ISMARA results: e2f1

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PRJNA207719: Tissue specific transcriptome profiling

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Results for e2f1_e2f7

Z-value: 2.24

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Transcription factors associated with e2f1_e2f7

Gene Symbol	Gene ID	Gene Info
e2f1 NCBI UniProt	ENSDARG00000103868	E2F transcription factor 1
e2f7 NCBI UniProt	ENSDARG00000008986	E2F transcription factor 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
e2f1	dr11_v1_chr23_-_43486714_43486714	0.96	1.1e-02	Click!
e2f7	dr11_v1_chr4_-_2545310_2545345	0.29	6.4e-01	Click!

Activity profile of e2f1_e2f7 motif

Sorted Z-values of e2f1_e2f7 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_48391415 Show fit	2.82	ENSDART00000170726 ENSDART00000169577	si:ch73-359m17.2 NCBI UniProt Show fit	si:ch73-359m17.2
chr16_-_41990421 Show fit	1.93	ENSDART00000055921	pycard NCBI UniProt Show fit	PYD and CARD domain containing
chr9_-_33081978 Show fit	1.50	ENSDART00000100918	zgc:172053 NCBI UniProt Show fit	zgc:172053
chr5_+_22970617 Show fit	1.48	ENSDART00000192859	hmgn7 NCBI UniProt Show fit	high mobility group nucleosomal binding domain 7
chr8_-_1219815 Show fit	1.33	ENSDART00000016800 ENSDART00000149969	znf367 NCBI UniProt Show fit	zinc finger protein 367
chr6_+_12968101 Show fit	1.33	ENSDART00000013781	mcm6 NCBI UniProt Show fit	minichromosome maintenance complex component 6
chr20_-_29498178 Show fit	1.32	ENSDART00000152986 ENSDART00000027851 ENSDART00000152954	rrm2 NCBI UniProt Show fit	ribonucleotide reductase M2 polypeptide
chr3_+_25999477 Show fit	1.27	ENSDART00000024316	mcm5 NCBI UniProt Show fit	minichromosome maintenance complex component 5
chr14_+_14841685 Show fit	1.26	ENSDART00000158291 ENSDART00000162039	slbp NCBI UniProt Show fit	stem-loop binding protein
chr20_+_34770197 Show fit	1.25	ENSDART00000018304	mcm3 NCBI UniProt Show fit	minichromosome maintenance complex component 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f1_e2f7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	5.3	GO:0036388	pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.2	2.6	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
0.0	2.5	GO:0006334	nucleosome assembly(GO:0006334)
0.1	2.2	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.5	2.0	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	2.0	GO:0006289	nucleotide-excision repair(GO:0006289)
0.0	1.7	GO:0071427	mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.2	1.6	GO:0000727	double-strand break repair via break-induced replication(GO:0000727)
0.0	1.6	GO:0006261	DNA-dependent DNA replication(GO:0006261)
0.3	1.3	GO:0097510	base-excision repair, AP site formation via deaminated base removal(GO:0097510)

Showing 1 to 10 of 84 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.4	GO:0042555	MCM complex(GO:0042555)
0.0	4.9	GO:0000785	chromatin(GO:0000785)
0.4	2.0	GO:0005662	DNA replication factor A complex(GO:0005662)
0.5	1.9	GO:0061702	inflammasome complex(GO:0061702)
0.4	1.6	GO:0033186	CAF-1 complex(GO:0033186)
0.3	1.6	GO:0000811	GINS complex(GO:0000811)
0.2	1.2	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.3	1.1	GO:0008622	epsilon DNA polymerase complex(GO:0008622)
0.2	1.1	GO:0035101	FACT complex(GO:0035101)
0.2	1.1	GO:0005663	DNA replication factor C complex(GO:0005663)

Showing 1 to 10 of 42 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.0	GO:0043142	single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142)
0.2	3.0	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	3.0	GO:0042393	histone binding(GO:0042393)
0.0	2.8	GO:0030246	carbohydrate binding(GO:0030246)
0.4	2.6	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	2.3	GO:0003697	single-stranded DNA binding(GO:0003697)
0.0	2.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	1.9	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0	1.7	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1	1.6	GO:0031491	nucleosome binding(GO:0031491)

Showing 1 to 10 of 57 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.9	PID E2F PATHWAY	E2F transcription factor network
0.1	4.1	PID FANCONI PATHWAY	Fanconi anemia pathway
0.0	2.6	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.0	1.2	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	0.6	PID ATR PATHWAY	ATR signaling pathway
0.0	0.5	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	0.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.4	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.4	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.3	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Showing 1 to 10 of 13 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	6.9	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.2	4.4	REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1	3.0	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.1	2.7	REACTOME G1 PHASE	Genes involved in G1 Phase
0.4	1.9	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	1.4	REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	Genes involved in Activation of the pre-replicative complex
0.1	1.3	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1	1.0	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	1.0	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.1	0.9	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA

Showing 1 to 10 of 30 entries

Results for e2f1_e2f7

Z-value: 2.24

Motif logo

Transcription factors associated with e2f1_e2f7

Activity-expression correlation:

Activity profile of e2f1_e2f7 motif

Sorted Z-values of e2f1_e2f7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f1_e2f7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: