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PRJNA195909:zebrafish embryo and larva development

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Results for rreb1a+rreb1b

Z-value: 1.19

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Transcription factors associated with rreb1a+rreb1b

Gene Symbol Gene ID Gene Info
rreb1b
ENSDARG00000042652 ras responsive element binding protein 1b
rreb1a
ENSDARG00000063701 ras responsive element binding protein 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rreb1adr11_v1_chr24_-_2423791_2423791-0.655.6e-02Click!
rreb1bdr11_v1_chr2_+_21048661_21048661-0.571.1e-01Click!

Activity profile of rreb1a+rreb1b motif

Sorted Z-values of rreb1a+rreb1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_56351 2.76 ENSDART00000168334
col14a1b
collagen, type XIV, alpha 1b
chr2_-_22535 2.53 ENSDART00000157877
CABZ01092282.1

chr7_-_2039060 2.40 ENSDART00000173879
si:cabz01007794.1
si:cabz01007794.1
chr22_-_34872533 2.40 ENSDART00000167176
slit1b
slit homolog 1b (Drosophila)
chr15_+_47161917 1.31 ENSDART00000167860
gap43
growth associated protein 43
chr19_-_5358443 1.30 ENSDART00000105036
cyt1l
type I cytokeratin, enveloping layer, like
chr19_-_5364649 1.27 ENSDART00000004812
cyt1
type I cytokeratin, enveloping layer
chr20_-_54462551 1.26 ENSDART00000171769
ENSDART00000169692
evlb
Enah/Vasp-like b
chr8_+_54284961 1.24 ENSDART00000122692
plxnd1
plexin D1
chr17_-_122680 1.23 ENSDART00000066430
actc1b
actin, alpha, cardiac muscle 1b
chr12_+_42436328 1.22 ENSDART00000167324
ebf3a
early B cell factor 3a
chr21_+_28445052 1.18 ENSDART00000077871
pygma
phosphorylase, glycogen, muscle A
chr22_+_10090673 1.13 ENSDART00000186680
si:dkey-102c8.3
si:dkey-102c8.3
chr25_-_173165 1.11 ENSDART00000193594
CABZ01114053.1

chr4_-_16345227 1.02 ENSDART00000079521
kera
keratocan
chr9_+_30294096 0.99 ENSDART00000026551
srpx
sushi-repeat containing protein, X-linked
chr3_-_5664123 0.98 ENSDART00000145866
si:ch211-106h11.1
si:ch211-106h11.1
chr14_-_9522364 0.97 ENSDART00000054689
atoh8
atonal bHLH transcription factor 8
chr19_+_42983613 0.95 ENSDART00000033724
fabp3
fatty acid binding protein 3, muscle and heart
chr7_-_73752955 0.93 ENSDART00000171254
ENSDART00000009888
casq1b
calsequestrin 1b
chr19_+_30633453 0.93 ENSDART00000052124
fam49al
family with sequence similarity 49, member A-like
chr13_-_638485 0.90 ENSDART00000066080
ENSDART00000128969
slit1a
slit homolog 1a (Drosophila)
chr7_-_74090168 0.88 ENSDART00000050528
tyrp1a
tyrosinase-related protein 1a
chr5_-_72125551 0.87 ENSDART00000149412
smyd1a
SET and MYND domain containing 1a
chr9_+_21722733 0.86 ENSDART00000102021
sox1a
SRY (sex determining region Y)-box 1a
chr2_-_44183613 0.83 ENSDART00000079596
cadm3
cell adhesion molecule 3
chr4_+_77735212 0.80 ENSDART00000160716
si:dkey-238k10.1
si:dkey-238k10.1
chr2_-_44183451 0.79 ENSDART00000111246
cadm3
cell adhesion molecule 3
chr21_+_19834072 0.77 ENSDART00000147555
ccdc80l2
coiled-coil domain containing 80 like 2
chr23_+_44745317 0.75 ENSDART00000165654
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr2_-_51700709 0.74 ENSDART00000188601
tgm1l1
transglutaminase 1 like 1
chr13_-_11536951 0.74 ENSDART00000018155
adss
adenylosuccinate synthase
chr13_-_31435137 0.74 ENSDART00000057441
rtn1a
reticulon 1a
chr8_+_6954984 0.74 ENSDART00000145610
si:ch211-255g12.6
si:ch211-255g12.6
chr10_-_35542071 0.73 ENSDART00000162139
si:ch211-244c8.4
si:ch211-244c8.4
chr21_-_41305748 0.73 ENSDART00000170457
nsg2
neuronal vesicle trafficking associated 2
chr1_-_9104631 0.73 ENSDART00000146642
si:ch211-14k19.8
si:ch211-14k19.8
chr1_+_59538755 0.73 ENSDART00000166354
sp6
Sp6 transcription factor
chr23_-_9768700 0.72 ENSDART00000045126
lama5
laminin, alpha 5
chr20_-_10120442 0.72 ENSDART00000144970
meis2b
Meis homeobox 2b
chr9_-_23033818 0.72 ENSDART00000022392
rnd3b
Rho family GTPase 3b
chr2_+_33368414 0.72 ENSDART00000077462
slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr15_-_452347 0.72 ENSDART00000115233
VSTM5
V-set and transmembrane domain containing 5
chr12_+_13244149 0.72 ENSDART00000186984
ENSDART00000105896
atp2a1l
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like
chr5_-_5147220 0.69 ENSDART00000187026
ENSDART00000162334
lmx1ba
LIM homeobox transcription factor 1, beta a
chr17_+_53311618 0.68 ENSDART00000166517
asb2b
ankyrin repeat and SOCS box containing 2b
chr19_-_5380770 0.68 ENSDART00000000221
krt91
keratin 91
chr25_+_7982979 0.67 ENSDART00000171904
ucmab
upper zone of growth plate and cartilage matrix associated b
chr6_-_60031693 0.67 ENSDART00000160275
CABZ01079262.1

chr6_-_18976168 0.66 ENSDART00000170039
sept9b
septin 9b
chr23_+_44732863 0.66 ENSDART00000160044
ENSDART00000172268
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr6_+_59818275 0.64 ENSDART00000165213
caskb
calcium/calmodulin-dependent serine protein kinase b
chr19_-_45960191 0.62 ENSDART00000052434
ENSDART00000172732
eif3hb
eukaryotic translation initiation factor 3, subunit H, b
chr6_+_59808677 0.62 ENSDART00000164469
caskb
calcium/calmodulin-dependent serine protein kinase b
chr3_-_38692920 0.61 ENSDART00000155042
mpp3a
membrane protein, palmitoylated 3a (MAGUK p55 subfamily member 3)
chr15_-_42736433 0.60 ENSDART00000154379
si:ch211-181d7.1
si:ch211-181d7.1
chr23_-_15284757 0.59 ENSDART00000139135
sulf2b
sulfatase 2b
chr4_+_76619791 0.59 ENSDART00000184042
ms4a17a.8
membrane-spanning 4-domains, subfamily A, member 17A.8
chr17_-_20711735 0.58 ENSDART00000150056
ank3b
ankyrin 3b
chr14_+_34514336 0.57 ENSDART00000024440
foxi3b
forkhead box I3b
chr16_+_22587661 0.57 ENSDART00000129612
ENSDART00000142241
she
Src homology 2 domain containing E
chr12_+_2677303 0.57 ENSDART00000093113
antxr1c
anthrax toxin receptor 1c
chr25_+_37480285 0.56 ENSDART00000166187
CABZ01095001.1

chr16_-_54405976 0.54 ENSDART00000055395
osr2
odd-skipped related transciption factor 2
chr13_+_22675802 0.54 ENSDART00000145538
ENSDART00000143312
zgc:193505
zgc:193505
chr18_-_8889382 0.53 ENSDART00000058647
ENSDART00000184944
si:dkey-95h12.1
si:dkey-95h12.1
chr11_-_97817 0.53 ENSDART00000092903
elmo2
engulfment and cell motility 2
chr23_+_3591690 0.51 ENSDART00000180822
si:dkey-9l20.3
si:dkey-9l20.3
chr1_+_59533317 0.51 ENSDART00000166821
sp6
Sp6 transcription factor
chr17_+_52822422 0.51 ENSDART00000158273
ENSDART00000161414
meis2a
Meis homeobox 2a
chr5_+_23630384 0.51 ENSDART00000013745
cx39.9
connexin 39.9
chr3_+_23703704 0.51 ENSDART00000024256
hoxb6a
homeobox B6a
chr6_-_53426773 0.51 ENSDART00000162791
mst1
macrophage stimulating 1
chr13_-_45523026 0.51 ENSDART00000020663
rhd
Rh blood group, D antigen
chr2_-_50298337 0.50 ENSDART00000155125
cntnap2b
contactin associated protein like 2b
chr8_+_37489495 0.50 ENSDART00000141516
fmodb
fibromodulin b
chr7_+_39634873 0.50 ENSDART00000114774
ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr7_-_57949117 0.50 ENSDART00000138803
ank2b
ankyrin 2b, neuronal
chr3_-_1190132 0.49 ENSDART00000149709
smdt1a
single-pass membrane protein with aspartate-rich tail 1a
chr22_+_661505 0.49 ENSDART00000149460
elf3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr21_-_45613564 0.48 ENSDART00000160324
LO018363.1

chr6_+_59967994 0.48 ENSDART00000050457
zgc:65895
zgc:65895
chr1_-_59251874 0.48 ENSDART00000168919
olfm2b
olfactomedin 2b
chr10_+_16756546 0.47 ENSDART00000168624
CABZ01024659.1

chr6_-_21189295 0.47 ENSDART00000137136
obsl1a
obscurin-like 1a
chr8_+_4368534 0.46 ENSDART00000015214
pptc7a
PTC7 protein phosphatase homolog a
chr4_-_193762 0.46 ENSDART00000169667
ptpro
protein tyrosine phosphatase, receptor type, O
chr17_+_15388479 0.46 ENSDART00000052439
si:ch211-266g18.6
si:ch211-266g18.6
chr25_+_1732838 0.46 ENSDART00000159555
ENSDART00000168161
FBLN1
fibulin 1
chr23_-_4855122 0.45 ENSDART00000133701
slc6a1a
solute carrier family 6 (neurotransmitter transporter), member 1a
chr9_+_36946340 0.45 ENSDART00000135281
si:dkey-3d4.3
si:dkey-3d4.3
chr19_+_233143 0.45 ENSDART00000175273
syngap1a
synaptic Ras GTPase activating protein 1a
chr7_+_31838320 0.45 ENSDART00000144679
ENSDART00000174217
ENSDART00000122506
mybpc3
myosin binding protein C, cardiac
chr1_+_47585700 0.44 ENSDART00000153746
ENSDART00000084457
sh3pxd2aa
SH3 and PX domains 2Aa
chr16_+_10918252 0.44 ENSDART00000172949
pou2f2a
POU class 2 homeobox 2a
chr11_+_38280454 0.43 ENSDART00000171496
CDK18
si:dkey-166c18.1
chr13_+_41022502 0.43 ENSDART00000026808
dkk1a
dickkopf WNT signaling pathway inhibitor 1a
chr13_+_255067 0.43 ENSDART00000102505
foxg1d
forkhead box G1d
chr15_-_40175894 0.43 ENSDART00000156632
si:ch211-281l24.3
si:ch211-281l24.3
chr25_+_5044780 0.43 ENSDART00000153980
parvb
parvin, beta
chr10_+_22772084 0.42 ENSDART00000144845
ENSDART00000165222
tmem88a
transmembrane protein 88 a
chr25_+_258883 0.42 ENSDART00000155256
zgc:92481
zgc:92481
chr25_+_25464630 0.41 ENSDART00000150537
rassf7a
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7a
chr10_-_24343507 0.41 ENSDART00000002974
pitpnab
phosphatidylinositol transfer protein, alpha b
chr5_-_28029558 0.41 ENSDART00000078649
abcb9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr3_+_60007703 0.41 ENSDART00000157351
ENSDART00000153928
ENSDART00000155876
si:ch211-110e21.3
si:ch211-110e21.3
chr11_-_3334248 0.41 ENSDART00000154314
ENSDART00000121861
prph
peripherin
chr8_-_1909840 0.41 ENSDART00000147408
si:dkey-178e17.3
si:dkey-178e17.3
chr25_-_37501371 0.40 ENSDART00000160498
CABZ01088346.1

chr14_+_52563794 0.40 ENSDART00000168874
rpl26
ribosomal protein L26
chr1_-_5543065 0.39 ENSDART00000103755
fn1b
fibronectin 1b
chr17_+_51517750 0.39 ENSDART00000180896
ENSDART00000193528
pxdn
peroxidasin
chr18_+_45990394 0.38 ENSDART00000024068
mmp23bb
matrix metallopeptidase 23bb
chr20_-_35246150 0.38 ENSDART00000090549
fzd3a
frizzled class receptor 3a
chr2_+_28889936 0.37 ENSDART00000078232
cdh10a
cadherin 10, type 2a (T2-cadherin)
chr1_-_625875 0.37 ENSDART00000167331
appa
amyloid beta (A4) precursor protein a
chr4_+_5798223 0.37 ENSDART00000059440
si:ch73-352p4.8
si:ch73-352p4.8
chr2_+_22694382 0.37 ENSDART00000139196
kif1ab
kinesin family member 1Ab
chr25_-_10564721 0.37 ENSDART00000154776
galn
galanin/GMAP prepropeptide
chr23_+_3587230 0.36 ENSDART00000055103
si:dkey-9l20.3
si:dkey-9l20.3
chr10_-_43294933 0.36 ENSDART00000062631
hapln1b
hyaluronan and proteoglycan link protein 1b
chr3_-_30685401 0.36 ENSDART00000151097
si:ch211-51c14.1
si:ch211-51c14.1
chr20_+_52595220 0.36 ENSDART00000180610
si:dkey-235d18.5
si:dkey-235d18.5
chr20_+_4392687 0.36 ENSDART00000187271
im:7142702
im:7142702
chr18_+_21122818 0.35 ENSDART00000060015
ENSDART00000060184
chka
choline kinase alpha
chr18_-_81280 0.35 ENSDART00000149810
ENSDART00000149321
hdc
histidine decarboxylase
chr10_+_3875716 0.35 ENSDART00000189268
ENSDART00000180624
TTC28
tetratricopeptide repeat domain 28
chr21_+_25765734 0.35 ENSDART00000021664
cldnb
claudin b
chr15_-_12500938 0.34 ENSDART00000159627
scn4ba
sodium channel, voltage-gated, type IV, beta a
chr23_+_44580254 0.34 ENSDART00000185069
pfn1
profilin 1
chr10_+_8527196 0.34 ENSDART00000141147
si:ch211-193e13.5
si:ch211-193e13.5
chr16_+_68069 0.34 ENSDART00000185385
ENSDART00000159652
sox4b
SRY (sex determining region Y)-box 4b
chr21_+_53504 0.34 ENSDART00000170452
dmgdh
dimethylglycine dehydrogenase
chr12_+_1398404 0.33 ENSDART00000026303
rasd1
RAS, dexamethasone-induced 1
chr12_+_2676878 0.33 ENSDART00000185909
antxr1c
anthrax toxin receptor 1c
chr23_+_3616224 0.33 ENSDART00000190917
si:dkey-9l20.3
si:dkey-9l20.3
chr7_+_35229645 0.33 ENSDART00000144327
tppp3
tubulin polymerization-promoting protein family member 3
chr7_+_36552725 0.32 ENSDART00000173682
chd9
chromodomain helicase DNA binding protein 9
chr19_-_47456787 0.32 ENSDART00000168792
tfap2e
transcription factor AP-2 epsilon
chr25_+_5288665 0.32 ENSDART00000169540
CABZ01039861.1

chr5_+_71802014 0.32 ENSDART00000124939
ENSDART00000097164
LHX3
LIM homeobox 3
chr14_-_853176 0.32 ENSDART00000041988
slc34a1a
solute carrier family 34 (type II sodium/phosphate cotransporter), member 1a
chr22_+_1028724 0.31 ENSDART00000149625
si:ch73-352p18.4
si:ch73-352p18.4
chr24_-_40860603 0.31 ENSDART00000188032
CU633479.7

chr16_-_54640315 0.31 ENSDART00000101207
spag1b
sperm associated antigen 1b
chr12_-_1951233 0.31 ENSDART00000005676
ENSDART00000127937
sox9a
SRY (sex determining region Y)-box 9a
chr5_-_5147041 0.30 ENSDART00000180236
lmx1ba
LIM homeobox transcription factor 1, beta a
chr6_-_48311 0.30 ENSDART00000131010
zgc:114175
zgc:114175
chr18_-_49078428 0.30 ENSDART00000160702
ENSDART00000174103
BX663503.3

chr1_+_2129164 0.30 ENSDART00000074923
ENSDART00000124534
mbnl2
muscleblind-like splicing regulator 2
chr23_-_969844 0.30 ENSDART00000127037
cdh26.2
cadherin 26, tandem duplicate 2
chr8_+_68864 0.30 ENSDART00000164574
prr16
proline rich 16
chr16_+_41826584 0.30 ENSDART00000147523
si:dkey-199f5.6
si:dkey-199f5.6
chr25_-_10565006 0.30 ENSDART00000130608
ENSDART00000190212
galn
galanin/GMAP prepropeptide
chr18_+_1154189 0.29 ENSDART00000135090
si:ch1073-75f15.2
si:ch1073-75f15.2
chr5_-_71838520 0.29 ENSDART00000174396
CU927890.1

chr1_-_8012476 0.29 ENSDART00000177051
CR855320.3

chr12_-_4540564 0.29 ENSDART00000106566
CABZ01030107.1

chr19_+_32856907 0.29 ENSDART00000148232
rpl30
ribosomal protein L30
chr19_+_2279051 0.29 ENSDART00000182103
itgb8
integrin, beta 8
chr25_-_37489917 0.28 ENSDART00000160688
psma1
proteasome subunit alpha 1
chr7_+_65876335 0.28 ENSDART00000150143
tead1b
TEA domain family member 1b
chr6_-_346084 0.28 ENSDART00000162599
pde6ha
phosphodiesterase 6H, cGMP-specific, cone, gamma, paralog a
chr21_-_44009169 0.28 ENSDART00000028960
ndufa2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2
chr17_-_52643970 0.27 ENSDART00000190594
spred1
sprouty-related, EVH1 domain containing 1
chr24_-_31439841 0.27 ENSDART00000169952
cngb3.2
cyclic nucleotide gated channel beta 3, tandem duplicate 2
chr16_+_43347966 0.27 ENSDART00000171308
zmp:0000000930
zmp:0000000930
chr5_-_201600 0.27 ENSDART00000158495
CABZ01088906.1

chr23_+_44497701 0.26 ENSDART00000149903
si:ch73-375g18.1
si:ch73-375g18.1
chr18_+_22793743 0.26 ENSDART00000150106
gnao1a
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
chr13_+_51853716 0.26 ENSDART00000175341
ENSDART00000187855
LT631684.1

chr19_-_13923091 0.26 ENSDART00000169993
ENSDART00000158992
stx12
syntaxin 12
chr3_+_18398876 0.26 ENSDART00000141100
ENSDART00000138107
rps2
ribosomal protein S2
chr5_+_480119 0.25 ENSDART00000055681
tek
TEK tyrosine kinase, endothelial
chr3_-_62380146 0.25 ENSDART00000155853
gprc5ba
G protein-coupled receptor, class C, group 5, member Ba
chr21_+_25660613 0.25 ENSDART00000134017
si:dkey-17e16.15
si:dkey-17e16.15
chr22_+_1186866 0.25 ENSDART00000167710
eps8l3a
EPS8-like 3a
chr23_-_38054 0.25 ENSDART00000170393
CABZ01074076.1

chr21_+_6151953 0.25 ENSDART00000131854
si:dkey-93m18.6
si:dkey-93m18.6
chr5_-_26181863 0.25 ENSDART00000098500
ccdc125
coiled-coil domain containing 125
chr5_-_16351306 0.24 ENSDART00000168643
CABZ01088700.1

chr5_-_43959972 0.24 ENSDART00000180517
si:ch211-204c21.1
si:ch211-204c21.1
chr11_-_4235811 0.24 ENSDART00000121716
si:ch211-236d3.4
si:ch211-236d3.4
chr1_+_109798 0.24 ENSDART00000165402
F7 (1 of many)
zgc:163025
chr15_-_5742531 0.23 ENSDART00000045985
phkg1a
phosphorylase kinase, gamma 1a (muscle)
chr7_-_5191797 0.23 ENSDART00000172955
si:ch73-223f5.1
si:ch73-223f5.1
chr4_+_20263097 0.23 ENSDART00000138820
lrtm2a
leucine-rich repeats and transmembrane domains 2a
chr18_-_45617146 0.23 ENSDART00000146543
wt1b
wilms tumor 1b
chr6_+_38381957 0.23 ENSDART00000087300
gabrb3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr7_+_50849142 0.23 ENSDART00000073806
pcolceb
procollagen C-endopeptidase enhancer b
chr4_-_6459863 0.22 ENSDART00000138367
foxp2
forkhead box P2
chr12_+_10053852 0.22 ENSDART00000078497
slc4a1b
solute carrier family 4 (anion exchanger), member 1b (Diego blood group)
chr19_+_43256986 0.22 ENSDART00000182336
DGKD
diacylglycerol kinase delta
chr25_+_37268900 0.22 ENSDART00000156737
si:dkey-234i14.6
si:dkey-234i14.6
chr12_-_48992527 0.22 ENSDART00000169696
CDHR1 (1 of many)
cadherin related family member 1
chr7_+_72630369 0.22 ENSDART00000170698
FO905040.1

chr5_+_20589472 0.22 ENSDART00000130911
cmklr1
chemokine-like receptor 1
chr13_-_20519001 0.22 ENSDART00000168955
gfra1a
gdnf family receptor alpha 1a
chr17_+_8925232 0.22 ENSDART00000036668
psmc1a
proteasome 26S subunit, ATPase 1a
chr4_+_76722754 0.21 ENSDART00000153867
ms4a17a.3
membrane-spanning 4-domains, subfamily A, member 17A.3

Network of associatons between targets according to the STRING database.

First level regulatory network of rreb1a+rreb1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0052575 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
0.3 1.0 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.3 0.9 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.2 0.7 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.1 0.6 GO:0009957 epidermal cell fate specification(GO:0009957)
0.1 0.4 GO:0060923 negative regulation of striated muscle cell differentiation(GO:0051154) negative regulation of cardiac muscle tissue development(GO:0055026) cardiac muscle cell fate commitment(GO:0060923) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901296) negative regulation of cardiocyte differentiation(GO:1905208) negative regulation of cardiac muscle cell differentiation(GO:2000726)
0.1 0.4 GO:0001692 histamine metabolic process(GO:0001692)
0.1 1.1 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.1 0.5 GO:0071205 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
0.1 0.9 GO:1901998 toxin transport(GO:1901998)
0.1 0.5 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.9 GO:0042438 melanin biosynthetic process(GO:0042438)
0.1 1.2 GO:0003209 cardiac atrium morphogenesis(GO:0003209)
0.1 2.8 GO:0021602 cranial nerve morphogenesis(GO:0021602)
0.1 1.0 GO:0021592 fourth ventricle development(GO:0021592)
0.1 1.3 GO:0016198 axon choice point recognition(GO:0016198)
0.1 1.4 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 0.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 1.2 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.1 0.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.7 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.0 0.3 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 0.3 GO:0010801 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0 1.3 GO:0051289 protein homotetramerization(GO:0051289)
0.0 0.4 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.0 0.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.2 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.2 GO:0043703 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.0 0.2 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 0.4 GO:0071679 commissural neuron axon guidance(GO:0071679)
0.0 0.4 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.8 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.9 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.2 GO:0007343 egg activation(GO:0007343)
0.0 0.7 GO:0035141 medial fin morphogenesis(GO:0035141)
0.0 0.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.4 GO:1990399 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.1 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.2 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.0 0.1 GO:0035739 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0 1.0 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.1 GO:0009750 response to fructose(GO:0009750)
0.0 0.1 GO:0021730 trigeminal sensory nucleus development(GO:0021730)
0.0 0.6 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 0.2 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.1 GO:0090183 regulation of morphogenesis of a branching structure(GO:0060688) positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of kidney development(GO:0090183) positive regulation of kidney development(GO:0090184) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0 0.3 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.0 0.6 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.2 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.4 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.2 GO:0045471 response to ethanol(GO:0045471)
0.0 0.4 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 0.1 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 0.3 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 0.1 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.1 GO:0006837 serotonin transport(GO:0006837) serotonin uptake(GO:0051610)
0.0 0.3 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.2 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 0.1 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.0 0.4 GO:0035329 hippo signaling(GO:0035329)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.5 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.4 GO:0046785 microtubule polymerization(GO:0046785)
0.0 0.5 GO:0030282 bone mineralization(GO:0030282)
0.0 0.2 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.4 GO:0045103 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.3 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.3 GO:0070286 axonemal dynein complex assembly(GO:0070286)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0032584 growth cone membrane(GO:0032584)
0.1 1.4 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.1 0.9 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.1 0.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.1 1.2 GO:0005869 dynactin complex(GO:0005869)
0.1 0.9 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 0.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 0.5 GO:0033010 paranodal junction(GO:0033010)
0.1 1.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.1 GO:0043034 costamere(GO:0043034)
0.0 0.3 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.0 0.3 GO:0070062 extracellular exosome(GO:0070062)
0.0 0.9 GO:0031430 M band(GO:0031430)
0.0 0.5 GO:1990246 uniplex complex(GO:1990246)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 3.7 GO:0005882 intermediate filament(GO:0005882)
0.0 0.7 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.4 GO:0002102 podosome(GO:0002102)
0.0 0.5 GO:0030315 T-tubule(GO:0030315)
0.0 0.6 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.0 0.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.2 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0043291 RAVE complex(GO:0043291)
0.0 0.7 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.3 GO:0005903 brush border(GO:0005903)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.2 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0008184 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.1 0.4 GO:0046978 TAP1 binding(GO:0046978)
0.1 1.3 GO:0005522 profilin binding(GO:0005522)
0.1 0.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 1.3 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.4 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.3 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.1 1.1 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.4 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.4 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.1 0.4 GO:0001948 glycoprotein binding(GO:0001948) proteoglycan binding(GO:0043394)
0.1 0.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.3 GO:0051430 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.3 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 0.7 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.4 GO:0016176 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.2 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.2 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.4 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 1.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0050699 WW domain binding(GO:0050699)
0.0 0.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.6 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.6 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.2 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.6 GO:0030553 cGMP binding(GO:0030553)
0.0 0.6 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.1 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.0 0.2 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:1990518 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.0 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.0 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0030116 glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0004001 adenosine kinase activity(GO:0004001)
0.0 0.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.2 GO:0005452 inorganic anion exchanger activity(GO:0005452)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.5 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.9 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 0.7 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.2 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling