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PRJNA207719: Tissue specific transcriptome profiling

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Results for e2f3

Z-value: 0.37

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Transcription factors associated with e2f3

Gene Symbol Gene ID Gene Info
e2f3
ENSDARG00000070463 E2F transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f3dr11_v1_chr19_-_29294457_292944570.098.9e-01Click!

Activity profile of e2f3 motif

Sorted Z-values of e2f3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_904850 0.64 ENSDART00000161847
si:ch73-208h1.1
si:ch73-208h1.1
chr16_-_25085327 0.44 ENSDART00000077661
prss1
protease, serine 1
chr25_+_186583 0.39 ENSDART00000161504
pclaf
PCNA clamp associated factor
chr9_-_2892045 0.34 ENSDART00000137201
cdca7a
cell division cycle associated 7a
chr9_-_2892250 0.31 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr15_-_2954443 0.28 ENSDART00000161053
zgc:153184
zgc:153184
chr21_-_26490186 0.23 ENSDART00000009889
zgc:110540
zgc:110540
chr2_-_44344321 0.22 ENSDART00000084174
lig1
ligase I, DNA, ATP-dependent
chr20_-_44090624 0.14 ENSDART00000048978
ENSDART00000082283
ENSDART00000082276
runx2b
runt-related transcription factor 2b
chr3_-_32275975 0.14 ENSDART00000178448
cpt1cb
carnitine palmitoyltransferase 1Cb
chr14_+_22076596 0.13 ENSDART00000106147
ENSDART00000100278
ENSDART00000131489
slc43a1a
solute carrier family 43 (amino acid system L transporter), member 1a
chr11_-_11792766 0.12 ENSDART00000011657
cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr19_-_43757568 0.12 ENSDART00000058491
ppt1
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr1_-_9980765 0.10 ENSDART00000142906
si:dkeyp-75b4.7
si:dkeyp-75b4.7
chr4_-_9909371 0.10 ENSDART00000102656
si:dkey-22l11.6
si:dkey-22l11.6
chr14_+_14841685 0.10 ENSDART00000158291
ENSDART00000162039
slbp
stem-loop binding protein
chr8_-_11988065 0.09 ENSDART00000005140
med27
mediator complex subunit 27
chr7_+_67434677 0.09 ENSDART00000165971
ENSDART00000166702
kars
lysyl-tRNA synthetase
chr5_+_66433287 0.09 ENSDART00000170757
kntc1
kinetochore associated 1
chr19_+_43604643 0.08 ENSDART00000151168
si:ch211-199g17.9
si:ch211-199g17.9
chr3_+_38540411 0.08 ENSDART00000154943
si:dkey-7f16.3
si:dkey-7f16.3
chr17_-_6535941 0.08 ENSDART00000109249
cenpo
centromere protein O
chr18_+_34861568 0.08 ENSDART00000192825
LO018333.1

chr7_+_34236238 0.08 ENSDART00000052474
tipin
timeless interacting protein
chr11_-_44945636 0.08 ENSDART00000157658
orc2
origin recognition complex, subunit 2
chr14_-_30918662 0.07 ENSDART00000176631
si:ch211-126c2.4
si:ch211-126c2.4
chr25_+_6451038 0.07 ENSDART00000009971
snx33
sorting nexin 33
chr15_-_37425468 0.06 ENSDART00000059630
si:ch211-113j13.2
si:ch211-113j13.2
chr3_-_54607166 0.06 ENSDART00000021977
dnmt1
DNA (cytosine-5-)-methyltransferase 1
chr6_+_7533601 0.05 ENSDART00000057823
pa2g4a
proliferation-associated 2G4, a
chr16_+_40575742 0.05 ENSDART00000161503
ccne2
cyclin E2
chr20_+_4392687 0.05 ENSDART00000187271
im:7142702
im:7142702
chr24_+_21684189 0.05 ENSDART00000014696
pdx1
pancreatic and duodenal homeobox 1
chr25_+_36339867 0.05 ENSDART00000152195
si:ch211-113a14.18
si:ch211-113a14.18
chr17_+_6536152 0.05 ENSDART00000062952
ENSDART00000121789
slc5a6b
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr15_+_33991928 0.04 ENSDART00000170177
vwde
von Willebrand factor D and EGF domains
chr19_+_2546775 0.04 ENSDART00000148527
ENSDART00000097528
sp4
sp4 transcription factor
chr20_+_26394324 0.04 ENSDART00000078093
zbtb2b
zinc finger and BTB domain containing 2b
chr24_-_38657683 0.04 ENSDART00000154843
si:ch1073-164k15.3
si:ch1073-164k15.3
chr4_-_72100774 0.03 ENSDART00000170099
slco1f1
solute carrier organic anion transporter family, member 1F1
chr24_+_39108243 0.03 ENSDART00000156353
mss51
MSS51 mitochondrial translational activator
chr15_-_14884332 0.03 ENSDART00000165237
si:ch211-24o8.4
si:ch211-24o8.4
chr22_-_5822147 0.03 ENSDART00000011076
cers5
ceramide synthase 5
chr19_+_636886 0.03 ENSDART00000149192
tert
telomerase reverse transcriptase
chr3_-_53486169 0.03 ENSDART00000115243
soul5
heme-binding protein soul5
chr17_+_6535694 0.03 ENSDART00000191681
slc5a6b
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr17_-_29224908 0.02 ENSDART00000156288
si:dkey-28g23.6
si:dkey-28g23.6
chr1_-_46663997 0.02 ENSDART00000134450
ebpl
emopamil binding protein-like
chr23_-_18913032 0.02 ENSDART00000136678
si:ch211-209j10.6
si:ch211-209j10.6
chr7_+_26534131 0.01 ENSDART00000173980
si:dkey-62k3.5
si:dkey-62k3.5
chr8_+_23355484 0.01 ENSDART00000085361
ENSDART00000125729
dnmt3ba
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
chr1_-_42289704 0.00 ENSDART00000150124
si:ch211-71k14.1
si:ch211-71k14.1
chr3_-_10612186 0.00 ENSDART00000191034
map2k4a
mitogen-activated protein kinase kinase 4a

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0051103 DNA ligation(GO:0006266) DNA ligation involved in DNA repair(GO:0051103)
0.0 0.4 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.1 GO:0015878 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.0 0.6 GO:0048538 thymus development(GO:0048538)
0.0 0.1 GO:0043111 replication fork arrest(GO:0043111)
0.0 0.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.1 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.0 0.0 GO:0007571 age-dependent general metabolic decline(GO:0007571)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031511 Mis6-Sim4 complex(GO:0031511)
0.0 0.1 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.1 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.0 0.0 GO:0000333 telomerase catalytic core complex(GO:0000333)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.2 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.1 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.1 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.0 0.0 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.2 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.0 0.2 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex