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PRJNA195909:zebrafish embryo and larva development

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Results for twist1a+twist1b+twist3

Z-value: 1.12

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Transcription factors associated with twist1a+twist1b+twist3

Gene Symbol Gene ID Gene Info
twist3
ENSDARG00000019646 twist3
twist1a
ENSDARG00000030402 twist family bHLH transcription factor 1a
twist1b
ENSDARG00000076010 twist family bHLH transcription factor 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
twist1bdr11_v1_chr16_+_19732543_19732543-0.971.8e-05Click!
twist3dr11_v1_chr23_+_2669_2669-0.942.0e-04Click!
twist1adr11_v1_chr19_-_2231146_2231188-0.627.5e-02Click!

Activity profile of twist1a+twist1b+twist3 motif

Sorted Z-values of twist1a+twist1b+twist3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_1590858 2.85 ENSDART00000081875
nnr
nanor
chr23_-_44574059 2.21 ENSDART00000123007
si:ch73-160p18.3
si:ch73-160p18.3
chr21_-_43666420 2.12 ENSDART00000139008
ENSDART00000183996
ENSDART00000183395
si:dkey-229d11.3
si:dkey-229d11.5
si:dkey-229d11.3
si:dkey-229d11.5
chr17_+_1360192 1.61 ENSDART00000184561
siva1
SIVA1, apoptosis-inducing factor
chr5_+_6670945 1.30 ENSDART00000185686
pxna
paxillin a
chr3_+_58472305 1.05 ENSDART00000154122
si:ch211-165g14.1
si:ch211-165g14.1
chr5_-_30080332 1.03 ENSDART00000140049
bco2a
beta-carotene oxygenase 2a
chr11_-_40257225 1.00 ENSDART00000139009
TRIM62 (1 of many)
si:ch211-193i15.2
chr15_-_766015 0.97 ENSDART00000190648
si:dkey-7i4.15
si:dkey-7i4.15
chr8_-_14067517 0.97 ENSDART00000140948
dedd
death effector domain containing
chr13_+_1381953 0.94 ENSDART00000019983
rab23
RAB23, member RAS oncogene family
chr7_-_9674073 0.90 ENSDART00000187902
lrrk1
leucine-rich repeat kinase 1
chr5_-_11809404 0.83 ENSDART00000132564
nf2a
neurofibromin 2a (merlin)
chr20_-_44575103 0.82 ENSDART00000192573
ubxn2a
UBX domain protein 2A
chr17_-_40876680 0.81 ENSDART00000127200
supt7l
SPT7-like STAGA complex gamma subunit
chr5_-_23696926 0.80 ENSDART00000021462
rnf128a
ring finger protein 128a
chr6_-_55423220 0.78 ENSDART00000158929
ctsa
cathepsin A
chr23_+_2914577 0.74 ENSDART00000184897
DHX35
zgc:158828
chr20_+_2134816 0.73 ENSDART00000039249
l3mbtl3
l(3)mbt-like 3 (Drosophila)
chr5_-_15321451 0.72 ENSDART00000139203
txnrd2.1
thioredoxin reductase 2, tandem duplicate 1
chr3_+_22935183 0.69 ENSDART00000157378
hdac5
histone deacetylase 5
chr2_+_38002717 0.65 ENSDART00000139564
dcaf8
DDB1 and CUL4 associated factor 8
chr22_-_26251563 0.60 ENSDART00000060888
ENSDART00000142821
ccdc130
coiled-coil domain containing 130
chr11_-_34232906 0.59 ENSDART00000162150
lsg1
large 60S subunit nuclear export GTPase 1
chr1_+_45925365 0.59 ENSDART00000144245
eif5b
eukaryotic translation initiation factor 5B
chr3_+_16663373 0.58 ENSDART00000100961
zgc:55558
zgc:55558
chr18_+_45666489 0.58 ENSDART00000180147
ENSDART00000151351
prrg4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr4_+_77973876 0.56 ENSDART00000057423
terfa
telomeric repeat binding factor a
chr8_+_247163 0.52 ENSDART00000122378
cep120
centrosomal protein 120
chr6_-_10728057 0.50 ENSDART00000002247
sp3b
Sp3b transcription factor
chr1_+_45925150 0.47 ENSDART00000074689
eif5b
eukaryotic translation initiation factor 5B
chr13_+_35690023 0.45 ENSDART00000128865
ENSDART00000130050
psme4a
proteasome activator subunit 4a
chr24_+_39660124 0.45 ENSDART00000066500
stub1
STIP1 homology and U-Box containing protein 1
chr21_-_26520629 0.41 ENSDART00000142731
rce1b
Ras converting CAAX endopeptidase 1b
chr9_-_40014339 0.41 ENSDART00000166918
IKZF2
si:zfos-1425h8.1
chr8_+_20140321 0.41 ENSDART00000012120
acsbg2
acyl-CoA synthetase bubblegum family member 2
chr21_-_35325466 0.40 ENSDART00000134780
ENSDART00000145930
ENSDART00000076715
ENSDART00000065341
ENSDART00000162189
ublcp1
ubiquitin-like domain containing CTD phosphatase 1
chr6_+_42693288 0.39 ENSDART00000155010
si:ch211-207d10.2
si:ch211-207d10.2
chr3_+_59411956 0.39 ENSDART00000166982
sec14l1
SEC14-like lipid binding 1
chr1_-_55058795 0.38 ENSDART00000187293
peli1a
pellino E3 ubiquitin protein ligase 1a
chr6_+_42693114 0.36 ENSDART00000154353
si:ch211-207d10.2
si:ch211-207d10.2
chr5_-_32505109 0.36 ENSDART00000188219
ntmt1
N-terminal Xaa-Pro-Lys N-methyltransferase 1
chr4_+_33830944 0.32 ENSDART00000170238
znf1026
zinc finger protein 1026
chr6_-_10728921 0.30 ENSDART00000151484
sp3b
Sp3b transcription factor
chr20_-_22193190 0.28 ENSDART00000047624
tmem165
transmembrane protein 165
chr16_-_31791165 0.28 ENSDART00000148389
chd4b
chromodomain helicase DNA binding protein 4b
chr13_-_9119867 0.28 ENSDART00000137255
si:dkey-112g5.15
si:dkey-112g5.15
chr16_-_21047483 0.27 ENSDART00000136235
cbx3b
chromobox homolog 3b
chr7_-_12596727 0.26 ENSDART00000186413
adamtsl3
ADAMTS-like 3
chr3_+_49021079 0.25 ENSDART00000162012
zgc:163083
zgc:163083
chr13_+_35689749 0.24 ENSDART00000158726
psme4a
proteasome activator subunit 4a
chr14_-_31087830 0.22 ENSDART00000002250
hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr7_+_17485782 0.20 ENSDART00000098083
CU179759.1
Danio rerio novel immune-type receptor 1d (nitr1d), mRNA.
chr22_-_5752009 0.19 ENSDART00000190052
bcdin3d
BCDIN3 domain containing
chr10_+_40737540 0.18 ENSDART00000125577
taar19a
trace amine associated receptor 19a
chr6_+_103361 0.16 ENSDART00000151899
ldlrb
low density lipoprotein receptor b
chr23_-_24047054 0.16 ENSDART00000184308
ENSDART00000185902
CR925720.1

chr20_-_46046758 0.15 ENSDART00000127455
taar12j
trace amine associated receptor 12j
chr6_+_16982613 0.15 ENSDART00000156104
pimr8
Pim proto-oncogene, serine/threonine kinase, related 8
chr16_-_19568795 0.11 ENSDART00000185141
abcb5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr10_+_1052591 0.09 ENSDART00000123405
unc5c
unc-5 netrin receptor C
chr15_-_46736432 0.09 ENSDART00000124567
ilkap
integrin-linked kinase-associated serine/threonine phosphatase
chr14_+_46216703 0.09 ENSDART00000136045
ENSDART00000142317
mgst2
microsomal glutathione S-transferase 2
chr13_-_12602920 0.09 ENSDART00000102311
lrit3b
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b
chr20_-_2134620 0.06 ENSDART00000064375
tmem244
transmembrane protein 244
chr18_-_35842554 0.03 ENSDART00000088488
opa3
optic atrophy 3
chr21_-_35419486 0.03 ENSDART00000138529
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr16_-_21047872 0.02 ENSDART00000131582
cbx3b
chromobox homolog 3b
chr5_-_2752573 0.02 ENSDART00000168121
lzts3a
leucine zipper, putative tumor suppressor family member 3a

Network of associatons between targets according to the STRING database.

First level regulatory network of twist1a+twist1b+twist3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0032207 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208)
0.1 0.4 GO:0080120 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.1 0.5 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.1 0.4 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
0.1 0.7 GO:0035093 spermatid nucleus differentiation(GO:0007289) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 1.0 GO:0016121 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.1 0.3 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.1 1.3 GO:0061055 myotome development(GO:0061055)
0.1 0.4 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.1 0.4 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 1.0 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 0.2 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA(GO:0070920) regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798)
0.0 0.8 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.1 GO:0046689 response to mercury ion(GO:0046689) detoxification of mercury ion(GO:0050787)
0.0 0.9 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.6 GO:0033753 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 0.7 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 1.0 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.8 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.7 GO:0072114 pronephros morphogenesis(GO:0072114)
0.0 0.4 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.1 GO:0019370 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.0 0.7 GO:0097191 extrinsic apoptotic signaling pathway(GO:0097191)
0.0 0.9 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.8 GO:0030914 STAGA complex(GO:0030914)
0.0 0.6 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.6 GO:0070187 telosome(GO:0070187)
0.0 0.6 GO:0015030 Cajal body(GO:0015030)
0.0 0.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.9 GO:0005776 autophagosome(GO:0005776)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.4 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.1 1.0 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.1 0.7 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 0.6 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 0.7 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.3 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.2 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 1.6 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.0 0.4 GO:0016405 CoA-ligase activity(GO:0016405)
0.0 0.4 GO:0051879 Hsp70 protein binding(GO:0030544) Hsp90 protein binding(GO:0051879)
0.0 0.1 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.0 0.6 GO:0019003 GDP binding(GO:0019003)
0.0 0.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.1 GO:0003743 translation initiation factor activity(GO:0003743)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.8 PID MYC PATHWAY C-MYC pathway
0.0 0.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.0 ST FAS SIGNALING PATHWAY Fas Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 0.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.2 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis