr23_-_17657348 8.08 ENSDART00000054736
bhlhe23
basic helix-loop-helix family, member e23
chr10_+_21807497 8.07 ENSDART00000164634
pcdh1g32
protocadherin 1 gamma 32
chr6_+_41255485 8.01 ENSDART00000042683
ENSDART00000186013
cadpsb
Ca2+-dependent activator protein for secretion b
chr21_-_17482465 7.98 ENSDART00000004548
barhl1b
BarH-like homeobox 1b
chr7_+_17229980 7.93 ENSDART00000184910
slc6a5
solute carrier family 6 (neurotransmitter transporter), member 5
chr5_-_29643930 7.85 ENSDART00000161250
grin1b
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr5_+_71802014 7.84 ENSDART00000124939
ENSDART00000097164
LHX3
LIM homeobox 3
chr18_+_28988373 7.77 ENSDART00000018685
syt9a
synaptotagmin IXa
chr10_+_23022263 7.40 ENSDART00000138955
si:dkey-175g6.2
si:dkey-175g6.2
chr5_-_29643381 7.11 ENSDART00000034849
grin1b
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr1_+_54911458 7.01 ENSDART00000089603
golga7ba
golgin A7 family, member Ba
chr6_+_21740672 6.88 ENSDART00000193734
lhfpl4a
lipoma HMGIC fusion partner-like 4a
chr6_+_43903209 6.73 ENSDART00000006435
gpr27
G protein-coupled receptor 27
chr21_-_42100471 6.72 ENSDART00000166148
gabra1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr20_+_27020201 6.49 ENSDART00000126919
ENSDART00000016014
chga
chromogranin A
chr14_-_2264494 6.45 ENSDART00000191149
pcdh2ab9
protocadherin 2 alpha b 9
chr7_+_31879986 6.38 ENSDART00000138491
mybpc3
myosin binding protein C, cardiac
chr17_-_10249095 6.31 ENSDART00000159963
sstr1a
somatostatin receptor 1a
chr12_-_1951233 6.30 ENSDART00000005676
ENSDART00000127937
sox9a
SRY (sex determining region Y)-box 9a
chr14_-_1998501 6.17 ENSDART00000189052
pcdh2g5
protocadherin 2 gamma 5
chr19_-_43552252 6.16 ENSDART00000138308
gpr186
G protein-coupled receptor 186
chr10_-_29892486 6.15 ENSDART00000099983
bsx
brain-specific homeobox
chr14_-_2032753 5.98 ENSDART00000111335
pcdh2g5
protocadherin 2 gamma 5
chr11_+_77526 5.95 ENSDART00000193521
CABZ01072242.1

chr16_+_46148990 5.92 ENSDART00000083919
sv2a
synaptic vesicle glycoprotein 2A
chr7_+_17229282 5.68 ENSDART00000097982
slc6a5
solute carrier family 6 (neurotransmitter transporter), member 5
chr23_+_35759843 5.63 ENSDART00000047082
gdap1l1
ganglioside induced differentiation associated protein 1-like 1
chr25_+_35250976 5.62 ENSDART00000003494
slc17a6a
solute carrier family 17 (vesicular glutamate transporter), member 6a
chr5_-_29750377 5.22 ENSDART00000051474
barhl1a
BarH-like homeobox 1a
chr20_+_38724575 5.19 ENSDART00000015095
ENSDART00000152972
uts1
urotensin 1
chr15_-_47841259 5.03 ENSDART00000155384
kbtbd3
kelch repeat and BTB (POZ) domain containing 3
chr18_-_44611252 5.02 ENSDART00000173095
spred3
sprouty-related, EVH1 domain containing 3
chr18_+_50089000 4.60 ENSDART00000058936
scamp5b
secretory carrier membrane protein 5b
chr7_-_52876683 4.58 ENSDART00000172910
map1aa
microtubule-associated protein 1Aa
chr13_+_25846528 4.50 ENSDART00000087426
bcl11aa
B cell CLL/lymphoma 11Aa
chr14_-_1987121 4.41 ENSDART00000135733
pcdh2g5
protocadherin 2 gamma 5
chr3_-_26204867 4.41 ENSDART00000103748
gdpd3a
glycerophosphodiester phosphodiesterase domain containing 3a
chr6_-_43092175 4.30 ENSDART00000084389
lrrn1
leucine rich repeat neuronal 1
chr18_+_26337869 4.05 ENSDART00000109257
RASGRF1
si:ch211-234p18.3
chr19_-_42244358 4.01 ENSDART00000102697
cart4
cocaine- and amphetamine-regulated transcript 4
chr12_+_24561832 3.96 ENSDART00000088159
nrxn1a
neurexin 1a
chr7_-_69521481 3.93 ENSDART00000148465
slc1a1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr5_-_32092856 3.86 ENSDART00000086181
ENSDART00000181677
cabp7b
calcium binding protein 7b
chr18_+_36806545 3.74 ENSDART00000098958
ttc9b
tetratricopeptide repeat domain 9B
chr2_-_5776030 3.66 ENSDART00000133851
nyap2b
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2b
chr15_+_24212847 3.66 ENSDART00000155502
sez6b
seizure related 6 homolog b
chr14_-_1963369 3.65 ENSDART00000125521
pcdh2g5
protocadherin 2 gamma 5
chr14_-_2267515 3.47 ENSDART00000180988
ENSDART00000130712
pcdh2aa15
protocadherin 2 alpha a 15
chr1_-_38538284 3.45 ENSDART00000009777
glra3
glycine receptor, alpha 3
chr10_-_36927594 3.30 ENSDART00000162046
sez6a
seizure related 6 homolog a
chr23_+_45579497 3.26 ENSDART00000110381
egr4
early growth response 4
chr23_+_30859086 3.23 ENSDART00000053661
zgc:198371
zgc:198371
chr25_-_19443421 3.13 ENSDART00000067362
cart2
cocaine- and amphetamine-regulated transcript 2
chr14_-_2193248 2.87 ENSDART00000128659
pcdh2ab10
protocadherin 2 alpha b 10
chr6_-_30210378 2.69 ENSDART00000157359
ENSDART00000113924
lrrc7
leucine rich repeat containing 7
chr23_+_41800052 2.59 ENSDART00000141484
pdyn
prodynorphin
chr16_+_5539189 2.52 ENSDART00000178106
CR848788.2

chr23_+_40452157 2.38 ENSDART00000113106
ENSDART00000140136
soga3b
SOGA family member 3b
chr17_-_33552363 2.25 ENSDART00000154400
tmem121aa
transmembrane protein 121Aa
chr24_-_6029314 2.20 ENSDART00000136155
ftr60
finTRIM family, member 60
chr1_+_19515228 2.14 ENSDART00000103091
clrn2
clarin 2
chr23_+_45910033 2.11 ENSDART00000165025
abcg2a
ATP-binding cassette, sub-family G (WHITE), member 2a
chr16_-_40727455 2.00 ENSDART00000162331
si:dkey-22o22.2
si:dkey-22o22.2
chr2_+_45049290 1.95 ENSDART00000075152
prss56
protease, serine, 56
chr3_-_37476475 1.91 ENSDART00000148107
si:ch211-278a6.1
si:ch211-278a6.1
chr7_-_30087048 1.85 ENSDART00000112743
nmbb
neuromedin Bb
chr21_+_23135322 1.85 ENSDART00000159586
ENSDART00000125907
htr3a
5-hydroxytryptamine (serotonin) receptor 3A
chr3_-_13921173 1.82 ENSDART00000159177
ENSDART00000165174
si:dkey-61n16.5
si:dkey-61n16.5
chr14_-_2004291 1.81 ENSDART00000114039
pcdh2g5
protocadherin 2 gamma 5
chr9_-_27649406 1.61 ENSDART00000181270
ENSDART00000187112
stxbp5l
syntaxin binding protein 5-like
chr20_-_35052464 1.47 ENSDART00000037195
kif26bb
kinesin family member 26Bb
chr7_-_31940590 1.40 ENSDART00000131009
bdnf
brain-derived neurotrophic factor
chr20_+_19212962 1.24 ENSDART00000063706
fndc4a
fibronectin type III domain containing 4a
chr24_+_26742226 1.08 ENSDART00000079721
ghsrb
growth hormone secretagogue receptor b
chr12_+_19305390 1.08 ENSDART00000183987
ENSDART00000066391
csnk1e
casein kinase 1, epsilon
chr11_+_19780717 0.89 ENSDART00000157394
cadpsa
Ca2+-dependent activator protein for secretion a
chr24_+_854877 0.62 ENSDART00000188408
piezo2a.2
piezo-type mechanosensitive ion channel component 2a, tandem duplicate 2
chr12_-_16524727 0.58 ENSDART00000166645
FO704724.1

chr20_+_45741566 0.53 ENSDART00000113454
chgb
chromogranin B
chr11_+_19781053 0.39 ENSDART00000029680
ENSDART00000182743
cadpsa
Ca2+-dependent activator protein for secretion a
chr1_-_201004 0.28 ENSDART00000188956
FO681286.1

chr2_+_57504073 0.25 ENSDART00000129811
onecut3b
one cut homeobox 3b
chr24_+_19592368 0.20 ENSDART00000180193
slco5a1a
solute carrier organic anion transporter family member 5A1a
chr4_-_76488581 0.20 ENSDART00000174291
ftr51
finTRIM family, member 51
chr4_-_17391091 0.20 ENSDART00000056002
th2
tyrosine hydroxylase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of rest

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 22.0 GO:0015860 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
2.2 6.5 GO:0090278 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
2.0 8.2 GO:0086005 ventricular cardiac muscle cell action potential(GO:0086005)
2.0 36.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.9 14.9 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
1.7 6.9 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
1.7 13.6 GO:0043090 amino acid import(GO:0043090) L-amino acid import(GO:0043092)
1.3 6.7 GO:0070208 protein heterotrimerization(GO:0070208)
1.3 9.3 GO:1990504 dense core granule exocytosis(GO:1990504)
1.3 6.4 GO:0003210 cardiac atrium formation(GO:0003210)
1.2 11.8 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
1.1 4.5 GO:2000171 negative regulation of dendrite development(GO:2000171)
1.1 31.9 GO:0016082 synaptic vesicle priming(GO:0016082)
0.9 6.1 GO:0021982 pineal gland development(GO:0021982)
0.8 5.0 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.8 24.7 GO:0007631 feeding behavior(GO:0007631)
0.7 13.3 GO:0071436 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.6 6.3 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.5 4.3 GO:0021627 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.5 11.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.5 20.5 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.4 6.3 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.3 8.3 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.3 8.1 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.3 3.5 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.2 1.9 GO:0046887 positive regulation of hormone secretion(GO:0046887)
0.2 53.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 12.5 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.2 2.7 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.2 7.0 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.2 4.4 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.2 4.6 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.2 6.7 GO:0033500 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
0.1 1.9 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.1 1.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 10.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.6 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.1 12.2 GO:0002040 sprouting angiogenesis(GO:0002040)
0.1 0.2 GO:0042416 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
0.1 3.3 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.1 5.9 GO:0006836 neurotransmitter transport(GO:0006836)
0.1 1.6 GO:0050708 regulation of protein secretion(GO:0050708)
0.0 11.1 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 10.0 GO:0030334 regulation of cell migration(GO:0030334)
0.0 2.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 8.2 GO:1904888 cranial skeletal system development(GO:1904888)
0.0 4.2 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 1.1 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 2.4 GO:0010506 regulation of autophagy(GO:0010506)
0.0 31.4 GO:0007399 nervous system development(GO:0007399)
0.0 1.9 GO:0042391 regulation of membrane potential(GO:0042391)
0.0 0.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 31.9 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
2.4 36.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
2.3 6.9 GO:0060077 inhibitory synapse(GO:0060077)
1.3 13.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
1.1 7.8 GO:0031045 dense core granule(GO:0031045)
1.0 14.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.7 2.1 GO:1904949 ATP-binding cassette (ABC) transporter complex(GO:0043190) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)
0.6 6.5 GO:0042583 chromaffin granule(GO:0042583)
0.6 12.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.5 7.0 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.3 8.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 9.3 GO:0098978 glutamatergic synapse(GO:0098978)
0.2 6.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 11.8 GO:0030141 secretory granule(GO:0030141)
0.1 11.9 GO:0030018 Z disc(GO:0030018)
0.1 3.5 GO:0034707 chloride channel complex(GO:0034707)
0.1 19.2 GO:0099503 secretory vesicle(GO:0099503)
0.1 2.6 GO:0043679 axon terminus(GO:0043679) neuron projection terminus(GO:0044306)
0.1 44.4 GO:0045202 synapse(GO:0045202)
0.1 22.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 2.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.6 GO:0031201 SNARE complex(GO:0031201)
0.0 49.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 41.4 GO:0005615 extracellular space(GO:0005615)
0.0 1.5 GO:0005871 kinesin complex(GO:0005871)
0.0 86.6 GO:0016021 integral component of membrane(GO:0016021)
0.0 3.2 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 22.0 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
4.3 21.5 GO:0031843 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
1.8 36.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.1 14.9 GO:0005326 neurotransmitter transporter activity(GO:0005326)
1.0 8.2 GO:0019871 sodium channel inhibitor activity(GO:0019871)
1.0 13.6 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.8 31.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.8 6.3 GO:0004994 somatostatin receptor activity(GO:0004994)
0.7 13.3 GO:0001671 ATPase activator activity(GO:0001671)
0.6 21.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.6 6.4 GO:0032036 myosin heavy chain binding(GO:0032036)
0.5 2.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.5 6.7 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.5 10.0 GO:0008143 poly(A) binding(GO:0008143)
0.4 20.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.4 3.5 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.3 6.9 GO:0050811 GABA receptor binding(GO:0050811)
0.3 8.3 GO:0042162 telomeric DNA binding(GO:0042162)
0.2 4.4 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 1.9 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.2 2.6 GO:0031628 opioid receptor binding(GO:0031628)
0.1 7.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 15.2 GO:0005179 hormone activity(GO:0005179)
0.1 1.6 GO:0045159 myosin II binding(GO:0045159)
0.1 1.4 GO:0005163 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.1 57.6 GO:0005509 calcium ion binding(GO:0005509)
0.1 11.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.2 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 5.0 GO:0019901 protein kinase binding(GO:0019901)
0.0 3.9 GO:0015293 symporter activity(GO:0015293)
0.0 0.6 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 36.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 11.0 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 11.6 GO:0003779 actin binding(GO:0003779)
0.0 10.0 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 1.5 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.2 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 11.9 PID ILK PATHWAY Integrin-linked kinase signaling
0.2 4.1 PID RAS PATHWAY Regulation of Ras family activation
0.1 3.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 1.1 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.1 8.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.1 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.9 13.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.9 11.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.6 3.9 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.6 22.0 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.5 8.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 12.0 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 2.6 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 8.3 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 1.1 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock