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PRJNA207719: Tissue specific transcriptome profiling

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Results for en1a

Z-value: 1.17

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Transcription factors associated with en1a

Gene Symbol Gene ID Gene Info
en1a
ENSDARG00000014321 engrailed homeobox 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
en1adr11_v1_chr9_-_785444_785444-0.513.8e-01Click!

Activity profile of en1a motif

Sorted Z-values of en1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_28428222 1.01 ENSDART00000135003
si:ch211-222e20.4
si:ch211-222e20.4
chr5_-_44843738 0.96 ENSDART00000003926
fbp1a
fructose-1,6-bisphosphatase 1a
chr16_+_26017360 0.95 ENSDART00000149466
prss59.2
protease, serine, 59, tandem duplicate 2
chr19_-_18626515 0.91 ENSDART00000160624
rps18
ribosomal protein S18
chr3_+_14543953 0.88 ENSDART00000161710
epor
erythropoietin receptor
chr3_-_3939785 0.86 ENSDART00000049593
unm_sa1506
un-named sa1506
chr2_-_51794472 0.84 ENSDART00000186652
BX908782.3

chr20_-_25518488 0.84 ENSDART00000186993
cyp2n13
cytochrome P450, family 2, subfamily N, polypeptide 13
chr7_-_20582842 0.80 ENSDART00000169750
ENSDART00000111719
si:dkey-19b23.11
si:dkey-19b23.11
chr18_-_43866526 0.74 ENSDART00000111309
treh
trehalase (brush-border membrane glycoprotein)
chr8_-_50147948 0.74 ENSDART00000149010
hp
haptoglobin
chr24_-_24983047 0.73 ENSDART00000066631
slc51a
solute carrier family 51, alpha subunit
chr5_+_22459087 0.71 ENSDART00000134781
BX546499.1

chr5_-_31942621 0.70 ENSDART00000049178
svopb
SV2 related protein b
chr3_+_26345732 0.69 ENSDART00000128613
rps15a
ribosomal protein S15a
chr4_+_28997595 0.66 ENSDART00000133357
si:dkey-13e3.1
si:dkey-13e3.1
chr13_-_34858500 0.66 ENSDART00000184843
sptlc3
serine palmitoyltransferase, long chain base subunit 3
chr7_+_31879986 0.64 ENSDART00000138491
mybpc3
myosin binding protein C, cardiac
chr16_+_23924040 0.64 ENSDART00000161124
si:dkey-7f3.14
si:dkey-7f3.14
chr2_+_26498446 0.63 ENSDART00000078412
rps8a
ribosomal protein S8a
chr20_-_37813863 0.60 ENSDART00000147529
batf3
basic leucine zipper transcription factor, ATF-like 3
chr22_+_19220459 0.60 ENSDART00000163070
si:dkey-21e2.7
si:dkey-21e2.7
chr25_-_26018424 0.59 ENSDART00000089332
acsbg1
acyl-CoA synthetase bubblegum family member 1
chr5_-_65021736 0.59 ENSDART00000162368
ENSDART00000161876
anxa1c
annexin A1c
chr25_-_26018240 0.58 ENSDART00000150800
acsbg1
acyl-CoA synthetase bubblegum family member 1
chr23_+_28770225 0.57 ENSDART00000132179
ENSDART00000142273
masp2
mannan-binding lectin serine peptidase 2
chr14_-_21123551 0.57 ENSDART00000171679
ENSDART00000165882
si:dkey-74k8.4
si:dkey-74k8.4
chr19_+_43780970 0.57 ENSDART00000063870
rpl11
ribosomal protein L11
chr2_+_32780138 0.56 ENSDART00000082250
zgc:136930
zgc:136930
chr7_+_17120811 0.54 ENSDART00000147140
prmt3
protein arginine methyltransferase 3
chr12_-_30540699 0.53 ENSDART00000167712
ENSDART00000102464
zgc:153920
zgc:153920
chr2_+_36606019 0.51 ENSDART00000098415
ing5b
inhibitor of growth family, member 5b
chr7_+_30178453 0.51 ENSDART00000174420
si:ch211-107o10.3
si:ch211-107o10.3
chr7_-_73856073 0.51 ENSDART00000181793
FP236812.2

chr25_-_13023569 0.50 ENSDART00000167232
ccl39.1
chemokine (C-C motif) ligand 39, duplicate 1
chr12_-_10365875 0.49 ENSDART00000142386
ENSDART00000007335
ndc80
NDC80 kinetochore complex component
chr2_+_36114194 0.47 ENSDART00000113547
traj39
T-cell receptor alpha joining 39
chr10_-_21542702 0.47 ENSDART00000146761
ENSDART00000134502
zgc:165539
zgc:165539
chr1_-_11607062 0.47 ENSDART00000158253
si:dkey-26i13.6
si:dkey-26i13.6
chr9_+_44994214 0.46 ENSDART00000141434
retsatl
retinol saturase (all-trans-retinol 13,14-reductase) like
chr22_+_835728 0.46 ENSDART00000003325
dennd2db
DENN/MADD domain containing 2Db
chr5_+_9360394 0.45 ENSDART00000124642
FP236810.2

chr16_+_41570653 0.45 ENSDART00000102665
aste1a
asteroid homolog 1a
chr3_+_28939759 0.45 ENSDART00000141904
lgals1l1
lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1
chr9_-_9998087 0.45 ENSDART00000124423
ugt1ab
UDP glucuronosyltransferase 1 family a, b
chr22_+_25733817 0.44 ENSDART00000176962
ENSDART00000187865
si:dkeyp-98a7.9
si:dkeyp-98a7.9
chr18_-_7422787 0.44 ENSDART00000081386
si:dkey-30c15.12
si:dkey-30c15.12
chr15_+_14854666 0.44 ENSDART00000163066
diabloa
diablo, IAP-binding mitochondrial protein a
chr3_+_12784460 0.43 ENSDART00000168382
cyp2k8
cytochrome P450, family 2, subfamily K, polypeptide 8
chr3_-_4579214 0.43 ENSDART00000164456
ftr50
finTRIM family, member 50
chr19_+_4076259 0.42 ENSDART00000160633
zgc:173581
zgc:173581
chr11_-_669270 0.42 ENSDART00000172834
pparg
peroxisome proliferator-activated receptor gamma
chr2_+_45441563 0.42 ENSDART00000151882
si:ch211-66k16.27
si:ch211-66k16.27
chr13_-_45201300 0.42 ENSDART00000074750
ENSDART00000180265
runx3
runt-related transcription factor 3
chr3_+_12732382 0.41 ENSDART00000158403
cyp2k19
cytochrome P450, family 2, subfamily k, polypeptide 19
chr7_-_34265481 0.41 ENSDART00000173596
si:ch211-98n17.5
si:ch211-98n17.5
chr25_-_30357027 0.41 ENSDART00000171137
pdia3
protein disulfide isomerase family A, member 3
chr1_-_56951369 0.40 ENSDART00000152294
si:ch211-1f22.2
si:ch211-1f22.2
chr23_-_10722664 0.39 ENSDART00000146526
ENSDART00000129022
ENSDART00000104985
foxp1a
forkhead box P1a
chr9_-_30555725 0.39 ENSDART00000079222
chaf1b
chromatin assembly factor 1, subunit B
chr14_+_45732081 0.39 ENSDART00000110103
ccdc88b
coiled-coil domain containing 88B
chr9_+_3113211 0.39 ENSDART00000139476
ppp1r9ala
protein phosphatase 1 regulatory subunit 9A-like A
chr13_-_1130096 0.39 ENSDART00000010261
pno1
partner of NOB1 homolog
chr5_-_69716501 0.39 ENSDART00000158956
mob1a
MOB kinase activator 1A
chr8_+_40284973 0.38 ENSDART00000018401
orai1a
ORAI calcium release-activated calcium modulator 1a
chr16_-_46578523 0.38 ENSDART00000131061
si:dkey-152b24.6
si:dkey-152b24.6
chr23_-_33738945 0.36 ENSDART00000136386
si:ch211-210c8.7
si:ch211-210c8.7
chr11_-_669558 0.36 ENSDART00000173450
pparg
peroxisome proliferator-activated receptor gamma
chr12_-_8070969 0.36 ENSDART00000020995
tmem26b
transmembrane protein 26b
chr1_+_58205904 0.35 ENSDART00000147324
si:dkey-222h21.12
si:dkey-222h21.12
chr22_+_19247255 0.35 ENSDART00000144053
si:dkey-21e2.10
si:dkey-21e2.10
chr11_-_13611132 0.35 ENSDART00000113055
si:ch211-1a19.2
si:ch211-1a19.2
chr12_-_26537145 0.35 ENSDART00000138437
ENSDART00000163931
ENSDART00000132737
acsf2
acyl-CoA synthetase family member 2
chr12_-_30523216 0.34 ENSDART00000152896
ENSDART00000153191
plekhs1
pleckstrin homology domain containing, family S member 1
chr22_+_1123873 0.34 ENSDART00000137708
si:ch1073-181h11.2
si:ch1073-181h11.2
chr7_-_10560964 0.34 ENSDART00000172761
ENSDART00000170476
mthfs
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
chr9_+_1313418 0.34 ENSDART00000191361
casp8l2
caspase 8, apoptosis-related cysteine peptidase, like 2
chr7_+_49664174 0.34 ENSDART00000137059
ENSDART00000131210
rassf7b
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7b
chr3_+_23768898 0.33 ENSDART00000110682
hoxb1a
homeobox B1a
chr10_+_15088534 0.33 ENSDART00000142865
si:ch211-95j8.3
si:ch211-95j8.3
chr23_+_1730663 0.33 ENSDART00000149545
tgm1
transglutaminase 1, K polypeptide
chr24_-_2423791 0.33 ENSDART00000190402
rreb1a
ras responsive element binding protein 1a
chr2_+_3201345 0.33 ENSDART00000130349
wnt9a
wingless-type MMTV integration site family, member 9A
chr1_-_11606903 0.32 ENSDART00000136093
si:dkey-26i13.6
si:dkey-26i13.6
chr5_-_30615901 0.32 ENSDART00000147769
si:ch211-117m20.5
si:ch211-117m20.5
chr4_-_52165969 0.32 ENSDART00000171130
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr6_-_53391727 0.32 ENSDART00000155483
si:ch211-161c3.6
si:ch211-161c3.6
chr5_-_8164439 0.31 ENSDART00000189912
slc1a3a
solute carrier family 1 (glial high affinity glutamate transporter), member 3a
chr14_-_9277152 0.31 ENSDART00000189048
asb12b
ankyrin repeat and SOCS box-containing 12b
chr15_+_25158104 0.31 ENSDART00000128267
slc35f2l
info solute carrier family 35, member F2, like
chr3_-_4557653 0.31 ENSDART00000111305
ftr50
finTRIM family, member 50
chr16_-_22303130 0.31 ENSDART00000142181
si:dkey-92i15.4
si:dkey-92i15.4
chr11_+_24716837 0.30 ENSDART00000145217
zgc:153953
zgc:153953
chr2_-_3045861 0.30 ENSDART00000105818
ENSDART00000187575
guk1a
guanylate kinase 1a
chr2_+_22495274 0.30 ENSDART00000167915
lrrc8da
leucine rich repeat containing 8 VRAC subunit Da
chr3_-_26184018 0.30 ENSDART00000191604
si:ch211-11k18.4
si:ch211-11k18.4
chr21_+_25198637 0.29 ENSDART00000164972
si:dkey-183i3.6
si:dkey-183i3.6
chr6_+_46320693 0.29 ENSDART00000128621
ENSDART00000155917
si:dkeyp-67f1.2
si:dkeyp-67f1.2
chr9_-_17417628 0.29 ENSDART00000060425
ENSDART00000141997
ftr53
finTRIM family, member 53
chr18_+_33322515 0.29 ENSDART00000136603
v2ra18
vomeronasal 2 receptor, a18
chr23_+_44374041 0.29 ENSDART00000136056
ephb4b
eph receptor B4b
chr7_-_60096318 0.29 ENSDART00000189125
BX511067.1

chr20_+_34845672 0.29 ENSDART00000128895
emilin1a
elastin microfibril interfacer 1a
chr17_-_6349044 0.29 ENSDART00000081707
oct2
organic cation transporter 2
chr7_+_49695904 0.28 ENSDART00000183550
ENSDART00000126991
ascl1b
achaete-scute family bHLH transcription factor 1b
chr1_+_12009673 0.28 ENSDART00000080100
slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr16_-_22744806 0.28 ENSDART00000139243
tlr19
toll-like receptor 19
chr7_+_31879649 0.28 ENSDART00000099789
mybpc3
myosin binding protein C, cardiac
chr2_+_49631850 0.28 ENSDART00000114274
ENSDART00000114516
si:dkey-53k12.18
si:dkey-53k12.18
chr25_-_3836597 0.28 ENSDART00000115154
si:ch211-247i17.1
si:ch211-247i17.1
chr17_-_8886735 0.28 ENSDART00000121997
nkl.3
NK-lysin tandem duplicate 3
chr23_-_20363261 0.28 ENSDART00000054651
si:rp71-17i16.5
si:rp71-17i16.5
chr7_+_38507006 0.27 ENSDART00000173830
slc7a9
solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
chr19_+_25476228 0.27 ENSDART00000112808
col28a1a
collagen, type XXVIII, alpha 1a
chr18_-_14901437 0.27 ENSDART00000145842
ENSDART00000008035
trabd
TraB domain containing
chr16_+_35395597 0.27 ENSDART00000158143
si:dkey-34d22.5
si:dkey-34d22.5
chr5_-_68022631 0.27 ENSDART00000143199
wasf3a
WAS protein family, member 3a
chr4_+_57099307 0.27 ENSDART00000131654
si:ch211-238e22.2
si:ch211-238e22.2
chr17_+_42274825 0.27 ENSDART00000020156
pax1a
paired box 1a
chr2_-_6518785 0.26 ENSDART00000146108
rgs1
regulator of G protein signaling 1
chr14_-_38872536 0.26 ENSDART00000184315
ENSDART00000127479
gsr
glutathione reductase
chr15_-_1485086 0.26 ENSDART00000191651
si:dkeyp-97b10.3
si:dkeyp-97b10.3
chr22_-_31020690 0.26 ENSDART00000130604
ssuh2.4
ssu-2 homolog, tandem duplicate 4
chr5_-_38197080 0.26 ENSDART00000140708
si:ch211-284e13.9
si:ch211-284e13.9
chr4_+_77905736 0.25 ENSDART00000144471
si:zfos-2131b9.2
si:zfos-2131b9.2
chr16_+_23383316 0.25 ENSDART00000103220
krtcap2
keratinocyte associated protein 2
chr12_-_44018667 0.25 ENSDART00000170692
si:dkey-201i2.4
si:dkey-201i2.4
chr16_-_41535690 0.25 ENSDART00000102662
rpp25l
ribonuclease P/MRP 25 subunit-like
chr4_-_5831522 0.25 ENSDART00000008898
foxm1
forkhead box M1
chr7_-_17258635 0.25 ENSDART00000173934
ENSDART00000173668
ENSDART00000161797
nitr12
novel immune-type receptor 12
chr21_+_19517492 0.25 ENSDART00000123168
ENSDART00000187993
gzmk
granzyme K
chr4_+_66853199 0.25 ENSDART00000170223
si:dkey-29m1.2
si:dkey-29m1.2
chr1_+_22654875 0.25 ENSDART00000019698
ENSDART00000161874
anxa5b
annexin A5b
chr10_-_16062565 0.25 ENSDART00000188728
si:dkey-184a18.5
si:dkey-184a18.5
chr2_-_985417 0.25 ENSDART00000140540
si:ch211-241e1.3
si:ch211-241e1.3
chr12_+_38940731 0.24 ENSDART00000193360
si:dkey-239b22.1
si:dkey-239b22.1
chr2_-_6519017 0.24 ENSDART00000181716
rgs1
regulator of G protein signaling 1
chr7_+_53199763 0.24 ENSDART00000160097
cdh28
cadherin 28
chr15_+_714203 0.24 ENSDART00000153847
si:dkey-7i4.24
si:dkey-7i4.24
chr20_+_10723292 0.24 ENSDART00000152805
si:ch211-182e10.4
si:ch211-182e10.4
chr5_-_57723929 0.24 ENSDART00000144237
gig2p
grass carp reovirus (GCRV)-induced gene 2p
chr2_-_24398324 0.24 ENSDART00000165226
zgc:154006
zgc:154006
chr7_-_18712482 0.24 ENSDART00000173517
ENSDART00000122564
ENSDART00000173905
trmt10a
tRNA methyltransferase 10A
chr17_+_3128273 0.24 ENSDART00000122453
zgc:136872
zgc:136872
chr7_-_35409027 0.24 ENSDART00000128334
lpcat2
lysophosphatidylcholine acyltransferase 2
chr9_-_33121535 0.23 ENSDART00000166371
ENSDART00000138052
zgc:172014
zgc:172014
chr14_+_26247319 0.23 ENSDART00000192793
CCDC69
coiled-coil domain containing 69
chr7_-_6470431 0.23 ENSDART00000081359
zgc:110425
zgc:110425
chr8_+_25616946 0.23 ENSDART00000133983
slc38a5a
solute carrier family 38, member 5a
chr2_-_1514001 0.23 ENSDART00000057736
c8b
complement component 8, beta polypeptide
chr3_-_13921173 0.22 ENSDART00000159177
ENSDART00000165174
si:dkey-61n16.5
si:dkey-61n16.5
chr4_+_12333168 0.22 ENSDART00000172455
ENSDART00000146166
pimr214
pimr171
Pim proto-oncogene, serine/threonine kinase, related 214
Pim proto-oncogene, serine/threonine kinase, related 171
chr1_-_11627289 0.22 ENSDART00000163312
si:dkey-26i13.3
si:dkey-26i13.3
chr9_+_23003208 0.22 ENSDART00000021060
eaf2
ELL associated factor 2
chr15_-_37835638 0.22 ENSDART00000128922
si:dkey-238d18.3
si:dkey-238d18.3
chr21_-_25618175 0.22 ENSDART00000133512
fosl1b
FOS-like antigen 1b
chr17_-_6613458 0.22 ENSDART00000175024
si:ch211-189e2.3
si:ch211-189e2.3
chr9_+_21277846 0.22 ENSDART00000139620
ENSDART00000110996
ENSDART00000111899
lats2
large tumor suppressor kinase 2
chr18_+_19456648 0.22 ENSDART00000079695
zwilch
zwilch kinetochore protein
chr23_-_28120058 0.22 ENSDART00000087815
b4galnt1a
beta-1,4-N-acetyl-galactosaminyl transferase 1a
chr9_-_135774 0.21 ENSDART00000160435
FQ377903.1

chr2_+_33726862 0.21 ENSDART00000146745
si:dkey-31m5.5
si:dkey-31m5.5
chr5_+_35955209 0.21 ENSDART00000074630
zgc:103697
zgc:103697
chr17_-_868004 0.21 ENSDART00000112803
wdr20a
WD repeat domain 20a
chr20_+_51833030 0.21 ENSDART00000074330
taf1a
TATA box binding protein (TBP)-associated factor, RNA polymerase I, A
chr22_-_23228669 0.21 ENSDART00000079536
nek7
NIMA-related kinase 7
chr7_+_4592867 0.21 ENSDART00000192614
si:dkey-83f18.15
si:dkey-83f18.15
chr16_-_9425451 0.21 ENSDART00000149163
ccr8.1
chemokine (C-C motif) receptor 8.1
chr5_-_23843636 0.21 ENSDART00000193280
GBGT1 (1 of many)
si:ch211-135f11.5
chr7_+_55314206 0.21 ENSDART00000132852
ctu2
cytosolic thiouridylase subunit 2 homolog (S. pombe)
chr7_+_44713135 0.21 ENSDART00000170721
si:dkey-56m19.5
si:dkey-56m19.5
chr12_-_10381282 0.21 ENSDART00000152788
mki67
marker of proliferation Ki-67
chr2_+_45479841 0.20 ENSDART00000151856
si:ch211-66k16.28
si:ch211-66k16.28
chr25_+_7504314 0.20 ENSDART00000163231
ifitm5
interferon induced transmembrane protein 5
chr13_-_15700060 0.20 ENSDART00000170689
ENSDART00000010986
ENSDART00000101741
ENSDART00000139124
ckba
creatine kinase, brain a
chr6_+_6822592 0.20 ENSDART00000151057
si:ch211-85n16.4
si:ch211-85n16.4
chr6_-_10698125 0.20 ENSDART00000151636
dnah9l
dynein, axonemal, heavy polypeptide 9 like
chr10_-_39052264 0.20 ENSDART00000144036
igsf5a
immunoglobulin superfamily, member 5a
chr19_-_5264517 0.20 ENSDART00000001821
prf1.3
perforin 1.3
chr13_-_3516473 0.20 ENSDART00000146240
prkn
parkin RBR E3 ubiquitin protein ligase
chr8_+_17167876 0.20 ENSDART00000134665
cenph
centromere protein H
chr3_+_5504990 0.20 ENSDART00000143626
si:ch73-264i18.2
si:ch73-264i18.2
chr22_-_10440688 0.19 ENSDART00000111962
nol8
nucleolar protein 8
chr7_-_3630019 0.19 ENSDART00000138164
ENSDART00000064277
si:dkey-192d15.3
si:dkey-192d15.3
chr23_-_31512496 0.19 ENSDART00000158755
ENSDART00000143425
eya4
EYA transcriptional coactivator and phosphatase 4
chr13_+_11876437 0.19 ENSDART00000179753
trim8a
tripartite motif containing 8a
chr1_+_10129099 0.19 ENSDART00000187740
rbm46
RNA binding motif protein 46
chr4_-_75707991 0.19 ENSDART00000166358
ENSDART00000160021
si:dkey-165o8.2
si:dkey-165o8.2
chr2_+_45100963 0.19 ENSDART00000160122
CU929150.2

chr20_+_43942278 0.18 ENSDART00000100571
clic5b
chloride intracellular channel 5b
chr6_+_18321627 0.18 ENSDART00000183107
ENSDART00000189715
card14
caspase recruitment domain family, member 14
chr8_-_38403018 0.18 ENSDART00000134100
sorbs3
sorbin and SH3 domain containing 3
chr21_+_10866421 0.18 ENSDART00000137858
alpk2
alpha-kinase 2
chr3_-_41795917 0.18 ENSDART00000182662
grifin
galectin-related inter-fiber protein
chr10_-_36633882 0.18 ENSDART00000077161
ENSDART00000137688
rsf1b.1
rsf1b.1
remodeling and spacing factor 1b, tandem duplicate 1
remodeling and spacing factor 1b, tandem duplicate 1
chr4_-_2945306 0.18 ENSDART00000128934
ENSDART00000019518
aebp2
AE binding protein 2
chr21_+_15824182 0.18 ENSDART00000065779
gnrh2
gonadotropin-releasing hormone 2
chr1_-_38171648 0.18 ENSDART00000137451
ENSDART00000047159
hmgb2a
high mobility group box 2a
chr18_-_22717565 0.17 ENSDART00000142185
ENSDART00000059945
si:ch73-113g13.1
si:ch73-113g13.1
chr9_+_3175201 0.17 ENSDART00000179022
ENSDART00000007756
ENSDART00000182108
dync1i2a
dynein, cytoplasmic 1, intermediate chain 2a

Network of associatons between targets according to the STRING database.

First level regulatory network of en1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0005986 sucrose metabolic process(GO:0005985) sucrose biosynthetic process(GO:0005986) disaccharide biosynthetic process(GO:0046351)
0.2 0.7 GO:0005991 disaccharide metabolic process(GO:0005984) trehalose metabolic process(GO:0005991)
0.2 0.9 GO:0003210 cardiac atrium formation(GO:0003210)
0.2 0.5 GO:1903504 regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.6 GO:0001781 neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 0.3 GO:0090278 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.1 0.3 GO:0060292 long term synaptic depression(GO:0060292)
0.1 0.4 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.1 0.3 GO:0042543 protein N-linked glycosylation via arginine(GO:0042543)
0.1 0.7 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.1 0.2 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.1 1.2 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 0.8 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.1 0.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.3 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.3 GO:0021570 rhombomere 4 development(GO:0021570) rhombomere 4 morphogenesis(GO:0021661)
0.0 0.2 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.0 0.5 GO:1900407 regulation of cellular response to oxidative stress(GO:1900407)
0.0 0.4 GO:0031179 peptide modification(GO:0031179)
0.0 0.2 GO:0070227 lymphocyte apoptotic process(GO:0070227)
0.0 0.3 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.2 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.0 1.8 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.5 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.0 0.1 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.0 0.3 GO:0016576 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.5 GO:2001235 positive regulation of apoptotic signaling pathway(GO:2001235)
0.0 0.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.2 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 0.6 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 0.2 GO:0072395 signal transduction involved in cell cycle checkpoint(GO:0072395)
0.0 0.4 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.4 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.1 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.2 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.1 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.2 GO:0046620 secondary heart field specification(GO:0003139) regulation of organ growth(GO:0046620)
0.0 0.3 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.3 GO:0071156 regulation of cell cycle arrest(GO:0071156)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.3 GO:0050930 regulation of positive chemotaxis(GO:0050926) positive regulation of positive chemotaxis(GO:0050927) induction of positive chemotaxis(GO:0050930)
0.0 0.2 GO:0006603 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.0 0.1 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.3 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.1 GO:0098586 cytoplasmic pattern recognition receptor signaling pathway in response to virus(GO:0039528) cellular response to virus(GO:0098586)
0.0 0.2 GO:0014812 muscle cell migration(GO:0014812)
0.0 0.4 GO:0019835 cytolysis(GO:0019835)
0.0 0.3 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.0 0.2 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.5 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.1 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.0 0.1 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.1 GO:1900045 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.1 GO:0071632 optomotor response(GO:0071632) caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.1 GO:0061620 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.5 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.2 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 0.7 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.2 GO:0031213 RSF complex(GO:0031213)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.3 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 2.2 GO:0015935 small ribosomal subunit(GO:0015935)
0.0 0.5 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.2 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.2 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0031526 brush border membrane(GO:0031526)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.7 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.2 0.7 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.2 0.8 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.3 GO:0047760 medium-chain fatty acid-CoA ligase activity(GO:0031956) butyrate-CoA ligase activity(GO:0047760)
0.1 0.6 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.7 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 1.2 GO:0016405 CoA-ligase activity(GO:0016405)
0.1 0.3 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 0.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 0.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.2 GO:0048030 disaccharide binding(GO:0048030)
0.1 0.2 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.1 0.2 GO:0005183 gonadotropin hormone-releasing hormone activity(GO:0005183) gonadotropin-releasing hormone receptor binding(GO:0031530)
0.1 0.3 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.0 0.2 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.4 GO:0016936 galactoside binding(GO:0016936)
0.0 0.1 GO:0033961 cis-stilbene-oxide hydrolase activity(GO:0033961)
0.0 0.4 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.4 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.5 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.3 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.4 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.5 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 1.8 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.1 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.2 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.9 GO:0019843 rRNA binding(GO:0019843)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 3.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.2 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.0 0.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.5 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.2 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.2 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.1 GO:0022821 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.0 0.1 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046) core promoter binding(GO:0001047)
0.0 0.1 GO:0070095 6-phosphofructokinase activity(GO:0003872) fructose-6-phosphate binding(GO:0070095)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.9 PID EPO PATHWAY EPO signaling pathway
0.0 0.3 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.5 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 0.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.0 0.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA