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PRJNA207719: Tissue specific transcriptome profiling

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Results for e2f4

Z-value: 0.67

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Transcription factors associated with e2f4

Gene Symbol Gene ID Gene Info
e2f4
ENSDARG00000101578 E2F transcription factor 4
e2f4
ENSDARG00000109320 E2F transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f4dr11_v1_chr25_+_17405201_17405201-0.731.7e-01Click!

Activity profile of e2f4 motif

Sorted Z-values of e2f4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_48391415 0.58 ENSDART00000170726
ENSDART00000169577
si:ch73-359m17.2
si:ch73-359m17.2
chr7_+_24814866 0.58 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr7_+_24881680 0.48 ENSDART00000058843
krcp
kelch repeat-containing protein
chr20_-_29498178 0.40 ENSDART00000152986
ENSDART00000027851
ENSDART00000152954
rrm2
ribonucleotide reductase M2 polypeptide
chr19_-_47570672 0.39 ENSDART00000112155
rrm2
ribonucleotide reductase M2 polypeptide
chr3_+_29641181 0.38 ENSDART00000151517
eif3d
eukaryotic translation initiation factor 3, subunit D
chr22_+_3153876 0.36 ENSDART00000163327
rpl36
ribosomal protein L36
chr7_-_6429031 0.33 ENSDART00000173413
zgc:112234
zgc:112234
chr25_-_774350 0.31 ENSDART00000166321
ENSDART00000160386
IRAK4
interleukin 1 receptor associated kinase 4
chr25_+_192116 0.30 ENSDART00000153983
zgc:114188
zgc:114188
chr24_+_21621654 0.30 ENSDART00000002595
rpl21
ribosomal protein L21
chr17_-_15189397 0.28 ENSDART00000133710
ENSDART00000110507
wdhd1
WD repeat and HMG-box DNA binding protein 1
chr10_+_6884123 0.26 ENSDART00000149095
ENSDART00000148772
ENSDART00000149334
ddx4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr25_-_35124576 0.25 ENSDART00000128017
zgc:171759
zgc:171759
chr4_-_17725008 0.22 ENSDART00000016658
chpt1
choline phosphotransferase 1
chr20_-_33462961 0.21 ENSDART00000135927
si:dkey-65b13.1
si:dkey-65b13.1
chr7_+_5960491 0.21 ENSDART00000145370
zgc:112234
zgc:112234
chr20_+_35445462 0.21 ENSDART00000124497
tdrd6
tudor domain containing 6
chr7_-_6459481 0.20 ENSDART00000173158
zgc:112234
zgc:112234
chr25_-_35109536 0.19 ENSDART00000185229
CU302436.5

chr7_-_6415991 0.18 ENSDART00000173349
CU457819.3
Histone H3.2
chr6_-_425378 0.18 ENSDART00000192190
fam83fb
family with sequence similarity 83, member Fb
chr7_-_6351021 0.18 ENSDART00000159542
zgc:112234
zgc:112234
chr7_-_6345507 0.17 ENSDART00000173032
CU457819.4
Histone H3.2
chr11_+_31680513 0.17 ENSDART00000139900
ENSDART00000040305
diaph3
diaphanous-related formin 3
chr20_-_28433990 0.16 ENSDART00000182824
ENSDART00000193381
wdr21
WD repeat domain 21
chr25_-_36370292 0.15 ENSDART00000152766
CR354435.1
Histone H2B 1/2
chr6_-_33978622 0.14 ENSDART00000151725
ENSDART00000124917
mpl
MPL proto-oncogene, thrombopoietin receptor
chr6_-_39653972 0.14 ENSDART00000155859
larp4ab
La ribonucleoprotein domain family, member 4Ab
chr17_+_43889371 0.14 ENSDART00000156871
ENSDART00000154702
msh4
mutS homolog 4
chr14_+_94603 0.14 ENSDART00000162480
mcm7
minichromosome maintenance complex component 7
chr25_+_35062353 0.13 ENSDART00000089844
zgc:113983
zgc:113983
chr10_-_37487612 0.13 ENSDART00000167964
ENSDART00000171326
si:dkey-65j4.2
si:dkey-65j4.2
chr16_+_35595312 0.13 ENSDART00000170438
si:ch211-1i11.3
si:ch211-1i11.3
chr13_+_48359573 0.13 ENSDART00000161959
ENSDART00000165311
msh6
mutS homolog 6 (E. coli)
chr23_-_19831739 0.13 ENSDART00000125066
haus7
HAUS augmin-like complex, subunit 7
chr18_+_17020967 0.13 ENSDART00000189168
chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr3_-_61592417 0.12 ENSDART00000155082
nptx2a
neuronal pentraxin 2a
chr3_+_58119571 0.12 ENSDART00000108979
si:ch211-256e16.4
si:ch211-256e16.4
chr7_+_20393386 0.12 ENSDART00000173471
si:dkey-33c9.6
si:dkey-33c9.6
chr4_-_75175407 0.11 ENSDART00000180125
CABZ01043953.1

chr20_-_28433616 0.11 ENSDART00000169289
wdr21
WD repeat domain 21
chr13_-_45942000 0.10 ENSDART00000158534
ENSDART00000171822
ENSDART00000166442
si:ch211-62a1.4
si:ch211-62a1.4
chr13_+_15933168 0.10 ENSDART00000131390
fignl1
fidgetin-like 1
chr25_+_35058088 0.10 ENSDART00000156838
zgc:112234
zgc:112234
chr7_-_73854476 0.10 ENSDART00000186481
zgc:173552
zgc:173552
chr7_+_34453185 0.10 ENSDART00000173875
ENSDART00000173921
ENSDART00000173995
si:cabz01009626.1
si:cabz01009626.1
chr2_-_57378748 0.09 ENSDART00000149235
tcf3a
transcription factor 3a
chr23_-_45568816 0.09 ENSDART00000076086
cyp17a2
cytochrome P450, family 17, subfamily A, polypeptide 2
chr3_-_7897305 0.08 ENSDART00000169757
ubn2b
ubinuclein 2b
chr14_+_94946 0.08 ENSDART00000165766
ENSDART00000163778
mcm7
minichromosome maintenance complex component 7
chr16_+_11834516 0.07 ENSDART00000146611
cxcr3.3
chemokine (C-X-C motif) receptor 3, tandem duplicate 3
chr17_-_50020672 0.06 ENSDART00000188942
filip1a
filamin A interacting protein 1a
chr8_+_8947623 0.06 ENSDART00000131215
slc35a2
solute carrier family 35 (UDP-galactose transporter), member 2
chr4_+_77740228 0.06 ENSDART00000193397
si:zfos-2131b9.2
si:zfos-2131b9.2
chr3_-_7897563 0.06 ENSDART00000185232
ubn2b
ubinuclein 2b
chr18_+_17021391 0.04 ENSDART00000100160
chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr25_+_35155676 0.03 ENSDART00000114598
zgc:112234
zgc:112234
chr17_-_11368662 0.03 ENSDART00000159061
ENSDART00000188694
ENSDART00000190932
si:ch211-185a18.2
si:ch211-185a18.2
chr25_+_35067318 0.02 ENSDART00000186828
CU302436.1

chr5_+_20453874 0.02 ENSDART00000124545
ENSDART00000008402
sart3
squamous cell carcinoma antigen recognized by T cells 3
chr21_+_30355767 0.02 ENSDART00000189948
CR749164.1

chr21_-_27413294 0.01 ENSDART00000131646
slc29a2
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr10_+_6010570 0.01 ENSDART00000190025
ENSDART00000163680
hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.1 0.8 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.1 GO:0002566 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.2 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.2 GO:0030719 P granule organization(GO:0030719)
0.0 0.1 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 0.3 GO:0051445 regulation of meiotic cell cycle(GO:0051445)
0.0 0.1 GO:0008207 C21-steroid hormone metabolic process(GO:0008207)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0033391 chromatoid body(GO:0033391)
0.1 0.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.1 GO:0032301 MutSalpha complex(GO:0032301)
0.0 0.4 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0098808 mRNA cap binding(GO:0098808)
0.1 0.8 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.2 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.0 0.2 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.1 GO:0032138 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.0 0.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.1 GO:0030983 mismatched DNA binding(GO:0030983)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.2 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC