ISMARA results: si:dkey-43p13.5+uncx

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PRJNA195909:zebrafish embryo and larva development

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Results for si:dkey-43p13.5+uncx

Z-value: 0.72

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Transcription factors associated with si:dkey-43p13.5+uncx

Gene Symbol	Gene ID	Gene Info
uncx NCBI UniProt	ENSDARG00000102976	UNC homeobox
si_dkey-43p13.5 NCBI UniProt	ENSDARG00000104199	si_dkey-43p13.5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
si:dkey-43p13.5	dr11_v1_chr3_+_43086548_43086548	0.77	1.5e-02	Click!
uncx	dr11_v1_chr3_-_43356082_43356082	-0.35	3.5e-01	Click!

Activity profile of si:dkey-43p13.5+uncx motif

Sorted Z-values of si:dkey-43p13.5+uncx motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr21_+_25777425 Show fit	2.02	ENSDART00000021620	cldnd NCBI UniProt Show fit	claudin d
chr11_-_6452444 Show fit	1.34	ENSDART00000137879 ENSDART00000134957 ENSDART00000004483	larp6b NCBI UniProt Show fit	La ribonucleoprotein domain family, member 6b
chr10_-_34916208 Show fit	1.30	ENSDART00000187371	ccna1 NCBI UniProt Show fit	cyclin A1
chr24_+_12835935 Show fit	1.20	ENSDART00000114762	nanog NCBI UniProt Show fit	nanog homeobox
chr8_+_45334255 Show fit	1.18	ENSDART00000126848 ENSDART00000134161 ENSDART00000142322 ENSDART00000145011 ENSDART00000183560	pabpc1l NCBI UniProt Show fit	poly(A) binding protein, cytoplasmic 1-like
chr10_-_34915886 Show fit	1.08	ENSDART00000141201 ENSDART00000002166	ccna1 NCBI UniProt Show fit	cyclin A1
chr1_-_18811517 Show fit	1.07	ENSDART00000142026	si:dkey-167i21.2 NCBI UniProt Show fit	si:dkey-167i21.2
chr12_-_14143344 Show fit	1.06	ENSDART00000152742	buc2l NCBI UniProt Show fit	bucky ball 2-like
chr18_-_40708537 Show fit	1.06	ENSDART00000077577	si:ch211-132b12.8 NCBI UniProt Show fit	si:ch211-132b12.8
chr10_-_21362071 Show fit	1.01	ENSDART00000125167	avd NCBI UniProt Show fit	avidin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of si:dkey-43p13.5+uncx

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	2.8	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1	2.7	GO:1904029	regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1	2.1	GO:0051445	regulation of meiotic cell cycle(GO:0051445)
0.0	1.9	GO:0060968	regulation of gene silencing(GO:0060968)
0.1	1.7	GO:0035803	binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.2	1.6	GO:0043046	DNA methylation involved in gamete generation(GO:0043046)
0.0	1.5	GO:0034504	protein localization to nucleus(GO:0034504)
0.1	1.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	1.1	GO:0017148	negative regulation of translation(GO:0017148)
0.2	0.9	GO:0060283	negative regulation of oocyte development(GO:0060283)

Showing 1 to 10 of 173 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.6	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.8	2.4	GO:0097124	cyclin A2-CDK2 complex(GO:0097124)
0.1	2.3	GO:0043186	P granule(GO:0043186)
0.2	1.6	GO:0071546	pi-body(GO:0071546)
0.0	1.5	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	1.2	GO:0005802	trans-Golgi network(GO:0005802)
0.0	0.9	GO:0005657	replication fork(GO:0005657)
0.0	0.8	GO:0042555	MCM complex(GO:0042555)
0.0	0.8	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.8	GO:0005905	clathrin-coated pit(GO:0005905)

Showing 1 to 10 of 74 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.5	GO:0042802	identical protein binding(GO:0042802)
0.0	2.7	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0	2.4	GO:0003724	RNA helicase activity(GO:0003724)
0.4	2.0	GO:0009374	biotin binding(GO:0009374)
0.1	1.7	GO:0032190	acrosin binding(GO:0032190)
0.1	1.6	GO:0061608	nuclear import signal receptor activity(GO:0061608)
0.1	1.2	GO:0034584	piRNA binding(GO:0034584)
0.1	1.2	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	1.2	GO:0035091	phosphatidylinositol binding(GO:0035091)
0.0	1.0	GO:0004527	exonuclease activity(GO:0004527)

Showing 1 to 10 of 135 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	1.8	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	1.2	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	0.9	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	0.7	PID AURORA B PATHWAY	Aurora B signaling
0.0	0.7	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	0.6	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	0.6	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.6	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.5	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Showing 1 to 10 of 29 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	1.2	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	1.0	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	0.9	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.7	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	0.7	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0	0.6	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.6	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	0.5	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.0	0.4	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis

Showing 1 to 10 of 42 entries

Results for si:dkey-43p13.5+uncx

Z-value: 0.72

Motif logo

Transcription factors associated with si:dkey-43p13.5+uncx

Activity-expression correlation:

Activity profile of si:dkey-43p13.5+uncx motif

Sorted Z-values of si:dkey-43p13.5+uncx motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of si:dkey-43p13.5+uncx

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: