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PRJNA207719: Tissue specific transcriptome profiling

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Results for egr3

Z-value: 0.75

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Transcription factors associated with egr3

Gene Symbol Gene ID Gene Info
egr3
ENSDARG00000089156 early growth response 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
egr3dr11_v1_chr8_+_50727220_50727220-0.335.9e-01Click!

Activity profile of egr3 motif

Sorted Z-values of egr3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_56422311 0.61 ENSDART00000171958
gpr39
G protein-coupled receptor 39
chr17_-_2584423 0.60 ENSDART00000013506
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr9_+_56422517 0.52 ENSDART00000168620
gpr39
G protein-coupled receptor 39
chr23_-_29556844 0.37 ENSDART00000138021
rbp7a
retinol binding protein 7a, cellular
chr7_+_46019780 0.35 ENSDART00000163991
ccne1
cyclin E1
chr15_+_9294620 0.34 ENSDART00000133588
ENSDART00000140009
slc37a4a
solute carrier family 37 (glucose-6-phosphate transporter), member 4a
chr8_+_6576940 0.33 ENSDART00000138135
vsig8b
V-set and immunoglobulin domain containing 8b
chr14_+_29769336 0.31 ENSDART00000105898
si:dkey-34l15.1
si:dkey-34l15.1
chr22_-_10591876 0.31 ENSDART00000105846
si:dkey-42i9.8
si:dkey-42i9.8
chr7_-_46019756 0.26 ENSDART00000162583
zgc:162297
zgc:162297
chr22_+_9806867 0.25 ENSDART00000137182
ENSDART00000106103
si:ch211-236g6.1
si:ch211-236g6.1
chr20_+_13894123 0.25 ENSDART00000007744
slc30a1a
solute carrier family 30 (zinc transporter), member 1a
chr5_+_29831235 0.24 ENSDART00000109660
f11r.1
F11 receptor, tandem duplicate 1
chr4_+_30785713 0.23 ENSDART00000165945
si:dkey-178j11.5
si:dkey-178j11.5
chr8_+_8927870 0.22 ENSDART00000081985
pim2
Pim-2 proto-oncogene, serine/threonine kinase
chr16_-_47381519 0.22 ENSDART00000032188
ENSDART00000150136
si:dkey-256h2.1
si:dkey-256h2.1
chr7_-_6364168 0.21 ENSDART00000173332
zgc:112234
zgc:112234
chr12_-_990149 0.20 ENSDART00000054367
kdelr2b
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2b
chr19_-_617246 0.20 ENSDART00000062551
cyp51
cytochrome P450, family 51
chr3_+_22984098 0.20 ENSDART00000043190
lsm12a
LSM12 homolog a
chr11_+_1565806 0.20 ENSDART00000137479
mybl2b
v-myb avian myeloblastosis viral oncogene homolog-like 2b
chr7_+_55518519 0.20 ENSDART00000098476
ENSDART00000149915
cdt1
chromatin licensing and DNA replication factor 1
chr23_-_31645760 0.19 ENSDART00000035031
sgk1
serum/glucocorticoid regulated kinase 1
chr5_-_2689753 0.18 ENSDART00000172699
gng10
guanine nucleotide binding protein (G protein), gamma 10
chr1_+_12295142 0.17 ENSDART00000158595
gne
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr16_-_54405976 0.17 ENSDART00000055395
osr2
odd-skipped related transciption factor 2
chr25_-_18125769 0.17 ENSDART00000140484
kitlga
kit ligand a
chr4_+_63484571 0.16 ENSDART00000169518
ENSDART00000168681
si:dkey-11d20.1
si:dkey-11d20.1
chr4_+_30775376 0.16 ENSDART00000158528
si:dkey-11d20.1
si:dkey-11d20.1
chr3_-_49504023 0.15 ENSDART00000168108
prkacaa
protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
chr2_+_105748 0.13 ENSDART00000169601
CABZ01098670.1

chr21_-_217589 0.13 ENSDART00000185017
CZQB01146713.1

chr6_-_53391727 0.13 ENSDART00000155483
si:ch211-161c3.6
si:ch211-161c3.6
chr3_-_7106678 0.12 ENSDART00000175293
ENSDART00000187732
ENSDART00000158652
zgc:113102
BX005085.2
zgc:113102

chr18_+_19974289 0.12 ENSDART00000090334
ENSDART00000192982
skor1b
SKI family transcriptional corepressor 1b
chr15_+_36105581 0.12 ENSDART00000184099
col4a3
collagen, type IV, alpha 3
chr12_+_5215795 0.11 ENSDART00000170270
SLC35G1
si:ch211-197g18.2
chr20_+_27712714 0.11 ENSDART00000008306
zbtb1
zinc finger and BTB domain containing 1
chr4_-_64709908 0.10 ENSDART00000161032
si:dkey-9i5.2
si:dkey-9i5.2
chr22_+_34784075 0.08 ENSDART00000167538
lcor
ligand dependent nuclear receptor corepressor
chr16_+_10918252 0.08 ENSDART00000172949
pou2f2a
POU class 2 homeobox 2a
chr18_+_3004572 0.08 ENSDART00000190328
CABZ01002690.1

chr15_-_16121496 0.08 ENSDART00000128624
sgk494a
uncharacterized serine/threonine-protein kinase SgK494a
chr12_-_44016898 0.08 ENSDART00000175304
si:dkey-201i2.4
si:dkey-201i2.4
chr3_+_23737795 0.07 ENSDART00000182247
hoxb3a
homeobox B3a
chr15_-_14038227 0.07 ENSDART00000139068
zgc:114130
zgc:114130
chr21_-_43398122 0.07 ENSDART00000050533
ccni2
cyclin I family, member 2
chr4_+_70556298 0.06 ENSDART00000170985
si:dkey-11d20.1
si:dkey-11d20.1
chr12_-_26537145 0.06 ENSDART00000138437
ENSDART00000163931
ENSDART00000132737
acsf2
acyl-CoA synthetase family member 2
chr19_-_48039400 0.06 ENSDART00000166748
ENSDART00000165921
csf3b
colony stimulating factor 3 (granulocyte) b
chr14_+_36220479 0.05 ENSDART00000148319
pitx2
paired-like homeodomain 2
chr24_+_3328354 0.05 ENSDART00000147468
bdh1
3-hydroxybutyrate dehydrogenase, type 1
chr3_-_38918697 0.05 ENSDART00000145630
si:dkey-106c17.2
si:dkey-106c17.2
chr21_-_41369539 0.05 ENSDART00000187546
cpeb4b
cytoplasmic polyadenylation element binding protein 4b
chr6_+_42818963 0.04 ENSDART00000184833
sema3fa
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa
chr22_-_6651382 0.04 ENSDART00000124308
si:ch211-209l18.4
si:ch211-209l18.4
chr3_+_24537023 0.04 ENSDART00000077702
sp100.1
SP110 nuclear body protein, tandem duplicate 1
chr20_+_28803642 0.04 ENSDART00000188526
fntb
farnesyltransferase, CAAX box, beta
chr22_+_1806235 0.03 ENSDART00000158966
znf1168
zinc finger protein 1168
chr16_+_4138331 0.02 ENSDART00000192403
ENSDART00000193036
mtf1
metal-regulatory transcription factor 1
chr3_-_5228137 0.02 ENSDART00000137105
myh9b
myosin, heavy chain 9b, non-muscle
chr13_+_35925490 0.02 ENSDART00000046115
mfsd2aa
major facilitator superfamily domain containing 2aa
chr7_+_41340520 0.02 ENSDART00000005127
garem
GRB2 associated, regulator of MAPK1
chr11_-_165288 0.01 ENSDART00000108703
ENSDART00000173151
tegt
testis enhanced gene transcript (BAX inhibitor 1)
chr22_-_16275236 0.01 ENSDART00000149051
cdc14ab
cell division cycle 14Ab
chr9_-_30363770 0.01 ENSDART00000147030
sytl5
synaptotagmin-like 5
chr17_+_48164536 0.01 ENSDART00000161750
ENSDART00000156923
plekhd1
pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
chr5_+_6617401 0.01 ENSDART00000060532
zgc:110796
zgc:110796
chr4_-_73587205 0.01 ENSDART00000150837
znf1015
zinc finger protein 1015
chr13_-_36141486 0.00 ENSDART00000044115
med6
mediator complex subunit 6
chr21_-_41369370 0.00 ENSDART00000159290
cpeb4b
cytoplasmic polyadenylation element binding protein 4b

Network of associatons between targets according to the STRING database.

First level regulatory network of egr3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1990359 detoxification of zinc ion(GO:0010312) stress response to zinc ion(GO:1990359)
0.0 0.6 GO:0007339 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.2 GO:0071322 cellular response to carbohydrate stimulus(GO:0071322) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.0 0.2 GO:0050892 intestinal absorption(GO:0050892)
0.0 0.2 GO:0000076 DNA replication checkpoint(GO:0000076)
0.0 0.4 GO:0060972 left/right pattern formation(GO:0060972)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.0 0.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.2 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 0.2 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 0.2 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) N-acylmannosamine kinase activity(GO:0009384)
0.1 0.6 GO:0035804 structural constituent of egg coat(GO:0035804)
0.0 0.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.2 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.1 GO:0031956 medium-chain fatty acid-CoA ligase activity(GO:0031956) butyrate-CoA ligase activity(GO:0047760)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.2 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline