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PRJNA195909:zebrafish embryo and larva development

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Results for srfa+srfb

Z-value: 3.76

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Transcription factors associated with srfa+srfb

Gene Symbol Gene ID Gene Info
srfa
ENSDARG00000053918 serum response factor a
srfb
ENSDARG00000102867 serum response factor b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
srfadr11_v1_chr22_+_35089031_35089031-0.826.4e-03Click!
srfbdr11_v1_chr13_-_51922290_51922290-0.059.1e-01Click!

Activity profile of srfa+srfb motif

Sorted Z-values of srfa+srfb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_21336385 15.10 ENSDART00000054460
egr1
early growth response 1
chr20_-_9980318 12.28 ENSDART00000080664
ACTC1
zgc:86709
chr7_+_29952169 10.20 ENSDART00000173540
ENSDART00000173940
ENSDART00000173906
ENSDART00000173772
ENSDART00000173506
ENSDART00000039657
tpma
alpha-tropomyosin
chr5_-_32309129 9.97 ENSDART00000123003
myhz1.1
myosin, heavy polypeptide 1.1, skeletal muscle
chr7_+_29951997 9.63 ENSDART00000173453
tpma
alpha-tropomyosin
chr13_+_24279021 8.87 ENSDART00000058629
acta1b
actin, alpha 1b, skeletal muscle
chr1_+_53945934 8.74 ENSDART00000052838
acta1a
actin, alpha 1a, skeletal muscle
chr12_-_26064480 8.66 ENSDART00000158215
ENSDART00000171206
ENSDART00000171212
ENSDART00000182956
ENSDART00000186779
ldb3b
LIM domain binding 3b
chr5_-_32292965 8.35 ENSDART00000183522
ENSDART00000131983
myhz1.2
myosin, heavy polypeptide 1.2, skeletal muscle
chr12_-_26064105 7.76 ENSDART00000168825
ldb3b
LIM domain binding 3b
chr3_+_23707691 7.40 ENSDART00000025449
hoxb5a
homeobox B5a
chr5_+_37087583 7.06 ENSDART00000049900
tagln2
transgelin 2
chr3_-_35602233 7.03 ENSDART00000055269
gng13b
guanine nucleotide binding protein (G protein), gamma 13b
chr12_+_27129659 6.62 ENSDART00000076161
hoxb5b
homeobox B5b
chr6_+_1787160 6.32 ENSDART00000113505
myl9b
myosin, light chain 9b, regulatory
chr14_+_34514336 6.13 ENSDART00000024440
foxi3b
forkhead box I3b
chr19_+_19759577 5.95 ENSDART00000169480
hoxa5a
homeobox A5a
chr8_+_40628926 5.85 ENSDART00000163598
dusp2
dual specificity phosphatase 2
chr21_+_6780340 5.80 ENSDART00000139493
ENSDART00000140478
olfm1b
olfactomedin 1b
chr5_+_49744713 5.73 ENSDART00000133384
nr2f1a
nuclear receptor subfamily 2, group F, member 1a
chr2_+_30916188 5.63 ENSDART00000137012
myom1a
myomesin 1a (skelemin)
chr2_-_24554416 5.32 ENSDART00000052061
cnn2
calponin 2
chr23_+_36118738 5.29 ENSDART00000139319
hoxc5a
homeobox C5a
chr22_-_15602593 5.00 ENSDART00000036075
tpm4a
tropomyosin 4a
chr23_+_42813415 4.92 ENSDART00000055577
myl9a
myosin, light chain 9a, regulatory
chr20_-_48485354 4.88 ENSDART00000124040
ENSDART00000148437
insm1a
insulinoma-associated 1a
chr10_+_6318227 4.87 ENSDART00000170872
ENSDART00000162428
ENSDART00000158994
tpm2
tropomyosin 2 (beta)
chr12_+_42436328 4.58 ENSDART00000167324
ebf3a
early B cell factor 3a
chr22_-_15602760 4.49 ENSDART00000009054
tpm4a
tropomyosin 4a
chr21_+_25765734 4.43 ENSDART00000021664
cldnb
claudin b
chr4_-_22310956 4.37 ENSDART00000162585
hcls1
hematopoietic cell-specific Lyn substrate 1
chr17_-_42213285 4.32 ENSDART00000140549
nkx2.2a
NK2 homeobox 2a
chr24_+_31277360 4.18 ENSDART00000165993
f3a
coagulation factor IIIa
chr1_-_69444 3.61 ENSDART00000166954
si:zfos-1011f11.1
si:zfos-1011f11.1
chr13_+_33606739 3.56 ENSDART00000026464
cfl1l
cofilin 1 (non-muscle), like
chr17_-_25326296 3.51 ENSDART00000168822
pabpc4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr14_+_49251331 3.46 ENSDART00000148882
anxa6
annexin A6
chr10_-_29816467 3.44 ENSDART00000055913
hist2h2l
histone 2, H2, like
chr25_+_33192796 3.41 ENSDART00000125892
ENSDART00000121680
ENSDART00000014851
TPM1 (1 of many)
zgc:171719
chr20_-_42702832 3.30 ENSDART00000134689
ENSDART00000045816
plg
plasminogen
chr1_+_50976975 3.25 ENSDART00000022290
ENSDART00000140982
mdh1aa
malate dehydrogenase 1Aa, NAD (soluble)
chr18_-_46258612 3.23 ENSDART00000153930
si:dkey-244a7.1
si:dkey-244a7.1
chr12_-_20373058 3.09 ENSDART00000066382
aqp8a.1
aquaporin 8a, tandem duplicate 1
chr25_+_33192404 3.08 ENSDART00000193592
TPM1 (1 of many)
zgc:171719
chr20_+_40150612 3.01 ENSDART00000143680
ENSDART00000109681
ENSDART00000101041
ENSDART00000121818
trdn
triadin
chr23_-_45439903 2.74 ENSDART00000170729
NPNT (1 of many)
nephronectin
chr5_-_55395964 2.71 ENSDART00000145791
prune2
prune homolog 2 (Drosophila)
chr12_-_29624638 2.70 ENSDART00000126744
nrg3b
neuregulin 3b
chr12_-_35054354 2.67 ENSDART00000075351
zgc:112285
zgc:112285
chr13_+_29238850 2.66 ENSDART00000026000
myofl
myoferlin like
chr1_+_1805294 2.63 ENSDART00000103850
atp1a1a.3
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 3
chr8_+_25902170 2.61 ENSDART00000193130
rhoab
ras homolog gene family, member Ab
chr22_-_36856405 2.61 ENSDART00000029588
kng1
kininogen 1
chr15_-_551177 2.58 ENSDART00000066774
ENSDART00000154617
tagln
transgelin
chr23_-_44207349 2.55 ENSDART00000186276
zgc:158659
zgc:158659
chr20_-_29420713 2.54 ENSDART00000147464
ryr3
ryanodine receptor 3
chr17_-_43666166 2.51 ENSDART00000077990
egr2a
early growth response 2a
chr8_-_11229523 2.28 ENSDART00000002164
unc45b
unc-45 myosin chaperone B
chr12_+_17100021 2.27 ENSDART00000177923
acta2
actin, alpha 2, smooth muscle, aorta
chr13_-_9598320 2.27 ENSDART00000184613
cpxm1a
carboxypeptidase X (M14 family), member 1a
chr5_+_37785152 2.25 ENSDART00000053511
ENSDART00000189812
myo1ca
myosin Ic, paralog a
chr15_+_7064819 2.16 ENSDART00000155268
pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
chr10_-_22057001 2.15 ENSDART00000016575
tlx3b
T cell leukemia homeobox 3b
chr1_+_52560549 2.14 ENSDART00000167514
abca1a
ATP-binding cassette, sub-family A (ABC1), member 1A
chr2_-_24269911 2.12 ENSDART00000099532
myh7
myosin heavy chain 7
chr20_+_6590220 2.11 ENSDART00000136567
tns3.2
tensin 3, tandem duplicate 2
chr22_-_29922872 2.10 ENSDART00000020249
dusp5
dual specificity phosphatase 5
chr8_+_10561922 2.10 ENSDART00000133348
fam19a5l
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5-like
chr11_-_472547 2.10 ENSDART00000005923
zgc:77375
zgc:77375
chr7_-_18168493 2.10 ENSDART00000127428
peli3
pellino E3 ubiquitin protein ligase family member 3
chr16_-_31754102 2.06 ENSDART00000185043
ptpn6
protein tyrosine phosphatase, non-receptor type 6
chr4_+_12612723 2.05 ENSDART00000133767
lmo3
LIM domain only 3
chr20_-_47732703 1.96 ENSDART00000193975
tfap2d
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr1_-_14332283 1.95 ENSDART00000090025
wfs1a
Wolfram syndrome 1a (wolframin)
chr11_+_6281647 1.93 ENSDART00000002459
ctns
cystinosin, lysosomal cystine transporter
chr13_-_3155243 1.90 ENSDART00000139183
ENSDART00000050934
pkdcca
protein kinase domain containing, cytoplasmic a
chr2_+_38264964 1.87 ENSDART00000182068
dhrs1
dehydrogenase/reductase (SDR family) member 1
chr17_-_20979077 1.87 ENSDART00000006676
phyhipla
phytanoyl-CoA 2-hydroxylase interacting protein-like a
chr13_+_29773153 1.85 ENSDART00000144443
ENSDART00000133796
ENSDART00000141310
ENSDART00000139782
pax2a
paired box 2a
chr1_+_55293424 1.84 ENSDART00000152464
zgc:172106
zgc:172106
chr6_+_58915889 1.83 ENSDART00000083628
ddit3
DNA-damage-inducible transcript 3
chr16_+_28383758 1.82 ENSDART00000059038
ENSDART00000141061
itga8
integrin, alpha 8
chr10_+_29816681 1.79 ENSDART00000100022
h2afx1
H2A histone family member X1
chr12_-_35095414 1.79 ENSDART00000153229
si:dkey-21e13.3
si:dkey-21e13.3
chr3_+_32553714 1.73 ENSDART00000165638
pax10
paired box 10
chr1_-_8652648 1.71 ENSDART00000138324
ENSDART00000141407
ENSDART00000054987
actb1
actin, beta 1
chr21_-_17603182 1.71 ENSDART00000020048
ENSDART00000177270
gsna
gelsolin a
chr1_+_45754868 1.70 ENSDART00000084512
pkn1a
protein kinase N1a
chr10_-_1718395 1.70 ENSDART00000137620
si:ch73-46j18.5
si:ch73-46j18.5
chr18_-_41650648 1.69 ENSDART00000024087
fzd9b
frizzled class receptor 9b
chr8_+_50727220 1.69 ENSDART00000127062
egr3
early growth response 3
chr20_+_1996202 1.68 ENSDART00000184143
CABZ01092781.1

chr3_-_22228602 1.62 ENSDART00000017750
myl4
myosin, light chain 4, alkali; atrial, embryonic
chr5_-_41845116 1.58 ENSDART00000112382
si:dkey-65b12.6
si:dkey-65b12.6
chr22_-_29336268 1.55 ENSDART00000132776
ENSDART00000186351
ENSDART00000121599
pdgfba
platelet-derived growth factor beta polypeptide a
chr7_-_71758307 1.54 ENSDART00000161067
ENSDART00000165253
myom1b
myomesin 1b
chr20_+_13969414 1.49 ENSDART00000049864
rd3
retinal degeneration 3
chr12_+_35654749 1.47 ENSDART00000169889
ENSDART00000167873
baiap2b
BAI1-associated protein 2b
chr10_-_690072 1.44 ENSDART00000164871
ENSDART00000142833
glis3
GLIS family zinc finger 3
chr13_-_40398556 1.44 ENSDART00000191921
nkx3.3
NK3 homeobox 3
chr20_+_20186706 1.39 ENSDART00000002507
rhoj
ras homolog family member J
chr3_-_40945710 1.39 ENSDART00000138719
ENSDART00000102416
cyp3c4
cytochrome P450, family 3, subfamily C, polypeptide 4
chr2_-_24270062 1.37 ENSDART00000192445
myh7
myosin heavy chain 7
chr20_+_53577502 1.36 ENSDART00000126983
myh6
myosin, heavy chain 6, cardiac muscle, alpha
chr7_-_71758613 1.35 ENSDART00000166724
myom1b
myomesin 1b
chr3_+_58167288 1.35 ENSDART00000155874
ENSDART00000010395
uqcrc2a
ubiquinol-cytochrome c reductase core protein 2a
chr20_-_2949028 1.34 ENSDART00000104667
ENSDART00000193151
ENSDART00000131946
cdk19
cyclin-dependent kinase 19
chr1_-_8651718 1.33 ENSDART00000133319
actb1
actin, beta 1
chr6_-_45905746 1.33 ENSDART00000025428
epha2a
eph receptor A2 a
chr20_-_46554440 1.32 ENSDART00000043298
ENSDART00000060680
fosab
v-fos FBJ murine osteosarcoma viral oncogene homolog Ab
chr21_+_8533533 1.30 ENSDART00000077924
FO834888.1

chr3_-_18410968 1.28 ENSDART00000041842
ndufb10
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10
chr23_+_28378543 1.24 ENSDART00000145327
zgc:153867
zgc:153867
chr22_-_11493236 1.17 ENSDART00000002691
tspan7b
tetraspanin 7b
chr1_+_9994811 1.17 ENSDART00000143719
ENSDART00000110749
si:dkeyp-75b4.10
si:dkeyp-75b4.10
chr7_+_5494565 1.16 ENSDART00000135271
MYADM
si:dkeyp-67a8.2
chr9_+_6587056 1.16 ENSDART00000193421
fhl2a
four and a half LIM domains 2a
chr7_-_28549361 1.09 ENSDART00000173918
ENSDART00000054368
ENSDART00000113313
st5
suppression of tumorigenicity 5
chr9_+_6587364 1.08 ENSDART00000122279
fhl2a
four and a half LIM domains 2a
chr5_+_38462121 1.07 ENSDART00000144425
gltpd2
glycolipid transfer protein domain containing 2
chr15_-_42760110 1.05 ENSDART00000152490
si:ch211-181d7.3
si:ch211-181d7.3
chr10_+_42169982 1.04 ENSDART00000190905
CU467905.1

chr13_-_377256 1.01 ENSDART00000137398
ch1073-291c23.1
ch1073-291c23.1
chr9_-_202805 1.01 ENSDART00000182260
CABZ01067557.1

chr23_+_44611864 1.00 ENSDART00000145905
ENSDART00000132361
eno3
enolase 3, (beta, muscle)
chr23_-_16692312 0.99 ENSDART00000046784
fkbp1ab
FK506 binding protein 1Ab
chr1_-_37383741 0.98 ENSDART00000193155
ENSDART00000191887
ENSDART00000189077
scpp1
secretory calcium-binding phosphoprotein 1
chr9_-_44948488 0.93 ENSDART00000059228
vil1
villin 1
chr4_-_16644708 0.92 ENSDART00000042307
sinhcaf
SIN3-HDAC complex associated factor
chr11_-_16152400 0.86 ENSDART00000123665
arpc4l
actin related protein 2/3 complex, subunit 4, like
chr3_+_45401472 0.83 ENSDART00000156693
baiap3
BAI1-associated protein 3
chr14_+_17137023 0.76 ENSDART00000080712
slc43a3b
solute carrier family 43, member 3b
chr8_+_36942262 0.75 ENSDART00000188173
iqsec2b
IQ motif and Sec7 domain 2b
chr11_+_25459697 0.74 ENSDART00000161481
opn1sw2
opsin 1 (cone pigments), short-wave-sensitive 2
chr21_+_42930558 0.73 ENSDART00000135234
stk32a
serine/threonine kinase 32A
chr21_-_31286428 0.72 ENSDART00000185334
ca4c
carbonic anhydrase IV c
chr8_+_8937723 0.71 ENSDART00000145970
si:dkey-83k24.5
si:dkey-83k24.5
chr22_-_4780010 0.70 ENSDART00000192844
si:ch73-256j6.5
si:ch73-256j6.5
chr11_+_37178271 0.69 ENSDART00000161771
itih3b
inter-alpha-trypsin inhibitor heavy chain 3b
chr2_+_31804582 0.69 ENSDART00000086646
rnf182
ring finger protein 182
chr19_-_42424599 0.68 ENSDART00000077042
zgc:153441
zgc:153441
chr14_-_30747686 0.67 ENSDART00000008373
fosl1a
FOS-like antigen 1a
chr1_-_50791280 0.65 ENSDART00000181224
CABZ01031870.1

chr19_+_46158078 0.65 ENSDART00000183933
ENSDART00000164055
cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr18_-_14941840 0.62 ENSDART00000091729
mlc1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr4_-_6623645 0.62 ENSDART00000060861
foxp2
forkhead box P2
chr23_+_45579497 0.61 ENSDART00000110381
egr4
early growth response 4
chr2_+_10771787 0.60 ENSDART00000187782
gfi1aa
growth factor independent 1A transcription repressor a
chr1_+_57331813 0.60 ENSDART00000152440
ENSDART00000062841
epn3b
epsin 3b
chr3_-_40529782 0.60 ENSDART00000055194
ENSDART00000141737
actb2
actin, beta 2
chr20_-_14875308 0.59 ENSDART00000141290
dnm3a
dynamin 3a
chr21_+_20949976 0.57 ENSDART00000135342
htr1ab
5-hydroxytryptamine (serotonin) receptor 1A b
chr11_+_40657612 0.57 ENSDART00000183271
slc45a1
solute carrier family 45, member 1
chr1_-_6494384 0.54 ENSDART00000109356
klf7a
Kruppel-like factor 7a
chr4_+_5180650 0.52 ENSDART00000067390
fgf6b
fibroblast growth factor 6b
chr10_-_32920690 0.51 ENSDART00000136245
cux1a
cut-like homeobox 1a
chr18_+_36769758 0.51 ENSDART00000180375
ENSDART00000136463
ENSDART00000133487
ENSDART00000130206
fosb
FBJ murine osteosarcoma viral oncogene homolog B
chr7_+_71764665 0.50 ENSDART00000171996
myl12.1
myosin, light chain 12, genome duplicate 1
chr14_-_25309058 0.49 ENSDART00000159569
htr4
5-hydroxytryptamine receptor 4
chr16_-_25607266 0.47 ENSDART00000192602
zgc:110410
zgc:110410
chr16_-_30421275 0.46 ENSDART00000003752
cct3
chaperonin containing TCP1, subunit 3 (gamma)
chr4_-_49133107 0.43 ENSDART00000150806
znf1146
zinc finger protein 1146
chr8_+_26268726 0.43 ENSDART00000180883
slc26a6
solute carrier family 26, member 6
chr25_-_19031019 0.42 ENSDART00000191707
cacna2d4b
calcium channel, voltage-dependent, alpha 2/delta subunit 4b
chr13_-_30713236 0.41 ENSDART00000112372
ENSDART00000142221
tmem72
transmembrane protein 72
chr25_-_19486399 0.40 ENSDART00000155076
ENSDART00000156016
zgc:193812
zgc:193812
chr16_+_23816933 0.39 ENSDART00000183428
si:dkey-7f3.9
si:dkey-7f3.9
chr3_+_54761569 0.38 ENSDART00000135913
ENSDART00000180983
si:ch211-74m13.1
si:ch211-74m13.1
chr4_+_33461796 0.35 ENSDART00000150445
si:dkey-247i3.1
si:dkey-247i3.1
chr11_-_16152105 0.34 ENSDART00000081062
arpc4l
actin related protein 2/3 complex, subunit 4, like
chr14_+_743346 0.34 ENSDART00000110511
klb
klotho beta
chr11_-_34097418 0.29 ENSDART00000028301
ENSDART00000138579
tdo2b
tryptophan 2,3-dioxygenase b
chr13_+_23132666 0.29 ENSDART00000164639
sorbs1
sorbin and SH3 domain containing 1
chr16_+_12632428 0.29 ENSDART00000184600
ENSDART00000180537
nat14
N-acetyltransferase 14 (GCN5-related, putative)
chr12_+_19362335 0.29 ENSDART00000041711
gspt1
G1 to S phase transition 1
chr14_+_48964628 0.28 ENSDART00000105427
mif
macrophage migration inhibitory factor
chr14_+_4276394 0.27 ENSDART00000038301
gnpda2
glucosamine-6-phosphate deaminase 2
chr3_-_56896702 0.26 ENSDART00000023265
ush1ga
Usher syndrome 1Ga (autosomal recessive)
chr23_-_37514493 0.24 ENSDART00000083267
dnajc16
DnaJ (Hsp40) homolog, subfamily C, member 16
chr7_+_56651759 0.24 ENSDART00000073600
kcng4b
potassium voltage-gated channel, subfamily G, member 4b
chr20_+_9211237 0.23 ENSDART00000139527
si:ch211-59d15.4
si:ch211-59d15.4
chr15_+_8043751 0.21 ENSDART00000193701
cadm2b
cell adhesion molecule 2b
chr7_-_66868543 0.19 ENSDART00000149680
ampd3a
adenosine monophosphate deaminase 3a
chr22_-_382955 0.18 ENSDART00000082406
ora3
olfactory receptor class A related 3
chr11_+_16152316 0.18 ENSDART00000081054
tada3l
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr3_+_1724941 0.17 ENSDART00000193402
BX321875.2

chr3_-_2592350 0.15 ENSDART00000192325
si:dkey-217f16.5
si:dkey-217f16.5
chr20_-_40750953 0.12 ENSDART00000061256
cx28.9
connexin 28.9
chr3_-_37351225 0.12 ENSDART00000174685
si:ch211-278a6.1
si:ch211-278a6.1
chr21_+_20950161 0.12 ENSDART00000079698
htr1ab
5-hydroxytryptamine (serotonin) receptor 1A b
chr23_-_35064785 0.11 ENSDART00000172240
BX294434.1

chr23_-_44466257 0.08 ENSDART00000150126
si:ch1073-228j22.2
si:ch1073-228j22.2
chr3_-_32898626 0.07 ENSDART00000103201
kat7a
K(lysine) acetyltransferase 7a
chr16_-_31675669 0.07 ENSDART00000168848
ENSDART00000158331
c1r
complement component 1, r subcomponent
chr14_-_10492072 0.05 ENSDART00000182525
lpar4
lysophosphatidic acid receptor 4
chr3_-_33395233 0.04 ENSDART00000167349
si:dkey-283b1.6
si:dkey-283b1.6
chr3_+_28594713 0.01 ENSDART00000179799
sept12
septin 12

Network of associatons between targets according to the STRING database.

First level regulatory network of srfa+srfb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 11.0 GO:0090131 mesenchyme migration(GO:0090131)
1.5 6.1 GO:0009957 epidermal cell fate specification(GO:0009957)
1.4 4.3 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
1.2 3.6 GO:0030043 actin filament fragmentation(GO:0030043)
1.1 3.3 GO:0042730 fibrinolysis(GO:0042730)
0.9 3.5 GO:0001778 plasma membrane repair(GO:0001778) chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418)
0.8 7.1 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011)
0.7 3.5 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.7 4.9 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.7 7.2 GO:0050909 sensory perception of taste(GO:0050909)
0.7 2.6 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.7 3.3 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.6 8.0 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.5 2.1 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.5 6.6 GO:0010002 cardioblast differentiation(GO:0010002)
0.5 1.8 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.4 2.1 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.4 9.5 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.4 15.1 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.4 2.6 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.3 1.8 GO:0021588 cerebellum formation(GO:0021588)
0.2 6.7 GO:0001757 somite specification(GO:0001757)
0.2 4.7 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.2 2.7 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.2 0.9 GO:0072673 lamellipodium morphogenesis(GO:0072673) regulation of lamellipodium morphogenesis(GO:2000392)
0.2 1.9 GO:0070293 renal absorption(GO:0070293)
0.2 1.4 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.2 5.3 GO:0043535 regulation of blood vessel endothelial cell migration(GO:0043535)
0.2 19.8 GO:0061515 myeloid cell development(GO:0061515)
0.2 1.6 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.2 1.5 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 2.6 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 1.0 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.1 1.3 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.1 2.7 GO:0007520 myoblast fusion(GO:0007520)
0.1 4.4 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 0.3 GO:0006041 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
0.1 0.2 GO:0055057 neuroblast division(GO:0055057)
0.1 13.4 GO:0006936 muscle contraction(GO:0006936)
0.1 3.3 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.1 0.4 GO:0051454 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.1 1.7 GO:0051014 actin filament severing(GO:0051014)
0.1 4.3 GO:0014904 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.1 1.2 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198) serotonin receptor signaling pathway(GO:0007210)
0.1 1.4 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.1 0.6 GO:0034394 protein localization to cell surface(GO:0034394)
0.1 17.5 GO:0009952 anterior/posterior pattern specification(GO:0009952)
0.1 1.4 GO:0003323 type B pancreatic cell development(GO:0003323)
0.1 0.3 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.1 16.4 GO:0061061 muscle structure development(GO:0061061)
0.0 0.7 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 2.0 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.6 GO:0045471 response to ethanol(GO:0045471)
0.0 3.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.3 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 1.7 GO:0035567 non-canonical Wnt signaling pathway(GO:0035567)
0.0 0.6 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 2.3 GO:0032835 glomerulus development(GO:0032835)
0.0 0.3 GO:0050957 equilibrioception(GO:0050957)
0.0 2.1 GO:0046474 glycerophospholipid biosynthetic process(GO:0046474)
0.0 0.6 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.4 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.6 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 3.8 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 1.5 GO:0007596 blood coagulation(GO:0007596)
0.0 0.5 GO:2000027 regulation of organ morphogenesis(GO:2000027)
0.0 0.9 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 0.7 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 2.3 GO:0016485 protein processing(GO:0016485)
0.0 1.8 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.0 0.2 GO:0032264 IMP salvage(GO:0032264)
0.0 0.3 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.1 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 19.9 GO:0005869 dynactin complex(GO:0005869)
0.7 3.6 GO:0097433 dense body(GO:0097433)
0.6 2.3 GO:0060171 stereocilium membrane(GO:0060171)
0.5 54.2 GO:0005884 actin filament(GO:0005884)
0.4 8.5 GO:0031430 M band(GO:0031430)
0.3 2.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.2 2.3 GO:0031672 A band(GO:0031672)
0.2 4.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 0.9 GO:0032433 filopodium tip(GO:0032433)
0.2 22.3 GO:0016459 myosin complex(GO:0016459)
0.1 4.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 1.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 7.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 3.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.9 GO:0016580 Sin3 complex(GO:0016580)
0.1 3.5 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 2.6 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.3 GO:0018444 translation release factor complex(GO:0018444)
0.0 2.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 2.2 GO:0030018 Z disc(GO:0030018)
0.0 0.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 1.8 GO:0008305 integrin complex(GO:0008305)
0.0 4.4 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 9.5 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 0.6 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 1.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.3 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 2.6 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 16.4 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.7 3.6 GO:0098973 structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.7 3.3 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.6 1.9 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.6 15.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.6 8.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.4 4.7 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.4 2.1 GO:0090554 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.3 3.1 GO:0015250 water channel activity(GO:0015250)
0.3 7.0 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.3 1.4 GO:0048763 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.3 2.6 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.3 3.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.2 2.7 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.2 80.6 GO:0051015 actin filament binding(GO:0051015)
0.2 1.6 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.2 2.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 1.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 1.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.3 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1 1.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.3 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 2.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.6 GO:0008506 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 2.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 6.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 1.7 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.1 1.2 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 2.7 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.7 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 5.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 3.3 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.3 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.3 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 40.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 1.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.2 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 2.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.5 GO:0004896 cytokine receptor activity(GO:0004896)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 17.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2 2.6 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.2 3.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 4.2 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 3.9 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 1.8 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.1 4.8 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 3.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.4 PID AP1 PATHWAY AP-1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 17.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.5 3.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.3 7.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 1.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 2.6 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 3.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.2 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 0.5 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 1.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.5 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 1.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.3 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 1.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases