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PRJNA195909:zebrafish embryo and larva development

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Results for tp53

Z-value: 0.98

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Transcription factors associated with tp53

Gene Symbol Gene ID Gene Info
tp53
ENSDARG00000035559 tumor protein p53
tp53
ENSDARG00000115148 tumor protein p53

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tp53dr11_v1_chr5_+_24089334_240893340.462.1e-01Click!

Activity profile of tp53 motif

Sorted Z-values of tp53 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_35043007 1.67 ENSDART00000086954
sesn3
sestrin 3
chr24_+_22485710 1.28 ENSDART00000146058
si:dkey-40h20.1
si:dkey-40h20.1
chr21_+_25688388 1.17 ENSDART00000125709
bicdl2
bicaudal-D-related protein 2
chr20_-_27225876 1.16 ENSDART00000149204
ENSDART00000149732
si:dkey-85n7.7
si:dkey-85n7.7
chr25_-_7520937 1.15 ENSDART00000170050
cdkn1cb
cyclin-dependent kinase inhibitor 1Cb
chr10_-_4980150 1.11 ENSDART00000093228
mat2al
methionine adenosyltransferase II, alpha-like
chr15_-_29387446 1.08 ENSDART00000145976
ENSDART00000035096
serpinh1b
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr23_-_5759242 0.99 ENSDART00000055087
phlda3
pleckstrin homology-like domain, family A, member 3
chr19_-_27462720 0.99 ENSDART00000135901
si:ch73-25f10.6
si:ch73-25f10.6
chr22_+_37888249 0.91 ENSDART00000076082
fetub
fetuin B
chr10_+_8629275 0.84 ENSDART00000129643
aplnrb
apelin receptor b
chr23_+_23232136 0.84 ENSDART00000126479
ENSDART00000187764
plekhn1
pleckstrin homology domain containing, family N member 1
chr25_+_34641536 0.75 ENSDART00000167033
CABZ01079011.1

chr10_+_4987766 0.71 ENSDART00000121959
si:ch73-234b20.5
si:ch73-234b20.5
chr6_+_49095646 0.69 ENSDART00000103385
slc25a55a
solute carrier family 25, member 55a
chr4_+_25630555 0.67 ENSDART00000133425
acot15
acyl-CoA thioesterase 15
chr5_-_57686487 0.66 ENSDART00000074264
crfb12
cytokine receptor family member B12
chr15_-_18067220 0.66 ENSDART00000113142
phldb1b
pleckstrin homology-like domain, family B, member 1b
chr14_+_36231126 0.65 ENSDART00000141766
elovl6
ELOVL fatty acid elongase 6
chr23_-_31428763 0.62 ENSDART00000053545
zgc:153284
zgc:153284
chr10_+_38512270 0.57 ENSDART00000109752
serpinh1a
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a
chr18_+_45200043 0.56 ENSDART00000015786
large2
LARGE xylosyl- and glucuronyltransferase 2
chr4_-_40589466 0.55 ENSDART00000133295
ENSDART00000124872
si:dkey-207m2.4
si:dkey-207m2.4
chr18_-_16924221 0.53 ENSDART00000122102
wee1
WEE1 G2 checkpoint kinase
chr5_+_27898226 0.51 ENSDART00000098604
ENSDART00000180251
adam28
ADAM metallopeptidase domain 28
chr12_+_27537357 0.51 ENSDART00000136212
etv4
ets variant 4
chr13_+_28705143 0.51 ENSDART00000183338
ldb1a
LIM domain binding 1a
chr7_+_26049818 0.49 ENSDART00000173611
si:dkey-6n21.12
si:dkey-6n21.12
chr7_-_26049282 0.48 ENSDART00000136389
ENSDART00000101124
rnaseka
ribonuclease, RNase K a
chr8_+_28593707 0.48 ENSDART00000097213
tcf15
transcription factor 15
chr9_+_51882534 0.47 ENSDART00000165493
CABZ01079550.1

chr3_-_58205045 0.47 ENSDART00000130740
si:ch211-256e16.11
si:ch211-256e16.11
chr20_-_32332736 0.46 ENSDART00000062982
foxo3b
forkhead box O3b
chr3_-_50277959 0.46 ENSDART00000082773
ENSDART00000139524
arl16
ADP-ribosylation factor-like 16
chr11_+_6281647 0.46 ENSDART00000002459
ctns
cystinosin, lysosomal cystine transporter
chr9_-_15789526 0.44 ENSDART00000141318
si:dkey-103d23.3
si:dkey-103d23.3
chr2_-_27900518 0.44 ENSDART00000109561
ENSDART00000077720
zgc:163121
zgc:163121
chr4_+_23127104 0.44 ENSDART00000139543
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr19_+_34274504 0.44 ENSDART00000132046
si:ch211-9n13.3
si:ch211-9n13.3
chr8_+_7322465 0.44 ENSDART00000192380
ssuh2rs1
ssu-2 homolog, related sequence 1
chr7_+_48805534 0.42 ENSDART00000145375
ENSDART00000148744
cpt1aa
carnitine palmitoyltransferase 1Aa (liver)
chr23_-_1017428 0.41 ENSDART00000110588
ENSDART00000183158
cdh26.1
cadherin 26, tandem duplicate 1
chr15_+_627619 0.40 ENSDART00000157207
si:ch211-210b2.1
si:ch211-210b2.1
chr6_-_3514529 0.40 ENSDART00000151020
ENSDART00000082151
uqcrh
ubiquinol-cytochrome c reductase hinge protein
chr23_-_1017605 0.40 ENSDART00000138290
cdh26.1
cadherin 26, tandem duplicate 1
chr15_-_23761580 0.39 ENSDART00000137918
bbc3
BCL2 binding component 3
chr3_+_23692462 0.39 ENSDART00000145934
hoxb7a
homeobox B7a
chr3_+_16229911 0.38 ENSDART00000121728
rpl19
ribosomal protein L19
chr6_-_3514753 0.37 ENSDART00000151765
uqcrh
ubiquinol-cytochrome c reductase hinge protein
chr3_-_47294365 0.37 ENSDART00000191039
tnfsf18
TNF superfamily member 18
chr4_+_25607743 0.36 ENSDART00000028297
acot14
acyl-CoA thioesterase 14
chr4_+_34417403 0.36 ENSDART00000186032
ENSDART00000167909
si:ch211-246b8.2
si:ch211-246b8.2
chr17_-_23412705 0.36 ENSDART00000126995
si:ch211-149k12.3
si:ch211-149k12.3
chr13_+_31144305 0.35 ENSDART00000189602
CR931802.4

chr14_+_22132896 0.35 ENSDART00000138274
ccng1
cyclin G1
chr4_-_71311438 0.34 ENSDART00000168021
si:dkeyp-123a12.2
si:dkeyp-123a12.2
chr5_-_6508250 0.32 ENSDART00000060535
crybb3
crystallin, beta B3
chr20_+_52546186 0.32 ENSDART00000110777
ENSDART00000153377
ENSDART00000153013
ENSDART00000042704
eef1db
eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein)
chr19_+_9150041 0.32 ENSDART00000127803
ENSDART00000091533
clk2a
CDC-like kinase 2a
chr16_-_48400639 0.31 ENSDART00000159372
eif3ha
eukaryotic translation initiation factor 3, subunit H, a
chr3_-_50146854 0.30 ENSDART00000157047
si:dkey-120c6.5
si:dkey-120c6.5
chr16_-_30931651 0.29 ENSDART00000132643
slc45a4
solute carrier family 45, member 4
chr5_-_29570141 0.28 ENSDART00000043259
entpd2a.2
ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 2
chr25_-_36044583 0.28 ENSDART00000073432
rbl2
retinoblastoma-like 2 (p130)
chr3_-_49815223 0.28 ENSDART00000181208
gcgra
glucagon receptor a
chr25_+_19095231 0.27 ENSDART00000154066
isg20
interferon stimulated exonuclease gene
chr4_-_62206968 0.27 ENSDART00000193074
si:dkeyp-35e5.5
si:dkeyp-35e5.5
chr3_-_31078348 0.27 ENSDART00000055360
elob
elongin B
chr3_-_11040575 0.27 ENSDART00000159802
CR382337.2

chr20_-_26929685 0.25 ENSDART00000132556
ftr79
finTRIM family, member 79
chr15_+_44053244 0.25 ENSDART00000059550
lrrc51
leucine rich repeat containing 51
chr19_+_43780970 0.24 ENSDART00000063870
rpl11
ribosomal protein L11
chr16_-_30931468 0.24 ENSDART00000187838
slc45a4
solute carrier family 45, member 4
chr16_+_35595312 0.24 ENSDART00000170438
si:ch211-1i11.3
si:ch211-1i11.3
chr5_+_24089334 0.24 ENSDART00000183748
tp53
tumor protein p53
chr9_+_29671553 0.24 ENSDART00000015377
rnaseh2b
ribonuclease H2, subunit B
chr5_-_69804433 0.24 ENSDART00000028954
rilpl2
Rab interacting lysosomal protein-like 2
chr6_+_59913147 0.23 ENSDART00000156543
aamp
angio-associated, migratory cell protein
chr18_+_11970987 0.23 ENSDART00000144111
si:dkeyp-2c8.3
si:dkeyp-2c8.3
chr4_+_23127284 0.23 ENSDART00000122675
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr25_-_36044294 0.23 ENSDART00000182207
rbl2
retinoblastoma-like 2 (p130)
chr9_+_8929764 0.23 ENSDART00000102562
ankrd10b
ankyrin repeat domain 10b
chr4_+_77808579 0.22 ENSDART00000166325
si:dkey-238k10.3
si:dkey-238k10.3
chr4_-_70050522 0.22 ENSDART00000100252
si:ch211-171l17.14
si:ch211-171l17.14
chr9_+_50110763 0.22 ENSDART00000162990
cobll1b
cordon-bleu WH2 repeat protein-like 1b
chr14_+_28438947 0.22 ENSDART00000006489
acsl4a
acyl-CoA synthetase long chain family member 4a
chr19_+_44009473 0.21 ENSDART00000151004
nkd3
naked cuticle homolog 3
chr20_-_15132151 0.21 ENSDART00000063884
si:dkey-239i20.4
si:dkey-239i20.4
chr10_-_27566481 0.21 ENSDART00000078920
auts2a
autism susceptibility candidate 2a
chr8_+_23639124 0.20 ENSDART00000083108
nt5dc2
5'-nucleotidase domain containing 2
chr9_+_55075526 0.20 ENSDART00000139555
ENSDART00000133864
gpr143
G protein-coupled receptor 143
chr7_+_4194055 0.20 ENSDART00000105073
si:dkey-28d5.14
si:dkey-28d5.14
chr17_-_8268406 0.20 ENSDART00000149873
ENSDART00000064668
ENSDART00000148403
ahi1
Abelson helper integration site 1
chr17_+_25849332 0.19 ENSDART00000191994
acss1
acyl-CoA synthetase short chain family member 1
chr13_+_1726953 0.19 ENSDART00000103004
zmp:0000000760
zmp:0000000760
chr4_-_2440175 0.19 ENSDART00000058059
OSBPL8
oxysterol binding protein like 8
chr4_+_23126558 0.19 ENSDART00000162859
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr15_+_29113616 0.18 ENSDART00000190015
ENSDART00000191099
capns1b
calpain, small subunit 1 b
chr19_+_25154066 0.18 ENSDART00000163220
si:ch211-239d6.2
si:ch211-239d6.2
chr17_-_22137199 0.18 ENSDART00000089689
mrps5
mitochondrial ribosomal protein S5
chr25_-_35136267 0.18 ENSDART00000109751
zgc:173585
zgc:173585
chr4_+_13931578 0.18 ENSDART00000142466
pphln1
periphilin 1
chr22_+_1947494 0.17 ENSDART00000159121
si:dkey-15h8.15
si:dkey-15h8.15
chr20_-_7133546 0.17 ENSDART00000160910
si:ch211-121a2.4
si:ch211-121a2.4
chr14_+_4796168 0.17 ENSDART00000041468
ap1ar
adaptor-related protein complex 1 associated regulatory protein
chr4_+_13931733 0.16 ENSDART00000141742
ENSDART00000067175
pphln1
periphilin 1
chr18_+_5172848 0.16 ENSDART00000190642
CABZ01080599.1

chr4_+_40265583 0.16 ENSDART00000151870
si:ch211-246n15.2
si:ch211-246n15.2
chr21_+_5932140 0.16 ENSDART00000193767
rexo4
REX4 homolog, 3'-5' exonuclease
chr4_+_34417798 0.16 ENSDART00000157757
si:ch211-246b8.2
si:ch211-246b8.2
chr4_+_77839900 0.15 ENSDART00000162243
si:dkey-207m2.4
si:dkey-207m2.4
chr23_+_11285662 0.15 ENSDART00000111028
chl1a
cell adhesion molecule L1-like a
chr3_-_50147160 0.15 ENSDART00000191341
btr02
bloodthirsty-related gene family, member 2
chr20_-_45708962 0.15 ENSDART00000124283
gpcpd1
glycerophosphocholine phosphodiesterase 1
chr23_-_15090782 0.15 ENSDART00000133624
si:ch211-218g4.2
si:ch211-218g4.2
chr8_-_48770603 0.14 ENSDART00000159712
pimr184
Pim proto-oncogene, serine/threonine kinase, related 184
chr10_+_36029537 0.14 ENSDART00000165386
hmgb1a
high mobility group box 1a
chr17_-_10838434 0.14 ENSDART00000064597
lgals3b
lectin, galactoside binding soluble 3b
chr3_+_30922947 0.14 ENSDART00000184060
cldni
claudin i
chr20_-_43663494 0.14 ENSDART00000144564
BX470188.1

chr4_+_59246094 0.14 ENSDART00000160587
si:dkey-105i14.1
si:dkey-105i14.1
chr20_-_13673566 0.13 ENSDART00000181641
TAGAP
si:ch211-122h15.4
chr13_+_4225173 0.13 ENSDART00000058242
ENSDART00000143456
mea1
male-enhanced antigen 1
chr4_-_13931508 0.13 ENSDART00000067174
zcrb1
zinc finger CCHC-type and RNA binding motif 1
chr11_-_13618412 0.13 ENSDART00000137289
sid1
secreted immunoglobulin domain 1
chr22_+_9793923 0.13 ENSDART00000063323
si:dkey-102c8.2
si:dkey-102c8.2
chr15_+_1134870 0.12 ENSDART00000155392
p2ry13
purinergic receptor P2Y13
chr11_-_37693019 0.11 ENSDART00000102898
zgc:158258
zgc:158258
chr9_+_56103173 0.11 ENSDART00000172063
edar
ectodysplasin A receptor
chr11_+_577092 0.11 ENSDART00000191827
mkrn2os.1
MKRN2 opposite strand, tandem duplicate 1
chr14_+_46287296 0.11 ENSDART00000183620
cabp2b
calcium binding protein 2b
chr3_-_34082283 0.11 ENSDART00000151264
ighv4-3
immunoglobulin heavy variable 4-3
chr18_+_14619544 0.11 ENSDART00000010821
utp4
UTP4, small subunit processome component
chr2_-_51316187 0.11 ENSDART00000163362
ENSDART00000166871
ENSDART00000160262
pigrl3.5
polymeric immunoglobulin receptor-like 3.5
chr23_+_11347313 0.11 ENSDART00000135406
chl1a
cell adhesion molecule L1-like a
chr23_-_24047054 0.11 ENSDART00000184308
ENSDART00000185902
CR925720.1

chr4_+_59245846 0.11 ENSDART00000104921
si:dkey-105i14.1
si:dkey-105i14.1
chr20_-_26936887 0.10 ENSDART00000160827
ftr79
finTRIM family, member 79
chr6_-_18960105 0.10 ENSDART00000185278
ENSDART00000162968
sept9b
septin 9b
chr13_-_37189560 0.10 ENSDART00000134789
si:dkeyp-77c8.2
si:dkeyp-77c8.2
chr10_+_35953068 0.10 ENSDART00000015279
rtn4rl1a
reticulon 4 receptor-like 1a
chr4_-_13931293 0.10 ENSDART00000067172
zcrb1
zinc finger CCHC-type and RNA binding motif 1
chr16_+_40508882 0.09 ENSDART00000126129
nagpa
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr3_+_3992590 0.09 ENSDART00000180211
ENSDART00000054840
BX005421.2

chr22_+_9854088 0.09 ENSDART00000122678
BX539307.1

chr15_+_29362714 0.09 ENSDART00000099916
ENSDART00000126196
gucy2f
guanylate cyclase 2F, retinal
chr11_-_29737088 0.09 ENSDART00000159828
si:ch211-218g23.6
si:ch211-218g23.6
chr6_-_42049350 0.08 ENSDART00000022949
parp3
poly (ADP-ribose) polymerase family, member 3
chr20_+_7398090 0.08 ENSDART00000108649
pcsk9
proprotein convertase subtilisin/kexin type 9
chr20_-_16404014 0.08 ENSDART00000152328
LRRC52
si:dkey-52j6.3
chr8_+_15277874 0.08 ENSDART00000146965
dnttip2
deoxynucleotidyltransferase, terminal, interacting protein 2
chr7_-_20464133 0.08 ENSDART00000078192
cnpy4
canopy4
chr14_+_36869273 0.08 ENSDART00000111674
F2RL3
si:ch211-132p1.2
chr4_-_44509477 0.08 ENSDART00000102949
ENSDART00000135262
si:dkeyp-100h4.1
si:dkeyp-100h4.1
chr7_-_2004159 0.07 ENSDART00000181965
ENSDART00000173821
zgc:171424
zgc:171424
zgc:171424
zgc:171424
chr4_-_34455848 0.07 ENSDART00000184208
si:ch211-64i20.3
si:ch211-64i20.3
chr8_-_4694458 0.07 ENSDART00000019828
zgc:63587
zgc:63587
chr5_+_29831235 0.06 ENSDART00000109660
f11r.1
F11 receptor, tandem duplicate 1
chr10_+_35952532 0.06 ENSDART00000184730
rtn4rl1a
reticulon 4 receptor-like 1a
chr5_-_1999417 0.06 ENSDART00000155437
ENSDART00000145781
si:ch211-160e1.5
si:ch211-160e1.5
chr24_-_30862168 0.06 ENSDART00000168540
ptbp2a
polypyrimidine tract binding protein 2a
chr3_-_36602069 0.06 ENSDART00000165414
rrn3
RRN3 homolog, RNA polymerase I transcription factor
chr4_+_34418211 0.06 ENSDART00000160070
si:ch211-246b8.2
si:ch211-246b8.2
chr18_+_33340868 0.06 ENSDART00000099139
v2rh14
vomeronasal 2 receptor, h14
chr1_-_11596829 0.06 ENSDART00000140725
si:dkey-26i13.7
si:dkey-26i13.7
chr12_+_6098713 0.06 ENSDART00000139054
sgms1
sphingomyelin synthase 1
chr23_-_33775145 0.06 ENSDART00000132147
ENSDART00000027959
ENSDART00000160116
racgap1
Rac GTPase activating protein 1
chr22_+_24770744 0.06 ENSDART00000142882
si:rp71-23d18.4
si:rp71-23d18.4
chr3_-_7940522 0.06 ENSDART00000159710
ENSDART00000167201
trim35-25
tripartite motif containing 35-25
chr14_+_16022157 0.06 ENSDART00000167092
npy7r
neuropeptide Y receptor Y7
chr18_+_7150144 0.06 ENSDART00000114690
vwf
von Willebrand factor
chr5_+_52067723 0.05 ENSDART00000166902
setbp1
SET binding protein 1
chr8_-_48770163 0.05 ENSDART00000160959
pimr184
Pim proto-oncogene, serine/threonine kinase, related 184
chr1_+_27070760 0.05 ENSDART00000186790
bnc2
basonuclin 2
chr8_-_47818282 0.05 ENSDART00000137149
kank3
KN motif and ankyrin repeat domains 3
chr21_-_19919020 0.05 ENSDART00000147396
ppp1r3b
protein phosphatase 1, regulatory subunit 3B
chr2_-_24068848 0.05 ENSDART00000145526
slc12a7a
solute carrier family 12 (potassium/chloride transporter), member 7a
chr8_-_17926814 0.05 ENSDART00000147344
lhx8b
LIM homeobox 8b
chr4_-_44508975 0.04 ENSDART00000180528
si:dkeyp-100h4.1
si:dkeyp-100h4.1
chr24_+_12200260 0.04 ENSDART00000181391
CR855257.2

chr22_+_2598998 0.04 ENSDART00000176665
CU570894.1

chr20_+_9211237 0.04 ENSDART00000139527
si:ch211-59d15.4
si:ch211-59d15.4
chr4_-_71554068 0.04 ENSDART00000167414
si:dkey-27n6.1
si:dkey-27n6.1
chr9_+_23511913 0.04 ENSDART00000137759
cntnap5a
contactin associated protein-like 5a
chr7_+_4583139 0.04 ENSDART00000143777
si:dkey-83f18.4
si:dkey-83f18.4
chr1_-_9134045 0.03 ENSDART00000142132
palb2
partner and localizer of BRCA2
chr23_+_20863145 0.03 ENSDART00000129992
pax7b
paired box 7b
chr12_+_44610912 0.03 ENSDART00000179030
ENSDART00000178008
FAM196A (1 of many)
family with sequence similarity 196 member A
chr11_+_6764207 0.03 ENSDART00000104292
pde4cb
phosphodiesterase 4C, cAMP-specific b
chr8_-_17926620 0.03 ENSDART00000187864
lhx8b
LIM homeobox 8b
chr11_+_14295011 0.03 ENSDART00000060226
si:ch211-262i1.4
si:ch211-262i1.4
chr21_-_41065369 0.03 ENSDART00000143749
larsb
leucyl-tRNA synthetase b
chr17_-_2386569 0.03 ENSDART00000121614
PLCB2
phospholipase C beta 2
chr5_-_63286077 0.03 ENSDART00000131274
tbcelb
tubulin folding cofactor E-like b
chr18_-_22717565 0.02 ENSDART00000142185
ENSDART00000059945
si:ch73-113g13.1
si:ch73-113g13.1
chr21_-_5799122 0.02 ENSDART00000129351
ENSDART00000151202
ccni
cyclin I
chr6_+_27315173 0.02 ENSDART00000108831
espnla
espin like a
chr19_+_3215466 0.02 ENSDART00000181288
zgc:86598
zgc:86598
chr16_+_38201840 0.02 ENSDART00000044971
myo1eb
myosin IE, b
chr18_+_2554666 0.02 ENSDART00000167218
p2ry2.1
purinergic receptor P2Y2, tandem duplicate 1

Network of associatons between targets according to the STRING database.

First level regulatory network of tp53

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0055107 Golgi to secretory granule transport(GO:0055107)
0.2 1.7 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.2 0.8 GO:1903589 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903589)
0.2 0.8 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.2 0.9 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.2 1.2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.2 1.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 0.7 GO:0070254 mucus secretion(GO:0070254)
0.1 1.0 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.1 0.5 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.1 0.2 GO:0043525 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.1 0.4 GO:0090200 regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 0.8 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 0.7 GO:0043490 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.1 0.3 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.1 0.5 GO:0070293 renal absorption(GO:0070293)
0.0 0.3 GO:0033986 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
0.0 1.8 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.5 GO:0043901 negative regulation of immune effector process(GO:0002698) negative regulation of multi-organism process(GO:0043901)
0.0 0.4 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.0 0.2 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.0 0.2 GO:1900744 regulation of p38MAPK cascade(GO:1900744)
0.0 0.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.5 GO:0035108 limb morphogenesis(GO:0035108)
0.0 0.2 GO:0019427 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.0 0.2 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.7 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0050848 regulation of calcium-mediated signaling(GO:0050848)
0.0 0.4 GO:0002286 T cell activation involved in immune response(GO:0002286)
0.0 0.1 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0 0.5 GO:1902807 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.1 GO:0090299 regulation of neural crest formation(GO:0090299)
0.0 0.2 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.0 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.2 GO:0003382 epithelial cell morphogenesis(GO:0003382)
0.0 1.0 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.4 GO:0042476 odontogenesis(GO:0042476)
0.0 0.3 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 0.3 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.9 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.2 GO:0042541 hemoglobin biosynthetic process(GO:0042541)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.8 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 0.2 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.3 GO:0030891 VCB complex(GO:0030891)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.7 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.8 GO:0016342 catenin complex(GO:0016342)
0.0 0.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.3 0.8 GO:1901612 cardiolipin binding(GO:1901612)
0.3 1.1 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.2 1.7 GO:0070728 leucine binding(GO:0070728)
0.2 0.8 GO:0060182 apelin receptor activity(GO:0060182)
0.2 0.8 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 0.5 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 1.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.7 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 0.2 GO:0072545 tyrosine binding(GO:0072545)
0.1 0.4 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.3 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.0 0.1 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.0 0.6 GO:0042285 xylosyltransferase activity(GO:0042285)
0.0 1.6 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.7 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.6 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.2 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 1.0 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 0.3 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.3 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.1 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.5 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.5 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 0.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 0.9 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.5 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport