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PRJNA207719: Tissue specific transcriptome profiling

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Results for en1b_en2a+en2b_gbx1_emx1

Z-value: 1.14

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Transcription factors associated with en1b_en2a+en2b_gbx1_emx1

Gene Symbol Gene ID Gene Info
en1b
ENSDARG00000098730 engrailed homeobox 1b
en2a
ENSDARG00000026599 engrailed homeobox 2a
en2b
ENSDARG00000038868 engrailed homeobox 2b
en2a
ENSDARG00000115233 engrailed homeobox 2a
gbx1
ENSDARG00000071418 gastrulation brain homeobox 1
emx1
ENSDARG00000039569 empty spiracles homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
en2adr11_v1_chr7_-_40993456_409934560.995.9e-04Click!
en2bdr11_v1_chr2_+_29976419_299764190.991.3e-03Click!
en1bdr11_v1_chr1_+_7679328_76793280.976.3e-03Click!
emx1dr11_v1_chr13_+_15004398_150043980.951.3e-02Click!
gbx1dr11_v1_chr24_+_34113424_341134240.885.2e-02Click!

Activity profile of en1b_en2a+en2b_gbx1_emx1 motif

Sorted Z-values of en1b_en2a+en2b_gbx1_emx1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_64732036 2.10 ENSDART00000073950
olfm1a
olfactomedin 1a
chr5_+_64732270 2.04 ENSDART00000134241
olfm1a
olfactomedin 1a
chr6_+_39232245 1.79 ENSDART00000187351
b4galnt1b
beta-1,4-N-acetyl-galactosaminyl transferase 1b
chr11_-_42554290 1.66 ENSDART00000130573
atp6ap1la
ATPase H+ transporting accessory protein 1 like a
chr23_+_40460333 1.65 ENSDART00000184658
soga3b
SOGA family member 3b
chr19_+_5543072 1.57 ENSDART00000082080
jupb
junction plakoglobin b
chr23_+_44741500 1.53 ENSDART00000166421
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr7_+_30787903 1.48 ENSDART00000174000
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr2_+_50608099 1.47 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr7_+_13418812 1.39 ENSDART00000191905
ENSDART00000091567
dagla
diacylglycerol lipase, alpha
chr22_+_4488454 1.27 ENSDART00000170620
ctxn1
cortexin 1
chr21_+_28958471 1.24 ENSDART00000144331
ENSDART00000005929
ppp3ca
protein phosphatase 3, catalytic subunit, alpha isozyme
chr23_+_26946744 1.19 ENSDART00000115141
cacnb3b
calcium channel, voltage-dependent, beta 3b
chr16_+_5774977 1.19 ENSDART00000134202
ccka
cholecystokinin a
chr22_+_17828267 1.18 ENSDART00000136016
hapln4
hyaluronan and proteoglycan link protein 4
chr15_+_44366556 1.14 ENSDART00000133449
GUCY1A2
guanylate cyclase 1 soluble subunit alpha 2
chr24_-_41320037 1.12 ENSDART00000129058
rheb
Ras homolog, mTORC1 binding
chr19_-_5805923 1.11 ENSDART00000134340
si:ch211-264f5.8
si:ch211-264f5.8
chr24_+_16547035 1.09 ENSDART00000164319
sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr8_-_50888806 1.09 ENSDART00000053750
acsl2
acyl-CoA synthetase long chain family member 2
chr17_-_200316 1.08 ENSDART00000190561
CABZ01083778.1

chr24_-_31843173 1.08 ENSDART00000185782
steap2
STEAP family member 2, metalloreductase
chr15_-_9272328 1.06 ENSDART00000172114
calm2a
calmodulin 2a (phosphorylase kinase, delta)
chr6_-_6487876 1.05 ENSDART00000137642
cep170ab
centrosomal protein 170Ab
chr11_+_38280454 1.03 ENSDART00000171496
CDK18
si:dkey-166c18.1
chr12_+_24342303 1.02 ENSDART00000111239
nrxn1a
neurexin 1a
chr16_+_47207691 1.01 ENSDART00000062507
ica1
islet cell autoantigen 1
chr18_+_11506561 1.01 ENSDART00000121647
PRMT8
protein arginine methyltransferase 8
chr1_-_50859053 0.97 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
si:dkeyp-123h10.2
chr19_+_14921000 0.97 ENSDART00000144052
oprd1a
opioid receptor, delta 1a
chr7_+_23515966 0.96 ENSDART00000186893
ENSDART00000186189
zgc:109889
zgc:109889
chr5_-_23280098 0.92 ENSDART00000126540
ENSDART00000051533
plp1b
proteolipid protein 1b
chr1_-_47071979 0.91 ENSDART00000160817
itsn1
intersectin 1 (SH3 domain protein)
chr7_-_72261721 0.91 ENSDART00000172229
RASGRP2
RAS guanyl releasing protein 2
chr1_+_16397063 0.91 ENSDART00000159794
micu3a
mitochondrial calcium uptake family, member 3a
chr9_-_20372977 0.90 ENSDART00000113418
igsf3
immunoglobulin superfamily, member 3
chr4_+_9400012 0.90 ENSDART00000191960
tmtc1
transmembrane and tetratricopeptide repeat containing 1
chr25_+_21324588 0.87 ENSDART00000151842
lrrn3a
leucine rich repeat neuronal 3a
chr9_+_38372216 0.86 ENSDART00000141895
plcd4b
phospholipase C, delta 4b
chr25_-_32869794 0.86 ENSDART00000162784
tmem266
transmembrane protein 266
chr11_+_25129013 0.84 ENSDART00000132879
ndrg3a
ndrg family member 3a
chr2_-_56385373 0.82 ENSDART00000169101
cers4b
ceramide synthase 4b
chr20_-_29864390 0.81 ENSDART00000161834
ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr4_+_11384891 0.80 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
pcloa
piccolo presynaptic cytomatrix protein a
chr10_+_35952532 0.80 ENSDART00000184730
rtn4rl1a
reticulon 4 receptor-like 1a
chr7_+_32722227 0.80 ENSDART00000126565
si:ch211-150g13.3
si:ch211-150g13.3
chr23_-_333457 0.77 ENSDART00000114486
uhrf1bp1
UHRF1 binding protein 1
chr19_-_5865766 0.77 ENSDART00000191007
LO018585.1

chr10_-_44508249 0.77 ENSDART00000160018
DUSP26
dual specificity phosphatase 26
chr23_+_28582865 0.77 ENSDART00000020296
l1cama
L1 cell adhesion molecule, paralog a
chr8_+_53423408 0.76 ENSDART00000164792
cacna1db
calcium channel, voltage-dependent, L type, alpha 1D subunit, b
chr22_-_11137268 0.76 ENSDART00000178882
atp6ap2
ATPase H+ transporting accessory protein 2
chr2_-_31936966 0.76 ENSDART00000169484
ENSDART00000192492
ENSDART00000027689
amph
amphiphysin
chr25_-_5119162 0.74 ENSDART00000153961
shisal1b
shisa like 1b
chr1_-_46981134 0.73 ENSDART00000130607
pknox1.2
pbx/knotted 1 homeobox 1.2
chr4_+_21129752 0.73 ENSDART00000169764
syt1a
synaptotagmin Ia
chr8_+_7756893 0.73 ENSDART00000191894
fgd1
FYVE, RhoGEF and PH domain containing 1
chr21_-_39177564 0.73 ENSDART00000065143
unc119b
unc-119 homolog b (C. elegans)
chr6_+_21001264 0.72 ENSDART00000044519
ENSDART00000151278
cx44.2
connexin 44.2
chr9_+_17983463 0.71 ENSDART00000182150
akap11
A kinase (PRKA) anchor protein 11
chr18_+_9615147 0.71 ENSDART00000160284
pclob
piccolo presynaptic cytomatrix protein b
chr2_+_1714640 0.67 ENSDART00000086761
ENSDART00000111613
adgrl2b.1
adgrl2b.1
adhesion G protein-coupled receptor L2b, tandem duplicate 1
adhesion G protein-coupled receptor L2b, tandem duplicate 1
chr20_-_46362606 0.67 ENSDART00000153087
bmf2
BCL2 modifying factor 2
chr11_+_28476298 0.67 ENSDART00000122319
lrrc38b
leucine rich repeat containing 38b
chr17_+_24722646 0.67 ENSDART00000138356
mtfr1l
mitochondrial fission regulator 1-like
chr12_+_31744217 0.67 ENSDART00000190361
RNF157
si:dkey-49c17.3
chr15_+_1796313 0.66 ENSDART00000126253
fam124b
family with sequence similarity 124B
chr14_+_45406299 0.66 ENSDART00000173142
ENSDART00000112377
map1lc3cl
microtubule-associated protein 1 light chain 3 gamma, like
chr10_+_15255198 0.66 ENSDART00000139047
ENSDART00000172107
ENSDART00000183413
ENSDART00000185314
vldlr
very low density lipoprotein receptor
chr19_-_20113696 0.65 ENSDART00000188813
npy
neuropeptide Y
chr10_+_17371356 0.65 ENSDART00000122663
sppl3
signal peptide peptidase 3
chr17_+_21902058 0.65 ENSDART00000142178
plekha1a
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1a
chr22_-_11136625 0.65 ENSDART00000016873
ENSDART00000125561
atp6ap2
ATPase H+ transporting accessory protein 2
chr22_-_881725 0.64 ENSDART00000035514
cept1b
choline/ethanolamine phosphotransferase 1b
chr5_+_59392183 0.63 ENSDART00000082983
ENSDART00000180882
clip2
CAP-GLY domain containing linker protein 2
chr22_+_17205608 0.62 ENSDART00000181267
rab3b
RAB3B, member RAS oncogene family
chr3_+_34919810 0.62 ENSDART00000055264
ca10b
carbonic anhydrase Xb
chr2_-_14390627 0.62 ENSDART00000172367
sgip1b
SH3-domain GRB2-like (endophilin) interacting protein 1b
chr6_-_12275836 0.62 ENSDART00000189980
pkp4
plakophilin 4
chr5_+_30624183 0.62 ENSDART00000141444
abcg4a
ATP-binding cassette, sub-family G (WHITE), member 4a
chr15_-_11683529 0.62 ENSDART00000161445
fkrp
fukutin related protein
chr12_+_2446837 0.61 ENSDART00000112032
ARHGAP22
si:dkey-191m6.4
chr17_-_12336987 0.61 ENSDART00000172001
snap25b
synaptosomal-associated protein, 25b
chr19_-_30524952 0.60 ENSDART00000103506
hpcal4
hippocalcin like 4
chr15_+_15856178 0.59 ENSDART00000080338
dusp14
dual specificity phosphatase 14
chr1_+_49266886 0.59 ENSDART00000137179
caly
calcyon neuron-specific vesicular protein
chr14_+_8940326 0.59 ENSDART00000159920
rps6kal
ribosomal protein S6 kinase a, like
chr16_-_35329803 0.59 ENSDART00000161729
ENSDART00000157700
ENSDART00000184584
ENSDART00000174713
ENSDART00000162518
ptprub
protein tyrosine phosphatase, receptor type, U, b
chr11_-_472547 0.57 ENSDART00000005923
zgc:77375
zgc:77375
chr22_+_5176693 0.56 ENSDART00000160927
cers1
ceramide synthase 1
chr10_+_15777064 0.56 ENSDART00000114483
apba1b
amyloid beta (A4) precursor protein-binding, family A, member 1b
chr12_+_47698356 0.55 ENSDART00000112010
lzts2b
leucine zipper, putative tumor suppressor 2b
chr3_+_13637383 0.54 ENSDART00000166000
si:ch211-194b1.1
si:ch211-194b1.1
chr1_+_52929185 0.54 ENSDART00000147683
inpp4b
inositol polyphosphate-4-phosphatase type II B
chr13_+_38430466 0.53 ENSDART00000132691
adgrb3
adhesion G protein-coupled receptor B3
chr21_+_1381276 0.53 ENSDART00000192907
TCF4
transcription factor 4
chr18_-_8857137 0.53 ENSDART00000126331
prrt4
proline-rich transmembrane protein 4
chr12_-_18393408 0.52 ENSDART00000159674
tom1l2
target of myb1 like 2 membrane trafficking protein
chr2_-_11258547 0.52 ENSDART00000165803
ENSDART00000193817
slc44a5a
solute carrier family 44, member 5a
chr16_+_12286148 0.52 ENSDART00000130736
si:dkey-26c10.5
si:dkey-26c10.5
chr8_+_49778486 0.52 ENSDART00000131732
ntrk2a
neurotrophic tyrosine kinase, receptor, type 2a
chr7_-_25895189 0.52 ENSDART00000173599
ENSDART00000079235
ENSDART00000173786
ENSDART00000173602
ENSDART00000079245
ENSDART00000187568
ENSDART00000173505
cd99l2
CD99 molecule-like 2
chr16_+_46111849 0.52 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr19_-_31402429 0.52 ENSDART00000137292
tmem106bb
transmembrane protein 106Bb
chr5_-_21970881 0.51 ENSDART00000182907
arhgef9a
Cdc42 guanine nucleotide exchange factor (GEF) 9a
chr23_+_4646194 0.51 ENSDART00000092344
LO017700.1

chr2_+_20332044 0.50 ENSDART00000112131
plppr4a
phospholipid phosphatase related 4a
chr17_+_31185276 0.50 ENSDART00000062887
disp2
dispatched homolog 2 (Drosophila)
chr1_-_38756870 0.50 ENSDART00000130324
ENSDART00000148404
gpm6ab
glycoprotein M6Ab
chr11_+_45323455 0.50 ENSDART00000189249
mafgb
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Gb
chr17_+_12813316 0.50 ENSDART00000155629
ralgapa1
Ral GTPase activating protein, alpha subunit 1 (catalytic)
chr17_-_21418340 0.49 ENSDART00000007021
atp6v1ba
ATPase, H+ transporting, lysosomal, V1 subunit B, member a
chr14_+_23717165 0.49 ENSDART00000006373
ndfip1
Nedd4 family interacting protein 1
chr2_-_11512819 0.49 ENSDART00000142013
penka
proenkephalin a
chr2_-_32558795 0.49 ENSDART00000140026
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr16_-_29437373 0.49 ENSDART00000148405
si:ch211-113g11.6
si:ch211-113g11.6
chr20_-_31808779 0.49 ENSDART00000133788
stxbp5a
syntaxin binding protein 5a (tomosyn)
chr4_+_12612145 0.48 ENSDART00000181201
lmo3
LIM domain only 3
chr15_-_33925851 0.48 ENSDART00000187807
ENSDART00000187780
mag
myelin associated glycoprotein
chr19_-_30510259 0.48 ENSDART00000135128
ENSDART00000186169
ENSDART00000182974
ENSDART00000187797
bag6l
BCL2 associated athanogene 6, like
chr8_-_1838315 0.46 ENSDART00000114476
ENSDART00000140077
pi4kab
phosphatidylinositol 4-kinase, catalytic, alpha b
chr22_+_5176255 0.46 ENSDART00000092647
cers1
ceramide synthase 1
chr15_-_22074315 0.46 ENSDART00000149830
drd2a
dopamine receptor D2a
chr9_+_52492639 0.46 ENSDART00000078939
march4
membrane-associated ring finger (C3HC4) 4
chr5_-_12219572 0.46 ENSDART00000167834
nos1
nitric oxide synthase 1 (neuronal)
chr3_-_60827402 0.45 ENSDART00000053494
anks4b
ankyrin repeat and sterile alpha motif domain containing 4B
chr3_+_45364849 0.45 ENSDART00000153974
ube2ia
ubiquitin-conjugating enzyme E2Ia
chr25_+_7784582 0.45 ENSDART00000155016
dgkzb
diacylglycerol kinase, zeta b
chr16_-_29458806 0.44 ENSDART00000047931
lingo4b
leucine rich repeat and Ig domain containing 4b
chr8_+_18624658 0.44 ENSDART00000089141
fsd1
fibronectin type III and SPRY domain containing 1
chr3_-_61099004 0.43 ENSDART00000112043
cacng4b
calcium channel, voltage-dependent, gamma subunit 4b
chr21_-_42100471 0.43 ENSDART00000166148
gabra1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr8_-_19649617 0.43 ENSDART00000189033
fam78bb
family with sequence similarity 78, member B b
chr15_-_35252522 0.43 ENSDART00000144153
ENSDART00000059195
mff
mitochondrial fission factor
chr20_+_19238382 0.42 ENSDART00000136757
fndc4a
fibronectin type III domain containing 4a
chr3_+_32443395 0.42 ENSDART00000188447
prr12b
proline rich 12b
chr24_-_1341543 0.42 ENSDART00000169341
nrp1a
neuropilin 1a
chr10_+_3049636 0.42 ENSDART00000081794
ENSDART00000183167
ENSDART00000191634
ENSDART00000183514
rasgrf2a
Ras protein-specific guanine nucleotide-releasing factor 2a
chr3_+_33341640 0.42 ENSDART00000186352
pyya
peptide YYa
chr16_+_35661331 0.41 ENSDART00000161725
map7d1a
MAP7 domain containing 1a
chr20_-_9436521 0.41 ENSDART00000133000
zgc:101840
zgc:101840
chr7_-_24699985 0.41 ENSDART00000052802
calb2b
calbindin 2b
chr20_+_27020201 0.41 ENSDART00000126919
ENSDART00000016014
chga
chromogranin A
chr18_-_1185772 0.41 ENSDART00000143245
nptnb
neuroplastin b
chr1_+_7517454 0.40 ENSDART00000016139
lancl1
LanC antibiotic synthetase component C-like 1 (bacterial)
chr10_+_42690374 0.40 ENSDART00000123496
rhobtb2b
Rho-related BTB domain containing 2b
chr3_+_56366395 0.40 ENSDART00000154367
cacng5b
calcium channel, voltage-dependent, gamma subunit 5b
chr20_+_34933183 0.40 ENSDART00000062738
snap25a
synaptosomal-associated protein, 25a
chr20_+_26349002 0.40 ENSDART00000152842
syne1a
spectrin repeat containing, nuclear envelope 1a
chr3_+_13842554 0.40 ENSDART00000162317
ENSDART00000158068
ilf3b
interleukin enhancer binding factor 3b
chr13_+_15838151 0.39 ENSDART00000008987
klc1a
kinesin light chain 1a
chr18_+_1154189 0.39 ENSDART00000135090
si:ch1073-75f15.2
si:ch1073-75f15.2
chr6_-_40352215 0.39 ENSDART00000103992
ttll3
tubulin tyrosine ligase-like family, member 3
chr10_+_42423318 0.39 ENSDART00000134282
npy8ar
neuropeptide Y receptor Y8a
chr16_+_20161805 0.38 ENSDART00000192146
c16h2orf66
chromosome 16 C2orf66 homolog
chr11_+_30057762 0.38 ENSDART00000164139
nhsb
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr8_+_29986265 0.38 ENSDART00000148258
ptch1
patched 1
chr4_+_4849789 0.38 ENSDART00000130818
ENSDART00000127751
ptprz1b
protein tyrosine phosphatase, receptor-type, Z polypeptide 1b
chr10_+_15255012 0.37 ENSDART00000023766
vldlr
very low density lipoprotein receptor
chr14_-_34044369 0.37 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cyfip2
cytoplasmic FMR1 interacting protein 2
chr2_+_366429 0.37 ENSDART00000111746
si:dkey-33c14.6
si:dkey-33c14.6
chr25_-_19224298 0.37 ENSDART00000149917
acanb
aggrecan b
chr23_-_35790235 0.37 ENSDART00000142369
ENSDART00000141141
ENSDART00000011004
mfsd5
major facilitator superfamily domain containing 5
chr18_+_38908903 0.37 ENSDART00000159834
myo5aa
myosin VAa
chr8_+_52503340 0.36 ENSDART00000168838
si:ch1073-392o20.1
si:ch1073-392o20.1
chr3_-_23406964 0.36 ENSDART00000114723
rapgefl1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr4_+_12612723 0.36 ENSDART00000133767
lmo3
LIM domain only 3
chr23_-_14990865 0.36 ENSDART00000147799
ndrg3b
ndrg family member 3b
chr17_-_28198099 0.36 ENSDART00000156143
htr1d
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
chr24_-_5786759 0.36 ENSDART00000152069
chst2b
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2b
chr24_-_11057305 0.36 ENSDART00000186494
asap1b
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b
chr20_+_52442870 0.36 ENSDART00000163100
arhgap39
Rho GTPase activating protein 39
chr24_+_10310577 0.36 ENSDART00000141718
otulina
OTU deubiquitinase with linear linkage specificity a
chr5_-_62925282 0.36 ENSDART00000188048
specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr1_-_44701313 0.35 ENSDART00000193926
si:dkey-28b4.8
si:dkey-28b4.8
chr25_+_16116740 0.35 ENSDART00000139778
far1
fatty acyl CoA reductase 1
chr20_-_5052786 0.35 ENSDART00000138818
ENSDART00000181655
ENSDART00000164274
arid1b
AT rich interactive domain 1B (SWI1-like)
chr3_-_61065055 0.35 ENSDART00000074199
cacng1b
calcium channel, voltage-dependent, gamma subunit 1b
chr8_+_49778756 0.35 ENSDART00000083790
ntrk2a
neurotrophic tyrosine kinase, receptor, type 2a
chr20_+_27087539 0.35 ENSDART00000062094
tmem251
transmembrane protein 251
chr8_-_49908978 0.35 ENSDART00000172642
agtpbp1
ATP/GTP binding protein 1
chr18_+_10884996 0.34 ENSDART00000147613
mical3a
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr3_-_46811611 0.34 ENSDART00000134092
elavl3
ELAV like neuron-specific RNA binding protein 3
chr1_+_33668236 0.34 ENSDART00000122316
ENSDART00000102184
arl13b
ADP-ribosylation factor-like 13b
chr8_+_22930627 0.34 ENSDART00000187860
sypa
synaptophysin a
chr20_+_35382482 0.34 ENSDART00000135284
vsnl1a
visinin-like 1a
chr20_-_53321499 0.33 ENSDART00000179894
ENSDART00000127427
ENSDART00000084952
wasf1
WAS protein family, member 1
chr20_+_53181017 0.33 ENSDART00000189692
ENSDART00000177109
FIG4
FIG4 phosphoinositide 5-phosphatase
chr25_+_18889332 0.33 ENSDART00000017043
cax2
cation/H+ exchanger protein 2
chr20_-_47188966 0.33 ENSDART00000152965
si:dkeyp-104f11.9
si:dkeyp-104f11.9
chr20_-_45060241 0.33 ENSDART00000185227
klhl29
kelch-like family member 29
chr2_-_31302615 0.33 ENSDART00000034784
ENSDART00000060812
adcyap1b
adenylate cyclase activating polypeptide 1b
chr20_-_32110882 0.33 ENSDART00000030324
grm1a
glutamate receptor, metabotropic 1a
chr1_-_23157583 0.33 ENSDART00000144208
adgrl3.1
adhesion G protein-coupled receptor L3.1
chr18_+_24921587 0.32 ENSDART00000191345
rgma
repulsive guidance molecule family member a
chr18_-_2433011 0.32 ENSDART00000181922
ENSDART00000193276
CR769778.1

chr17_+_23298928 0.32 ENSDART00000153652
zgc:165461
zgc:165461
chr17_-_21162821 0.32 ENSDART00000157283
abhd12
abhydrolase domain containing 12
chr14_-_30587814 0.32 ENSDART00000144912
ENSDART00000149714
tmem265
transmembrane protein 265
chr19_-_20430892 0.32 ENSDART00000111409
tbc1d5
TBC1 domain family, member 5

Network of associatons between targets according to the STRING database.

First level regulatory network of en1b_en2a+en2b_gbx1_emx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.1 GO:0061075 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.3 1.4 GO:0071926 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.3 1.6 GO:0002159 desmosome assembly(GO:0002159)
0.3 0.9 GO:0099538 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.3 1.1 GO:0015677 copper ion import(GO:0015677)
0.2 1.0 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.2 0.7 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.2 0.7 GO:0045938 positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.2 0.8 GO:0016322 neuron remodeling(GO:0016322)
0.2 0.5 GO:0098917 retrograde trans-synaptic signaling(GO:0098917)
0.2 1.5 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.1 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.4 GO:0021519 optic cup formation involved in camera-type eye development(GO:0003408) spinal cord association neuron specification(GO:0021519)
0.1 1.8 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.4 GO:0002792 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.1 0.6 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.1 0.5 GO:0060074 synapse maturation(GO:0060074)
0.1 0.6 GO:0042772 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.1 0.1 GO:0001659 temperature homeostasis(GO:0001659)
0.1 0.3 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500) protein localization to ciliary membrane(GO:1903441)
0.1 0.4 GO:1900271 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.1 0.5 GO:0060055 angiogenesis involved in wound healing(GO:0060055)
0.1 0.3 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.1 0.7 GO:2001286 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1 0.8 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.3 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 1.3 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 0.4 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.3 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.1 1.2 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 1.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.2 GO:0007414 axonal defasciculation(GO:0007414)
0.1 1.5 GO:0071436 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 0.2 GO:0090219 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.1 0.9 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.5 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 0.4 GO:1902514 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.1 0.5 GO:0051013 microtubule severing(GO:0051013)
0.1 0.2 GO:0097378 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.1 0.3 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 1.2 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.3 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 0.3 GO:0046462 phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.1 0.6 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.1 0.3 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.1 1.2 GO:0050796 regulation of insulin secretion(GO:0050796)
0.1 0.2 GO:0021742 abducens nucleus development(GO:0021742)
0.1 0.2 GO:0039015 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.1 0.4 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.4 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.1 0.3 GO:0035627 ceramide transport(GO:0035627)
0.1 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.5 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 0.8 GO:0051481 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.3 GO:0015744 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.1 0.2 GO:2000434 regulation of protein neddylation(GO:2000434)
0.0 0.2 GO:0071543 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.8 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.0 0.2 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.0 0.9 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 1.1 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.2 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 0.5 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 1.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.0 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 0.6 GO:0035336 long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.0 1.1 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.4 GO:0050795 regulation of behavior(GO:0050795)
0.0 0.4 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.2 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.3 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.0 0.3 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.2 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.1 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.1 GO:0014814 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.0 1.2 GO:0046847 filopodium assembly(GO:0046847)
0.0 1.8 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.3 GO:0006543 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.0 0.2 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.5 GO:0032418 lysosome localization(GO:0032418)
0.0 0.9 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.2 GO:0090104 pancreatic D cell differentiation(GO:0003311) pancreatic epsilon cell differentiation(GO:0090104)
0.0 0.2 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 2.2 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 0.7 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.0 0.1 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.0 0.3 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.3 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.4 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.1 GO:0042832 response to protozoan(GO:0001562) defense response to protozoan(GO:0042832)
0.0 0.5 GO:0050708 regulation of protein secretion(GO:0050708)
0.0 0.1 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.4 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.1 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.0 0.2 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.0 0.6 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.2 GO:0050820 positive regulation of blood coagulation(GO:0030194) positive regulation of coagulation(GO:0050820) positive regulation of hemostasis(GO:1900048)
0.0 0.3 GO:0045842 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 0.1 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.0 0.5 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 1.4 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.3 GO:0001964 startle response(GO:0001964)
0.0 0.1 GO:0090148 membrane fission(GO:0090148)
0.0 0.1 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.0 0.2 GO:0071467 cellular response to pH(GO:0071467)
0.0 0.3 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.7 GO:1903322 positive regulation of protein modification by small protein conjugation or removal(GO:1903322)
0.0 0.4 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.9 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.3 GO:0048923 posterior lateral line neuromast hair cell differentiation(GO:0048923)
0.0 0.2 GO:2000650 negative regulation of sodium ion transmembrane transport(GO:1902306) negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.0 0.1 GO:0035994 response to muscle stretch(GO:0035994)
0.0 0.1 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.0 1.5 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 0.5 GO:0007631 feeding behavior(GO:0007631)
0.0 0.1 GO:1900182 positive regulation of protein localization to nucleus(GO:1900182) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.0 0.2 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.0 0.7 GO:0036269 swimming behavior(GO:0036269)
0.0 0.2 GO:0098900 regulation of action potential(GO:0098900)
0.0 0.2 GO:0003428 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.0 0.0 GO:0042364 water-soluble vitamin biosynthetic process(GO:0042364)
0.0 0.2 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.1 GO:0072592 oxygen metabolic process(GO:0072592) regulation of oxygen metabolic process(GO:2000374) positive regulation of oxygen metabolic process(GO:2000376)
0.0 1.6 GO:0010506 regulation of autophagy(GO:0010506)
0.0 0.1 GO:0097032 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.6 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:1901825 tetraterpenoid metabolic process(GO:0016108) tetraterpenoid biosynthetic process(GO:0016109) carotenoid metabolic process(GO:0016116) carotenoid biosynthetic process(GO:0016117) xanthophyll metabolic process(GO:0016122) xanthophyll biosynthetic process(GO:0016123) zeaxanthin metabolic process(GO:1901825) zeaxanthin biosynthetic process(GO:1901827)
0.0 0.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.2 GO:0030073 insulin secretion(GO:0030073)
0.0 0.1 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:1903828 negative regulation of cellular protein localization(GO:1903828)
0.0 0.1 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.0 0.8 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.2 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.1 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.0 0.1 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.1 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.0 0.0 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.2 GO:0045471 response to ethanol(GO:0045471)
0.0 0.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.0 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.6 GO:0046474 glycerophospholipid biosynthetic process(GO:0046474)
0.0 0.0 GO:0061182 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.0 1.2 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.6 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.2 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 1.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.1 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.5 GO:0007586 digestion(GO:0007586)
0.0 0.0 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.0 0.1 GO:0036372 opsin transport(GO:0036372)
0.0 0.1 GO:0060114 vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.0 0.2 GO:0099633 protein localization to postsynaptic specialization membrane(GO:0099633) neurotransmitter receptor localization to postsynaptic specialization membrane(GO:0099645)
0.0 0.0 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.0 0.3 GO:0007379 somite specification(GO:0001757) segment specification(GO:0007379)
0.0 0.9 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 0.2 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 0.0 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 1.9 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.3 GO:0035305 negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.0 0.7 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.1 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.1 GO:0010043 response to zinc ion(GO:0010043)
0.0 0.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.2 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.4 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.5 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.1 GO:0001881 receptor recycling(GO:0001881)
0.0 0.2 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.0 0.1 GO:0021576 hindbrain formation(GO:0021576)
0.0 0.1 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.1 GO:0055017 cardiac muscle tissue growth(GO:0055017) cardiac muscle cell proliferation(GO:0060038)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.2 1.3 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.2 1.2 GO:0005955 calcineurin complex(GO:0005955)
0.2 0.8 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.2 1.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.2 1.5 GO:0098982 GABA-ergic synapse(GO:0098982)
0.1 0.7 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.8 GO:0043083 synaptic cleft(GO:0043083)
0.1 1.3 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.7 GO:0031209 SCAR complex(GO:0031209)
0.1 1.2 GO:1990246 uniplex complex(GO:1990246)
0.1 0.6 GO:0071818 BAT3 complex(GO:0071818)
0.1 1.4 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.4 GO:0042583 chromaffin granule(GO:0042583)
0.1 1.0 GO:0034361 very-low-density lipoprotein particle(GO:0034361)
0.1 0.7 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 1.2 GO:0030057 desmosome(GO:0030057)
0.1 0.2 GO:0097189 apoptotic body(GO:0097189)
0.1 1.0 GO:0030667 secretory granule membrane(GO:0030667)
0.1 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.2 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.0 0.9 GO:0043209 myelin sheath(GO:0043209)
0.0 0.4 GO:0035060 brahma complex(GO:0035060)
0.0 0.2 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 1.0 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.3 GO:0071797 LUBAC complex(GO:0071797)
0.0 2.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.3 GO:0016586 RSC complex(GO:0016586)
0.0 2.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.9 GO:0043679 axon terminus(GO:0043679)
0.0 0.5 GO:0043204 perikaryon(GO:0043204)
0.0 0.3 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 3.9 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.2 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.7 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 2.7 GO:0030424 axon(GO:0030424)
0.0 0.5 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.1 GO:0070724 BMP receptor complex(GO:0070724)
0.0 0.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.2 GO:0032021 NELF complex(GO:0032021)
0.0 0.1 GO:0005879 axonemal microtubule(GO:0005879)
0.0 0.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.1 GO:0035517 PR-DUB complex(GO:0035517)
0.0 1.2 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 9.2 GO:0045202 synapse(GO:0045202)
0.0 0.1 GO:0032426 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142) stereocilium tip(GO:0032426)
0.0 0.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.2 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0038046 enkephalin receptor activity(GO:0038046)
0.3 0.9 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.3 1.1 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.3 1.0 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.2 1.1 GO:0031841 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.2 1.2 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 0.9 GO:0004307 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.2 1.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 0.7 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.2 0.5 GO:0070738 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.2 0.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.5 GO:0016521 pituitary adenylate cyclase activating polypeptide activity(GO:0016521)
0.1 1.8 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 1.2 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.5 GO:0050699 WW domain binding(GO:0050699)
0.1 1.1 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 0.3 GO:0035620 ceramide transporter activity(GO:0035620) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.1 0.8 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.4 GO:0097108 hedgehog family protein binding(GO:0097108)
0.1 2.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 1.5 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.1 0.6 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 1.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.5 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 1.4 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.3 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.1 0.5 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.5 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 0.5 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.1 0.9 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.3 GO:0043295 glutathione binding(GO:0043295)
0.1 0.3 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 2.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.8 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 0.3 GO:0015140 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.1 0.7 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.2 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.6 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.2 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.0 1.6 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.4 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.3 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 0.1 GO:0031716 calcitonin receptor binding(GO:0031716)
0.0 0.5 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 1.8 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 1.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0051139 calcium:proton antiporter activity(GO:0015369) metal ion:proton antiporter activity(GO:0051139)
0.0 1.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.3 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 1.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 3.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.5 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.1 GO:0019777 Atg12 transferase activity(GO:0019777)
0.0 0.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.1 GO:0080132 fatty acid alpha-hydroxylase activity(GO:0080132)
0.0 0.5 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.3 GO:0004359 glutaminase activity(GO:0004359)
0.0 1.1 GO:0019003 GDP binding(GO:0019003)
0.0 0.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.5 GO:0045159 myosin II binding(GO:0045159)
0.0 0.1 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.0 0.3 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.5 GO:0033691 sialic acid binding(GO:0033691)
0.0 1.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.6 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.1 GO:0004061 arylformamidase activity(GO:0004061)
0.0 0.1 GO:0022889 serine transmembrane transporter activity(GO:0022889)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 1.2 GO:0044325 ion channel binding(GO:0044325)
0.0 0.1 GO:0004408 holocytochrome-c synthase activity(GO:0004408)
0.0 0.2 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.7 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.4 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.1 GO:0016415 octanoyltransferase activity(GO:0016415)
0.0 0.2 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.2 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.5 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0052885 retinol isomerase activity(GO:0050251) all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity(GO:0052885)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.3 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.2 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.2 GO:0035925 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.3 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.0 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.2 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0035804 structural constituent of egg coat(GO:0035804)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.0 GO:0031005 filamin binding(GO:0031005)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 0.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.0 PID REELIN PATHWAY Reelin signaling pathway
0.0 1.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.0 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.9 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.8 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.8 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.2 PID ARF 3PATHWAY Arf1 pathway
0.0 0.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 0.9 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 1.5 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 1.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 1.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 0.4 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 1.0 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 0.9 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 1.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME PEPTIDE HORMONE BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.2 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.2 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.5 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.4 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.2 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.3 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors