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PRJNA195909:zebrafish embryo and larva development

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Results for tfap2e

Z-value: 0.60

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Transcription factors associated with tfap2e

Gene Symbol Gene ID Gene Info
tfap2e
ENSDARG00000008861 transcription factor AP-2 epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap2edr11_v1_chr19_-_47452874_474528740.255.2e-01Click!

Activity profile of tfap2e motif

Sorted Z-values of tfap2e motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_11205795 0.96 ENSDART00000019078
lhx8a
LIM homeobox 8a
chr23_-_9965148 0.80 ENSDART00000137308
plxnb1a
plexin b1a
chr14_-_34605607 0.65 ENSDART00000191608
afap1l1a
actin filament associated protein 1-like 1a
chr14_-_34605804 0.61 ENSDART00000144547
afap1l1a
actin filament associated protein 1-like 1a
chr3_-_54607166 0.58 ENSDART00000021977
dnmt1
DNA (cytosine-5-)-methyltransferase 1
chr11_-_28050559 0.57 ENSDART00000136859
ece1
endothelin converting enzyme 1
chr2_-_15041846 0.56 ENSDART00000139050
si:dkey-10f21.4
si:dkey-10f21.4
chr19_+_42660158 0.55 ENSDART00000018328
fbxl2
F-box and leucine-rich repeat protein 2
chr19_-_31707892 0.54 ENSDART00000088427
ripor2
RHO family interacting cell polarization regulator 2
chr2_+_11206317 0.51 ENSDART00000144982
lhx8a
LIM homeobox 8a
chr2_+_1988036 0.49 ENSDART00000155956
ssx2ipa
synovial sarcoma, X breakpoint 2 interacting protein a
chr2_+_30547018 0.47 ENSDART00000193747
ankrd33bb
ankyrin repeat domain 33Bb
chr16_-_46393154 0.47 ENSDART00000132154
si:ch73-59c19.1
si:ch73-59c19.1
chr23_-_18668836 0.45 ENSDART00000138792
ENSDART00000051182
arhgap4b
Rho GTPase activating protein 4b
chr24_-_21903360 0.43 ENSDART00000091252
spata13
spermatogenesis associated 13
chr19_+_2835240 0.42 ENSDART00000190838
CDCP1
CUB domain containing protein 1
chr24_-_21903588 0.41 ENSDART00000180991
spata13
spermatogenesis associated 13
chr20_+_6533260 0.41 ENSDART00000135005
ENSDART00000166356
si:ch211-191a24.4
si:ch211-191a24.4
chr7_+_39011852 0.40 ENSDART00000093009
dgkza
diacylglycerol kinase, zeta a
chr3_+_25990052 0.39 ENSDART00000007398
gcat
glycine C-acetyltransferase
chr6_+_153146 0.38 ENSDART00000097468
zglp1
zinc finger, GATA-like protein 1
chr3_-_49163683 0.38 ENSDART00000166146
dnajb1a
DnaJ (Hsp40) homolog, subfamily B, member 1a
chr23_-_35347714 0.36 ENSDART00000161770
ENSDART00000165615
cpne9
copine family member IX
chr11_+_30253968 0.34 ENSDART00000157272
ENSDART00000003475
ppef1
protein phosphatase, EF-hand calcium binding domain 1
chr16_-_39859119 0.33 ENSDART00000138388
rbms3
RNA binding motif, single stranded interacting protein
chr22_+_1440702 0.33 ENSDART00000165677
si:dkeyp-53d3.3
si:dkeyp-53d3.3
chr14_+_29609245 0.32 ENSDART00000043058
TENM2
si:dkey-34l15.2
chr14_-_31465905 0.32 ENSDART00000173108
gpc3
glypican 3
chr3_-_55328548 0.29 ENSDART00000082944
dock6
dedicator of cytokinesis 6
chr19_-_30510930 0.28 ENSDART00000088760
ENSDART00000181043
bag6l
BCL2 associated athanogene 6, like
chr5_+_27267186 0.27 ENSDART00000182238
ENSDART00000087857
unc5db
unc-5 netrin receptor Db
chr14_+_39258569 0.27 ENSDART00000103298
diaph2
diaphanous-related formin 2
chr25_+_11281970 0.26 ENSDART00000180094
AKAP13
si:dkey-187e18.1
chr19_+_32979331 0.26 ENSDART00000078066
spire1a
spire-type actin nucleation factor 1a
chr7_+_39011355 0.25 ENSDART00000173855
dgkza
diacylglycerol kinase, zeta a
chr10_-_2526526 0.25 ENSDART00000191726
ENSDART00000192767
CU856539.1

chr11_+_13067028 0.21 ENSDART00000186126
zfyve9b
zinc finger, FYVE domain containing 9b
chr19_-_10395683 0.21 ENSDART00000109488
zgc:194578
zgc:194578
chr22_+_15633013 0.21 ENSDART00000188095
ENSDART00000048763
CABZ01090041.1

chr15_+_44929497 0.21 ENSDART00000111373
pdgfd
platelet derived growth factor d
chr17_+_34186632 0.20 ENSDART00000014306
mpp5a
membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5)
chr7_-_23563092 0.20 ENSDART00000132275
gpr185b
G protein-coupled receptor 185 b
chr5_+_25736979 0.19 ENSDART00000175959
abhd17b
abhydrolase domain containing 17B
chr17_-_53440103 0.18 ENSDART00000156719
ENSDART00000156396
mycbp
c-myc binding protein
chr11_+_31323746 0.18 ENSDART00000180220
ENSDART00000189937
sipa1l2
signal-induced proliferation-associated 1 like 2
chr1_+_16548733 0.17 ENSDART00000048855
mtus1b
microtubule associated tumor suppressor 1b
chr17_-_53439866 0.17 ENSDART00000154826
mycbp
c-myc binding protein
chr5_+_63302660 0.16 ENSDART00000142131
si:ch73-376l24.2
si:ch73-376l24.2
chr7_-_15252540 0.16 ENSDART00000173072
ENSDART00000125258
si:dkey-172h23.2
si:dkey-172h23.2
chr23_-_4930229 0.15 ENSDART00000189456
ngfa
nerve growth factor a (beta polypeptide)
chr21_-_21089781 0.15 ENSDART00000144361
ank1b
ankyrin 1, erythrocytic b
chr11_+_31324335 0.15 ENSDART00000088093
sipa1l2
signal-induced proliferation-associated 1 like 2
chr22_-_57177 0.14 ENSDART00000163959
CABZ01085139.1

chr12_+_15165736 0.13 ENSDART00000180398
adprh
ADP-ribosylarginine hydrolase
chr3_+_3454610 0.13 ENSDART00000024900
zgc:165453
zgc:165453
chr4_+_77966055 0.13 ENSDART00000174203
ENSDART00000130100
ENSDART00000080665
ENSDART00000174317
ENSDART00000190123
zgc:113921
zgc:113921
chr24_+_31374324 0.12 ENSDART00000172335
ENSDART00000163162
cpne3
copine III
chr16_+_36906693 0.12 ENSDART00000160645
si:ch73-215d9.1
si:ch73-215d9.1
chr6_-_25369295 0.12 ENSDART00000191475
PKN2 (1 of many)
zgc:153916
chr1_-_25486471 0.12 ENSDART00000134200
ENSDART00000141892
ENSDART00000102501
arfip1
ADP-ribosylation factor interacting protein 1 (arfaptin 1)
chr18_+_34478959 0.11 ENSDART00000059394
kcnab1a
potassium voltage-gated channel, shaker-related subfamily, beta member 1 a
chr24_-_6898302 0.11 ENSDART00000158646
dpp6a
dipeptidyl-peptidase 6a
chr7_-_33921366 0.11 ENSDART00000052397
pias1a
protein inhibitor of activated STAT, 1a
chr5_-_14509137 0.10 ENSDART00000180742
si:ch211-244o22.2
si:ch211-244o22.2
chr9_+_32358514 0.10 ENSDART00000144608
plcl1
phospholipase C like 1
chr7_+_32693890 0.10 ENSDART00000121972
slc39a13
solute carrier family 39 (zinc transporter), member 13
chr9_+_32978302 0.08 ENSDART00000007630
nhlh2
nescient helix loop helix 2
chr17_-_53440284 0.08 ENSDART00000126976
mycbp
c-myc binding protein
chr7_+_22680560 0.07 ENSDART00000133761
ponzr4
plac8 onzin related protein 4
chr11_+_1657221 0.07 ENSDART00000164394
lrp1aa
low density lipoprotein receptor-related protein 1Aa
chr19_+_1184878 0.07 ENSDART00000163539
scrt1a
scratch family zinc finger 1a
chr15_-_44512461 0.07 ENSDART00000155456
gria4a
glutamate receptor, ionotropic, AMPA 4a
chr9_-_2892250 0.07 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr5_+_38673168 0.06 ENSDART00000135267
si:dkey-58f10.12
si:dkey-58f10.12
chr5_-_26936861 0.06 ENSDART00000191032
htra4
HtrA serine peptidase 4
chr16_-_29458806 0.05 ENSDART00000047931
lingo4b
leucine rich repeat and Ig domain containing 4b
chr21_-_32680638 0.05 ENSDART00000147203
adamts2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr14_-_33821515 0.05 ENSDART00000173218
vimr2
vimentin-related 2
chr21_-_14773692 0.05 ENSDART00000142145
glulc
glutamate-ammonia ligase (glutamine synthase) c
chr8_-_11004726 0.05 ENSDART00000192594
ENSDART00000020116
trim33
tripartite motif containing 33
chr23_+_37323962 0.05 ENSDART00000102881
fam43b
family with sequence similarity 43, member B
chr23_+_27778670 0.04 ENSDART00000053863
kmt2d
lysine (K)-specific methyltransferase 2D
chr25_-_19574146 0.03 ENSDART00000156811
si:ch211-59o9.10
si:ch211-59o9.10
chr15_-_16098531 0.03 ENSDART00000080377
aldoca
aldolase C, fructose-bisphosphate, a
chr1_-_53476758 0.03 ENSDART00000074221
b3gnt2a
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2a
chr9_-_2892045 0.02 ENSDART00000137201
cdca7a
cell division cycle associated 7a
chr14_-_30805091 0.02 ENSDART00000078186
prss23
protease, serine, 23
chr7_-_51476276 0.01 ENSDART00000082464
nhsl2
NHS-like 2
chr22_+_5971404 0.01 ENSDART00000122153
BX322587.1

chr16_+_45571956 0.01 ENSDART00000143867
syngap1b
synaptic Ras GTPase activating protein 1b
chr25_+_5249513 0.01 ENSDART00000126814
CABZ01039863.1

chr14_-_26704829 0.01 ENSDART00000078563
neurog1
neurogenin 1
chr5_-_38451082 0.00 ENSDART00000136428
chrne
cholinergic receptor, nicotinic, epsilon
chr1_+_26467071 0.00 ENSDART00000112329
ENSDART00000159318
ENSDART00000193833
ENSDART00000011809
uso1
USO1 vesicle transport factor
chr13_+_24279021 0.00 ENSDART00000058629
acta1b
actin, alpha 1b, skeletal muscle

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2e

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:2000405 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of lymphocyte migration(GO:2000402) negative regulation of T cell migration(GO:2000405)
0.1 0.6 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.1 1.5 GO:0021884 forebrain neuron development(GO:0021884)
0.1 0.2 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.4 GO:0006567 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.0 0.3 GO:0060976 coronary vasculature development(GO:0060976)
0.0 0.8 GO:1902287 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 0.6 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.3 GO:0040038 meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038)
0.0 0.4 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.2 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.1 GO:1902260 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.3 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.3 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.2 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.2 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.4 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.1 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0060171 stereocilium membrane(GO:0060171)
0.1 1.3 GO:0002102 podosome(GO:0002102)
0.0 0.3 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.8 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 0.4 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.0 0.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.0 0.3 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.8 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.4 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.3 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.2 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 1.3 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0005163 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.0 0.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis