ISMARA results: atf4a+atf4b

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PRJNA207719: Tissue specific transcriptome profiling

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Results for atf4a+atf4b

Z-value: 1.10

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Transcription factors associated with atf4a+atf4b

Gene Symbol	Gene ID	Gene Info
atf4b NCBI UniProt	ENSDARG00000038141	activating transcription factor 4b
atf4a NCBI UniProt	ENSDARG00000111939	activating transcription factor 4a
atf4b NCBI UniProt	ENSDARG00000114163	activating transcription factor 4b
atf4b NCBI UniProt	ENSDARG00000114542	activating transcription factor 4b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
atf4b	dr11_v1_chr3_+_24197934_24197934	0.65	2.3e-01	Click!
atf4a	dr11_v1_chr6_+_269204_269204	-0.45	4.4e-01	Click!

Activity profile of atf4a+atf4b motif

Sorted Z-values of atf4a+atf4b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_31119548 Show fit	1.52	ENSDART00000136578	syn1 NCBI UniProt Show fit	synapsin I
chr16_+_34523515 Show fit	1.28	ENSDART00000041007	stmn1b NCBI UniProt Show fit	stathmin 1b
chr12_+_46960579 Show fit	1.27	ENSDART00000149032	oat NCBI UniProt Show fit	ornithine aminotransferase
chr19_-_9712530 Show fit	1.13	ENSDART00000134816	slc2a3a NCBI UniProt Show fit	solute carrier family 2 (facilitated glucose transporter), member 3a
chr18_-_16179129 Show fit	1.02	ENSDART00000125353	slc6a15 NCBI UniProt Show fit	solute carrier family 6 (neutral amino acid transporter), member 15
chr15_+_29085955 Show fit	1.01	ENSDART00000156799	si:ch211-137a8.4 NCBI UniProt Show fit	si:ch211-137a8.4
chr21_-_43949208 Show fit	1.00	ENSDART00000150983	camk2a NCBI UniProt Show fit	calcium/calmodulin-dependent protein kinase II alpha
chr23_-_27345425 Show fit	0.94	ENSDART00000022042 ENSDART00000191870	scn8aa NCBI UniProt Show fit	sodium channel, voltage gated, type VIII, alpha subunit a
chr6_+_41255485 Show fit	0.91	ENSDART00000042683 ENSDART00000186013	cadpsb NCBI UniProt Show fit	Ca2+-dependent activator protein for secretion b
chr15_-_24869826 Show fit	0.91	ENSDART00000127047	tusc5a NCBI UniProt Show fit	tumor suppressor candidate 5a

Showing 1 to 10 of 149 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of atf4a+atf4b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.2	GO:0007019	microtubule depolymerization(GO:0007019)
0.0	1.5	GO:0003146	heart jogging(GO:0003146)
0.0	1.5	GO:0099643	neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.1	1.3	GO:0006527	arginine catabolic process(GO:0006527)
0.1	1.2	GO:0006797	polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.3	1.0	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.2	0.9	GO:0007638	mechanosensory behavior(GO:0007638)
0.1	0.9	GO:1990504	dense core granule exocytosis(GO:1990504)
0.0	0.9	GO:0051923	sulfation(GO:0051923)
0.2	0.8	GO:0009098	leucine biosynthetic process(GO:0009098)

Showing 1 to 10 of 42 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	1.6	GO:0043025	neuronal cell body(GO:0043025)
0.0	0.9	GO:0098978	glutamatergic synapse(GO:0098978)
0.2	0.8	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.8	GO:0001518	voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0	0.7	GO:0005811	lipid particle(GO:0005811)
0.0	0.7	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.1	0.6	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.1	0.2	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	0.2	GO:0005899	insulin receptor complex(GO:0005899)

Showing 1 to 10 of 12 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.5	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.1	1.3	GO:0008483	transaminase activity(GO:0008483)
0.1	1.2	GO:0004309	exopolyphosphatase activity(GO:0004309)
0.2	1.0	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.9	GO:0008146	sulfotransferase activity(GO:0008146)
0.2	0.8	GO:0004084	branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2	0.8	GO:0097016	L27 domain binding(GO:0097016)
0.1	0.8	GO:0015189	L-lysine transmembrane transporter activity(GO:0015189)
0.1	0.8	GO:0015186	L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.8	GO:0005248	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)

Showing 1 to 10 of 30 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.0	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	0.8	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	0.7	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway

Showing 1 to 4 of 4 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.9	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.3	1.5	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.3	1.0	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.1	1.0	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.2	0.9	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.2	0.8	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.8	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.1	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation

Showing 1 to 8 of 8 entries

Results for atf4a+atf4b

Z-value: 1.10

Motif logo

Transcription factors associated with atf4a+atf4b

Activity-expression correlation:

Activity profile of atf4a+atf4b motif

Sorted Z-values of atf4a+atf4b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of atf4a+atf4b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: