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PRJNA207719: Tissue specific transcriptome profiling
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Results for elf2a+elf2b
Z-value: 3.02
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Transcription factors associated with elf2a+elf2b
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000019459 | E74-like factor 2a (ets domain transcription factor) | |
| ENSDARG00000079626 | E74-like factor 2b (ets domain transcription factor) | |
| ENSDARG00000117064 | E74-like factor 2b (ets domain transcription factor) |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| elf2a | dr11_v1_chr14_-_46070802_46070802 | 0.90 | 4.0e-02 | Click! |
| elf2b | dr11_v1_chr1_-_13989643_13989643 | 0.87 | 5.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_42272517 Show fit | 1.52 |
ENSDART00000137692
ENSDART00000164363 |
si:ch211-207c6.2 |
|
| chr3_-_32337653 Show fit | 1.13 |
ENSDART00000156918
ENSDART00000156551 |
si:dkey-16p21.8 |
|
| chr15_+_42573909 Show fit | 1.08 |
ENSDART00000181801
|
zgc:110333 |
|
| chr9_-_33081781 Show fit | 1.05 |
ENSDART00000165748
|
zgc:172053 |
|
| chr4_-_76383223 Show fit | 0.96 |
ENSDART00000161866
ENSDART00000168456 ENSDART00000174287 ENSDART00000174048 |
zgc:123107 |
|
| chr11_-_41084358 Show fit | 0.95 |
ENSDART00000166999
|
zgc:175088 |
|
| chr25_-_13659249 Show fit | 0.91 |
ENSDART00000045488
|
casein kinase 2, alpha prime polypeptide b |
|
| chr6_-_39313027 Show fit | 0.89 |
ENSDART00000012644
|
keratin 4 |
|
| chr22_-_26353916 Show fit | 0.88 |
ENSDART00000077958
|
calpain 2, (m/II) large subunit b |
|
| chr20_+_46040666 Show fit | 0.87 |
ENSDART00000060744
|
si:dkey-7c18.24 |
Network of associatons between targets according to the STRING database.
First level regulatory network of elf2a+elf2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.8 | GO:0008380 | RNA splicing(GO:0008380) |
| 0.1 | 2.9 | GO:0045324 | late endosome to vacuole transport(GO:0045324) |
| 0.1 | 2.4 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.0 | 1.7 | GO:0061640 | cytoskeleton-dependent cytokinesis(GO:0061640) |
| 0.2 | 1.6 | GO:0033182 | regulation of histone ubiquitination(GO:0033182) |
| 0.0 | 1.6 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.1 | 1.5 | GO:0030497 | fatty acid elongation(GO:0030497) |
| 0.1 | 1.4 | GO:0018120 | peptidyl-arginine ADP-ribosylation(GO:0018120) |
| 0.0 | 1.4 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.1 | 1.3 | GO:0006825 | copper ion transport(GO:0006825) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.1 | 1.8 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 1.8 | GO:0001726 | ruffle(GO:0001726) |
| 0.1 | 1.7 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.1 | 1.7 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.0 | 1.6 | GO:0031970 | mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970) |
| 0.1 | 1.5 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.1 | 1.4 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 1.3 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.2 | 1.2 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.3 | 1.6 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.3 | 1.4 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.1 | 1.4 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.0 | 1.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 1.3 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.2 | 1.1 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.2 | 1.1 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.1 | 1.1 | GO:0102337 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.0 | 1.1 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 2.6 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.1 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.1 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.1 | 0.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 0.7 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.7 | PID CD40 PATHWAY | CD40/CD40L signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.4 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 1.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.4 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.0 | 1.3 | REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX | Genes involved in Formation of the HIV-1 Early Elongation Complex |
| 0.0 | 1.3 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 0.4 | 1.2 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 1.2 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.1 | 1.1 | REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |