ISMARA results: creb1a+creb1b+crema+cremb

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PRJNA207719: Tissue specific transcriptome profiling

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Results for creb1a+creb1b+crema+cremb

Z-value: 2.69

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Transcription factors associated with creb1a+creb1b+crema+cremb

Gene Symbol	Gene ID	Gene Info
crema NCBI UniProt	ENSDARG00000023217	cAMP responsive element modulator a
creb1a NCBI UniProt	ENSDARG00000053586	cAMP responsive element binding protein 1a
creb1b NCBI UniProt	ENSDARG00000093420	cAMP responsive element binding protein 1b
cremb NCBI UniProt	ENSDARG00000102899	cAMP responsive element modulator b
cremb NCBI UniProt	ENSDARG00000109505	cAMP responsive element modulator b
cremb NCBI UniProt	ENSDARG00000116064	cAMP responsive element modulator b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
cremb	dr11_v1_chr24_+_31361407_31361407	-0.87	5.7e-02	Click!
crema	dr11_v1_chr2_-_43168292_43168292	-0.85	6.8e-02	Click!
creb1b	dr11_v1_chr9_-_28275600_28275600	-0.72	1.7e-01	Click!
creb1a	dr11_v1_chr1_-_33557915_33557915	-0.67	2.2e-01	Click!

Activity profile of creb1a+creb1b+crema+cremb motif

Sorted Z-values of creb1a+creb1b+crema+cremb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_52232630 Show fit	1.21	ENSDART00000006216	plpp2a NCBI UniProt Show fit	phospholipid phosphatase 2a
chr19_-_27339670 Show fit	1.02	ENSDART00000139323	znrd1 NCBI UniProt Show fit	zinc ribbon domain containing 1
chr9_+_145093 Show fit	1.00	ENSDART00000162764	rrp1 NCBI UniProt Show fit	ribosomal RNA processing 1
chr15_-_1765098 Show fit	0.96	ENSDART00000149980 ENSDART00000093074	bud23 NCBI UniProt Show fit	BUD23, rRNA methyltransferase and ribosome maturation factor
chr4_+_72578548 Show fit	0.96	ENSDART00000174035	si:cabz01054394.5 NCBI UniProt Show fit	si:cabz01054394.5
chr19_+_2876106 Show fit	0.95	ENSDART00000189309	hgh1 NCBI UniProt Show fit	HGH1 homolog (S. cerevisiae)
chr4_+_77933084 Show fit	0.95	ENSDART00000148728	pacsin2 NCBI UniProt Show fit	protein kinase C and casein kinase substrate in neurons 2
chr19_-_27339844 Show fit	0.94	ENSDART00000052358 ENSDART00000148238 ENSDART00000147661 ENSDART00000137346	znrd1 NCBI UniProt Show fit	zinc ribbon domain containing 1
chr10_-_23099809 Show fit	0.93	ENSDART00000148333 ENSDART00000079703 ENSDART00000162444	nle1 NCBI UniProt Show fit	notchless homolog 1 (Drosophila)
chr23_+_25305431 Show fit	0.91	ENSDART00000143291	RPL41 NCBI UniProt Show fit	si:dkey-151g10.6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of creb1a+creb1b+crema+cremb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	43.1	GO:0006355	regulation of transcription, DNA-templated(GO:0006355)
0.0	3.1	GO:0006364	rRNA processing(GO:0006364)
0.1	2.2	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0	1.2	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.1	1.1	GO:0008535	respiratory chain complex IV assembly(GO:0008535)
0.2	1.0	GO:0036265	RNA (guanine-N7)-methylation(GO:0036265)
0.1	1.0	GO:0044857	membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.1	1.0	GO:0000470	maturation of LSU-rRNA(GO:0000470)
0.0	1.0	GO:0000027	ribosomal large subunit assembly(GO:0000027)
0.3	0.9	GO:0071047	U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)

Showing 1 to 10 of 47 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.2	GO:0005730	nucleolus(GO:0005730)
0.2	2.7	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	1.6	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	1.0	GO:0055038	recycling endosome membrane(GO:0055038)
0.1	0.9	GO:0000176	nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177)
0.1	0.7	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.7	GO:0032040	small-subunit processome(GO:0032040)
0.0	0.7	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.2	0.6	GO:0032545	CURI complex(GO:0032545) UTP-C complex(GO:0034456)
0.1	0.6	GO:0001669	acrosomal vesicle(GO:0001669)

Showing 1 to 10 of 23 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	43.8	GO:0001012	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	1.2	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	1.2	GO:0003724	RNA helicase activity(GO:0003724)
0.3	1.1	GO:0034511	U3 snoRNA binding(GO:0034511)
0.1	1.0	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.3	0.9	GO:0016436	rRNA (uridine) methyltransferase activity(GO:0016436)
0.1	0.9	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.2	0.8	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.2	0.8	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1	0.7	GO:0016864	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)

Showing 1 to 10 of 36 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.5	PID ATR PATHWAY	ATR signaling pathway

Showing 1 to 2 of 2 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	0.9	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.7	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.7	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1	0.6	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	0.6	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.5	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.5	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.4	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.4	REACTOME POL SWITCHING	Genes involved in Polymerase switching

Showing 1 to 10 of 13 entries

Results for creb1a+creb1b+crema+cremb

Z-value: 2.69

Motif logo

Transcription factors associated with creb1a+creb1b+crema+cremb

Activity-expression correlation:

Activity profile of creb1a+creb1b+crema+cremb motif

Sorted Z-values of creb1a+creb1b+crema+cremb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of creb1a+creb1b+crema+cremb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: