ISMARA results: cebpa

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PRJNA207719: Tissue specific transcriptome profiling

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Results for cebpa

Z-value: 1.74

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Transcription factors associated with cebpa

Gene Symbol	Gene ID	Gene Info
cebpa NCBI UniProt	ENSDARG00000036074	CCAAT enhancer binding protein alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
cebpa	dr11_v1_chr7_-_38087865_38087865	-0.82	8.9e-02	Click!

Activity profile of cebpa motif

Sorted Z-values of cebpa motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_-_50147948 Show fit	2.65	ENSDART00000149010	hp NCBI UniProt Show fit	haptoglobin
chr1_+_59067978 Show fit	1.67	ENSDART00000172613	MFAP4 (1 of many) NCBI UniProt Show fit	si:ch1073-110a20.7
chr5_-_63509581 Show fit	1.65	ENSDART00000097325	c5 NCBI UniProt Show fit	complement component 5
chr16_-_21785261 Show fit	1.60	ENSDART00000078858	si:ch73-86n18.1 NCBI UniProt Show fit	si:ch73-86n18.1
chr14_+_21107032 Show fit	1.40	ENSDART00000138319 ENSDART00000139103 ENSDART00000184735	aldob NCBI UniProt Show fit	aldolase b, fructose-bisphosphate
chr3_+_19299309 Show fit	1.30	ENSDART00000046297 ENSDART00000146955	ldlra NCBI UniProt Show fit	low density lipoprotein receptor a
chr14_+_21106444 Show fit	1.26	ENSDART00000075744 ENSDART00000132363	aldob NCBI UniProt Show fit	aldolase b, fructose-bisphosphate
chr9_+_38292947 Show fit	1.23	ENSDART00000146663	tfcp2l1 NCBI UniProt Show fit	transcription factor CP2-like 1
chr14_+_16345003 Show fit	1.19	ENSDART00000003040 ENSDART00000165193	itln3 NCBI UniProt Show fit	intelectin 3
chr22_-_26236188 Show fit	1.17	ENSDART00000162640 ENSDART00000167169 ENSDART00000138595	c3b.1 NCBI UniProt Show fit	complement component c3b, tandem duplicate 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of cebpa

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.7	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.1	2.7	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3	1.8	GO:0032367	intracellular cholesterol transport(GO:0032367)
0.1	1.8	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
0.0	1.6	GO:0010906	regulation of glucose metabolic process(GO:0010906)
0.4	1.2	GO:2000257	regulation of protein activation cascade(GO:2000257)
0.0	1.2	GO:0019835	cytolysis(GO:0019835)
0.1	1.1	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.2	1.0	GO:0019482	beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
0.1	1.0	GO:0032570	response to progesterone(GO:0032570)

Showing 1 to 10 of 129 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	20.2	GO:0005615	extracellular space(GO:0005615)
0.0	2.1	GO:0005759	mitochondrial matrix(GO:0005759)
0.6	1.8	GO:0005577	fibrinogen complex(GO:0005577)
0.1	1.2	GO:0005579	membrane attack complex(GO:0005579)
0.0	1.1	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.0	1.0	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	0.9	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.1	0.5	GO:0097134	cyclin E1-CDK2 complex(GO:0097134)
0.1	0.5	GO:0097268	cytoophidium(GO:0097268)
0.0	0.4	GO:0016282	eukaryotic 43S preinitiation complex(GO:0016282)

Showing 1 to 10 of 34 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.5	GO:0004866	endopeptidase inhibitor activity(GO:0004866)
0.3	2.7	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	2.1	GO:0003823	antigen binding(GO:0003823)
0.0	2.1	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	1.8	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	1.7	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2	1.6	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	1.5	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.3	1.3	GO:0030228	lipoprotein particle receptor activity(GO:0030228)
0.1	1.3	GO:0070492	oligosaccharide binding(GO:0070492)

Showing 1 to 10 of 104 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.3	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	2.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	2.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	2.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	0.8	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	0.7	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.6	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.2	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	0.2	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4

Showing 1 to 10 of 13 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.2	2.0	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.2	1.8	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	1.8	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.0	1.3	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	1.0	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.0	1.0	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	1.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	0.9	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.7	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development

Showing 1 to 10 of 32 entries

Results for cebpa

Z-value: 1.74

Motif logo

Transcription factors associated with cebpa

Activity-expression correlation:

Activity profile of cebpa motif

Sorted Z-values of cebpa motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of cebpa

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: