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PRJNA207719: Tissue specific transcriptome profiling

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Results for egr4

Z-value: 0.83

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Transcription factors associated with egr4

Gene Symbol Gene ID Gene Info
egr4
ENSDARG00000077799 early growth response 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
egr4dr11_v1_chr23_+_45579497_45579497-0.335.9e-01Click!

Activity profile of egr4 motif

Sorted Z-values of egr4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_44963154 1.02 ENSDART00000073735
rrad
Ras-related associated with diabetes
chr24_+_24831727 0.89 ENSDART00000080969
trim55b
tripartite motif containing 55b
chr25_+_30298377 0.80 ENSDART00000153622
C11orf96
chromosome 11 open reading frame 96
chr2_-_48753873 0.76 ENSDART00000189556
CABZ01044731.1

chr17_+_15297398 0.56 ENSDART00000156574
si:ch211-270g19.5
si:ch211-270g19.5
chr1_-_47431453 0.47 ENSDART00000101104
gja5b
gap junction protein, alpha 5b
chr17_-_10025234 0.41 ENSDART00000008355
cfl2
cofilin 2 (muscle)
chr22_-_16180849 0.40 ENSDART00000090390
vcam1b
vascular cell adhesion molecule 1b
chr19_+_390298 0.32 ENSDART00000136361
sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr2_+_35880600 0.31 ENSDART00000004277
lamc1
laminin, gamma 1
chr3_+_16722014 0.27 ENSDART00000008711
gys1
glycogen synthase 1 (muscle)
chr23_+_16910071 0.27 ENSDART00000104793
si:dkey-147f3.8
si:dkey-147f3.8
chr4_-_9579299 0.26 ENSDART00000183079
ENSDART00000192968
ENSDART00000091809
shank3b
SH3 and multiple ankyrin repeat domains 3b
chr25_-_207214 0.26 ENSDART00000193448
FP236318.3

chr20_+_6659770 0.26 ENSDART00000192135
tns3.2
tensin 3, tandem duplicate 2
chr12_+_14079097 0.25 ENSDART00000078033
si:ch211-217a12.1
si:ch211-217a12.1
chr18_-_45617146 0.24 ENSDART00000146543
wt1b
wilms tumor 1b
chr7_-_52498175 0.23 ENSDART00000129769
cgnl1
cingulin-like 1
chr24_-_39354829 0.21 ENSDART00000169108
kcnj12a
potassium inwardly-rectifying channel, subfamily J, member 12a
chr8_+_8927870 0.20 ENSDART00000081985
pim2
Pim-2 proto-oncogene, serine/threonine kinase
chr22_-_6991514 0.20 ENSDART00000148233
fgfr1bl
fibroblast growth factor receptor 1b, like
chr5_-_43819663 0.19 ENSDART00000022481
mccc2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr3_-_5228137 0.19 ENSDART00000137105
myh9b
myosin, heavy chain 9b, non-muscle
chr16_-_40508624 0.18 ENSDART00000075718
ndufaf6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr10_-_15919839 0.18 ENSDART00000065032
pip5k1ba
phosphatidylinositol-4-phosphate 5-kinase, type I, beta a
chr5_-_2689753 0.16 ENSDART00000172699
gng10
guanine nucleotide binding protein (G protein), gamma 10
chr18_+_8901846 0.16 ENSDART00000132109
ENSDART00000144247
si:dkey-5i3.5
si:dkey-5i3.5
chr8_+_45294767 0.16 ENSDART00000191527
ubap2b
ubiquitin associated protein 2b
chr19_+_342094 0.15 ENSDART00000151013
ENSDART00000187622
ensaa
endosulfine alpha a
chr11_+_14049131 0.14 ENSDART00000172471
grin3bb
glutamate receptor, ionotropic, N-methyl-D-aspartate 3Bb
chr5_-_21030934 0.13 ENSDART00000133461
ENSDART00000098667
camk2b1
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1
chr25_-_36827491 0.13 ENSDART00000170941
CU929365.1

chr12_-_26537145 0.13 ENSDART00000138437
ENSDART00000163931
ENSDART00000132737
acsf2
acyl-CoA synthetase family member 2
chr12_+_499881 0.12 ENSDART00000167527
mprip
myosin phosphatase Rho interacting protein
chr6_+_2271559 0.12 ENSDART00000165223
pbx1b
pre-B-cell leukemia homeobox 1b
chr11_+_12719944 0.12 ENSDART00000054837
ENSDART00000144954
ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr8_+_22438398 0.12 ENSDART00000135145
zgc:153759
zgc:153759
chr11_+_12720171 0.12 ENSDART00000135761
ENSDART00000122812
ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr13_-_31397987 0.11 ENSDART00000008287
pgam1a
phosphoglycerate mutase 1a
chr23_+_39606108 0.11 ENSDART00000109464
g0s2
G0/G1 switch 2
chr22_-_16275236 0.11 ENSDART00000149051
cdc14ab
cell division cycle 14Ab
chr4_+_842010 0.10 ENSDART00000067461
si:ch211-152c2.3
si:ch211-152c2.3
chr2_+_16710889 0.09 ENSDART00000017852
ubxn7
UBX domain protein 7
chr10_+_19554604 0.08 ENSDART00000063806
atp6v1b2
ATPase H+ transporting V1 subunit B2
chr5_+_42136359 0.07 ENSDART00000083731
trpv1
transient receptor potential cation channel, subfamily V, member 1
chr22_+_6757741 0.07 ENSDART00000140815
CT583625.1

chr21_-_41838284 0.07 ENSDART00000141067
cct6a
chaperonin containing TCP1, subunit 6A (zeta 1)
chr3_+_23737795 0.07 ENSDART00000182247
hoxb3a
homeobox B3a
chr20_+_27712714 0.07 ENSDART00000008306
zbtb1
zinc finger and BTB domain containing 1
chr23_+_9067131 0.06 ENSDART00000144533
ccm2l
cerebral cavernous malformation 2-like
chr4_+_70556298 0.06 ENSDART00000170985
si:dkey-11d20.1
si:dkey-11d20.1
chr14_+_15155684 0.06 ENSDART00000167966
zgc:158852
zgc:158852
chr16_-_12784373 0.06 ENSDART00000080396
foxj2
forkhead box J2
chr6_-_23117348 0.06 ENSDART00000154941
ENSDART00000154252
ten1
TEN1 CST complex subunit
chr1_-_411331 0.06 ENSDART00000092524
rasa3
RAS p21 protein activator 3
chr16_+_19029297 0.05 ENSDART00000115263
ENSDART00000114954
rapgef5b
Rap guanine nucleotide exchange factor (GEF) 5b
chr21_+_33172526 0.05 ENSDART00000183532
arl3l1
ADP-ribosylation factor-like 3, like 1
chr4_+_332709 0.05 ENSDART00000067486
tulp4a
tubby like protein 4a
chr13_-_49666615 0.05 ENSDART00000148083
tomm20a
translocase of outer mitochondrial membrane 20
chr6_+_40661703 0.04 ENSDART00000142492
eno1b
enolase 1b, (alpha)
chr21_-_43398457 0.04 ENSDART00000166530
ccni2
cyclin I family, member 2
chr22_+_1806235 0.03 ENSDART00000158966
znf1168
zinc finger protein 1168
chr3_+_31897029 0.03 ENSDART00000146275
strada
ste20-related kinase adaptor alpha
chr21_-_43398122 0.03 ENSDART00000050533
ccni2
cyclin I family, member 2
chr17_+_48164536 0.03 ENSDART00000161750
ENSDART00000156923
plekhd1
pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
chr4_+_28997595 0.03 ENSDART00000133357
si:dkey-13e3.1
si:dkey-13e3.1
chr14_-_38889840 0.03 ENSDART00000035779
zgc:101583
zgc:101583
chr1_-_10473630 0.02 ENSDART00000040116
tnrc5
trinucleotide repeat containing 5
chr9_-_48036 0.02 ENSDART00000165230
ENSDART00000171335
map4k4
mitogen-activated protein kinase kinase kinase kinase 4
chr22_-_5054773 0.02 ENSDART00000184207
matk
megakaryocyte-associated tyrosine kinase
chr14_+_40641350 0.02 ENSDART00000074506
tnmd
tenomodulin
chr3_+_22984098 0.02 ENSDART00000043190
lsm12a
LSM12 homolog a
chr23_+_804119 0.02 ENSDART00000148163
frmd4bb
FERM domain containing 4Bb
chr2_+_47906240 0.02 ENSDART00000122206
ftr23
finTRIM family, member 23
chr5_-_49012569 0.02 ENSDART00000184690
si:dkey-172m14.2
si:dkey-172m14.2
chr11_+_3308656 0.02 ENSDART00000082458
sarnp
SAP domain containing ribonucleoprotein
chr21_+_6212844 0.02 ENSDART00000150301
fnbp1b
formin binding protein 1b
chr15_+_36105581 0.01 ENSDART00000184099
col4a3
collagen, type IV, alpha 3
chr11_-_277599 0.01 ENSDART00000187109
npffl
neuropeptide FF-amide peptide precursor like
chr16_+_53519048 0.01 ENSDART00000124691
smpd5
sphingomyelin phosphodiesterase 5
chr7_+_41340520 0.01 ENSDART00000005127
garem
GRB2 associated, regulator of MAPK1
chr8_-_52859301 0.00 ENSDART00000162004
nr5a1a
nuclear receptor subfamily 5, group A, member 1a
chr11_-_165288 0.00 ENSDART00000108703
ENSDART00000173151
tegt
testis enhanced gene transcript (BAX inhibitor 1)

Network of associatons between targets according to the STRING database.

First level regulatory network of egr4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.4 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.3 GO:0097107 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.6 GO:0043462 regulation of ATPase activity(GO:0043462)
0.0 0.2 GO:0070650 actin filament bundle distribution(GO:0070650)
0.0 0.5 GO:0030534 adult behavior(GO:0030534)
0.0 0.2 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.3 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.1 GO:1904357 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.0 0.3 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.1 GO:0071850 mitotic cell cycle arrest(GO:0071850)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.1 GO:1990879 CST complex(GO:1990879)
0.0 0.1 GO:1902636 kinociliary basal body(GO:1902636)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 0.5 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.1 0.3 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.1 0.2 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.0 0.1 GO:0031956 medium-chain fatty acid-CoA ligase activity(GO:0031956) butyrate-CoA ligase activity(GO:0047760)
0.0 0.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)