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PRJNA195909:zebrafish embryo and larva development
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Results for zbtb16a+zbtb16b
Z-value: 1.84
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Transcription factors associated with zbtb16a+zbtb16b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| zbtb16a | dr11_v1_chr21_-_23331619_23331619 | -0.72 | 3.0e-02 | Click! |
| zbtb16b | dr11_v1_chr15_-_18361475_18361475 | -0.71 | 3.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of zbtb16a+zbtb16b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.0 | GO:0032402 | melanosome transport(GO:0032402) pigment granule transport(GO:0051904) |
| 0.1 | 3.2 | GO:0006606 | protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593) |
| 0.1 | 2.5 | GO:0036297 | interstrand cross-link repair(GO:0036297) |
| 0.0 | 2.5 | GO:0016042 | lipid catabolic process(GO:0016042) |
| 0.2 | 2.4 | GO:0006382 | adenosine to inosine editing(GO:0006382) |
| 0.1 | 2.3 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.1 | 2.2 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) |
| 0.1 | 2.1 | GO:0035493 | SNARE complex assembly(GO:0035493) |
| 0.7 | 2.0 | GO:0043388 | positive regulation of DNA binding(GO:0043388) |
| 0.3 | 2.0 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 2.1 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.0 | 2.0 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 2.0 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.1 | 1.8 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.1 | 1.6 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 1.6 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 1.5 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.1 | 1.5 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.1 | 1.4 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.0 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.0 | 2.9 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.8 | 2.5 | GO:0045145 | single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145) |
| 0.2 | 2.4 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.2 | 2.4 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.0 | 2.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 2.1 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.3 | 2.0 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.3 | 2.0 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 2.0 | GO:0032041 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.8 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 1.4 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.2 | 1.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 1.3 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.1 | 1.3 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.3 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.1 | 1.1 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.9 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 2.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 2.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 2.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 2.0 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 1.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.2 | 1.3 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 1.3 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.0 | 1.3 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.0 | 1.3 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |