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PRJNA195909:zebrafish embryo and larva development

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Results for zic4+zic6

Z-value: 0.50

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Transcription factors associated with zic4+zic6

Gene Symbol Gene ID Gene Info
zic4
ENSDARG00000031307 zic family member 4
zic6
ENSDARG00000071496 zic family member 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zic6dr11_v1_chr14_+_32022272_32022272-0.732.7e-02Click!
zic4dr11_v1_chr24_+_4978055_4978055-0.627.3e-02Click!

Activity profile of zic4+zic6 motif

Sorted Z-values of zic4+zic6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_4245311 1.49 ENSDART00000055379
gdf3
growth differentiation factor 3
chr17_-_4245902 1.08 ENSDART00000151851
gdf3
growth differentiation factor 3
chr19_-_27550768 0.66 ENSDART00000142313
si:dkeyp-46h3.8
si:dkeyp-46h3.8
chr13_+_37653851 0.57 ENSDART00000141988
ENSDART00000126902
ENSDART00000100352
phf3
PHD finger protein 3
chr11_-_44999858 0.51 ENSDART00000167759
ENSDART00000126845
ldb1b
LIM-domain binding 1b
chr21_-_21465111 0.46 ENSDART00000141487
nectin3b
nectin cell adhesion molecule 3b
chr24_-_34680956 0.43 ENSDART00000171009
ctnna1
catenin (cadherin-associated protein), alpha 1
chr5_+_13521081 0.42 ENSDART00000171975
si:ch211-230g14.6
si:ch211-230g14.6
chr17_+_34215886 0.41 ENSDART00000186775
mpp5a
membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5)
chr21_+_5926777 0.39 ENSDART00000121769
rexo4
REX4 homolog, 3'-5' exonuclease
chr3_+_17030665 0.38 ENSDART00000159849
ENSDART00000174491
ENSDART00000104519
ENSDART00000080854
stat3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr1_-_34450622 0.37 ENSDART00000083736
lmo7b
LIM domain 7b
chr18_-_20458412 0.36 ENSDART00000012241
kif23
kinesin family member 23
chr12_-_4243268 0.34 ENSDART00000131275
zgc:92313
zgc:92313
chr8_+_15269423 0.34 ENSDART00000020386
gclm
glutamate-cysteine ligase, modifier subunit
chr15_+_47746176 0.34 ENSDART00000154481
ENSDART00000160914
stard10
StAR-related lipid transfer (START) domain containing 10
chr20_-_28768109 0.33 ENSDART00000114611
ENSDART00000182443
sipa1l1
signal-induced proliferation-associated 1 like 1
chr19_+_40122160 0.30 ENSDART00000143966
si:ch211-173p18.3
si:ch211-173p18.3
chr10_-_4961923 0.30 ENSDART00000050177
ENSDART00000146066
snx30
sorting nexin family member 30
chr2_-_53500424 0.30 ENSDART00000037557
admp
anti-dorsalizing morphogenic protein
chr20_-_31743553 0.29 ENSDART00000087405
sash1a
SAM and SH3 domain containing 1a
chr12_+_20627505 0.29 ENSDART00000074384
stx4
syntaxin 4
chr1_-_34450784 0.28 ENSDART00000140515
lmo7b
LIM domain 7b
chr25_+_2776511 0.27 ENSDART00000115280
neo1b
neogenin 1b
chr20_-_53624645 0.27 ENSDART00000083427
ENSDART00000152920
slc25a29
solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
chr1_+_40613297 0.27 ENSDART00000040798
ENSDART00000168067
ENSDART00000130490
naa15b
N(alpha)-acetyltransferase 15, NatA auxiliary subunit b
chr12_+_20627164 0.27 ENSDART00000190179
stx4
syntaxin 4
chr12_-_2800809 0.27 ENSDART00000152682
ENSDART00000083784
ubtd1b
ubiquitin domain containing 1b
chr11_-_2504750 0.26 ENSDART00000173149
dgkab
diacylglycerol kinase, alpha b
chr8_-_29822527 0.25 ENSDART00000167487
slc20a2
solute carrier family 20 (phosphate transporter), member 2
chr5_+_30596822 0.25 ENSDART00000188375
hinfp
histone H4 transcription factor
chr20_-_14781904 0.24 ENSDART00000187200
ENSDART00000179912
ENSDART00000160481
ENSDART00000026969
suco
SUN domain containing ossification factor
chr10_-_15053507 0.24 ENSDART00000157446
ENSDART00000170441
CLDN23
si:ch211-95j8.5
chr5_-_61588998 0.22 ENSDART00000050912
pex12
peroxisomal biogenesis factor 12
chr5_+_37744625 0.21 ENSDART00000014031
dpf2
D4, zinc and double PHD fingers family 2
chr17_-_23895026 0.21 ENSDART00000122108
pdzd8
PDZ domain containing 8
chr8_+_12925385 0.21 ENSDART00000085377
KIF2A
zgc:103670
chr6_+_23026714 0.21 ENSDART00000124948
srp68
signal recognition particle 68
chr17_+_28670132 0.20 ENSDART00000076344
ENSDART00000164981
ENSDART00000182851
hectd1
HECT domain containing 1
chr24_-_20599781 0.20 ENSDART00000179664
ENSDART00000141823
zbtb47b
zinc finger and BTB domain containing 47b
chr4_+_64562090 0.19 ENSDART00000188810
si:ch211-223a21.3
si:ch211-223a21.3
chr21_-_14664445 0.19 ENSDART00000124223
ehmt1b
euchromatic histone-lysine N-methyltransferase 1b
chr18_+_31117136 0.19 ENSDART00000138403
tcf25
transcription factor 25 (basic helix-loop-helix)
chr18_+_20047374 0.17 ENSDART00000146957
uacaa
uveal autoantigen with coiled-coil domains and ankyrin repeats a
chr20_+_40769265 0.16 ENSDART00000061168
tbc1d32
TBC1 domain family, member 32
chr17_-_14523722 0.16 ENSDART00000024726
daam1a
dishevelled associated activator of morphogenesis 1a
chr2_-_42628028 0.16 ENSDART00000179866
myo10
myosin X
chr8_+_40210398 0.15 ENSDART00000167612
rnf34a
ring finger protein 34a
chr14_-_21097574 0.15 ENSDART00000186803
rnf20
ring finger protein 20, E3 ubiquitin protein ligase
chr5_+_36611128 0.14 ENSDART00000097684
nova1
neuro-oncological ventral antigen 1
chr1_-_58601636 0.14 ENSDART00000141143
si:ch73-236c18.8
si:ch73-236c18.8
chr19_-_17996162 0.14 ENSDART00000150928
ENSDART00000104491
ints8
integrator complex subunit 8
chr21_+_3093419 0.13 ENSDART00000162520
SHC3
SHC adaptor protein 3
chr23_+_44374041 0.13 ENSDART00000136056
ephb4b
eph receptor B4b
chr18_+_1615 0.13 ENSDART00000082450
homer2
homer scaffolding protein 2
chr21_-_37973819 0.13 ENSDART00000133405
ripply1
ripply transcriptional repressor 1
chr25_-_27729046 0.13 ENSDART00000131437
zgc:153935
zgc:153935
chr21_-_217589 0.13 ENSDART00000185017
CZQB01146713.1

chr3_-_40162843 0.12 ENSDART00000129664
ENSDART00000025285
drg2
developmentally regulated GTP binding protein 2
chr9_-_32191620 0.12 ENSDART00000139426
pimr143
Pim proto-oncogene, serine/threonine kinase, related 143
chr23_-_18982499 0.12 ENSDART00000012507
bcl2l1
bcl2-like 1
chr2_-_58919975 0.12 ENSDART00000114286
sugp1
SURP and G patch domain containing 1
chr13_-_32648382 0.11 ENSDART00000138571
ENSDART00000132820
bend3
BEN domain containing 3
chr25_-_1124851 0.11 ENSDART00000067558
spg11
spastic paraplegia 11
chr5_+_69697800 0.10 ENSDART00000178736
ENSDART00000162519
znf1005
zinc finger protein 1005
chr17_+_132555 0.10 ENSDART00000158159
zgc:77287
zgc:77287
chr19_-_17996336 0.10 ENSDART00000186143
ENSDART00000080751
ints8
integrator complex subunit 8
chr22_-_5099824 0.09 ENSDART00000122341
ENSDART00000161345
zfr2
zinc finger RNA binding protein 2
chr1_-_17711361 0.09 ENSDART00000078848
ufsp2
ufm1-specific peptidase 2
chr6_-_426041 0.09 ENSDART00000162789
fam83fb
family with sequence similarity 83, member Fb
chr5_-_15948833 0.09 ENSDART00000051649
ENSDART00000124467
xbp1
X-box binding protein 1
chr11_-_6070192 0.09 ENSDART00000162776
babam1
BRISC and BRCA1 A complex member 1
chr2_+_15128418 0.08 ENSDART00000141921
arhgap29b
Rho GTPase activating protein 29b
chr11_+_31558006 0.08 ENSDART00000024296
egln1b
egl-9 family hypoxia-inducible factor 1b
chr1_+_49652967 0.08 ENSDART00000191296
tsga10
testis specific, 10
chr8_-_1266181 0.08 ENSDART00000148654
ENSDART00000149924
cdc14b
cell division cycle 14B
chr3_-_37588855 0.08 ENSDART00000149258
arf2a
ADP-ribosylation factor 2a
chr22_-_26558166 0.08 ENSDART00000111125
glis2a
GLIS family zinc finger 2a
chr2_+_36004381 0.08 ENSDART00000098706
lamc2
laminin, gamma 2
chr15_-_26844591 0.08 ENSDART00000077582
pitpnm3
PITPNM family member 3
chr13_+_16521898 0.07 ENSDART00000122557
kcnma1a
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
chr16_-_46567344 0.07 ENSDART00000127721
si:dkey-152b24.7
si:dkey-152b24.7
chr6_+_103361 0.07 ENSDART00000151899
ldlrb
low density lipoprotein receptor b
chr3_-_19561058 0.07 ENSDART00000079323
zgc:163079
zgc:163079
chr1_-_17711636 0.06 ENSDART00000148322
ENSDART00000122670
ufsp2
ufm1-specific peptidase 2
chr2_-_14987282 0.06 ENSDART00000143057
hccsa.2
holocytochrome c synthase a, tandem duplicate 2
chr13_+_13821054 0.05 ENSDART00000127417
slc4a11
solute carrier family 4, sodium borate transporter, member 11
chr23_+_7471072 0.04 ENSDART00000135551
si:ch211-200e2.1
si:ch211-200e2.1
chr14_+_40852497 0.04 ENSDART00000128588
ENSDART00000166065
taf7
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr11_-_20956309 0.04 ENSDART00000188659
CABZ01008739.1

chr12_-_4206869 0.04 ENSDART00000106572
si:dkey-32n7.9
si:dkey-32n7.9
chr10_+_40737540 0.04 ENSDART00000125577
taar19a
trace amine associated receptor 19a
chr11_+_34921492 0.04 ENSDART00000128070
gnai2a
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a
chr5_-_23725480 0.04 ENSDART00000137063
si:dkey-110k5.10
si:dkey-110k5.10
chr19_-_81851 0.03 ENSDART00000172319
hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr5_+_31944270 0.03 ENSDART00000147850
ungb
uracil DNA glycosylase b
chr23_-_27547931 0.03 ENSDART00000144419
larp4aa
La ribonucleoprotein domain family, member 4Aa
chr7_-_38183331 0.02 ENSDART00000149382
abcc12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
chr2_+_15128027 0.02 ENSDART00000016071
arhgap29b
Rho GTPase activating protein 29b
chr4_+_76349919 0.02 ENSDART00000174194
si:ch73-158p21.2
si:ch73-158p21.2
chr8_-_33114202 0.02 ENSDART00000098840
ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr18_-_50947868 0.01 ENSDART00000174276
st7
suppression of tumorigenicity 7
chr19_-_82504 0.01 ENSDART00000027864
ENSDART00000160560
hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr9_-_37748513 0.01 ENSDART00000188967
ENSDART00000187886
sema5ba
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr11_+_31558207 0.01 ENSDART00000140204
egln1b
egl-9 family hypoxia-inducible factor 1b

Network of associatons between targets according to the STRING database.

First level regulatory network of zic4+zic6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.1 0.4 GO:0044320 leptin-mediated signaling pathway(GO:0033210) cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.1 0.4 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.1 0.3 GO:0060063 Spemann organizer formation at the embryonic shield(GO:0060063)
0.1 0.3 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.1 0.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.3 GO:0006844 acyl carnitine transport(GO:0006844)
0.1 0.2 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.1 0.4 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.2 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.0 0.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.2 GO:0046850 regulation of bone remodeling(GO:0046850)
0.0 0.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.1 GO:2001271 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.1 GO:0009217 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.0 0.1 GO:0021628 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.0 0.6 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.5 GO:0007286 spermatid development(GO:0007286)
0.0 0.1 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.2 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.1 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.0 0.1 GO:0072401 signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)
0.0 0.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.2 GO:0035435 phosphate ion transmembrane transport(GO:0035435)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.1 0.3 GO:0031415 NatA complex(GO:0031415)
0.1 0.2 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.6 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 0.4 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 0.5 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.3 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.0 0.2 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.1 GO:0016793 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 2.9 GO:0008083 growth factor activity(GO:0008083)
0.0 0.1 GO:0004408 holocytochrome-c synthase activity(GO:0004408)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0002039 p53 binding(GO:0002039)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 ST STAT3 PATHWAY STAT3 Pathway
0.0 1.0 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.4 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.6 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.6 REACTOME KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.1 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha