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PRJNA207719: Tissue specific transcriptome profiling
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Results for arnt2
Z-value: 5.62
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Transcription factors associated with arnt2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| arnt2 | dr11_v1_chr7_+_10701938_10701938 | 0.95 | 1.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_23429228 Show fit | 6.74 |
ENSDART00000049291
|
glutamate receptor, ionotropic, AMPA 3a |
|
| chr20_+_35382482 Show fit | 6.52 |
ENSDART00000135284
|
visinin-like 1a |
|
| chr9_-_44295071 Show fit | 5.70 |
ENSDART00000011837
|
neuronal differentiation 1 |
|
| chr18_+_7345417 Show fit | 5.05 |
ENSDART00000041429
|
GLI pathogenesis-related 1b |
|
| chr13_+_27314795 Show fit | 4.82 |
ENSDART00000128726
|
eukaryotic translation elongation factor 1 alpha 1a |
|
| chr11_+_7324704 Show fit | 4.61 |
ENSDART00000031937
|
DIRAS family, GTP-binding RAS-like 1a |
|
| chr5_+_32162684 Show fit | 4.59 |
ENSDART00000134472
|
TAO kinase 3b |
|
| chr5_+_36415978 Show fit | 4.41 |
ENSDART00000084464
|
family with sequence similarity 155, member B |
|
| chr12_+_35119762 Show fit | 4.21 |
ENSDART00000085774
|
si:ch73-127m5.1 |
|
| chr21_+_5169154 Show fit | 4.14 |
ENSDART00000102559
|
zgc:122979 |
Network of associatons between targets according to the STRING database.
First level regulatory network of arnt2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.6 | GO:0007411 | axon guidance(GO:0007411) |
| 0.0 | 9.6 | GO:0006897 | endocytosis(GO:0006897) |
| 2.8 | 8.3 | GO:0099538 | synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.5 | 8.3 | GO:0098943 | neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943) |
| 0.0 | 7.6 | GO:0006470 | protein dephosphorylation(GO:0006470) |
| 2.2 | 6.6 | GO:0060838 | lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845) |
| 0.7 | 6.2 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.0 | 6.1 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.3 | 6.0 | GO:1990035 | calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035) |
| 0.2 | 5.7 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.4 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.5 | 23.9 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 16.2 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 15.6 | GO:0043005 | neuron projection(GO:0043005) |
| 0.1 | 9.7 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 8.2 | GO:0099503 | exocytic vesicle(GO:0070382) secretory vesicle(GO:0099503) |
| 0.1 | 6.4 | GO:0030125 | clathrin vesicle coat(GO:0030125) |
| 0.1 | 5.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.9 | 5.2 | GO:0005955 | calcineurin complex(GO:0005955) |
| 1.7 | 5.0 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.5 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 11.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.6 | 9.4 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.0 | 8.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 2.8 | 8.3 | GO:0048403 | brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175) |
| 0.1 | 8.1 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 7.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.8 | 6.6 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 5.5 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.3 | 5.4 | GO:0008301 | DNA binding, bending(GO:0008301) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 4.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 2.9 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 2.8 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 2.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 2.4 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.1 | 2.1 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 2.0 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 1.4 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.3 | 5.7 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.3 | 5.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 4.4 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.2 | 4.1 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 3.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 2.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 2.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 2.3 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.2 | 2.2 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |