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PRJNA195909:zebrafish embryo and larva development

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Results for runx3

Z-value: 0.41

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Transcription factors associated with runx3

Gene Symbol Gene ID Gene Info
runx3
ENSDARG00000052826 RUNX family transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
runx3dr11_v1_chr13_-_45201300_45201300-0.353.6e-01Click!

Activity profile of runx3 motif

Sorted Z-values of runx3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_50710468 0.70 ENSDART00000080389
fam13a
family with sequence similarity 13, member A
chr6_-_9581949 0.58 ENSDART00000144335
cyp27c1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr16_+_28754403 0.46 ENSDART00000103340
s100v1
S100 calcium binding protein V1
chr15_-_20468302 0.43 ENSDART00000018514
dlc
deltaC
chr2_+_4146606 0.42 ENSDART00000171170
mib1
mindbomb E3 ubiquitin protein ligase 1
chr8_+_17184602 0.42 ENSDART00000050228
ENSDART00000140531
dimt1l
DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)
chr16_+_23431189 0.41 ENSDART00000004679
icn
ictacalcin
chr19_-_5380770 0.41 ENSDART00000000221
krt91
keratin 91
chr6_-_2154137 0.39 ENSDART00000162656
tgm5l
transglutaminase 5, like
chr2_-_56348727 0.35 ENSDART00000060745
uba52
ubiquitin A-52 residue ribosomal protein fusion product 1
chr15_-_2657508 0.34 ENSDART00000102086
cldna
claudin a
chr16_+_43344475 0.32 ENSDART00000085282
mrpl32
mitochondrial ribosomal protein L32
chr3_-_49382896 0.30 ENSDART00000169115
si:ch73-167f10.1
si:ch73-167f10.1
chr9_+_37141836 0.30 ENSDART00000024555
gli2a
GLI family zinc finger 2a
chr20_-_48485354 0.27 ENSDART00000124040
ENSDART00000148437
insm1a
insulinoma-associated 1a
chr9_-_20372977 0.25 ENSDART00000113418
igsf3
immunoglobulin superfamily, member 3
chr11_-_30636163 0.24 ENSDART00000140516
zgc:153665
zgc:153665
chr19_-_24443867 0.24 ENSDART00000163763
ENSDART00000043133
thbs3b
thrombospondin 3b
chr20_+_10723292 0.23 ENSDART00000152805
si:ch211-182e10.4
si:ch211-182e10.4
chr20_-_14012859 0.22 ENSDART00000152429
si:ch211-22i13.2
si:ch211-22i13.2
chr2_+_53114476 0.22 ENSDART00000080850
ENSDART00000104187
CR384061.1

chr5_-_10239079 0.21 ENSDART00000132739
si:ch73-42k18.1
si:ch73-42k18.1
chr14_-_24332786 0.21 ENSDART00000173164
fam13b
family with sequence similarity 13, member B
chr22_-_14161309 0.19 ENSDART00000133365
si:ch211-246m6.5
si:ch211-246m6.5
chr25_-_10503043 0.19 ENSDART00000155404
cox8b
cytochrome c oxidase subunit 8b
chr22_+_11520249 0.18 ENSDART00000063147
sgsh
N-sulfoglucosamine sulfohydrolase (sulfamidase)
chr7_+_25858380 0.17 ENSDART00000148780
ENSDART00000079218
mtmr1a
myotubularin related protein 1a
chr14_-_42231293 0.17 ENSDART00000185486
BX890543.1

chr2_-_183992 0.16 ENSDART00000126704
ENSDART00000191283
ENSDART00000034783
zgc:113518
zgc:113518
chr8_+_1065458 0.16 ENSDART00000081432
sprb
sepiapterin reductase b
chr16_-_7228276 0.16 ENSDART00000149030
nt5c3a
5'-nucleotidase, cytosolic IIIA
chr24_-_14212521 0.15 ENSDART00000130825
xkr9
XK, Kell blood group complex subunit-related family, member 9
chr22_+_9922301 0.15 ENSDART00000105924
blf
bloody fingers
chr19_-_72398 0.15 ENSDART00000165587
dnajc8
DnaJ (Hsp40) homolog, subfamily C, member 8
chr20_-_53321499 0.15 ENSDART00000179894
ENSDART00000127427
ENSDART00000084952
wasf1
WAS protein family, member 1
chr18_+_16986495 0.15 ENSDART00000147377
si:ch211-218c6.8
si:ch211-218c6.8
chr9_-_23747264 0.14 ENSDART00000141461
ENSDART00000010311
ndufa10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10
chr22_+_10757848 0.14 ENSDART00000145551
tmprss9
transmembrane protease, serine 9
chr7_+_56651759 0.14 ENSDART00000073600
kcng4b
potassium voltage-gated channel, subfamily G, member 4b
chr22_-_30973791 0.14 ENSDART00000104728
ssuh2.2
ssu-2 homolog, tandem duplicate 2
chr16_+_35870456 0.13 ENSDART00000184321
thrap3a
thyroid hormone receptor associated protein 3a
chr10_+_45148167 0.12 ENSDART00000172621
ogdhb
oxoglutarate (alpha-ketoglutarate) dehydrogenase b (lipoamide)
chr7_-_65492048 0.12 ENSDART00000162381
dkk3a
dickkopf WNT signaling pathway inhibitor 3a
chr15_+_29292154 0.11 ENSDART00000137817
rap1gap2a
RAP1 GTPase activating protein 2a
chr12_-_43711918 0.11 ENSDART00000193110
CU914622.2

chr14_-_16476863 0.10 ENSDART00000089021
canx
calnexin
chr17_-_27382826 0.10 ENSDART00000186657
ENSDART00000155986
ENSDART00000191060
ENSDART00000077608
si:ch1073-358c10.1
si:ch1073-358c10.1
chr1_+_54911458 0.10 ENSDART00000089603
golga7ba
golgin A7 family, member Ba
chr24_-_14711597 0.10 ENSDART00000131830
jph1a
junctophilin 1a
chr19_+_42219165 0.09 ENSDART00000163192
CU896644.1

chr13_-_17729474 0.09 ENSDART00000013011
vdac2
voltage-dependent anion channel 2
chr8_-_17184482 0.08 ENSDART00000025803
pola2
polymerase (DNA directed), alpha 2
chr11_-_17755444 0.08 ENSDART00000154627
eogt
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr1_-_43727418 0.08 ENSDART00000133715
ENSDART00000074597
ENSDART00000132542
ENSDART00000181792
bdh2
SLC9B2
3-hydroxybutyrate dehydrogenase, type 2
si:dkey-162b23.4
chr18_-_50524017 0.08 ENSDART00000150013
ENSDART00000149912
cd276
CD276 molecule
chr24_+_24064562 0.08 ENSDART00000144394
zgc:112408
zgc:112408
chr23_-_36313431 0.08 ENSDART00000125860
nfe2
nuclear factor, erythroid 2
chr10_+_45148005 0.07 ENSDART00000182501
ogdhb
oxoglutarate (alpha-ketoglutarate) dehydrogenase b (lipoamide)
chr3_+_14339728 0.07 ENSDART00000184127
plppr2a
phospholipid phosphatase related 2a
chr18_+_808911 0.07 ENSDART00000172518
cox5ab
cytochrome c oxidase subunit Vab
chr3_-_22228602 0.07 ENSDART00000017750
myl4
myosin, light chain 4, alkali; atrial, embryonic
chr23_+_20795781 0.07 ENSDART00000128577
ttc34
tetratricopeptide repeat domain 34
chr5_-_71995108 0.07 ENSDART00000124587
fam78ab
family with sequence similarity 78, member Ab
chr25_-_225964 0.07 ENSDART00000193424
CABZ01113818.1

chr15_-_31067589 0.06 ENSDART00000060157
lgals9l3
lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3
chr12_-_43819253 0.06 ENSDART00000160261
ENSDART00000170045
ENSDART00000159106
si:ch73-329n5.6
si:ch73-329n5.6
chr23_+_36308717 0.06 ENSDART00000131711
hnrnpa1b
heterogeneous nuclear ribonucleoprotein A1b
chr17_+_7522777 0.06 ENSDART00000184723
klhl10b.2
kelch-like family member 10b, tandem duplicate 2
chr20_-_2725930 0.06 ENSDART00000081643
akirin2
akirin 2
chr21_-_43992027 0.06 ENSDART00000188612
cdx1b
caudal type homeobox 1 b
chr18_-_50523399 0.05 ENSDART00000033591
cd276
CD276 molecule
chr15_+_37589698 0.05 ENSDART00000076066
ENSDART00000153894
ENSDART00000156298
lin37
lin-37 DREAM MuvB core complex component
chr19_+_2590182 0.05 ENSDART00000162293
si:ch73-345f18.3
si:ch73-345f18.3
chr1_+_16396870 0.05 ENSDART00000189245
ENSDART00000113266
micu3a
mitochondrial calcium uptake family, member 3a
chr10_+_21656654 0.05 ENSDART00000160464
pcdh1g2
protocadherin 1 gamma 2
chr22_-_25502977 0.05 ENSDART00000181749
CR769772.4

chr22_+_11144153 0.05 ENSDART00000047442
bcor
BCL6 corepressor
chr1_+_16397063 0.04 ENSDART00000159794
micu3a
mitochondrial calcium uptake family, member 3a
chr12_+_46883785 0.04 ENSDART00000008312
fam53b
family with sequence similarity 53, member B
chr11_-_8208464 0.04 ENSDART00000161283
pimr203
Pim proto-oncogene, serine/threonine kinase, related 203
chr21_+_15824182 0.04 ENSDART00000065779
gnrh2
gonadotropin-releasing hormone 2
chr1_+_39859782 0.04 ENSDART00000149984
irf2a
interferon regulatory factor 2a
chr6_-_11768198 0.04 ENSDART00000183463
march7
membrane-associated ring finger (C3HC4) 7
chr11_-_40519886 0.04 ENSDART00000172819
miip
migration and invasion inhibitory protein
chr25_-_210730 0.03 ENSDART00000187580
FP236318.1

chr22_-_25469751 0.03 ENSDART00000171670
CR769772.4

chr13_+_8255106 0.03 ENSDART00000080465
hells
helicase, lymphoid specific
chr6_+_25282671 0.03 ENSDART00000157575
si:ch211-180m24.3
si:ch211-180m24.3
chr2_-_51521079 0.03 ENSDART00000165504
LO018493.1

chr2_+_49864219 0.03 ENSDART00000187744
rpl37
ribosomal protein L37
chr12_-_23009312 0.03 ENSDART00000111801
mkxa
mohawk homeobox a
chr10_-_309894 0.03 ENSDART00000163287
CABZ01049607.1

chr9_+_34148714 0.03 ENSDART00000078051
gpr161
G protein-coupled receptor 161
chr6_-_141564 0.03 ENSDART00000151245
ENSDART00000063876
s1pr5b
sphingosine-1-phosphate receptor 5b
chr22_+_17203752 0.03 ENSDART00000143376
rab3b
RAB3B, member RAS oncogene family
chr5_+_7989210 0.02 ENSDART00000168071
gdnfb
glial cell derived neurotrophic factor b
chr1_-_8012476 0.02 ENSDART00000177051
CR855320.3

chr15_-_4037626 0.01 ENSDART00000160905
P2RY14
purinergic receptor P2Y14
chr3_+_6291635 0.01 ENSDART00000185055
ENSDART00000157707
si:ch211-12p12.2
si:ch211-12p12.2
chr1_+_23408622 0.00 ENSDART00000140706
chrna9
cholinergic receptor, nicotinic, alpha 9
chr19_-_40906161 0.00 ENSDART00000004514
bet1
Bet1 golgi vesicular membrane trafficking protein
chr6_+_44163727 0.00 ENSDART00000064878
gxylt2
glucoside xylosyltransferase 2
chr12_+_28910762 0.00 ENSDART00000076342
ENSDART00000160939
ENSDART00000076572
rnf40
ring finger protein 40
chr22_-_392224 0.00 ENSDART00000124720
CABZ01072989.1

Network of associatons between targets according to the STRING database.

First level regulatory network of runx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0021519 optic cup formation involved in camera-type eye development(GO:0003408) spinal cord association neuron specification(GO:0021519)
0.1 0.3 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.1 0.4 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.1 GO:0055057 neuroblast division(GO:0055057)
0.0 0.3 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.0 0.4 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.4 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.2 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 0.2 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 0.1 GO:0019184 nonribosomal peptide biosynthetic process(GO:0019184)
0.0 0.1 GO:0032689 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0 0.2 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.6 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.1 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.0 GO:0005183 gonadotropin hormone-releasing hormone activity(GO:0005183) gonadotropin-releasing hormone receptor binding(GO:0031530)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus